The First Generation of β-Galactosidase-Responsive Prodrugs Designed for the Selective Treatment of Solid Tumors in Prodrug Monotherapy

Design of Self-Immolative Linkers for Tumour-Activated Prodrug Therapy

(2013) I. Tranoy-Opalinski et al.   Anti-Cancer Agents in Medicinal Chemistry

Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells

(2012) Tanja Wirth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Antitumor Efficacy of a β-Glucuronidase-Responsive Albumin-Binding Prodrug of Doxorubicin

(2012) Thibaut Legigan et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Galactosidase-Responsive “Trojan Horse” for the Selective Targeting of Folate Receptor-Positive Tumor Cells

(2011) Mickaël Thomas et al.   ChemMedChem

Prodrugs for Targeted Tumor Therapies: Recent Developments in ADEPT, GDEPT and PMT

(2011) Lutz F. Tietze et al.   CURRENT PHARMACEUTICAL DESIGN

Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results

(2011) Gooitzen M van Dam et al.   NATURE MEDICINE

A new cyclopamine glucuronide prodrug with improved kinetics of drug release

(2011) Brigitte Renoux et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Glycosidic Prodrugs of Highly Potent Bifunctional Duocarmycin Derivatives for Selective Treatment of Cancer

(2010) Lutz F. Tietze et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Legumain Protease-Activated Auristatin Prodrugs Suppress Tumor Growth and Metastasis without Toxicity

(2010) Krishna Mohan Bajjuri  et al.   ChemMedChem

Antibody–drug conjugates: targeted drug delivery for cancer

(2010) Stephen C Alley et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Folate-Targeted Therapies for Cancer

(2010) Wei Xia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rotaxane-Based Propeptides: Protection and Enzymatic Release of a Bioactive Pentapeptide

(2009) Anthony Fernandes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antibody-Directed Enzyme Prodrug Therapy: A Promising Approach for a Selective Treatment of Cancer Based on Prodrugs and Monoclonal Antibodies

(2009) Lutz F. Tietze et al.   Chemical Biology & Drug Design

Folate-targeted therapeutic and imaging agents for cancer

(2009) Philip Stewart Low et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Biodistribution of HuCC49ΔCH2-β-galactosidase in colorectal cancer xenograft model

(2009) Yanke Yu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of Pyrrolo[2,1-c][1,4]benzodiazepine β-Galactoside Prodrugs for Selective Therapy of Cancer by ADEPT and PMT

(2008) Ahmed Kamal et al.   ChemMedChem

Prodrug Strategies in Anticancer Chemotherapy

(2007) Felix Kratz et al.   ChemMedChem