Article
Chemistry, Multidisciplinary
Justin T. Henthorn, George E. Cutsail, Thomas Weyhermueller, Serena DeBeer
Summary: This article investigates the electronic structure and spin states of mixed-valent iron-sulfur dimers and discovers a new interaction that can stabilize high spin states. By studying a series of mixed-valent complexes, complex interactions between antiferromagnetic coupling, Heisenberg double-exchange, and vibronic coupling are revealed.
Review
Microbiology
Lars Hederstedt
Summary: This review article discusses the role and protein components involved in the assembly of cytochrome c oxidase in animals, plants, and aerobic bacteria. The study focuses on the analysis of mutants and comparative biochemistry to understand the assembly process and its implications for disease and antimicrobial drug development.
Article
Biochemistry & Molecular Biology
Thorsten Friedrich, Daniel Wohlwend, Vitaliy B. Borisov
Summary: Cytochrome bd is a terminal oxidase in the membrane respiratory chains of prokaryotes that is unique in its ability to generate a proton motive force without pumping protons. It plays a crucial role not only in energy conservation but also in the response to environmental stressors in microbial cells. As a molecular drug target candidate, cytochrome bd promotes virulence in pathogenic species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Inorganic & Nuclear
Bach X. Nguyen, Warren Vandeven, Gregory A. Macneil, Wen Zhou, Alisa R. Paterson, Charles J. Walsby, Linus Chiang
Summary: High-valent metal complexes [ML] (+) were synthesized using a new tetradentate, tetraanionic bis(amidateanilido) ligand. The UV-vis-NIR, EPR, and XANES spectra of [ML] (+) indicate the presence of square planar, high-valent M-III species, with ligand-to-metal charge transfer transitions. The tetraanionic bis(amidateanilido) ligand showed exceptionally strong donating nature, enabling the stabilization of the high-valent metal centers.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Xingwei Cai, Yang Shen, Wei Li, Wentao Zhan, Fanjun Zhang, Chen Xu, Heng Song
Summary: In this study, an efficient tungsten-catalyzed homogeneous system was developed for the selective synthesis of various azoaromatics, azoxyaromatics, and 2-substituted indolone N-oxides from anilines. This was achieved by regulating the reaction solvent with peroxide as a terminal oxidant under additive-free conditions. These findings not only provide an experimental framework for exploring tungsten catalysis in organic synthesis but also offer an efficient and convenient tactic for the selective oxidation of anilines.
Article
Chemistry, Multidisciplinary
Lin Zhang, Eckhard Bill, Peter M. H. Kroneck, Oliver Einsle
Summary: Copper-containing nitrous oxide reductase (N2OR) is the only known enzyme capable of converting nitrous oxide to dinitrogen, with unique Cu-Z and CUA sites. Systematic mutagenesis of histidine and surrounding H-bonding residues revealed that only variants with protonable side chains like His, Asp, and Glu can mediate electron transfer at physiological pH.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Pharmacology & Pharmacy
Martina Medvedikova, Vaclav Ranc, Jan Vanco, Zdenek Travnicek, Pavel Anzenbacher
Summary: Two anticancer copper(II) mixed-ligand complexes were found to significantly inhibit different isoenzymes of cytochrome P450 (CYP), which may conflict with the metabolic pathways of chemotherapeutic agents.
Article
Chemistry, Multidisciplinary
Giuseppe Spedalotto, Marta Lovisari, Aidan R. McDonald
Summary: The researchers synthesized and characterized (NiNiIII)-Ni-II(mu-OH)(2) (2) and Ni-2(III) (mu-OH)(2) (3) species, with 3 demonstrating superior reaction rates and substrate oxidation efficiency compared to 2 and 2'. The kinetic superiority of 3 was attributed to a stronger bond in the product of oxidation for 3.
Article
Chemistry, Inorganic & Nuclear
Suman Dhara, Sanjib Panda, Goutam Kumar Lahiri
Summary: The facile reduction of 2,2'-dithiobisbenzothiazole through metal-to-ligand charge transfer or internal reducing equivalent is demonstrated, resulting in various binding modes of thiolates in a series of mononuclear and dinuclear ruthenium complexes. The electron transfer processes in the dinuclear complex resemble that of a [2Fe-2S] cluster.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
S. M. Gulam Rabbani, Andreas J. Achazi, Pere Miro
Summary: A computational study was conducted on the nucleation pathways of a POV alkoxide cluster in the absence of reducing agents, providing insights for controlling and manipulating the properties of the cluster.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Pragyansh Singh, Soeren Schlittenhardt, Dewendra Thakre, Saroj Kumar Kushvaha, Sunil Kumar, Harsha S. Karnamkkott, Mario Ruben, Masooma Ibrahim, Abhishek Banerjee, Kartik Chandra Mondal
Summary: Due to their potential future applications in high-density data storage devices, single-ion magnets (SIMs) have become one of the most exciting classes of materials for research at present. In this study, two mixed-valent organo-polyoxovanadyl complexes were investigated for their SIM properties using a combination of experimental techniques and computational methods. The complexes exhibited SIM behaviors characterized by maxima in the plots of out-of-phase magnetic susceptibility against AC frequency at different temperatures. The spin relaxation time was determined and different models were used to understand the slow relaxation process in the system under an applied DC magnetic field.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Cell Biology
Sue Ellen Brand, Martha Scharlau, Lois Geren, Marissa Hendrix, Clayre Parson, Tyler Elmendorf, Earl Neel, Kaila Pianalto, Jennifer Silva-Nash, Bill Durham, Francis Millett
Summary: Cytochrome c (Cc) has undergone accelerated evolution from anthropoid primates to humans, with several amino acid changes occurring near the binding site of the Cc:CcO complex. These changes affect the dissociation constant and the role of phosphorylation in regulating mitochondrial electron transport and membrane potential.
Article
Multidisciplinary Sciences
Agnes Moe, Justin Di Trani, John L. Rubinstein, Peter Brzezinski
Summary: Energy conversion in aerobic organisms involves electron transfer from low-potential donors to dioxygen through the membrane-bound respiratory chain. The formation of supercomplex CIII2CIV1/2 facilitates electron transfer by two-dimensional diffusion of cyt. c, increasing QH(2):O-2 oxidoreductase activity and suggesting a regulatory role for supercomplex formation in the respiratory chain.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Xiang Ma, Saurav Bhattacharya, Talha Nisar, Anja B. Mueller, Veit Wagner, Nikolai Kuhnert, Ulrich Kortz
Summary: We present the synthesis and structural characterization of the first Pd-IV-containing polyoxopalladate(ii) complex. This discrete mixed-valent polyoxopalladate(iv/ii) features a central Pd-IV ion surrounded by a six-membered Pd-II-oxo ring capped by six dimethylarsinate groups. The structure was analyzed using various techniques in the solid state, solution, and gas phase.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Wenxing Zou, Qihao Zhu, James C. Fettinger, Philip P. Power
Summary: This study synthesized two dimeric copper thiolato species and characterized their structures. These complexes have specific core structures similar to the interactions of copper atoms in nitrous oxide reductase.
INORGANIC CHEMISTRY
(2021)
