Article
Chemistry, Medicinal
Dandan Zhang, Guiqing Xu, Jie Zhao, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang, Chunhua Ma, Yuqin Jiang, Qingjie Ding
Summary: BTK inhibitors are promising drugs for hematological tumors treatment with high selectivity and reduced side effects. Designed range of inhibitors showed potent activity in vitro and can be further developed.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Physics, Multidisciplinary
Xin Shi, Anna-Katharina Pumm, Jonas Isensee, Wenxuan Zhao, Daniel Verschueren, Alejandro Martin-Gonzalez, Ramin Golestanian, Hendrik Dietz, Cees Dekker
Summary: Researchers have demonstrated a self-assembled DNA nanostructure that exhibits flow-driven rotary motion when docked onto a nanopore. These artificial nanoengines operate autonomously under physiological conditions, providing a new approach to constructing energy-transducing motors at nanoscale interfaces.
Article
Chemistry, Medicinal
Jiechun Tang, Jiuyu Liu, Xinzi He, Siyu Fu, Kang Wang, Chunting Li, Yuan Li, Yanli Zhu, Ping Gong, Yanfang Zhao, Yajing Liu, Yunlei Hou
Summary: In this study, new derivatives containing dithiocarbamate were designed and synthesized to investigate their inhibitory activities on PI3K. Compound 13 showed strong efficacy in inhibiting PI3K and two tumor cell lines, and induced tumor regression in a mouse model.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Nanoscience & Nanotechnology
Stefano Corra, Marina Tranfic Bakic, Jessica Groppi, Massimo Baroncini, Serena Silvi, Emanuele Penocchio, Massimiliano Esposito, Alberto Credi
Summary: This study presents a theoretical model and experimental evidence for the operation of an out-of-equilibrium photoactivated artificial molecular pump. The relationship between light energy input and the deviation of the dissipative state from thermodynamic equilibrium in this artificial system is quantitatively analyzed.
NATURE NANOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Xiao Xi, Yuan-Yuan Hei, Yuanxu Guo, Hong-Yi Zhao, Minhang Xin, Shemin Lu, Congshan Jiang, San-Qi Zhang
Summary: In this study, a series of 4-(N-norfloxacin-acyl)aminobenzamides were designed and synthesized, and compound A7 was identified as the most efficient microRNA-21 small molecule inhibitor. A7 demonstrated inhibitory effects on migration, colony formation, and apoptosis in Hela cells. Mechanistically, A7 reduced the levels of mature microRNA-21 by disrupting its transcription at the level of its primary form pri-miR-21. Furthermore, A7 upregulated the expression of downstream functional targets PTEN, EGR1 and SLIT2 of microRNA-21.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Physics, Fluids & Plasmas
Thomas Speck
Summary: This study investigates microscopic engines that utilize a single active particle as the working medium, demonstrating the recovery of energy for work during the directed motion of the particle at constant temperature. By considering the chemical degrees of freedom, a wide range of synthetic active particles can be studied without the need to determine the exact microscopic mechanism. Analytical results reveal that the quasistatic thermodynamic efficiency increases beyond the linear-response regime and reaches a maximum at high propulsion speeds, indicating the nontrivial consequences of driving in the active engine's efficiency.
Article
Chemistry, Medicinal
Walter D. Guerra, Daniel Lucena-Agell, Rafael Hortiguela, Roberto A. Rossi, J. Fernando Diaz, Jose M. Padron, Silvia M. Barolo
Summary: Researchers synthesized a series of potential anti-tumor dibenzothiazine compounds and identified two compounds with promising activity values. These compounds were shown to inhibit the proliferative activity of human solid tumor cells.
Article
Chemistry, Multidisciplinary
Guanying Li, Xunwu Hu, Xia Wu, Ye Zhang
Summary: By synthesizing peptide-based rotor molecules with the potential to self-assemble, researchers were able to target microtubules and inhibit cancer cell proliferation without inducing obvious neurotoxicity, showcasing a novel approach for cancer therapy.
Article
Nanoscience & Nanotechnology
Michael Kathan, Stefano Crespi, Niklas O. Thiel, Daniel L. Stares, Denis Morsa, John de Boer, Gianni Pacella, Tobias van den Enk, Piermichele Kobauri, Giuseppe Portale, Christoph A. Schalley, Ben L. Feringa
Summary: In this study, researchers reported a light-fuelled small-molecule ratchet capable of driving a coupled chemical equilibrium energetically uphill. By bridging imine macrocycles with a molecular motor, the machine can adopt different topologies, allowing for the coupling of continuous mechanical motion with a chemical transformation.
NATURE NANOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Mykola Tasinkevych, Artem Ryabov
Summary: We studied the dynamics of a chemical nanoswimmer in a periodically rocked ratchet potential, and found that mechanochemical coupling can be utilized to control the motion of chemically active particles at the nanoscale.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Multidisciplinary
Nicolai N. Bach, Verena Josef, Harald Maid, Henry Dube
Summary: Researchers have developed a macrocyclic molecular motor structure that can convert a flexible chain into unidirectional linear motion through active mechanical threading. This offers a new approach for molecular knitting technology.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Waleed A. Badawi, Mohamed Samir, Hazem M. Fathy, Tarek M. Okda, Mohamed H. Noureldin, Gamal M. K. Atwa, Omaima M. AboulWafa
Summary: This study focused on the signaling pathway of adenosine diphosphate receptor α1 in lingual osteoblasts and found that hydrazine methyl isoindole has selectivity towards adenosine diphosphate receptor α1. Compared to other pathway inhibitors, hydrazine methyl isoindole shows better selectivity. Furthermore, hydrazine methyl isoindole exhibits significant inhibitory effects on the activity and function of adenosine diphosphate receptor α1 in lingual osteoblasts.
BIOORGANIC CHEMISTRY
(2023)
Article
Mathematics, Applied
N. J. Lopez-Alamilla, R. U. L. Cachi
Summary: We present a methodology to approximate the entropy production for Brownian motion in a tilted periodic potential. The approximation is based on the well-known thermodynamic uncertainty relation and provides a tighter lower limit solely based on drift velocity and diffusion. The approach is systematically analyzed in the tight-binding regime, and a relatively simple rule is provided to validate using the tight-binding approach. The implications of the results outside the tight-binding regime are also discussed.
Article
Chemistry, Multidisciplinary
Sofie K. Jensen, Mathias S. Neumann, Rikke Frederiksen, Mathias L. Skavenborg, Mads C. Larsen, Stinne E. Wessel, Jan O. Jeppesen
Summary: Controlling the movement of CBPQT(4+) ring is essential for the full potential utilization of artificial molecular machines. In this study, two isomeric tri-stable [2]rotaxanes incorporating TTF and MPTTF units were synthesized to measure the energy barriers during the movement of CBPQT(4+) ring. By strategically exchanging thiomethyl barriers with thioethyl groups, the movement of CBPQT(4+) ring in the synthesized compounds can be controlled to occur in only one direction. Cyclic voltammetry and H-1 NMR spectroscopy were used to investigate the switching mechanism. The results demonstrate the first successful induction of directional movement of CBPQT(4+) ring in molecular machines using a combination of TTF and MPTTF units with 90% efficiency.
Article
Chemistry, Multidisciplinary
Anastasia Yu Gitlina, Farzaneh Fadaei-Tirani, Albert Ruggi, Carolina Plaice, Kay Severin
Summary: This study demonstrates that fac-Ir(C^N)(3) can be converted into the thermodynamically less stable mer form through a consecutive reaction with acid and base, which is fast, quantitative, and stereoselective and can be reversed by light. This new isomerization process opens up the possibility of using highly luminescent Ir(C^N)(3) complexes as molecular switches.
Article
Biochemistry & Molecular Biology
Johanna Kastl, Joachim Braun, Andreas Prestel, Heiko M. Moeller, Thomas Huhn, Thomas U. Mayer
ACS CHEMICAL BIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Andreas Heim, Anja Konietzny, Thomas U. Mayer
Article
Cell Biology
Lukas Badertscher, Thomas Wild, Christian Montellese, Leila T. Alexander, Lukas Bammert, Marie Sarazova, Michael Stebler, Gabor Csucs, Thomas U. Mayer, Nicola Zamboni, Ivo Zemp, Peter Horvath, Ulrike Kutay
Article
Biochemistry & Molecular Biology
Naowras Al-Obaidi, Timothy J. Mitchison, Craig M. Crews, Thomas U. Mayer
ACS CHEMICAL BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Martin M. Moeckel, Corinna Hund, Thomas U. Mayer
Retraction
Cell Biology
Saurav Malhotra, Palakkad Krishnanunni Vinod, Jorg Mansfeld, Olaf Stemmann, Thomas U. Mayer
DEVELOPMENTAL CELL
(2016)
Article
Multidisciplinary Sciences
Julia Locke, Agnel Praveen Joseph, Alejandro Pena, Martin M. Moeckel, Thomas U. Mayer, Maya Topf, Carolyn A. Moores
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Biology
Martin M. Moeckel, Andreas Heim, Thomas Tischer, Thomas U. Mayer
Article
Biochemistry & Molecular Biology
Joachim Braun, Martin M. Moeckel, Tobias Strittmatter, Andreas Marx, Ulrich Groth, Thomas U. Mayer
ACS CHEMICAL BIOLOGY
(2015)
Article
Chemistry, Multidisciplinary
Tatjana Schneider, Daniel Schneider, Daniel Roesner, Saurav Malhotra, Franziska Mortensen, Thomas U. Mayer, Martin Scheffner, Andreas Marx
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2014)
Article
Chemistry, Organic
Anne-Katrin Spaete, Verena F. Schart, Julia Haefner, Andrea Niederwieser, Thomas U. Mayer, Valentin Wittmann
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2014)
Article
Multidisciplinary Sciences
Julia Haefner, Monika I. Mayr, Martin M. Moeckel, Thomas U. Mayer
NATURE COMMUNICATIONS
(2014)
Article
Biochemistry & Molecular Biology
Andreas Heim, Thomas Tischer, Thomas U. Mayer
Article
Biochemistry & Molecular Biology
Lars Henschke, Matthias Frese, Susanne Hellmuth, Andreas Marx, Olaf Stemmann, Thomas U. Mayer
ACS CHEMICAL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
P. Ripani, J. Delp, K. Bode, M. E. Delgado, L. Dietrich, V. M. Betzler, N. Yan, G. von Scheven, T. U. Mayer, M. Leist, T. Brunner