Article
Chemistry, Multidisciplinary
Raul L. L. Carmo, Samuel L. Galster, Tomasz Wdowik, Chaeeon Song, Sherry R. Chemler
Summary: We report a catalytic enantioselective alkene aminooxygenation and dioxygenation method for the direct synthesis of enantioenriched2-formyl saturated heterocycles under aerobic conditions. Cyclic sulfonamides and alkenols are employed as substrates and readily available chiral copper complexes serve as catalysts. The reaction enables the preparation of various chiral nitrogen and oxygen heterocycles. These methods provide access to saturated heterocycles functionalized with carbonyl electrophiles, which are common components of bioactive small molecules.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Organic
Rakesh Mondal, Gargi Chakraborty, Amit Kumar Guin, Susmita Sarkar, Nanda D. Paul
Summary: An iron-catalyzed synthetic protocol for the construction of various trisubstituted pyrimidines is described in this study. A wide range of trisubstituted pyrimidines were prepared using a well-defined, bench-stable iron catalyst under mild aerobic conditions. The protocol offers a sustainable, economically affordable, and eco-friendly approach to synthesis.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Harjeet S. Soor, Diego B. Diaz, Katherine I. Burton, Andrei K. Yudin
Summary: The ongoing search for underdeveloped functional group combinations has led to the discovery of alpha-fluorinated aminoalkylboronic acids, a new class of molecules featuring the B-CF linkage. These compounds can be generated through electrophilic fluorination and show stability and unique structural properties.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Jun Tian, Shanshan Yu, Hongyu Guo, Maoshuai Zhu, Kai Lu, Yixuan Jiang, Jiaqiao Yang, Xiaoqi Yu, Lin Pu
Summary: 2,2'-Diformyl-1,1'-binaphthyl exhibits highly enantioselective fluorescence enhancement in the presence of various beta-amino alcohols and base. This provides a new method for determining the enantiomeric composition of substrates and has potential for high throughput analysis.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Xiaoyi Zhu, Ruibo Li, Hequan Yao, Aijun Lin
Summary: The palladium-catalyzed allenamide carbopalladation/allylation reaction with active methine compounds resulted in the formation of indoles and isoquinolinones bearing a quaternary carbon center. This reaction demonstrated good efficiency, a broad substrate scope, and good functional group tolerance by forming two new C-C bonds in one pot.
Article
Chemistry, Organic
Jigyansa Sahoo, Jeetendra Panda, Santanab Giri, Gokarneswar Sahoo
Summary: An investigation into the sensitivity of reaction conditions to a highly utilized protocol has been reported. The mono-Boc functionalization of prolinol can be controlled for the exclusive synthesis of N-Boc, O-Boc, or oxazolidinone derivatives. A successful chemoselective functionalization of the nucleophilic sites of prolinol by exploiting the relative acidity difference of NH and OH along with the reversed nucleophilicity of the corresponding conjugate bases N- and O- is reported. This protocol has also been used for the synthesis of several O-functionalized prolinol derived organocatalysts, few of which have been newly reported.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Iain Currie, Brad E. Sleebs
Summary: A one-step synthesis of acyl phosphoramidates from a variety of functionalized acyl azides has been developed using trimethylsilyl chloride as an activating agent in a modified Staudinger reaction. The methodology was further adapted to include in situ generation of acyl azides from a diverse selection of carboxylic acids and hydrazide starting synthons, and extended to include the synthesis of imidodiphosphates and the natural product Microcin C.
Article
Chemistry, Organic
Donghui Guo, Qiupeng Peng, Bei Zhang, Jian Wang
Summary: The novel method described in this report allows for the atroposelective generation of axially chiral amino esters using hemiaminals formed in situ, with a wide substrate scope, good functional group tolerance, and rapid assembly of axially chiral amino esters with high enantioselectivities in good to high yields.
Article
Multidisciplinary Sciences
Hairong Lyu, Ilia Kevlishvili, Xuan Yu, Peng Liu, Guangbin Dong
Summary: Mild methods for cleaving the C-O bond in alkyl ethers using dibromoboranes in the presence of a nickel catalyst and zinc reductant have been shown to simplify chemical syntheses and facilitate oxygen-to-nitrogen substitution or one-carbon homologation. Mechanistic studies have revealed a cleavage-then-rebound pathway via zinc/nickel tandem catalysis.
Review
Biochemistry & Molecular Biology
Mamona Mushtaq, Sehrish Naz, Keykavous Parang, Zaheer Ul-Haq
Summary: Dengue fever, caused by the dengue virus, infects approximately 400 million individuals annually, with factors contributing to its geographic expansion including urbanization, population density, and climate change. Despite progress, there is currently no effective antiviral therapy available, with research focusing on the NS2B-NS3 protease complex for potential treatments.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Organic
Svitlana O. Sotnik, Andrii Subota, Anton Y. Kliuchynskyi, Dmytro Yehorov, Anton S. Lytvynenko, Alexander B. Rozhenko, Sergey Kolotilov, Sergey Ryabukhin, Dmitriy M. Volochnyuk
Summary: A Cu-catalyzed one-pot synthesis of fused pyridines from cyclic ketones and propargylamine was described, optimized based on over 30 experiments. The protocol is cost-effective and scalable, suitable for preparing large quantities of fused pyridine-based building blocks without requiring high-pressure autoclave technique. Adjusting the catalyst amount allowed comparable yields with longer reaction times, while the reaction conditions showed tolerance to various protective functional groups in ketones.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Leixia Chu, Xiaoxia Luo, Taoting Zhu, Yingying Cao, Lili Zhang, Zixin Deng, Jiangtao Gao
Summary: In this study, the authors report the bioproduction of aminomethylphosphonate (AMP) and a chemical process for converting AMP to glyphosate. This research provides a green alternative in the production of glyphosate, a widely used herbicide.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Ryou Kubota, Shogo Torigoe, Itaru Hamachi
Summary: The fate of living cells depends on their ability to process temporally modulated information. Synthetic systems that can decode dynamically oscillating stimuli are challenging to create due to the lack of sophisticated reaction networks. In this study, the researchers report the morphological differentiation of synthetic dipeptide-based coacervates in response to temporally distinct patterns of light pulses. The results have implications for the design of smart supramolecular soft materials and the synthesis of sophisticated chemical cells.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Martin S. Maier, Andrej Shemet, Dirk Trauner
Summary: The 2'-phosphodiesterase inhibitor A-74528 is a complex type II polyketide with intriguing biosynthesis and unusual biological activity. This study focuses on the synthesis of A-74528, specifically the construction of its carbon skeleton and the installation of its stereocenters. The strategy involves various reactions to establish carbocycles and append the pyrone moiety.
Article
Chemistry, Multidisciplinary
Odin Bottrill, Matthew Boon, Franca Jones, Mauro Mocerino
Summary: Kidney stones are a common ailment with limited treatment options. This study investigates the impact of functionalized compounds on the nucleation, morphology, and zeta potential of calcium oxalate crystals in a synthetic urine environment. The findings suggest that functionalized compounds can stabilize calcium oxalate dihydrate and significantly affect crystal morphology.
Article
Chemistry, Multidisciplinary
Chun Guo, Christopher P. Watkins, Ryan Hili
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2015)
Article
Chemistry, Applied
Yi Lei, Dehui Kong, Ryan Hili
ACS COMBINATORIAL SCIENCE
(2015)
Article
Biochemical Research Methods
Chun Guo, Ryan Hili
BIOCONJUGATE CHEMISTRY
(2017)
Review
Chemistry, Applied
Dehui Kong, Wayland Yeung, Ryan Hili
ACS COMBINATORIAL SCIENCE
(2016)
Article
Chemistry, Multidisciplinary
Dehui Kong, Wayland Yeung, Ryan Hili
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Chemistry, Organic
Yi Lei, Ryan Hili
ORGANIC & BIOMOLECULAR CHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
K. Delaney Hook, John T. Chambers, Ryan Hili
Article
Chemistry, Organic
Chun Guo, Dehui Kong, Yi Lei, Ryan Hili
Article
Biochemical Research Methods
Sven Kochmann, An T. H. Le, Ryan Hili, Sergey N. Krylov
Article
Chemistry, Multidisciplinary
Ryan Hili, Jia Niu, David R. Liu
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2013)
Article
Chemistry, Multidisciplinary
Jia Niu, Ryan Hili, David R. Liu
Article
Biochemistry & Molecular Biology
Chun Guo, Yasaman Mahdavi-Amiri, Ryan Hili
Article
Biochemical Research Methods
Dehui Kong, Matina Movahedi, Yasaman Mandavi-Arniri, Wayland Yeung, Tristan Tiburcio, Dickson Chen, Ryan Hili
ACS SYNTHETIC BIOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Yasaman Mahdavi-Amiri, Kimberley Chung Kim Chung, Ryan Hili
Summary: This study describes a sequencing method with single-nucleotide resolution for N-6-adenine methylation sites in DNA and RNA. By using sodium nitrite under acidic conditions, chemoselective deamination of unmethylated adenines is achieved, allowing for identification of N-6-adenine sites in various sequence contexts. When combined with high-throughput DNA sequencing and mutational analysis, this approach provides a reliable method for identifying adenine methylation sites.
Article
Chemistry, Organic
Yi Lei, Joshua Washington, Ryan Hili
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)
