Article
Pharmacology & Pharmacy
Clea Chesneau, Alpha Oumar Sow, Fadila Hamachi, Laurent Michely, Sena Hamadi, Remy Pires, Andre Pawlak, Sabrina Belbekhouche
Summary: Tailor-made micro- and nanocarriers, combining cyclodextrin and calcium carbonate, were developed for loading hydrophobic drugs. The particle size of the resulting cyclodextrin-CaCO3 particles can be controlled by adjusting the concentration of PVSA or gly and the mixing time. These particles show high stability and biocompatibility, and exhibit selective release in acidic media.
Article
Biotechnology & Applied Microbiology
Yang Li, Chunyu Huang, Youhua Xu
Summary: Sonodynamic therapy (SDT) has unique advantages but also faces challenges such as low water solubility of sonosensitizers and the influence of tumor microenvironment (TME). In this study, a bionic nano-system (ECaC) was designed by coating mesoporous calcium carbonate nanoparticles (CaCO3 NPs) and sonosensitizer curcumin (Cur) into tumor-derived exosomes, aiming to enhance SDT. The biomimetic nano-system effectively targeted tumor cells and released the drug in response to the acidic microenvironment, resulting in significant anti-tumor effects without toxic side effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhongmin Geng, Xinyue Wang, Feng Wu, Zhenping Cao, Jinyao Liu
Summary: This study presents a cytocompatible approach of biointerface mineralization to generate an ultraresistant and self-removable coating on bacterial surface, addressing the challenges faced by bacteria during the manufacturing process. The mineral coating provides bacteria with resistance against oxygen exposure, ultraviolet irradiation, and ethanol. Upon oral ingestion, the coating actively neutralizes gastric acid and releases encapsulated bacteria through a rapid double-decomposition reaction. Furthermore, the generated calcium ions trigger bile acid micellar aggregation, enabling dual exemptions from gastric acid and bile acid insults for uncompromised bacterial viability. Supported by therapeutic efficacy in colitis mice, biointerface mineralization offers a versatile platform for developing next-generation living oral biotherapeutics.
Review
Chemistry, Multidisciplinary
Anna S. Vikulina, Jack Campbell
Summary: An undeniable trend in modern bioengineering and nanotechnology is the use of various biomolecules, primarily polymeric, for designing novel functional materials in controlled drug delivery, bioimaging, tissue engineering, and other bioapplications. Biogenic polymers with features like biocompatibility, biodegradability, replicating natural cellular microenvironments, and minimal toxicity, have gained growing interest as building blocks for fourth-generation biomaterials. Recent studies highlight the promise of hard-templating approach in fabricating nano- and microparticles using biopolymers, covering up-to-date knowledge on this topic and assessing the progress and challenges in the field.
Article
Chemistry, Multidisciplinary
Francesca Persano, Concetta Nobile, Clara Piccirillo, Giuseppe Gigli, Stefano Leporatti
Summary: Calcium carbonate (CaCO3) particles are a promising choice for drug delivery systems due to their biocompatibility, biodegradability, simplicity, cost-effectiveness, and stimulus-responsiveness. This study investigated the synthesis parameters that affect the particle size, and found that salt concentration and temperature had a significant impact, allowing the preparation of well-dispersed spherical nanoparticles below 200 nm. The successful encapsulation of the anti-tumor agent resveratrol into CaCO3 nanoparticles, without affecting their overall size and morphology, was achieved under optimized synthesis conditions.
Review
Pharmacology & Pharmacy
Yanqi Huang, Lin Cao, Bogdan V. Parakhonskiy, Andre G. Skirtach
Summary: This article introduces the characteristics and applications of inorganic calcium carbonate particles and organic alginate hydrogels as drug delivery carriers, as well as hybrid structures containing both types of carriers. It proposes the rational combination of these two carrier types to enhance their performance, and discusses their similarities and differences.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Baozhen Zhang, Ruijing Liang, Hui Ran, Denghui Zhu, Jian Ren, Lanlan Liu, Aiqing Ma, Lintao Cai
Summary: A self-driving yeast micro/nanorobot (Cur@ CaY-robot) is designed via dual biomineralization and acid catalysis, which demonstrates efficient motion in gastric acid and can penetrate the thick gastric mucus for improved drug accumulation in the stomach wall tissue. Additionally, the released Ca2+ cations from the robot synergistically repair the gastric motility of gastritis mice. The biocompatible and biodegradable nature of these yeast micro/nanorobots, along with their good drug loading capacity, make them promising for active drug delivery and precise therapy.
Article
Biochemistry & Molecular Biology
Kanglei Wang, Changwen Zhao, Yuhong Ma, Wantai Yang
Summary: This study presents a novel method for fabricating encapsulated yeast cells with a yolk-shell structure, and significantly prolongs the lag phase of the yeast cells by adjusting the thickness of the shell.
Article
Materials Science, Multidisciplinary
Anna Vikulina, Joseph Webster, Denis Voronin, Evgenii Ivanov, Rawil Fakhrullin, Vladimir Vinokurov, Dmitry Volodkin
Summary: Additive-free fabrication of mesoporous vaterite crystals ranging in size from submicron to tens of microns has been successfully achieved, offering new possibilities for drug delivery and tissue engineering in the field of biomedicine.
MATERIALS & DESIGN
(2021)
Article
Green & Sustainable Science & Technology
Jie Chen, Xiaoqing Lin, Minjie Li, Tieying Mao, Xiaodong Li, Jianhua Yan
Summary: This study proposes a novel carbonation treatment method for municipal solid waste incineration fly ash (MSWI FA), which can effectively solidify heavy metals and sequester CO2. The optimal treatment parameters were determined through orthogonal tests, and the method showed great potential for reducing leaching concentrations and increasing solidification efficiency.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Environmental Sciences
Xiaoqing Lin, Jie Chen, Shuaixi Xu, Tieying Mao, Weiping Liu, Jiezhen Wu, Xiaodong Li, Jianhua Yan
Summary: Calcium carbonate oligomers can be crystallized to solidify heavy metals in municipal solid waste incineration fly ash, and the addition of calcium chloride improves the solidification effect. Increasing the calcium amount enhances the solidification efficiency, while water-washing pretreatment significantly improves the solidification effect on heavy metals.
Article
Biotechnology & Applied Microbiology
Jialin Fu, Choe Peng Leo, Pau Loke Show
Summary: This review compares the synthesis routes and applications of pH-responsive CaCO3-based drug delivery systems, non-drug delivery systems, imaging techniques, sensors, and templates. Various methods have been developed to build pH-responsive solutions using biocompatible calcium carbonate (CaCO3). The review identifies the novelty, limitations, and potential applications of each synthesis and application. The use of CaCO3 in drug delivery systems shows great potential for cancer treatment, with impregnation and encapsulation being widely used. In addition, CaCO3 has been utilized in ultrasound imaging, sensors, and sacrificial templates, showcasing its versatility.
BIOCHEMICAL ENGINEERING JOURNAL
(2022)
Article
Environmental Sciences
Oriol Gibert, Cesar Valderrama, Maria M. Martinez, Rosa Mari Darbra, Josep Oliva Moncunill, Vicenc Marti
Summary: This study investigates the application of hydroxyapatite-coated calcite particles for the removal of Zn and Cu from contaminated water. The results show that the HAP-coated calcite particles exhibit high efficiency in removing Zn and Cu from acidic solutions, with a high removal capacity. Various mechanisms including surface complexation, ion exchange, and precipitation of new metal-containing phases contribute to the sorption of Zn and Cu onto HAP.
Review
Plant Sciences
Mohd Ishfaq Khan, Shahzad A. Pandith, Manzoor A. Shah, Zafar A. Reshi
Summary: From simple algal forms to the most advanced angiosperms, calcium oxalate (CaOx) crystals (CRs) are found in majority of photosynthetic organisms. Various studies have shown that CaOx biomineralization is genetically regulated and not a random event. They have roles in calcium regulation, detoxification, light reflectance, protection against grazing, and other functions, making it important to understand their synthesis and regulation in relation to potential crop improvement and climate change. This review critically addresses the origin, synthesis, significance, regulation, and fate of CaOx CRs in plants and soil, presenting them as potential biominerals for future climate-driven issues.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Environmental Sciences
Zhenlei Wang, Yunliang Zhao, Tong Wen, Tingting Zhang, Haoyu Bai, Shaoxian Song, Qiwu Zhang
Summary: Cd(II) pollution in water is a serious threat to the environment and human health. This study developed an activated calcium carbonate (CaCO3) material by modifying its crystallinity, particle size, and surface activity, and evaluated its effectiveness in removing Cd(II) from aqueous solutions. The activated CaCO3 exhibited excellent Cd(II) removal performance, achieving over 99.9% removal within 10 minutes. The mechanical activation of CaCO3 altered its surface activity, promoting the slow-release dissolution equilibrium of active carbonate groups and facilitating the coprecipitation of cadmium hydroxide and cadmium carbonate on CaCO3 particles. This research demonstrates the potential of mechanically activated CaCO3 as a remediation material for efficient removal of heavy metal pollution in water, addressing the issues of filtration difficulties and high effluent pH associated with alkaline precipitation.
WATER AIR AND SOIL POLLUTION
(2022)
Article
Chemistry, Multidisciplinary
Xiaofang Shi, Lin Ma, Yingjie Li, Zhenpu Shi, Qingcong Wei, Guanglei Ma, Weiwei Zhang, Yuming Guo, Peiyi Wu, Zhiguo Hu
Summary: Non-contact human-machine interaction is the future trend for wearable technologies, and the pandemic has emphasized the demand for it. A highly conductive hydrogel thermocell with anti-fatigue and self-powering capabilities has been designed. The thermocell stands out with its high seebeck coefficient and extraordinary toughness.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xiaobing Wang, Yihao Zhang, Yu Cao, Zhi Zheng, Xiaowei Guo, Jiabao Cui, Xiangdong Lou, Yuming Guo, Huijun Liang, Zhansheng Lu, Lin Yang, Hua Zhang, Xiaoming Ma
Summary: The novel tufted nanoneedle embedded localized microsphere (TELM) nanoarchitecture has been proposed and successfully synthesized. The TELM is composed of tufted rutile TiO2 nanoneedles embedded on the localized surface of anatase TiO2 microspheres (TiO2-TELM). The decay lifetime of photogenerated charge carriers (PCCs) in TiO2-TELM is significantly prolonged compared to pure rutile and anatase TiO2, and the TiO2-TELM with 1 wt% Pd loading achieves an ultrahigh H-2 production rate in pure water. Moreover, the photogenerated electrons and holes in TiO2-TELM migrate towards the rutile and anatase phases of TiO2, respectively. This study provides an effective strategy for the rational design and controlled synthesis of nanoarchitectures.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Applied
Qingcong Wei, Ziming Jin, Weiwei Zhang, Yanfei Zhao, Yaxing Wang, Yixing Wei, Xing He, Guanglei Ma, Yuming Guo, Yuqin Jiang, Zhiguo Hu
Summary: Bacterial infection, oxidative stress, and inflammation are the main obstacles in wound healing. Hydrogels with moist and inherent properties have been developed to promote wound healing. In this study, a honokiol-laden micelle-crosslinked hyaluronate-based hydrogel was fabricated by mixing honokiol-laden PF127-CHO micelles, 3,3'-dithiobis (propionohydrazide) grafted hyaluronic acid, and silver ions. This multifunctional hydrogel showed excellent self-healing properties, antioxidant, and antibacterial capabilities. It also promoted wound healing by regulating macrophage polarization and angiogenesis. This inherent hydrogel provides a promising strategy for designing bioactive compounds-based wound dressings.
CARBOHYDRATE POLYMERS
(2023)
Article
Automation & Control Systems
Biao Wang, Wenjing Wang, Guanglei Meng, Tiankuo Meng, Bin Song, Yingnan Wang, Yuming Guo, Zhihua Qiao, Zhizhong Mao
Summary: This paper proposes an ensemble detector called Selective Feature Bagging (SFB) that simultaneously considers variance and bias reduction. By dynamically selecting the most competent base detectors, SFB improves accuracy without deterioration of diversity. Experimental results demonstrate the superiority of SFB over Feature Bagging (FB) on multiple datasets.
ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE
(2023)
Article
Biology
Chaoyong Liao, Jian Cui, Jiaqi Lei, Yuming Guo, Bingkun Zhang
Summary: This study investigated the effect of Bacillus subtilis natto (B. subtilis) and its mutant NBMK308 on egg quality in aging laying hens. The results showed that supplementation of NB205 and NBMK308 significantly improved albumen height, Haugh units, and eggshell thickness. In addition, the supplementation regulated key apoptosis-related genes, increased ovalbumin expression, regulated tight junction proteins, reduced pro-inflammatory cytokine levels, and improved the health and productivity of aging laying hens. There were differences in the expression of vitamin K-dependent proteins between NB205 and NBMK308, but no significant differences in the improvement of egg quality.
Article
Environmental Sciences
Massimo Stafoggia, Paola Michelozzi, Alexandra Schneider, Ben Armstrong, Matteo Scortichini, Masna Rai, Souzana Achilleos, Barrak Alahmad, Antonis Analitis, Christofer Astrom, Michelle L. Bell, Neville Calleja, Hanne Krage Carlsen, Gabriel Carrasco, John Paul Cauchi, Micheline D. S. Z. S. Coelho, Patricia M. Correa, Magali H. Diaz, Alireza Entezari, Bertil Forsberg, Rebecca M. Garland, Yue Leon Guo, Yuming Guo, Masahiro Hashizume, Iulian H. Holobaca, Carmen Iniguez, Jouni J. K. Jaakkola, Haidong Kan, Klea Katsouyanni, Ho Kim, Jan Kysely, Eric Lavigne, Whanhee Lee, Shanshan Li, Marek Maasikmets, Joana Madureira, Fatemeh Mayvaneh, Chris Fook Sheng Ng, Baltazar Nunes, Hans Orru, Nicolas Ortega, Samuel Osorio, Alfonso D. L. Palomares, Shih-Chun Pan, Mathilde Pascal, Martina S. Ragettli, Shilpa Rao, Raanan Raz, Dominic Roye, Niilo Ryti, Paulo H. N. Saldiva, Evangelia Samoli, Joel Schwartz, Noah Scovronick, Francesco Sera, Aurelio Tobias, Shilu Tong, Cesar D. L. C. Valencia, Ana Maria Vicedo-Cabrera, Ales Urban, Antonio Gasparrini, Susanne Breitner, Francesca K. de Donato
Summary: Suggestive evidence of effect modification between air temperature and air pollutants on mortality during the warm period was found in a global dataset of 620 cities.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Computer Science, Artificial Intelligence
Yuming Guo
Summary: Crowdsourcing enables a more open and social approach to product development by connecting crowdsourcing resources and participants in open innovation. This paper proposes a privacy-aware strategy for combining crowdsourcing resources based on edge and cloud computing. The construction of a cloud crowdsourcing platform and the deployment of privacy-aware edge computing for complex tasks are examined. Testing shows that the proposed method can protect the privacy of crowdsourcing communities and efficiently optimize the mobilization of crowdsourced product development resources. A comparison with other optimization techniques demonstrates the superior computational performance of the cooperative bacteria foraging optimization algorithm.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Chemistry, Physical
Jiuli Chang, Luyao Ma, Wenfang Liang, Fang Xu, Dapeng Wu, Kai Jiang, Yuming Guo, Zhiyong Gao
Summary: In this study, hierarchical bismuthyl bromide (BiOBr) microspheres with laminar assembly were prepared via solvothermal reaction and tested as negative battery materials for aqueous alkali batteries. The redox reactions of Bi species in low potential enabled high battery capacity, and the porous texture with high hydrophilicity facilitated diffusion of OH- and faradaic reactions. The BiOBr exhibited decent specific capacity, rate capability, and cycleability when used as negative battery electrode, and the alkaline batteries based on BiOBr electrode showed high energy density and good cycleability. This work demonstrates the valuable application expansion of traditional BiOBr photocatalyst in battery systems.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Jiuli Chang, Wenyu Wang, Dapeng Wu, Fang Xu, Kai Jiang, Yuming Guo, Zhiyong Gao
Summary: Efficient catalytic electrodes are crucial for producing green hydrogen via water electrolysis. The replacement of oxygen evolution reaction by tailored electrooxidation of certain organics enables co-production of hydrogen and value-added chemicals, saving energy and ensuring safety.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Yi Wei, Yongfa Liu, Guang Li, Yuming Guo, Bingkun Zhang
Summary: This study found that supplementing quercetin and genistein can improve eggshell thickness, enhance egg quality, and reduce lipid accumulation in aging hens. These supplements also have significant effects on lipid levels in egg yolk, serum, and immune function.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Integrative & Complementary Medicine
Tao Su, Zhi-e Fang, Yu-ming Guo, Chun-yu Wang, Jia-bo Wang, Dong Ji, Zhao-fang Bai, Li Yang, Xiao-he Xiao
Summary: This study retrospectively assessed the risk of AA-associated cancer in patients with AAN. The results showed no cases of liver cancer were observed at the end of follow-up, but a high prevalence of urinary cancer was found in AAN patients.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Microbiology
Meihong Zhang, Depeng Li, Xinyue Yang, Fuxiao Wei, Qiu Wen, Yuqing Feng, Xiaolu Jin, Dan Liu, Yuming Guo, Yongfei Hu
Summary: Growing evidence suggests a close relationship between gut microbiota and chicken growth performance. Through integrated multi-omics analyses, this study reveals differences in gut microbiota composition and host-microbiota interactions between high body weight (HBW) and low body weight chickens. The HBW microbiota contributes to chicken growth by regulating gut function and homeostasis. Additionally, a specific bacterial consortium derived from HBW chickens shows potential as a chicken growth promoter. These findings provide new insights into the potential links between gut microbiota and chicken phenotypes, with implications for improving chicken growth performance.
Article
Agriculture, Dairy & Animal Science
Lu Gong, Tahir Mahmood, Yves Mercier, Huiping Xu, Xiaodan Zhang, Yizhu Zhao, Yimeng Luo, Yuming Guo
Summary: Dietary supplementation with DL-HMTBA can improve intestinal barrier function, enhance immune homeostasis, and optimize the microbiota in broiler chickens, promoting intestinal health status.
Article
Chemistry, Multidisciplinary
Fangli Gao, Liang Zhu, Liting Jiang, Jie Zhang, Shenglu Ji, Weihua Gao, Guanglei Ma, Yi Chang, Xiaoming Ma, Yuming Guo
Summary: The efficient penetration and retention of nanoparticles at the tumor site is crucial for enhancing the therapeutic efficacy of nanomedicines. A smart nanosystem is developed to address this dilemma and achieve multimodal tumor therapy through in situ aggregation of CuS nanoparticles and releasing therapeutic agents upon NIR irradiation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yi Chang, Bowen Pang, Weiyi Cheng, Penghui Song, Ruijuan Qi, Xiaobing Wang, Zhengyu Bai, Yuming Guo, Nana Ma, Xiaoming Ma
Summary: Researchers report a facile and universal synthesis method for producing biomimetic volvox-like double-core nested hollow materials, which possess a special structure and strong light-reflection capability, allowing for efficient capturing and utilization of solar energy.
