Article
Polymer Science
Clio Siebenmorgen, Guangyue Zu, Damla Keskin, Patrick van Rijn
Summary: The study focuses on designing innovative dynamic porous microstructures using dynamic matrices and Pickering emulsions. By using nanogels as stabilizing agents, dynamic covalent cross-linked hydrogel microstructures were successfully formed, with pH-triggerable responsive behavior and customizable physiochemical properties, making them suitable for a wide range of applications.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Qianqian Lu, Hongyue Yu, Tiancong Zhao, Guanjia Zhu, Xiaomin Li
Summary: In recent years, researchers have made significant progress in developing nanomedicines with transformable physicochemical properties, which enable responsive switching of size, shape, surface charge, and other parameters. These properties allow the nanomedicines to overcome biological barriers and achieve maximum delivery efficiency. This review summarizes recent developments in this field, including the analysis of biological dilemmas, the design and synthesis of nanomaterials with transformable properties, and the discussion of other switchable physicochemical parameters. The prospects and challenges for nanomedicines with these properties are also highlighted.
Article
Engineering, Biomedical
Mehdi Azizi, Rana Jahanban-Esfahlan, Hadi Samadian, Masoud Hamidi, Khaled Seidi, Alireza Dolatshahi-Pirouz, Amirhossein Ahmadieh Yazdi, Amin Shavandi, Sophie Laurent, Mahsa Be Omide Hagh, Nahid Kasaiyan, Helder A. Santos, Mohammad-Ali Shahbazi
Summary: In the past three decades, nanoscience has provided a unique solution for reducing the systemic toxicity and increasing therapeutic efficiency of chemotherapy drugs. However, the poor accumulation and pharmacokinetics of nanoparticles hinder their translation into clinical use. New findings suggest that the efficacy based on enhanced permeability and retention may be as low as 1%. This review focuses on the current barriers, available solutions, and strategies for efficient drug delivery using nanocarriers and the tumor environment.
MATERIALS TODAY BIO
(2023)
Article
Polymer Science
Jianhua Ren, Kensuke Hasuo, Yujun Wei, Isao Tabata, Teruo Hori, Kazumasa Hirogaki
Summary: Polymer-based monolithic composite aerogels with a durable cross-linked structure were fabricated using polyvinyl alcohol (PVA) and para-aramid nanofibers (ANFs) as precursors, and the influences of PVA molecular weights and dosage ratios on the properties of the composite aerogels were explored. The results showed that both the molecular weights and dosage ratios of PVA had significant effects on the chemical composition, porous nanostructure, porosity, and mechanical performance of the ANFs/PVA composite aerogels. This study provides valuable insights for the design and fabrication of polymer-based aerogels with desirable properties.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Flavia Carton, Manuela Malatesta
Summary: Nanoconstructs developed for biomedical purposes need to overcome biological barriers. In vivo models are complex and limited, so simplified in vitro models are preferred. Various in vitro models have been set up, including 2D cell cultures, cell monolayers, 3D cell cultures, and bioreactors. This review provides an overview of the most representative and performing in vitro models for studying biological barriers in nanomedical research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Inorganic & Nuclear
Utsab Manna, Abhishek Dutta, Manoj Kumar Baskey
Summary: In this study, a series of new Zn-II coordination complexes were designed and synthesized, and the crystal engineering-based design strategy for preparing metallogels was determined by investigating the structure-property correlation. Additionally, it was found that hand-ground nanoscale ZnCl2-based coordination complexes exhibited anticancer activities.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Alexandra Schroter, Carla Arnau del Valle, Maria J. Marin, Thomas Hirsch
Summary: This research introduces a bilayer-based strategy for surface modification of hydrophobic nanoparticles, allowing for excellent colloidal stability in aqueous environments and protection against disintegration while permitting surface functionalization. The potential of this strategy was demonstrated using upconversion nanoparticles. This surface engineering strategy is important for protecting and functionalizing inorganic nanoparticles in biological media for theranostic applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Tae Woong Kang, Atsushi Tamura, Yoshinori Arisaka, Nobuhiko Yui
Summary: Thin-layer photodegradable polyrotaxane (PRX) gel-immobilized surfaces were used to investigate the photoregulation of surface properties. By utilizing visible light irradiation, the surface properties and cell adhesiveness of the PRX-MTP gel surfaces could be regulated, affecting cell adhesion on the irradiated surfaces. These photodegradable PRX-MTP gel surfaces show potential for cell patterning, cell function control, and advanced cell culture systems.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Instruments & Instrumentation
Anvay Ukidve, Katharina Cu, Ninad Kumbhojkar, Joerg Lahann, Samir Mitragotri
Summary: This review focuses on efforts to overcome tumor-associated biological barriers and enhance the potency of immunotherapy, including understanding barriers that limit drug entry into tumors, in vitro techniques for investigating transport processes, and delivery strategies to overcome these barriers. The aim is to provide a framework for the rational development of technologies for improved solid tumor immunotherapy.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Engineering, Environmental
Chengxiang Chen, Weili Yang, Yanyan Bai, Yufeng Zhou, Xiao Cao, Zhengfeng Ma, Meirong Cai, Bin Zhang, Quan Chen, Feng Zhou, Weifeng Bu
Summary: The study demonstrated the construction of structurally dynamic gels in base oils through reversible ring opening reaction, allowing for homogeneous dispersion of nanoparticles. Experimental results showed that the composite gels exhibit excellent performance in reducing friction coefficient and wear volume, along with long-term colloidal stability.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Tomasz Osmalek, Anna Froelich, Barbara Jadach, Adam Tatarek, Piotr Gadzinski, Aleksandra Falana, Kinga Gralinska, Michal Ekert, Vinam Puri, Joanna Wrotynska-Barczynska, Bozena Michniak-Kohn
Summary: The vagina has long been considered as a potential drug administration route, with most formulations made of natural or synthetic polymers serving different functions. In addition to topical applications, the anatomical and physiological features of the vagina make it suitable for systemic drug absorption. Research shows that intravaginal products continue to attract scientific attention, with ongoing exploration of novel polymers and formulations.
Review
Chemistry, Multidisciplinary
Seongchan Kim, Taegon Oh, Hyojin Lee, Jwa-Min Nam
Summary: This article reviews the various types of nanoparticles used as delivery vehicles in clinical therapeutic applications, discussing their advantageous properties and functions, as well as the issues and limitations. The strategies to overcome biological barriers and harsh physiological conditions are summarized, and green synthesis methods and their environmental impacts are introduced and discussed. The article also provides perspectives on the biocompatibility, toxicity and environmental consequences of nanoparticles developed for biomedical applications.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Review
Chemistry, Multidisciplinary
Xuejian Li, Zhenkun Huang, Zhihuan Liao, Aijie Liu, Shuaidong Huo
Summary: Drug delivery systems have experienced massive studies and explosive growth in the past few decades. Nevertheless, barriers, such as biological barriers, still hinder the efficiency of nanomedicine delivery. Recent reports indicate that the physicochemical properties, including the morphologies of nanodrugs, significantly influence their biodistribution and bioavailability. Therefore, the development of transformable nanodrugs with different sizes and shapes shows promising potential in overcoming multiple biological barriers for efficient drug delivery. This review provides an overview of the recent advancements in transformable nanodrugs, including their design principles, transformation mechanisms, applications in overcoming biological barriers, current developments, and future perspectives.
Review
Chemistry, Multidisciplinary
Dong Wang, Peifeng Liu, Dan Luo
Summary: DNA, as a true polymer, has been utilized for constructing diverse materials for real-world applications due to its remarkable biological and polymeric characteristics. Recent research focuses on the construction of DNA-based networks without considering its genetic properties. With superb molecular recognition, self-assembly, and responsiveness, a growing number of DNA materials with various properties have been developed for general utilization.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Takuma Watabe, Hideyuki Otsuka
Summary: We present a new method for achieving swelling-induced mechanochemistry using a multinetwork (MN) strategy, which allows polymer networks to repeatedly swell with monomers and solvents. The isotropic expansion of the first network (FN) provides sufficient force to drive the mechanochemical scission of a radical-based mechanophore, difluorenylsuccinonitrile (DFSN). The MN polymers not only demonstrate the ability to modify networks through swelling force, but also show tunable reactivity of the dissociative unit through hierarchical network architecture design.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Meimei Fu, Yitao Zhao, Yue Wang, Yue Li, Min Wu, Qi Liu, Zhiguo Hou, Zhihui Lu, Keke Wu, Jinshan Guo
Summary: TE-CMBAs is a special type of bioadhesive dressing for diabetic wound healing. It has excellent properties such as fast gelation, shape adaptability, mechanical strength, tissue adhesiveness, antimicrobial activity, antioxidant activity, biocompatibility, and angiogenetic property. It also has self-healability and on-demand removability, offering effective treatment in the acidic environment of diabetic wounds.
Article
Chemistry, Inorganic & Nuclear
Haiming Cheng, Chi Cao, Shiyong Teng, Zhinan Zhang, Ying Zhang, Dayang Wang, Wensheng Yang, Renguo Xie
Summary: In this study, a new organic-inorganic hybrid halide material was designed and synthesized based on the combination of a d(10) metal cation (Cd2+) and choline chloride molecules. The material exhibited excellent photoelectric properties and belonged to the orthorhombic crystal system with a one-dimensional structure. This work provides guidance for the design and synthesis of emerging optical materials.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Liping Jing, Chongling Cheng, Bo Wang, Shun Wang, Renguo Xie, Haibing Xia, Dayang Wang
Summary: Freestanding membranes of CuCl2-implanted TpPa covalent organic frameworks (COFs) were produced using mechanochemical methods. These membranes exhibited high I2 adsorption capacity (566.78 gmol-1) in cyclohexane, with 2.2I2 per unit cell and 1.3I2 immobilized on 3Cl- ions (60%) and 0.9 on 3N atoms (40%). When placed in aqueous media, the membrane released 61.1% of its loaded I2 within 10 min, primarily from the Cl- ions, followed by the remaining 38.9% released mainly from the N atoms within about 5 h. The I2-loaded TpPa-CuCl2 COF membranes showed promising potential for instant and sustained disinfection, being able to repeatedly kill E. coli and retain bactericidal activity for several hours.
Article
Chemistry, Multidisciplinary
Xinru Yue, Xiang Zhang, Mengmeng Zhang, Wei Du, Haibing Xia
Summary: In this work, ultra-small core-shell Au-38.4@Au4.1Pt57.5 nanoparticles with an optimal Pt-to-Au ratio were prepared by etching treatment. These nanoparticles loaded on carbon black show superior electrocatalytic activity and durability for both the hydrogen evolution reaction and oxygen reduction reaction in acidic media.
Article
Engineering, Biomedical
Keke Wu, Meimei Fu, Yitao Zhao, Ethan Gerhard, Yue Li, Jian Yang, Jinshan Guo
Summary: This study developed a multifunctional bioadhesive made from the natural polyphenolic compound tannic acid, which possesses antioxidant, anti-inflammatory, and antimicrobial properties. The bioadhesive showed favorable biocompatibility and mechanical strength, and it promoted wound closure and scarless healing.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Rong Wang, Chongling Cheng, Huiyun Wang, Qi Tao, Dayang Wang
Summary: In this study, PVS-capped surfaces were constructed on PEMs via electrostatic assembly. The water wetting behavior on the resulting PVS-capped PEMs was meticulously studied. It was found that by adjusting the molecular packing density of surface sulfonate groups, the PVS capping promoted complete surface wetting by water and diminished the affinity to adhesion of ice, oil, and wax.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Environmental
Yujiao Xiahou, Junyang Liu, Junrong Zheng, Jun Yi, Dayang Wang, Haibing Xia
Summary: Macroscopically monocrystalline, self-assembled monolayers (M2-SAM) of gold nanoparticles coated with oleylamine (Au@OLA NPs) are achieved by optimizing their surface charges. The resulting M2-SAM of Au@OLA NPs exhibit unconventional Moire ' patterns beyond the imaging limit of scanning electron microscopy. The mono-crystallinity enables the M2-SAM to be used as SERS substrates for quantitative analysis and fabricate high precision and broad measurement span temperature sensors.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Jiali Yao, Chi Cao, Haiming Cheng, Renguo Xie, Dayang Wang, Wensheng Yang
Summary: Zero-dimensional (0D) metal halide perovskites (MHPs) have unique crystal and electronic structure. However, their luminescent efficiencies are lower than three-dimensional (3D) MHPs. This study synthesized Sn2+-doped 0D Rb4CdCl6 crystals with near-unity quantum efficiency (PLQY -98.04%) under UV excitation. The emission is attributed to self-trapped excitons, and Sn2+ dopant plays a vital role in improving the PLQY of 0D MHPs. These luminescent materials have promising applications in optoelectronic devices.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Mengmeng Zhang, Xiang Zhang, Min Lv, Xinru Yue, Zhaoke Zheng, Haibing Xia
Summary: In this work, the ethanol oxidation reaction (EOR) via the 12-electron (C1-12e) pathway on spiky Au@AuPd nanoparticles (NPs) with ultrathin AuPd alloy shells is achieved in alkaline media using near-infrared (NIR) light. The study found that OH radicals can be produced by the surfaces of Pd atoms in spiky Au@AuPd NPs under NIR light, and these OH radicals play a crucial role in breaking the C-C bonds of ethanol during the EOR process. The electrocatalytic performance of spiky Au@AuPd NPs for EOR under NIR light is significantly improved.
Article
Engineering, Biomedical
Yitao Zhao, Jintao Li, Lingli Liu, Yue Wang, Yan Ju, Chun Zeng, Zhihui Lu, Denghui Xie, Jinshan Guo
Summary: In this study, a porous microparticulate scaffold composed of bulk-modified zinc oxide (ZnO), tannic acid (TA), and silver nanoparticles (Ag NPs) was synthesized for repairing infected bone defects. The scaffold exhibited excellent antimicrobial activity, osteogenic properties, and immunomodulatory activity. It effectively promoted the osteogenic differentiation of bone marrow mesenchymal stem cells, controlled infection, and protected surrounding tissue.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Min Wu, Yitao Zhao, Meihan Tao, Meimei Fu, Yue Wang, Qi Liu, Zhihui Lu, Jinshan Guo
Summary: The study demonstrates the ability of l-malate to promote cellular bioenergetics and the development of a porous scaffold that supports cell growth and enhances wound healing through regulating metabolic microenvironment.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Jialu Li, Ash Dyer, Dan Smith, Paul Mulvaney
Summary: This study fabricates nanodrum resonators using nanometer-thick gold films as the drumheads and investigates their natural vibrations and mass sensitivity, finding that they can achieve high Q factors under specific conditions.
Article
Chemistry, Physical
Jiali Yao, Zixu Zhang, Dayang Wang, Keke Huang, Wensheng Yang, Litao Sun, Renguo Xie, Narayan Pradhan
Summary: Inorganic and hybrid metal halides have attracted increasing interest due to their diverse structures and properties. Mechanochemistry is considered a universal synthetic approach for their synthesis. The library of metal halides includes various types of compounds, and the structure-property relationships are well revealed. This study provides fundamental guidance for developing new metal halides with selective optoelectronic and magnetic properties.
CHEMISTRY OF MATERIALS
(2023)
Article
Engineering, Biomedical
Yue Wang, Yitao Zhao, Shiyuan Ma, Meimei Fu, Min Wu, Jintao Li, Keke Wu, Xiuli Zhuang, Zhihui Lu, Jinshan Guo
Summary: In this study, injective programmable proanthocyanidin-coordinated zinc-based composite hydrogels were developed to promote infected bone repair. These hydrogels exhibited strong antimicrobial and antioxidant properties, and could adapt to the microenvironment of infected bone defects by releasing antimicrobial substances and antioxidants while providing space for bone ingrowth.
ADVANCED HEALTHCARE MATERIALS
(2023)
