Article
Oncology
Mashari Alzahrani, Mark Clemons, Marta Sienkiewicz, Noa Shani Shrem, Sharon F. McGee, Lisa Vandermeer, Sandeep Sehdev, Marie France Savard, Arif Awan, Christina Canil, Brian Hutton, Gregory Pond, Deanna Saunders, Terry Ng
Summary: The optimal use of bone-modifying agent therapy in patients with bone metastases from breast and castrate-resistant prostate cancer is evolving. Study found misconceptions about the benefits of BMAs among patients, indicating a need for more patient education. Most patients were interested in further de-escalation of BMA therapy after 2 years of prior treatment.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Biochemistry & Molecular Biology
Yangyang Liu, Dongsheng Zhao, Chenghua Zhang, Hui Fang, Qingsitong Shen, Zhixian Wang, Jiangying Cao
Summary: Aminopeptidase N (APN) inhibitors, particularly pyrazoline-based hydroxamate derivatives, have shown significant potential as antitumor agents. Compound 14o exhibited the strongest inhibitory activity against APN, with IC50 value three orders of magnitude better than that of the positive control bestatin. Furthermore, compound 14o demonstrated potent anti-proliferative activities against tumor cells and anti-angiogenic activity.
Article
Medicine, Research & Experimental
Yana Epshtein, Rachel Blau, Evgeni Pisarevsky, Shani Koshrovski-Michael, Dikla Ben-Shushan, Sabina Pozzi, Gal Shenbach-Koltin, Lidar Fridrich, Marina Buzhor, Adva Krivitsky, Pradip Dey, Ronit Satchi-Fainaro
Summary: This study designed novel polymeric imaging and therapeutic systems for comprehensive melanoma treatment management. By utilizing advanced imaging tools and therapeutic drugs, it can improve treatment efficacy and prevent tumor metastasis.
Article
Chemistry, Organic
Saibin Zhu, Yeji Wang, Zhongqing Wen, Yanwen Duan, Yong Huang
Summary: The study revealed that Huanglongmycin congener 14 exhibited stronger cytotoxicity against tested cancer cells, and highlighted the critical role of the C-7 ethyl group of 14 in its binding to the DNA-topoisomerase I complex.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Marco Cordani, Esther Resines-Urien, Arturo Gamonal, Paula Milan-Rois, Lionel Salmon, Azzedine Bousseksou, Jose Sanchez Costa, Alvaro Somoza
Summary: Pancreatic cancer is a fatal disease with poor treatment outcomes. New triazole-based coordination trimers made with soluble Fe(II) were found effective in increasing reactive oxygen species and enhancing the efficacy of gemcitabine in pancreatic cancer cell lines. Further evaluation in animal models is necessary, but these results suggest potential for iron-based materials in biomedicine and pancreatic cancer treatment.
Article
Chemistry, Multidisciplinary
Hui-Ping Xiao, Ya-Shuai Hao, Xin-Xiong Li, Peng Xu, Ming-Dong Huang, Shou-Tian Zheng
Summary: This study reports a giant Sb-rich polyoxometalate (POM) {Sb21Tb7W56}, which contains the largest number of Sb atoms in a POM. The Sb-rich POM exhibits broad-spectrum antitumor activity against various cancer cell lines and is capable of suppressing the growth and metastasis of a breast cancer in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Mayursinh Zala, Jwalant J. Vora, Vijay M. Khedkar
Summary: To enhance the effectiveness of antitubercular drugs, a series of novel pyrazolylpyrazoline derivatives were synthesized through a one-pot multicomponent reaction. The green synthesis method offered advantages such as simplicity and shorter reaction time. Among the compounds tested, 9i, 9k, 9l, 9o, and 9p showed the highest efficacy against Mycobacterium tuberculosis H(37)Rv. Structural determination of the newly synthesized compounds was conducted using spectral methods. Molecular docking studies revealed strong binding affinities between these compounds and the active site of mycobacterial InhA enzyme.
Article
Cell Biology
Nicholas A. DaSilva, Benjamin J. Barlock, Prajna Guha, Chandra C. Ghosh, Catherine E. Trebino, Jodi L. Camberg, Steven C. Katz, David C. Rowley
Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in the tumor microenvironment, with unique programming at different metastatic sites. Utilizing SWATH-MS technology, distinct proteomes of MDSCs from different metastatic sites were identified, suggesting potential pharmacological manipulation of their activities.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Kerong Guo, Jian Li, Yingdong Jia, Xiaojuan Yang, Xiqing Yan, Liqiang Wu
Summary: In this study, novel quinolinedione-linked sulfonylpiperazine derivatives were investigated as NQO1-directed antitumor agents. Most of the compounds showed higher effectiveness in inhibiting cancer cell proliferation compared to 5-Fu and TSA. Among them, compound 22r exhibited significant anti-proliferative activity against NQO1-rich cancer cells and was recognized as an excellent substrate for NQO1. Mechanistic studies revealed that 22r induced ROS production, DNA damage, and apoptosis in HepG2 cells. Remarkably, compound 22r also showed excellent anticancer activity in HepG2 xenograft models. Overall, this study demonstrated that compound 22r could be a promising strategy for the treatment of malignant tumors.
BIOORGANIC CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Roger von Moos, Katie Lewis, Lucy Massey, Andrea Marongiu, Alex Rider, Anouchka Seesaghur
Summary: Based on European data, not all patients with bone metastases receive bone-targeted therapy immediately following diagnosis. Clinical decisions are primarily driven by bone pain symptoms when considering bone protection therapy for cancer patients.
Article
Chemistry, Medicinal
Antonio Laghezza, Luca Piemontese, Leonardo Brunetti, Alessia Caradonna, Mariangela Agamennone, Fulvio Loiodice, Paolo Tortorella
Summary: Matrix metalloproteinases (MMPs) play a crucial role in physiological tissue remodeling but overexpression of certain MMPs, associated with pathological conditions like cancer and metastasis, has led to exploration of MMP inhibitors (MMPIs) as a strategy to hinder metastasis. However, the clinical use of MMPIs has been limited by side effects, prompting the development of strategies to improve therapeutic profile and targeting specificity.
Article
Chemistry, Multidisciplinary
Hyunhong Kim, Sunyoung Woo, Hoesu Jung, Hyo-Suk Ahn, Ning Chen, HyungJoon Cho, Jongnam Park
Summary: This study reports on the synthesis of highly stable and compact Fe3+-rich ultrasmall IONPs functionalized with a multidentate catechol-based PEG polymer ligand through amine-assisted nanocoating. The resulting nanoparticles exhibit excellent stability, low nonspecific binding, and long circulation time in vivo, enabling high-resolution T-1 magnetic resonance angiography. This research opens up new possibilities for the application of metal oxide nanoparticles in various bio-applications.
NANOSCALE ADVANCES
(2023)
Review
Biotechnology & Applied Microbiology
Priyanka Thakur, Neeraj K. Saini, Vijay Kumar Thakur, Vijai Kumar Gupta, Reena V. Saini, Adesh K. Saini
Summary: Rhamnolipids are potent biosurfactants produced mainly by Pseudomonas aeruginosa, with a wide range of potential applications in therapy, immunomodulation, and antimicrobial activities. They also show promise in reducing post-harvest decay of food products.
MICROBIAL CELL FACTORIES
(2021)
Article
Chemistry, Physical
Ines Francisco, Francisco Vale, Victor Martin, Maria Helena Fernandes, Pedro Sousa Gomes
Summary: The study found that direct contact of L-PRF can enhance bone growth and increase mineral content, as well as induce stronger angiogenesis activity compared to indirect contact.
Article
Orthopedics
Yutaro Kanda, Kenichiro Kakutani, Takashi Yurube, Zhongying Zhang, Shingo Miyazaki, Yuji Kakiuchi, Yoshiki Takeoka, Ryu Tsujimoto, Kunihiko Miyazaki, Teruya Kawamoto, Toru Takada, Yuichi Hoshino, Yasuhiko Tabata, Ryosuke Kuroda
Summary: The study aimed to investigate the antitumor effects and safety of gelatin hydrogel microspheres incorporating cisplatin (GM-CDDP) as a sustained release system. Results showed that local administration of GM-CDDP significantly suppressed tumor growth and bone osteolysis and reduced loss of body weight and elevation of blood urea nitrogen compared with systemic administration of free CDDP.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Letter
Nanoscience & Nanotechnology
Helena F. Florindo, Asaf Madi, Ronit Satchi-Fainaro
NATURE NANOTECHNOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Nir Hananya, Ofir Press, Alakesh Das, Anna Scomparin, Ronit Satchi-Fainaro, Irit Sagi, Doron Shabat
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Article
Chemistry, Multidisciplinary
Ana Matos, Barbara Carreira, Carina Peres, Liane I. F. Moura, Joao Conniot, Thibaut Fourniols, Anna Scomparin, Agueda Martinez-Barriocanal, Diego Arango, Joao P. Conde, Veronique Preat, Ronit Satchi-Fainaro, Helena F. Florindo
JOURNAL OF CONTROLLED RELEASE
(2019)
Article
Chemistry, Multidisciplinary
Alessio Malfanti, Anna Scomparin, Sabina Pozzi, Hadas Gibori, Adva Krivitsky, Rachel Blau, Ronit Satchi-Fainaro, Francesca Mastrotto, Paolo Caliceti, Stefano Salmaso
JOURNAL OF CONTROLLED RELEASE
(2019)
Article
Chemistry, Multidisciplinary
Ella Borberg, Marina Zverzhinetsky, Adva Krivitsky, Alon Kosloff, Omri Heifler, Gal Degabli, Hagit Peretz Soroka, Ronit Satchi Fainaro, Larisao Burstein, Shlomi Reuveni, Haim Diamant, Vadim Krivitsky, Fernando Patolsky
Review
Nanoscience & Nanotechnology
Helena F. Florindo, Ron Kleiner, Daniella Vaskovich-Koubi, Rita C. Acurcio, Barbara Carreira, Eilam Yeini, Galia Tiram, Yulia Liubomirski, Ronit Satchi-Fainaro
NATURE NANOTECHNOLOGY
(2020)
Article
Multidisciplinary Sciences
Lea Monteran, Nour Ershaid, Idan Sabah, Ibrahim Fahoum, Yael Zait, Ophir Shani, Noam Cohen, Anat Eldar-Boock, Ronit Satchi-Fainaro, Neta Erez
SCIENTIFIC REPORTS
(2020)
Correction
Biology
Lee Shaashua, Anabel Eckerling, Boaz Israeli, Gali Yanovich, Ella Rosenne, Suzana Fichman-Horn, Ido Ben Zvi, Liat Sorski, Rita Haldar, Ronit Satchi-Fainaro, Tamar Geiger, Erica K. Sloan, Shamgar Ben-Eliyahu
Review
Pharmacology & Pharmacy
Carina Peres, Ana Matos, Liane I. F. Moura, Rita C. Acurcio, Barbara Carreira, Sabina Pozzi, Daniella Vaskovich-Koubi, Ron Kleiner, Ronit Satchi-Fainaro, Helena F. Florindo
Summary: Targeted immunotherapies have revolutionized cancer treatment, but tumor heterogeneity and immunosuppression mechanisms have hindered the success of cancer vaccines. Nanotechnology offers promising solutions, but the selection of appropriate preclinical models is crucial.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Cell Biology
Gali Yanovich-Arad, Paula Ofek, Eilam Yeini, Mariya Mardamshina, Artem Danilevsky, Noam Shomron, Rachel Grossman, Ronit Satchi-Fainaro, Tamar Geiger
Summary: This study utilized high-resolution mass spectrometry proteomics and RNA sequencing to analyze 87 GBM patients, identifying specific immune, metabolic, and developmental processes associated with survival. The findings revealed a stronger association between proteomic profiles and survival, establishing proteomic heterogeneity in GBM as a key factor in understanding poor survival.
Review
Pharmacology & Pharmacy
Sabina Pozzi, Anna Scomparin, Sahar Israeli Dangoor, Daniel Rodriguez Ajamil, Paula Ofek, Lena Neufeld, Adva Krivitsky, Daniella Vaskovich-Koubi, Ron Kleiner, Pradip Dey, Shani Koshrovski-Michael, Noa Reisman, Ronit Satchi-Fainaro
Summary: Three-dimensional cancer models have been developed to study a wide range of biological applications, including cell signaling pathways, metastatic cascade steps, and personalized medicine, in vitro. By combining different cell types and external stimuli, these models can more accurately mimic the biology and pathophysiology of in vivo tumors.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Multidisciplinary Sciences
Eilam Yeini, Paula Ofek, Sabina Pozzi, Nitzan Albeck, Dikla Ben-Shushan, Galia Tiram, Sapir Golan, Ron Kleiner, Ron Sheinin, Sahar Israeli Dangoor, Shlomit Reich-Zeliger, Rachel Grossman, Zvi Ram, Henry Brem, Thomas M. Hyde, Prerna Magod, Dinorah Friedmann-Morvinski, Asaf Madi, Ronit Satchi-Fainaro
Summary: The study revealed the crucial role of P-selectin in promoting GB proliferation and invasion, showing that inhibiting P-selectin could reduce tumor growth and increase survival in mouse models. The findings shed light on the function of tumor-associated microglia/macrophages and the mechanisms by which GB cells suppress the immune system and invade the brain, paving the way to exploit P-selectin as a target for GB therapy.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Adva Krivitsky, Sabina Pozzi, Eilam Yeini, Sahar Israeli Dangoor, Tal Zur, Sapir Golan, Vadim Krivitsky, Nitzan Albeck, Evgeny Pisarevsky, Paula Ofek, Asaf Madi, Ronit Satchi-Fainaro
Summary: The use of a sulfonated amphiphilic poly(alpha)glutamate nanocarrier decorated with sulfonate groups shows potential for targeted siRNA delivery to GB brain tumors, leading to specific gene silencing and reduced cell viability in both chemo-sensitive and chemo-resistant GB cells. This approach may strengthen therapeutic applications of siRNA for chemo-resistant GB tumors and serve as a combination therapy for chemo-sensitive GB tumors.
Article
Biology
Lee Shaashua, Anabel Eckerling, Boaz Israeli, Gali Yanovich, Ella Rosenne, Suzana Fichman-Horn, Ido Ben Zvi, Liat Sorski, Rita Haldar, Ronit Satchi-Fainaro, Tamar Geiger, Erica K. Sloan, Shamgar Ben-Eliyahu
Article
Chemistry, Multidisciplinary
Samer Gnaim, Anna Scomparin, Anat Eldar-Boock, Christoph R. Bauer, Ronit Satchi-Fainaro, Doron Shabat
