Profiling of Substrates for Zinc-dependent Lysine Deacylase Enzymes: HDAC3 Exhibits Decrotonylase Activity In Vitro

Expansion of the Lysine Acylation Landscape

(2012) Christian A. Olsen   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific Incorporation of ε-N-Crotonyllysine into Histones

(2012) Chan Hyuk Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Substrates for Efficient Fluorometric Screening Employing the NAD-Dependent Sirtuin 5 Lysine Deacylase (KDAC) Enzyme

(2012) Andreas S. Madsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Discovery of HDAC Inhibitors That Lack an Active Site Zn2+-Binding Functional Group

(2012) Chris J. Vickers et al.   ACS Medicinal Chemistry Letters

A Novel Class of Small Molecule Inhibitors of HDAC6

(2011) Elizabeth S. Inks et al.   ACS Chemical Biology

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

Old Enzymes, New Tricks: Sirtuins Are NAD+-Dependent De-acylases

(2011) Matthew D. Hirschey   Cell Metabolism

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

Epigenetic suppression of GAD65 expression mediates persistent pain

(2011) Zhi Zhang et al.   NATURE MEDICINE

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides That Restore Trafficking and Activity of ΔF508-CFTR

(2011) Darren M. Hutt et al.   ACS Medicinal Chemistry Letters

Peptide Arrays Identify Isoform-Selective Substrates for Profiling Endogenous Lysine Deacetylase Activity

(2010) Zachary A. Gurard-Levin et al.   ACS Chemical Biology

SIRT3 Substrate Specificity Determined by Peptide Arrays and Machine Learning

(2010) Brian C. Smith et al.   ACS Chemical Biology

Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity

(2010) Luciana Auzzas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

(2010) Kyle V. Butler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical phylogenetics of histone deacetylases

(2010) James E Bradner et al.   Nature Chemical Biology

Combinatorial profiling of chromatin binding modules reveals multisite discrimination

(2010) Adam L Garske et al.   Nature Chemical Biology

Identification of lysine succinylation as a new post-translational modification

(2010) Zhihong Zhang et al.   Nature Chemical Biology

Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin

(2010) Daniel M. Fass et al.   ACS Medicinal Chemistry Letters

Vorinostat-Like Molecules as Structural, Stereochemical, and Pharmacological Tools

(2010) Stephen Hanessian et al.   ACS Medicinal Chemistry Letters

Probing the Bioactive Conformation of an Archetypal Natural Product HDAC Inhibitor with Conformationally Homogeneous Triazole-Modified Cyclic Tetrapeptides

(2009) W. Seth Horne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Probes Identify a Role for Histone Deacetylase 3 in Friedreich's Ataxia Gene Silencing

(2009) Chunping Xu et al.   CHEMISTRY & BIOLOGY

Discovery of Potent and Selective Histone Deacetylase Inhibitors via Focused Combinatorial Libraries of Cyclic α3β-Tetrapeptides

(2009) Christian A. Olsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, Biological Evaluation, and Structural Characterization of Potent Histone Deacetylase Inhibitors Based on Cyclic α/β-Tetrapeptide Architectures

(2009) Ana Montero et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

(2009) Darren M Hutt et al.   Nature Chemical Biology

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

The Activity of HDAC8 Depends on Local and Distal Sequences of Its Peptide Substrates†

(2008) Zachary A. Gurard-Levin et al.   BIOCHEMISTRY

Pimelic Diphenylamide 106 Is a Slow, Tight-binding Inhibitor of Class I Histone Deacetylases

(2008) C. James Chou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase Inhibitors: From Bench to Clinic

(2008) Marielle Paris et al.   JOURNAL OF MEDICINAL CHEMISTRY

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

(2008) Aleksey G. Kazantsev et al.   NATURE REVIEWS DRUG DISCOVERY

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS