Article
Chemistry, Multidisciplinary
Sebastian Koniarz, Kinga Szydelko, Michal J. Bialek, Karolina Hurej, Piotr J. Chmielewski
Summary: A family of transition metal complexes based on meso-aryl-2-aza-21-carbaporphyrin (N-confused porphyrin, NCP) derivatives were synthesized and characterized. The chirality of these complexes was demonstrated by enantiomeric separation and analysis. Preliminary catalytic study showed the activity of iridium(III) ortho-metallated complexes in the N-heterocyclization of primary amines with diols.
Article
Chemistry, Multidisciplinary
Wenbo Ming, Xiaocui Liu, Lujia Mao, Xiao Gu, Qing Ye
Summary: This review article summarizes recent advances in transition-metal catalyzed preparation of chiral allylboronates, focusing on developments within the past three years and emphasizing asymmetric catalysis. The discussion is divided into substrate-controlled and catalyst-controlled synthesis based on mechanisms for achieving selectivity in terms of chemo-, regio-, stereo- and enantioselectivities.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jonathan Trouve, Paolo Zardi, Shaymaa Al-Shehimy, Thierry Roisnel, Rafael Gramage-Doria
Summary: Utilizing secondary interactions between substrates and catalysts is a promising approach to discover selective transition metal catalysts for atom-economy C-H bond functionalization. The most powerful catalysts are often discovered through trial-and-error screening, as small stereo-electronic modifications within the substrate and catalyst can lead to vastly different reactivities.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Juba Ghouilem, Morgane de Robichon, Franck Le Bideau, Angelique Ferry, Samir Messaoudi
Summary: Transition-metal-catalyzed C-H functionalization and photoredox nickel dual catalysis are innovative approaches for the synthesis of C-branched glycosides, providing efficient and mild methods for accessing a variety of complex C-branched glycosides of great interest.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Saptashwa Chakraborty, Bijoyananda Mishra, Pratim Kumar Das, Sandip Pasari, Srinivas Hotha
Summary: The silver-assisted gold-catalyzed activation of alkynyl glycosyl carbonate donors is a versatile approach for the synthesis of various types of N-glycosides, including purine and pyrimidine nucleosides, asparagine glycosides, and quinolin-2-one N-glycosides. This method enables the synthesis of nucleosides that are difficult to obtain through other means. Additionally, it can be used to easily synthesize 2'-modified nucleosides and dipeptide disaccharide units of chloroviruses.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Niklas W. Kinzel, Christophe Werle, Walter Leitner
Summary: The electrocatalytic transformation of carbon dioxide has long been a topic of interest, with recent focus on it as an alternative strategy for CO2 reduction. Studies have increasingly looked at direct electron transfer and molecular transition metal complexes as catalysts. This can lead to the production of C-1 compounds as well as more complex transformations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Yichen Wu, Peng Wang
Summary: Optically active organosilanes have been demonstrated to be versatile chiral reagents in synthetic chemistry. Monohydrosilanes, which bear a Si-H bond, are especially unique due to their facile transformations through stereospecific bond-formation reactions. In addition, they have also been used as chiral reagents for alcohol resolution, chiral auxiliaries, mechanistic probes, and potential optoelectronic materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Lu-Hua Zhang, Simon Mathew, Joeri Hessels, Joost N. H. Reek, Fengshou Yu
Summary: The pursuit of renewable production of storable fuels through electrocatalysis, particularly with water oxidation catalysis, remains a key focus in the scientific community. The coupling of these redox transformations to renewable energy sources presents a carbon neutral solution for long-term energy storage, yet challenges such as scalability still need to be addressed.
Article
Chemistry, Applied
Christoph M. Hendrich, Valentin D. Hannibal, Lukas Eberle, Leif E. Hertwig, Ute Zschieschang, Frank Rominger, Matthias Rudolph, Hagen Klauk, A. Stephen K. Hashmi
Summary: This study presents a gold-catalyzed bidirectional synthesis method for N-heteropolycyclic compounds bearing carbazole moieties, resulting in the synthesis of four previously unknown core structures. The approach is convergent and modular, with a key step involving a gold-catalyzed cascade reaction starting from stable di-azido compounds. The synthesized molecules were fully characterized, and their optical and electronic properties, as well as their performance in organic thin-film transistors generated by vacuum deposition, were studied, with charge-carrier mobilities of up to 0.3 cm(2)/Vs measured.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Review
Chemistry, Multidisciplinary
Abhishek Kumar, Shrivats Semwal, Joyanta Choudhury
Summary: Transition-metal-catalyzed hydride-transfer reactions play a crucial role in building a sustainable energy economy, with a focus on H-2 evolution and CO2 reduction/hydrogenation catalysis. Therefore, understanding the hydricity of transition-metal hydrides and its influencing factors is essential for designing efficient catalysts.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Organic
Lucas Pages, Racha Abed Ali Abdine, Florian Monnier, Marc Taillefer
Summary: This article introduces the widespread exploration of intermolecular transition-metal catalyzed hydroarylation of allenes since the early 1980s. This reaction allows the selective access to high-value allylic or vinylic motifs through the formation of C-C bonds. The article also mentions the use of arenes, organoboronic derivatives, and aryl halides as aryl sources, as well as the use of gold, palladium, and other transition metals as catalysts.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Jan Doubsky, Stanislav Radl, Josef Cinibulk, Robert Klvana
Summary: An efficient and scalable synthesis method for fingolimod hydrochloride has been developed, using the aziridine regioselective ring-opening reaction as a key step. The method is industrially applicable and has been successfully applied to 500 g scales of the target product.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Review
Chemistry, Multidisciplinary
Reka Adamik, Balazs Buchholcz, Ferenc Darvas, Gellert Sipos, Zoltan Novak
Summary: This review provides a conceptual and critical summary of micellar synthesis possibilities that are well suited to DEL synthesis, as well as discussion of existing examples of micellar DEL approaches and selection of micellar organic transformations fundamentally suitable for DEL.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Risto Savela, Carolina Mendez-Galvez
Summary: Isoindolinone structure is an important privileged scaffold found in a large variety of naturally occurring as well as synthetic, biologically and pharmaceutically active compounds. Synthetic methodologies for accessing this heterocyclic skeleton have received significant attention during the past decade, with two main categories of strategies identified.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Changpeng Chen, Feng-Shou Liu, Michal Szostak
Summary: The discovery of NHCs as ancillary ligands has greatly improved catalytic processes, with BIAN-NHC ligands in particular showing enhanced reactivity due to combinations of electronic and steric properties. The development of BIAN-NHC ligands has led to major advancements in catalysis and offers a practical alternative to classical NHCs.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Crystallography
Ashraf A. Aly, Martin Nieger, Stefan Braese, Momtaz E. M. Bakheet
Summary: The X-ray structure analyses of four compounds were conducted, revealing strong intramolecular hydrogen bonds that play significant roles in their crystal packing.
JOURNAL OF CHEMICAL CRYSTALLOGRAPHY
(2023)
Article
Chemistry, Organic
Jehan Y. Al-Humaidi, A. A. Nayl, Mohamed M. Abdalla, Sobhi M. Gomha
Summary: This study synthesized and tested the in-vivo activity of different compounds, and found that triazolo-tetrazine derivatives have excellent anticonvulsant and CNS-depressant activities. Further structure-activity relationship studies demonstrated that electron-releasing groups increase activity while electron-withdrawing groups decrease activity.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Multidisciplinary
N. Maximilian Bojanowski, Aleksandra Vranic, Vincent Hahn, Pascal Rietz, Tobias Messer, Julian Brueckel, Christopher Barner-Kowollik, Eva Blasco, Stefan Braese, Martin Wegener
Summary: Recent studies have introduced a new generation of photoinitiators for 3D laser nanoprinting, replacing two-photon absorption with two-step absorption. This can now be achieved using inexpensive blue laser diodes instead of expensive femtosecond laser systems. Additionally, researchers are exploring alternative photoinitiators that can be excited by one-color two-step absorption and be de-excited by a different laser color.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Chun Li, Henrik Schopmans, Lukas Langer, Stefan Marschner, Abhinav Chandresh, Jochen Buerck, Youichi Tsuchiya, Adachi Chihaya, Wolfgang Wenzel, Stefan Braese, Mariana Kozlowska, Lars Heinke
Summary: Researchers have successfully prepared a crystalline film based on porphyrin with chiral properties and demonstrated excellent optoelectronic performance. By assembling in a metal-organic framework film, the porphyrin core becomes twisted and chiral. The close packing and crystalline order of the porphyrin cores in the film result in outstanding optoelectronic properties. Through exciting the Soret band of porphyrin, efficient photoconduction with a high On-Off ratio is achieved. Moreover, handedness-dependent circularly-polarized-light photoconduction is obtained. The combination of assembly-induced chirality with the rich porphyrin chemistry opens up possibilities for organic materials with exceptional chiral and optoelectronic properties.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Editorial Material
Chemistry, Multidisciplinary
Zahid Hassan, Stefan Braese
Summary: Engineering novel micro-/nanoscale systems and devices based on supramolecular assembly has tremendous potential, but controlling the size, shape, and arrangements without templates remains a challenge.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
AbdElAziz A. Nayl, Ahmed I. Abd-Elhamid, Wael A. A. Arafa, Ismail M. Ahmed, Aref M. E. AbdEl-Rahman, Hesham M. A. Soliman, Mohamed A. Abdelgawad, Hazim M. Ali, Ashraf A. Aly, Stefan Braese
Summary: This study aimed to prepare a novel phosphate-embedded silica nanoparticles (P@SiO2) nanocomposite as an effective adsorbent. A mixed solution of sodium silicate and sodium phosphate was converted into hydrogen form using a strong acidic resin. The resultant solution was then hydrothermally treated to yield P@SiO2 nanocomposite.
Article
Chemistry, Multidisciplinary
Xujun Qiu, Julian Brueckel, Christoph Zippel, Martin Nieger, Frank Biedermann, Stefan Braese
Summary: In this article, a multifunctionalisable aryl azide, tris(4-azidophenyl)methanol, is reported. It can be used as a protecting group for thiols in peptoid synthesis and can be cleaved under mild reaction conditions via a Staudinger reduction. Additionally, the easily accessible aryl azide can be functionalised through copper-catalysed cycloaddition reactions, offering more possibilities for materials chemistry applications.
Article
Chemistry, Multidisciplinary
Hannes Kuehner, Louis Leyen, Zahid Hassan, Christof Woell, Stefan Brase
Summary: In this report, a modular synthesis approach towards a new series of non-centrosymmetric, dipolar 4,4'-bipyridines was described. The selective substitution on only one pyridyl motif that could contain electron-donating or electron-withdrawing groups causes electronic/steric effects on one nitrogen atom in 4,4'-bipyridines. This synthetic protocol was further applied to prepare azo-functionalized asymmetric bipyridines and non-centrosymmetric 4,4'-bipyridine N oxide scaffolds.
Article
Chemistry, Organic
Helena Simek Tosino, Andre Jung, Olaf Fuhr, Claudia Muhle-Goll, Nicole Jung, Stefan Braese
Summary: A photochemical cyclization of F-tagged, o-alkynylated N-alkylamides to indoles catalyzed by a specific iridium complex is described. This reaction involves a rearrangement due to an electron withdrawing group, resulting in the formation of 3-acylindoles. A four-step reaction sequence including the photoreaction has been developed and optimized, leading to the synthesis of 16 derivatives with different modifications in good yields.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Mirella Wawryszyn, Robin Wilhelm, John Kim, Xiaoyang Zhong, Jeffery E. Raymond, Richard Thelen, Vanessa Trouillet, Matthias Schwotzer, Stefan Braese, Do Hoon Kim, Nicholas L. Abbott, Joerg Lahann
Summary: In the past decade, the phosphorescence of metal-free confined polymer structures has gained attention due to their sustainability, low toxicity, and usage in sensing applications. This study presents the preparation of a free-standing array of nanofibers and compares their optical properties to films with identical composition. The nanofibers form laterally aligned membranes with a high internal order, hourglass-shaped features, and a long-lived emission in the blue region. This research is significant as it constitutes the first report of long-lived emission from solid-state poly(p-xylylenes) nanofibers, and these controlled polymer arrays have potential applications in organic sensors and optoelectronic devices.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Essmat M. El-Sheref, Stefan Braese, Hendawy N. Tawfeek, Fatmah Ali Alasmary, Bahaa G. M. Youssif
Summary: The reaction between 4-azido-quinolin-2(1H)-ones and active methylene compounds was studied, leading to the synthesis of a series of 4-(1,2,3-triazol-1-yl)quinolin-2(1H)-ones. Compounds 3f-j showed potent antiproliferative activity and exhibited potential as multi-target inhibitors of EGFR, BRAF(V600E), and EGFR(T790M). Moreover, compounds 3g and 3h demonstrated caspase activation, down-regulation of antiapoptotic Bcl2, and promising antioxidant activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Ismail M. Ahmed, Ahmed I. Abd-Elhamid, Ashraf A. Aly, Stefan Braese, AbdElAziz A. Nayl
Summary: Ni2+/Fe3+ LDH, (Ni-Fe-CO3 LDH) with Ni/Fe molar ratio 3.0 was synthesized by co -precipitation for the remediation of chromium (VI) and Alizarine Red-S (ARS-dye). The effects of hydrogen ion concentration, shaking time, ARS-dye and/or Cr(VI) concentration, and adsorbents mass on the process were studied. The results showed that Ni-Fe-CO3 LDH fitted well with the pseudo-second-order model, and Langmuir isotherm had a better adsorption effect on ARS-dye and Cr(VI).
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2023)
Article
Materials Science, Multidisciplinary
Zhen Zhang, Peng Wu, Ke Wang, Hong Lin, Eduard Spuling, Rongrong Xia, Youjun Wu, Jin Cao, Jianhua Zhang, Bin Wei, Stefan Braese, Zixing Wang
Summary: White organic light-emitting diodes (WOLEDs) are important for energy conservation and reducing carbon emissions due to their excellent electro-optic conversion efficiency. However, the complexity of the structure and high fabrication costs limit the practicality of traditional WOLEDs. To address these issues, WOLEDs based on platinum (Pt) complexes with a single light-emitting layer show great potential.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Steffen A. Otterbach, David Elsing, Alexander D. Schulz, Henrik Tappert, Wolfgang Wenzel, Mariana Kozlowska, Holger Roehm, Stefan Braese
Summary: In this study, eight different hole transport materials were synthesized via double CH activation. By varying the donor groups and pi-linkers, a wide range of ionization potentials (IPs) were achieved, demonstrating high customizability. One of the materials, DiPCP-2, showed good performance as a hole transport layer in PSCs, and its facile synthesis enables a cost reduction by two thirds.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Lena Pilz, Carsten Natzeck, Jonas Wohlgemuth, Nina Scheuermann, Simon Spiegel, Simon Osswald, Alexander Knebel, Stefan Braese, Christof Woell, Manuel Tsotsalas, Nicholaus Prasetya
Summary: This study presents a novel approach to enhance the properties of polymer membranes from MOFs through crosslinking of the organic linker molecules and subsequent metal-atom removal. The researchers automated the process and used machine learning optimization to ensure reproducibility and high quality of the resulting polymeric membranes. The SURMOF membranes showed improved gas selectivity after crosslinking, and the gas permeance could be restored to its initial condition after removing the metal centers. The resulting polymeric membrane outperforms commercially available polymer membranes for H2/CO2 gas separation.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
