Article
Oncology
Xing Huang, Feng Zhao, Quan Wu, Zitong Wang, Haiyue Ren, Qiqi Zhang, Zhe Wang, Jin Xu
Summary: For patients with pancreatic cancer, KIF2C is abnormally expressed and affects the prognosis. KIF2C promotes the proliferation, invasion, and metastasis of pancreatic cancer. The overexpression of KIF2C has potential therapeutic implications for pancreatic ductal adenocarcinoma (PDAC).
Article
Multidisciplinary Sciences
Yuexiang Liang, Jingli Cui, Fanghui Ding, Yiping Zou, Hanhan Guo, Quan Man, Shaofei Chang, Song Gao, Jihui Hao
Summary: The current TNM staging system for pancreatic ductal adenocarcinoma (PDAC) has shown inconsistent results in validating the revised definitions of T and N categories and stage groups. Thus, a new staging system incorporating various factors is proposed to improve the accuracy of prognosis assessment. This proposed staging system demonstrates superior prognostic performance compared to the TNM staging system, effectively stratifying survival and addressing the limitations of TNM staging in prognostication.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yun Bian, Zhilin Zheng, Xu Fang, Hui Jiang, Mengmeng Zhu, Jieyu Yu, Haiyan Zhao, Ling Zhang, Jiawen Yao, Le Lu, Jianping Lu, Chengwei Shao
Summary: In this study, an automated preoperative artificial intelligence algorithm was developed and validated for the segmentation of tumor and lymph nodes in patients with pancreatic ductal adenocarcinoma (PDAC) using CT imaging. The performance of the algorithm was compared to radiologists and clinical models, and it was found that the AI model outperformed the other models in predicting lymph node metastasis. The AI model-predicted positive LN metastasis was also associated with worse survival.
Article
Multidisciplinary Sciences
Mengyuan Xu, Lei Fang, Xin Guo, Henan Qin, Rui Sun, Zhen Ning, Aman Wang
Summary: The study revealed that RIOK3 promotes invasion and metastasis of pancreatic ductal adenocarcinoma (PDAC) by modulating focal adhesion kinase (FAK) protein expression and phosphorylation, providing a potential new therapeutic target for PDAC treatment. Additionally, RIOK3-related genes were found to be upregulated in PDAC patients and associated with poor prognosis.
Article
Biochemistry & Molecular Biology
Yanfen Lian, Dongxiao Jiang, Jiangtao Sun
Summary: The study found that miR-33a-5p expression is significantly decreased in PDAC tissues and cell lines, and its downregulation is significantly associated with TNM staging and lymph node metastasis. Overexpression of miR-33a-5p inhibits cell proliferation, migration, and invasion in SW1990 and PANC-1 cells, while knockdown of miR-33a-5p promotes these processes in BxPC-3 and ASPC-1 cells. Additionally, RAP2A was identified as a direct target of miR-33a-5p in PDAC cells, and its overexpression reversed the suppressive effects of miR-33a-5p in SW1990 and PANC-1 cells.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Review
Medicine, Research & Experimental
Vida Mashayekhi, Orsola Mocellin, Marcel H. A. M. Fens, Gerard C. Krijger, Lodewijk A. A. Brosens, Sabrina Oliveira
Summary: This review discusses the challenges in the treatment and early diagnosis of pancreatic ductal adenocarcinoma (PDAC), emphasizing the need for more effective and better-tolerated treatment options. It also highlights the discovery of transmembrane proteins that are overexpressed in PDAC cells, which could potentially serve as targets for treatment and diagnosis.
Article
Biochemistry & Molecular Biology
Tugba Mehmetoglu-Gurbuz, Rajkumar Lakshmanaswamy, Karla Perez, Mayra Sandoval, Casandra A. Jimenez, Jackelyn Rocha, Rachel Madeline Goldfarb, Courtney Perry, Alejandra Bencomo, Nishkala Neela, Jose A. Barragan, Raquel Sanchez, Risa Mia Swain, Ramadevi Subramani
Summary: This study found that nimbolide (NB) effectively blocks the growth and metastasis of pancreatic ductal adenocarcinomas (PDACs) by suppressing the expression and activity of superoxide dismutase 2 (SOD2). NB induces high levels of reactive oxygen species (ROS) generation, leading to increased apoptosis and reduced progression of PDACs. SOD2 plays an important role in regulating NB-induced ROS generation, presenting itself as a therapeutic option for PDACs.
Review
Cell Biology
Tianyi Zhang, Yanxian Ren, Pengfei Yang, Jufang Wang, Heng Zhou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a high deposition of extracellular matrix (ECM) and poor prognosis. ECM proteins derived from tumor cells reduce the effectiveness of conventional cancer treatment and contribute to tumor progression and metastasis. Cancer-associated fibroblasts (CAFs) in the ECM are promising targets for novel anti-tumor interventions.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Shuai Huang, Xudong Zhang, Kai Luo, Li Jiang, Jianhua Jiang, Renfeng Li
Summary: In this study, OSBP2 was found to be highly expressed in PDAC and its upregulation promoted the progression of PDAC, including increased cell migration, invasion, proliferation, chemotherapy resistance, and decreased apoptosis. Furthermore, overexpression of OSBP2 resulted in downregulation of the cell adhesion molecule E-cadherin and upregulation of other transcription factors. Therefore, OSBP2 may serve as a potential diagnostic and therapeutic target for PDAC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Motoki Miyazawa, Seiko Hirono, Manabu Kawai, Ken-ichi Okada, Yuji Kitahata, Hideki Motobayashi, Masatoshi Sato, Tomohiro Yoshimura, Masaki Ueno, Shinya Hayami, Atsushi Miyamoto, Atsushi Shimizu, Hiroki Yamaue
Summary: This study found that radiographic duodenal invasion (rDI) in patients with pancreatic ductal adenocarcinoma (PDAC) is associated with the biological aggressiveness of the tumor, leading to decreased overall survival, increased risk of recurrence, and frequent liver metastasis. Aggressive perioperative chemotherapy is recommended, especially for patients with resectable PDAC and rDI.
Article
Oncology
Hong-Bin Li, Jian-Li Wang, Xiao-Dong Jin, Lei Zhao, Hui-Li Ye, Yan-Bei Kuang, Yong Ma, Xiang-Yan Jiang, Ze-Yuan Yu
Summary: The study revealed that the expression levels of S100A family members were higher in PDAC tissues compared to normal pancreatic tissues, and their expressions were negatively correlated with patient survival, indicating their potential as prognostic biomarkers for PDAC patients.
Article
Multidisciplinary Sciences
Giulio Innamorati, Thomas M. Wilkie, Giorgio Malpeli, Salvatore Paiella, Silvia Grasso, Borislav Rusev, Biagio Eugenio Leone, Maria Teresa Valenti, Luca dalle Carbonare, Samuele Cheri, Alice Giacomazzi, Marco Zanotto, Vanessa Guardini, Michela Deiana, Donato Zipeto, Michela Serena, Marco Parenti, Francesca Guzzi, Rita Teresa Lawlor, Giovanni Malerba, Antonio Mori, Giuseppe Malleo, Luca Giacomello, Roberto Salvia, Claudio Bassi
Summary: The GNA15 gene is ectopically expressed in human pancreatic ductal adenocarcinoma cancer cells and is associated with poor prognosis. Elevated GNA15 expression in pancreatic cancer can affect signaling and cell motility during progression.
SCIENTIFIC REPORTS
(2021)
Article
Pathology
Akira Ishikawa, Hiroki Fujii, Takafumi Fukui, Aya Kido, Narutaka Katsuya, Kazuhiro Sentani, Kazuya Kuraoka, Sho Tazuma, Takeshi Sudo, Masahiro Serikawa, Shiro Oka, Naohide Oue
Summary: This study analyzed the expression and biological function of KIFC1 in pancreatic ductal adenocarcinoma (PDAC). The results showed that high expression of KIFC1 was significantly related to tumor size and poor overall survival. Furthermore, knockdown of KIFC1 significantly reduced the growth and spheroid colony formation of PDAC cells.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Huanyu Wang, Weilin Mao, Wenhui Lou, Dayong Jin, Wenchuan Wu, Dansong Wang, Tiantao Kuang, Yefei Rong, Xuefeng Xu, Lei Zhang
Summary: The study revealed that PYCR1 expression was significantly higher in tumor tissues compared to normal tissues; Inhibiting PYCR1 expression could significantly inhibit proliferation and promote apoptosis of PDAC cells; PYCR1 may serve as a potential therapeutic and prognostic biomarker for pancreatic cancer treatment.
Review
Oncology
Michal Gola, Aleksandra Sejda, Janusz Godlewski, Malgorzata Cieslak, Anna Starzynska
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with limited treatment options and poor prognosis. The tumor microenvironment in PDAC is characterized by a dense stroma and intricate cross-talk between various elements. Despite the presence of neural components, their role in PDAC remains poorly understood. Recent studies have explored the targeting of autonomic nerves as a novel treatment approach for PDAC. Perineural invasion is a common feature in PDAC and its severity is associated with a worse prognosis. Quantification methods that distinguish between perineural and endoneural invasion could potentially improve risk assessment for PDAC patients. The concepts of cancer-related neurogenesis and axonogenesis in PDAC are understudied and warrant further research. Understanding the interplay between nerves and cancer cells in the PDAC microenvironment could lead to new nerve-oriented treatment strategies and improved outcomes. This review aims to summarize the current knowledge and future challenges in the field of nerve-cancer interactions in PDAC.
Article
Gastroenterology & Hepatology
Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Yasuhiro Ushijima, Yukihisa Takayama, Daisuke Okamoto, Nobuhiro Fujita, Daisuke Tsurumaru, Osamu Togao, Koji Sagiyama, Tatsuya Manabe, Eiji Oki, Yuichiro Kubo, Tomoyuki Hida, Minako Hirahashi-Fujiwara, Jochen Keupp, Hiroshi Honda
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Surgery
Yoshihiko Sadakari, Shuntaro Nagai, Vittoria Vanessa Velasquez, Kinuko Nagayoshi, Hayato Fujita, Kenoki Ohuchida, Tatsuya Manabe, Takao Ohtsuka, Masafumi Nakamura
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2019)
Article
Oncology
Kenji Fujiwara, May Tun Saung, Hao Jing, Brian Herbst, MacKenzie Zarecki, Stephen Muth, Annie Wu, Elaine Bigelow, Linda Chen, Keyu Li, Neolle Jurcak, Alex B. Blair, Ding Ding, Michael Wichroski, Jordan Blum, Nathan Cheadle, Jennifer Koenitzer, Lei Zheng
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Multidisciplinary Sciences
Kenji Fujiwara, Toshihiro Masatsugu, Atsushi Abe, Tatsuya Hirano, Masayuki Sada
Article
Surgery
Kenji Fujiwara, Atsushi Abe, Toshihiro Masatsugu, Tatsuya Hirano, Masayuki Sada
Summary: This study clarified the cancer detection rates according to the size distribution of gallbladder polyps and evaluated the effectiveness of reported risk factors in predicting malignancy. The cancer detection rate significantly increased with an increase in lesion size, and risk factors such as sessile polyp morphology or an increase in lesion size were effective in predicting malignancy for small gallbladder polyps. It may be difficult to accurately predict the pathologic diagnoses preoperatively, as cholesterol polyps were most common, even in larger sizes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Education & Educational Research
Tatsuya Manabe, Mitsuhiro Takasaki, Takao Ide, Kenji Kitahara, Seiji Sato, Seiji Yunotani, Yoshimi Hirohashi, Akihiro Iyama, Masahiko Taniguchi, Toshiro Ogata, Shuji Shimizu, Hirokazu Noshiro
BMC MEDICAL EDUCATION
(2020)
Article
Multidisciplinary Sciences
Kenji Fujiwara, Atsushi Abe, Toshihiro Masatsugu, Tatsuya Hirano, Kiyohisa Hiraka, Masayuki Sada
Summary: This study evaluated the importance of preoperative factors and clinical scoring models in detecting complicated appendicitis and found that high serum CRP levels could be a useful predictor for complicated appendicitis before surgery.
Letter
Oncology
Xingyi Pan, Jiaojiao Zhou, Qian Xiao, Kenji Fujiwara, Mengwen Zhang, Guanglan Mo, Wei Gong, Lei Zheng
Summary: The study revealed that tumor cells from pancreatic ductal adenocarcinoma (PDAC) with liver or lung-specific metastatic potentials induce different methylation and metabolic gene expression in cancer-associated fibroblasts (CAFs), affecting CAF phenotypes. CAFs from liver metastasis showed a more homogeneous phenotype, while CAFs from lung metastasis maintained heterogeneity.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Immunology
Jianxin Wang, May Tun Saung, Keyu Li, Juan Fu, Kenji Fujiwara, Nan Niu, Stephen Muth, Junke Wang, Yao Xu, Noah Rozich, Haley Zlomke, Sophia Chen, Birginia Espinoza, MacKenzie Henderson, Vanessa Funes, Brian Herbst, Ding Ding, Christina Twyman-Saint Victor, Qihong Zhao, Amol Narang, Jin He, Lei Zheng
Summary: This preclinical study demonstrates the potential of CCR2/CCR5 dual-antagonist in counteracting radiation-induced suppressive signals and enhancing the effector T cell pathway. It supports the ongoing clinical trial of combining this therapy with radiation and anti-PD-1 antibody for locally advanced pancreatic cancer.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Oncology
Tao Xia, Keyu Li, Nan Niu, Yingkuan Shao, Ding Ding, Dwayne L. Thomas, Hao Jing, Kenji Fujiwara, Haijie Hu, Arsen Osipov, Chunhui Yuan, Christopher L. Wolfgang, Elizabeth D. Thompson, Robert A. Anders, Jin He, Yiping Mou, Adrian G. Murphy, Lei Zheng
Summary: This study reveals that the densities of Granzyme-B(+)CD8(+) effector T cells, non-exhausted PD-1(-)EOMES(-)CD8(+) T cells, and the PD-L1 status in tumor-associated macrophages are prognostic markers in cholangiocarcinoma. Targeting PD-L1(+) tumor-associated macrophages may be an effective immunotherapy for cholangiocarcinoma.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Letter
Oncology
Kenji Fujiwara, Yingkuan Shao, Nan Niu, Tengyi Zhang, Brian Herbst, Mackenzie Henderson, Stephen Muth, Pingbo Zhang, Lei Zheng
Summary: This study identified T cell epitopes in PDAC using mass spectrometry and found that these epitopes can be shared by patients with different HLA types. Furthermore, these epitopes induced immune responses in peripheral T cells, suggesting their potential application in both HLA-type matched and non-matched patients.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Oncology
Jianxin Wang, Tengyi Zhang, Pan Li, Jessica Gai, Sophia Chen, Gigi Espinoza, Heng-Chung Kung, Rui Zhang, Kenji Fujiwara, Juan Fu, Jun Yu, Lei Zheng
Summary: Researchers have identified a natural CD8+ T-cell epitope, LAMC2203211, in pancreatic ductal adenocarcinoma (PDAC) using mass spectrometry analysis. This epitope induces specific immune responses and suppresses the growth of PDAC cells. This study provides a new approach for developing PDAC immunotherapy strategies based on this epitope.
Article
Biochemistry & Molecular Biology
Mengwen Zhang, Xingyi Pan, Kenji Fujiwara, Noelle Jurcak, Stephen Muth, Jiaojiao Zhou, Qian Xiao, Anqi Li, Xu Che, Zihai Li, Lei Zheng
Summary: The study revealed that pancreatic ductal adenocarcinoma (PDA) tumor cells induce DNA methylation and downregulation of glucose metabolism genes selectively in M1-like macrophages, leading to their phenotypic reprogramming into M2-like macrophages. This process is mediated by GARP and integrin alpha V/beta 8 and results in the acquisition of pro-cancerous capabilities by M1-like macrophages through Il-10 activation. The research suggests that PDA cells can reprogram M1-like macrophages metabolically and functionally through DNA methylation to adopt a pro-cancerous fate.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Meeting Abstract
Oncology
Xingyi Pan, Mengwen Zhang, Kenji Fujiwara, Noelle R. Jurcak, Stephen Muth, Lei Zheng
Meeting Abstract
Oncology
Noelle R. Jurcak, Stephen Muth, Kenji Fujiwara, Agnieszka Rucki, Kelly Foley, Adrian Murphy, Elizabeth M. Jaffee, Lei Zheng
