Article
Chemistry, Multidisciplinary
Dong-Hao Li, Bradley D. Smith
Summary: ICG, a clinically approved near-infrared fluorescent dye, is unstable in water. Deuterated versions of ICG have longer shelf-lives and can be used in medical and clinical procedures. Self-aggregation of ICG promotes photoinduced electron transfer, offering a new paradigm for next-generation photodynamic therapies.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
David DiMeglio, Xinqi Zhou, Tatiana Wirth, Frederik Brondsted, Lauren Lesiak, Yuan Fang, Mehrdad Shadmehr, Cliff I. Stains
Summary: A significant barrier inhibiting multiplexed imaging in the near-infrared (NIR) is the extensive trial and error associated with fine-tuning NIR dyes. This study introduces a time-dependent density functional theory (TD-DFT) approach to rapidly estimate absorbance and emission of new dyes, saving significant time compared to synthesis and evaluation of dye derivatives.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Dong-Hao Li, Rananjaya S. Gamage, Allen G. Oliver, Nimit L. Patel, Syed Muhammad Usama, Joseph D. Kalen, Martin J. Schnermann, Bradley D. Smith
Summary: This study reports a synthetic method for producing novel doubly strapped zwitterionic heptamethine cyanine dyes with enhanced stability. These dyes, including a structural analogue of ZW800-1, can be conjugated to proteins, including monoclonal antibodies, without causing fluorophore degradation or dye stacking. The fluorescent antibody conjugates show excellent tumor-targeting specificity in a xenograft mouse tumor model. The enhanced stability provided by the doubly strapped molecular design enables new classes of in vivo NIR fluorescence imaging experiments with possible translation to humans.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Organic
Kilian Colas, Susanne Doloczki, Mauricio Posada Urrutia, Christine Dyrager
Summary: This minireview discusses the synthesis, structure-photophysical properties relationship, and bioimaging applications of fluorescent coumarins, xanthenes, BODIPYs, and cyanines. Advantages and disadvantages of the emissive units are also explored, along with general practical considerations when using fluorophores in a biological context.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Mengyao Zhao, Jianbo Wang, Zuhai Lei, Lingfei Lu, Shangfeng Wang, Hongxin Zhang, Benhao Li, Fan Zhang
Summary: The newly developed pTAS sensors can achieve high sensitivity tumor pH monitoring within a wider response region, extending the pH detection range. Through dual-channel ratiometric bioimaging, the dynamic changes in tumor pH can be visualized in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Florian Grimm, Jasmin Rehman, Stefan Stoldt, Taukeer A. Khan, Jan Gero Schlotel, Shamil Nizamov, Michael John, Vladimir N. Belov, Stefan W. Hell
Summary: In this study, new rhodamine dyes were successfully synthesized through a series of reactions, and conjugates of these dyes with small molecules were used for specific labeling of organelles and components of the cytoskeleton in living cells. These dyes were also combined with fluorescent probes such as 610CP and SiR, and applied in two-color STED microscopy.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Polymer Science
Cagla Girisken, Senem Avaz Seven, Osman Gokhan Ersoy, Yusuf Ziya Menceloglu
Summary: By incorporating cool black pigments with near-infrared (NIR) reflective or transparent properties into thermoplastic olefins, the temperature of black surfaces on vehicles can be reduced, resulting in compounds with good mechanical properties.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Fei Ding, Jing Feng, Xueli Zhang, Jielin Sun, Chunhai Fan, Zhilei Ge
Summary: Optical imaging is crucial in biomedicine and theragnostic, but faces limitations in deep-tissue visualization due to light scattering and tissue autofluorescence. Responsive optical probes are designed for precise diagnosis and surgery excision by specific reactions with biological analytes or disease biomarkers.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Shunsuke Yanagi, Akihisa Matsumoto, Naoyuki Toriumi, Yusuke Tanaka, Kazunori Miyamoto, Atsuya Muranaka, Masanobu Uchiyama
Summary: In this study, two bench-stable BzTAPs with 18 pi- and 20 pi-electron structures were designed and synthesized. It was found that the NIR-inert BzTAP can be converted to the NIR-active form in the presence of mild reducing agents. This finding is significant for the development of activatable NIR probes in reductive environments.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Tianzhu Wang, Zhiyong Jiang, Zhipeng Liu
Summary: In this study, a class of 1,4-bisvinylbenzene-bridged BODIPY dimers with fluorescence emission in the second near-infrared window (NIR-II, 1000-1700 nm) were reported. These dyes exhibit excellent NIR-II fluorescence properties and can be easily functionalized to achieve good water-solubility or tumor-targeting ability. In vivo imaging results demonstrate their high resolution and deep-penetration NIR-II imaging ability, making them promising NIR-II imaging agents.
Article
Chemistry, Multidisciplinary
Hana Janekova, Marina Russo, Urs Ziegler, Peter Stacko
Summary: This study developed a photocage that can be triggered by near-infrared light and successfully demonstrated its release function in live cells. The findings have significant implications for advancing the field of near-infrared photoactivation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Siyang Feng, Zhirong Qu, Zhikuan Zhou, Jiaying Chen, Lizhi Gai, Hua Lu
Summary: Two novel Si-bridged meso-annulated BODIPY dyes were prepared through intermolecular C-I silylation and subsequent intramolecular C-H silylation in a one-pot reaction. A marked redshift of the main spectral bands was observed due to efficient sigma*-pi* conjugation, resulting in notable stabilization of the LUMOs. Si-annulation blocks non-radiative decay and contributes to higher fluorescence quantum yields, making this strategy attractive for constructing highly emissive polycyclic aromatic hydrocarbons.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Frederik Brondsted, Yuan Fang, Lin Li, Xinqi Zhou, Steven Grant, Cliff I. Stains
Summary: Photoacoustic imaging is an emerging imaging technique that uses non-radiative relaxation events to produce ultrasound waves. This study reports the use of xanthene dyes for photoacoustic imaging and presents a design approach to stabilize ester-containing dyes. The constructed imaging probe can detect hypochlorous acid and has potential applications in non-invasive imaging of diseases.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Jin He, Qi Xiao, Ming Shao, Zhong'an Li
Summary: This review summarizes the advances of polymethine dyes for broadband and narrowband NIR OPDs. The polymethine dyes have advantages of simple synthesis and structural diversity, making them attractive material candidates for NIR OPDs. The relationship between the chemical structure and the aggregation behaviors of polymethine dyes and the device performance is carefully discussed.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Analytical
Jianlong Ma, Xiaofeng Lu, Yong Guo, Zhijun Wang
Summary: This study synthesized a near-infrared (NIR) Cys-special probe (MCyA) that could precisely and quickly detect Cys activity. The observations showed that the endogenous Cys activity was depressed under oxidative stress, but dramatically increased with omeprazole stimulation in HepG2 cells. MCyA was also successfully used to image the upregulation of Cys level in HepG2 cells in the presence of methionine (Met). Overall, MCyA is a novel and practical tool to study Cys-related physiological and pathological processes.
Article
Materials Science, Biomaterials
Jaesok Yu, Shao Pin, Xiangwei Lin, Meng Su, Mingfeng Bai, Kang Kim
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2018)
Article
Biochemical Research Methods
Rebecca C. Gilson, Rui Tang, Krishna Sharmah Gautam, Dorota Grabowska, Samuel Achilefu
BIOCONJUGATE CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Cong-Lin Liu, Xian Zhang, Jing Liu, Yunzhe Wang, Galina K. Sukhova, Gregory R. Wojtkiewicz, Tianxiao Liu, Rui Tang, Samuel Achilefu, Matthias Nahrendorf, Peter Libby, Junli Guo, Jin-Ying Zhang, Guo-Ping Shi
NATURE COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Rui Tang, Alexander Zheleznyak, Matthew Mixdorf, Anchal Ghai, Julie Prior, Kvar C. L. Black, Monica Shokeen, Nathan Reed, Pratim Biswas, Samuel Achilefu
Review
Chemistry, Multidisciplinary
Suman B. Mondal, Shaw-Wei D. Tsen, Samuel Achilefu
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Engineering, Biomedical
Jingyi Luan, Anushree Seth, Rohit Gupta, Zheyu Wang, Priya Rathi, Sisi Cao, Hamed Gholami Derami, Rui Tang, Baogang Xu, Samuel Achilefu, Jeremiah J. Morrissey, Srikanth Singamaneni
NATURE BIOMEDICAL ENGINEERING
(2020)
Article
Oncology
Kinan Alhallak, Jennifer Sun, Katherine Wasden, Nicole Guenthner, Julie O'Neal, Barbara Muz, Justin King, Daniel Kohnen, Ravi Vij, Samuel Achilefu, John F. DiPersio, Abdel Kareem Azab
Summary: This study developed nanoparticle-based bispecific T-cell engagers (nanoBiTEs) and nanoparticles targeting multiple cancer antigens (nanoMuTEs), overcoming the major limitations of current T-cell-based immunotherapy. These novel nanoparticles have a long half-life, enabling once-a-week administration while maintaining efficacy, with nanoMuTEs targeting multiple cancer antigens showing greater efficacy in myeloma cells.
Article
Oncology
Qing Xie, Meng Su, Yang Liu, Dawei Zhang, Zhen Li, Mingfeng Bai
Summary: Photodynamic therapy (PDT) is a clinically approved therapeutic strategy that combines a specific wavelength of light and light-activated photosensitizers (PSs). The usage of PDT for cancer treatment is often hindered by the lack of tumor selectivity of PSs, but the development of novel TSPO-PSs with high affinity for TSPO may provide efficient and target-specific PDT effect in tumors associated with high-TSPO expression.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Automation & Control Systems
Yucheng Li, Yang Liu, Kashu Yamazaki, Mingfeng Bai, Yue Chen
Summary: This article introduces a novel soft robot laparoscope design for accurate and safe deployment of PDT optical fiber for pancreatic tumor treatment. The robot can produce three degrees of freedom motions and is equipped with a micro camera for intraoperative image guidance. Benchtop characterization and in vivo mice model validation demonstrated successful tumor size reduction using the proposed system.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2021)
Article
Chemistry, Physical
Megan S. Michie, Baogang Xu, Gail Sudlow, Luke E. Springer, Christine T. N. Pham, Samuel Achilefu
Summary: In this study, NIR dye-peptide conjugates were synthesized and it was found that a peptide-driven strategy can alter the aggregation states of molecular probes in aqueous solutions, leading to effective imaging of inflammatory arthritis joints. The results suggest that peptide plays a dominant role in controlling the photophysical properties of these bioconjugates.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Jianquan Xu, Xuejiao Sun, Kwangho Kim, Rhonda M. Brand, Douglas Hartman, Hongqiang Ma, Randall E. Brand, Mingfeng Bai, Yang Liu
Summary: Researchers have developed a new fluorescent probe for superresolution imaging on clinical tissue, demonstrating the biological and clinical significance of imaging superresolved chromatin structure in cancer development and its potential clinical utility for cancer risk stratification.
Article
Hematology
Sena Kim, Sora Lim, Boram Kim, Julie Ritchey, Kiran Vij, Julie Prior, Lynne Marsala, Alyssa Stoner, Feng Gao, Samuel Achilefu, Matthew L. Cooper, John F. DiPersio, Jaebok Choi
Summary: By blocking the IFNGR signaling pathway, S100A9 is upregulated in T cells and acts as a novel suppressor of graft-versus-host disease (GVHD) while preserving graft-versus-leukemia (GVL) effects. In both mouse models of allo-HSCT and xenogeneic human peripheral blood mononuclear cell transplantation, overexpression of S100A9 or administration of anti-IFNGR antibody improved GVHD without compromising GVL and reduced T-cell trafficking to GVHD target organs.
Article
Rheumatology
Shaw-Wei D. Tsen, Luke E. Springer, Krishna Sharmah Gautam, Rui Tang, Kexian Liang, Gail Sudlow, Amir Kucharski, Christine T. N. Pham, Samuel Achilefu
Summary: LS301 selectively accumulates in regions of joint pathology in mouse models of RA, with a positive correlation with disease severity. Whole-body near-infrared imaging with LS301 allows tracking of spontaneous disease remission and therapeutic response after dexamethasone treatment. Histological analysis shows preferential accumulation of LS301 within chondrocytes and articular cartilage in arthritic mice, with colocalization observed between LS301 and pANXA2 in joint tissue.
ARTHRITIS RESEARCH & THERAPY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anchal Ghai, Alexander Zheleznyak, Matt Mixdorf, Julie O'Neal, Julie Ritchey, Michael Rettig, John DiPersio, Monica Shokeen, Samuel Achilefu
Summary: This study demonstrates the feasibility of [Zr-89]DFO-elotuzumab as a companion diagnostic for CS1-targeted therapies.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Chemistry, Multidisciplinary
Daniel D. Lane, Kvar C. L. Black, Ramesh Raliya, Nathan Reed, Nalinikanth Kotagiri, Rebecca Gilson, Rui Tang, Pratim Biswas, Samuel Achilefu
