Review
Biochemistry & Molecular Biology
Monika Zaborek-Lyczba, Jakub Lyczba, Paulina Mertowska, Sebastian Mertowski, Anna Hymos, Martyna Podgajna, Paulina Niedzwiedzka-Rystwej, Ewelina Grywalska
Summary: HLA-G, a non-classical MHC class I molecule, has been studied for its relevance in pathological conditions like autoimmune diseases. Current research aims to utilize HLA-G in clinical practice for diagnostics and therapeutic purposes, as it is known for its immunomodulatory role in reducing inflammation and immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Karthik Dhatchinamoorthy, Jeff D. Colbert, Kenneth L. Rock
Summary: Loss of MHC I antigen presentation is common in many cancers, which may impair immune responses and affect the efficacy of immunotherapy. Studies have discussed underlying mechanisms through which some cancers evade immune killing by shutting down the MHC I pathway, and proposed potential strategies to overcome this limitation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Uxia Gestal-Mato, Lina Herhaus
Summary: The major histocompatibility complex (MHC) class I presents peptide antigens to CD8+ T lymphocytes to trigger immune response. Besides the conventional antigen-processing pathway, autophagy also plays a role in MHC-I peptide loading and presentation. This review article explores the involvement of autophagy in MHC class I-restricted antigen presentation and its potential implications in T cell immunotherapies.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Jing Yu, Xi Wu, Jinen Song, Yujie Zhao, Huifang Li, Min Luo, Xiaowei Liu
Summary: Acquired drug resistance during MAPK-targeted therapy leads to loss of MHC-I antigen presentation on tumor cells, resulting in reduced T cell infiltration, which is associated with poorer clinical response and prognosis of anti-PD-1 therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Xi-Yang Tang, Zhong-Lin Luo, Yan-Lu Xiong, Jie Yang, An-Ping Shi, Kai-Fu Zheng, Yu-Jian Liu, Chen Shu, Nan Ma, Qiang Lu, Jin-Bo Zhao
Summary: Cancer is a serious health problem, and immunotherapy has become a major method for tumor treatment. However, there are challenges in this method, and more therapeutic targets and strategies are needed. This review focuses on the proliferative role of 15 immune checkpoints in tumors, providing a clearer understanding of their functions and mechanisms in tumor immunotherapy.
Review
Immunology
Anissa Guillemin, Anuj Kumar, Melanie Wencker, Emiliano P. Ricci
Summary: Innate immunity is the first line of defense against infections and tissue damage, and it relies on a dynamic and coordinated gene expression program. Transcriptional and post-transcriptional regulatory pathways, involving RNA-binding proteins and other effectors, play crucial roles in shaping the innate immune response. Recently, microRNAs and post-transcriptional modification of RNA bases have also emerged as essential players in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Benjamin Alexander Albert, Yunxiao Yang, Xiaoshan M. M. Shao, Dipika Singh, Kellie N. N. Smith, Valsamo Anagnostou, Rachel Karchin
Summary: Researchers propose a method based on long short-term memory ensembles and transfer learning to predict effective neoepitopes that elicit an immune response. This method can help address the challenge of predicting immunogenicity of neoepitopes in developing personalized cancer vaccines. Compared to other state-of-the-art classifiers, this method significantly improves the prediction of epitope presentation.
NATURE MACHINE INTELLIGENCE
(2023)
Article
Multidisciplinary Sciences
Lauren E. Stopfer, Nicholas J. Rettko, Owen Leddy, Joshua M. Mesfin, Eric Brown, Shannon Winski, Bryan Bryson, James A. Wells, Forest M. White
Summary: Combining multiple therapeutic strategies may improve survival benefits for NRAS/BRAF mutant melanoma patients. This study utilized immunopeptidomics to measure the impact of MEK inhibition on anti-tumor immunity and identified enhanced expression of specific tumor antigens following therapy. Targeting these upregulated tumor antigens can enhance cell killing.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Lousineh Arakelian, Julien Lion, Guillaume Churlaud, Rezlene Bargui, Briac Thierry, Evelyne Mutabazi, Patrick Bruneval, Antonio Jose Alberdi, Christelle Doliger, Maeva Veyssiere, Jerome Larghero, Nuala Mooney
Summary: Endothelial cells play crucial roles in blood transport, vessel homeostasis, inflammatory responses, transendothelial migration, and blood vessel formation. CD34 is commonly used as an endothelial marker, but its expression and function vary in different organs and pathological conditions. This study investigates the expression and function of CD34 in endothelial cells, revealing that CD34(high) cells have lower proliferation but higher expression of IL-33 and Angiopoietin 2 compared to CD34(low) cells. CD34(high) endothelial cells also enhance the proliferation of regulatory T lymphocytes, suggesting their immunogenic ability and potential role in tolerogenic response.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Hongjuan Zhao, Yatong Li, Beibei Zhao, Cuixia Zheng, Mengya Niu, Qingling Song, Xinxin Liu, Qianhua Feng, Zhenzhong Zhang, Lei Wang
Summary: The physical properties of nanoparticle-based vaccines, such as their shape, play a crucial role in antigen capture, lymphatic delivery, antigen presentation, and immune response in lymph nodes. Star-shaped gold nanoparticles (AuNPs) were found to capture and retain more repetitive antigen epitopes. Rods and star-shaped nanovaccines primarily drained into the lymph node follicles region, while cage-shaped nanovaccines showed stronger paracortex retention. Surprisingly, star-shaped nanovaccines elicited potent humoral immunity, preventing tumor growth in prophylactic studies. Cage-shaped nanovaccines preferentially presented peptide-MHC I complexes and showed the strongest therapeutic efficacy when combined with PD-1 checkpoint inhibitors in established tumor studies.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Engineering, Biomedical
Shupei Tang, Lan Zhou, Haiyang He, Liwei Cui, Zhicheng Ren, Yuhang Tai, Zhunyi Xie, Yi Cao, Dongwei Meng, Qiuli Liu, Yuzhang Wu, Jun Jiang, Xinyuan Zhou
Summary: This study developed a novel cancer vaccine that effectively enhances the immune response against tumor cells in the tumor microenvironment. The vaccine activates immune cells, boosts the production of tumor-specific T cells and pro-inflammatory cytokines, and suppresses tumor growth and metastasis.
Review
Biochemistry & Molecular Biology
Alicia Asin, Fayna Garcia-Martin, Jesus Hector Busto, Alberto Avenoza, Jesus Manuel Peregrina, Francisco Corzana
Summary: Immunotherapy, especially using MUC1 glycopeptides as vaccine candidates, has shown promising results in cancer treatment. In this study, the researchers designed three vaccines based on MUC1 glycopeptides with unnatural elements in their structure. The vaccines were found to elicit strong immune responses in mice and produce antibodies that can recognize human cancer cells. The study suggests that effective MUC1-based vaccines should mimic the conformational space of aberrantly glycosylated MUC1 glycopeptides found in tumors.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Microbiology
Giraldina Trevejo-Nunez, Becky Lin, Li Fan, Felix E. Y. Aggor, Partha S. Biswas, Kong Chen, Sarah L. Gaffen
Summary: Excessive inflammation can cause tissue damage and autoimmunity. Reg1 deficiency exacerbates autoimmune diseases but confers resistance to Klebsiella pneumoniae (KP) by affecting type I interferon regulation.
Review
Oncology
Anoop Kallingal, Mateusz Olszewski, Natalia Maciejewska, Wioletta Brankiewicz, Maciej Baginski
Summary: The mechanisms of antigen processing and presentation are important for the immune system's recognition and targeting of cancer cells. Cancer cells evade the immune system by downregulating or losing antigen recognition proteins, creating an immunosuppressive environment and altering antigen processing abilities. Understanding these mechanisms can aid in cancer diagnosis and treatment. Manipulating the epigenetic landscape of cancer cells can also suppress the immune response against cancer and improve the efficacy of immunotherapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Lei Zhan, Junhui Zhang, Jing Zhang, Xiaojing Liu, Suding Zhu, Yuchuan Shi, Yu He, Wenyan Wang, Yijing Wei, Zhenhai Tang, Guo Chen, Bing Wei, Yunxia Cao
Summary: In this study, the researchers found that upregulated autophagy and decreased expression of MHC-I and NLRC5 were associated with endometrial cancer (EC). Inhibition of autophagy was found to suppress MHC-I gene expression. They also discovered that LC3 interacted with NLRC5 to inhibit the NLRC5-mediated MHC-I antigen presentation pathway. These findings suggest that inhibiting LC3 and promoting NLRC5 may be a promising immunotherapy strategy for EC management.
Meeting Abstract
Gastroenterology & Hepatology
C. Strisciuglio, S. Vitale, L. Pisapia, E. Miele, P. Barba, A. Vitale, S. Cenni, G. Del Pozzo, R. Troncone, A. Staiano, C. Gianfrani
DIGESTIVE AND LIVER DISEASE
(2015)
Article
Immunology
Laura Pisapia, Alessandra Camarca, Stefania Picascia, Virginia Bassi, Pasquale Barba, Giovanna Del Pozzo, Carmen Gianfrani
JOURNAL OF AUTOIMMUNITY
(2016)
Editorial Material
Immunology
Carmen Gianfrani, Laura Pisapia, Stefania Picascia, Maria Strazzullo, Giovanna Del Pozzo
JOURNAL OF AUTOIMMUNITY
(2018)
Article
Multidisciplinary Sciences
Serena Vitale, Caterina Strisciuglio, Laura Pisapia, Erasmo Miele, Pasquale Barba, Alessandra Vitale, Sabrina Cenni, Virginia Bassi, Mariantonia Maglio, Giovanna Del Pozzo, Riccardo Troncone, Annamaria Staiano, Carmen Gianfrani
Article
Genetics & Heredity
Laura Pisapia, Ilaria Cerillo, Federica Farina, Arianna Zimbardo, Pasquale Barba, Giuseppe Orefice, Carmen Gianfrani, Maria Strazzullo, Giovanna Del Pozzo
INTERNATIONAL JOURNAL OF IMMUNOGENETICS
(2019)
Article
Cell Biology
Federica Farina, Stefania Picascia, Laura Pisapia, Pasquale Barba, Serena Vitale, Adriana Franzese, Enza Mozzillo, Carmen Gianfrani, Giovanna G. Del Pozzo
Article
Cell Biology
Laura Pisapia, Russell S. Hamilton, Federica Farina, Vito D'Agostino, Pasquale Barba, Maria Strazzullo, Alessandro Provenzani, Carmen Gianfrani, Giovanna Del Pozzo
Article
Multidisciplinary Sciences
Laura Pisapia, Stefania Picascia, Federica Farina, Pasquale Barba, Carmen Gianfrani, Giovanna Del Pozzo
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Federica Farina, Laura Pisapia, Mariavittoria Laezza, Gloria Serena, Antonio Rispo, Simona Ricciolino, Carmen Gianfrani, Alessio Fasano, Giovanna Del Pozzo
Summary: Macrophages play a crucial role in the development of celiac disease by expressing CD-associated HLA-DQ2.5 risk alleles differently from other antigen-presenting cells. Gliadin stimulation increases the expression of DQA1*05:01 and decreases the expression of DQB1*02:01 in macrophages, along with downregulation of DRB1 genes and CIITA transactivator.
Article
Virology
Andrea Del Mastro, Stefania Picascia, Luciana D'Apice, Maria Trovato, Pasquale Barba, Immacolata Di Biase, Sebastiano Di Biase, Marco Laccetti, Antonello Belli, Gerardino Amato, Potito Di Muro, Olga Credendino, Alessandra Picardi, Piergiuseppe De Berardinis, Giovanna Del Pozzo, Carmen Gianfrani
Summary: Kidney transplanted recipients (KTR) are at high risk of severe SARS-CoV-2 infection due to immunosuppressive therapy. Studies analyzed the immune response in KTR and healthy controls after the second and third dose of the mRNA vaccine. The third dose increased neutralizing antibody titers in both groups, but KTR had lower levels and showed low immunity to Omicron variant.
Review
Pediatrics
Giovanna Del Pozzo, Federica Farina, Stefania Picascia, Mariavittoria Laezza, Serena Vitale, Carmen Gianfrani
Summary: Celiac disease (CeD) is a chronic immune-mediated enteropathy caused by dietary gluten and the main predisposing factor is HLA class II heterodimers. In addition to genetic factors, environmental agents play a role in CeD risk. Personalized medical approaches are essential for early diagnosis and defining genotype-guided therapeutic strategies.
PEDIATRIC RESEARCH
(2021)
Article
Biology
Laura Pisapia, Sara Terreri, Pasquale Barba, Marianna Mastroianni, Maria Donnini, Vincenzo Mercadante, Alessandro Palmieri, Paolo Verze, Vincenzo Mirone, Vincenzo Altieri, Gianluigi Califano, Giovanna Lucia Liguori, Maria Strazzullo, Amelia Cimmino, Giovanna Del Pozzo
Meeting Abstract
Gastroenterology & Hepatology
C. Strisciuglio, S. Vitale, L. Pisapia, E. Miele, P. Barba, A. Vitale, S. Cenni, G. Del Pozzo, R. Troncone, A. Staiano, C. Gianfrani
JOURNAL OF CROHNS & COLITIS
(2016)