Article
Multidisciplinary Sciences
Cristian Aragon-Benedi, Ana Pascual-Bellosta, Sonia Ortega-Lucea, Sara Visiedo-Sanchez, Javier Martinez-Ubieto
Summary: This study aimed to assess the effects of spontaneous or pharmacological reversal of neuromuscular blockade on postoperative residual neuromuscular blockade and pulmonary complications. A prognostic model was also developed to predict the probability of postoperative residual neuromuscular blockade based on comorbidities and intraoperative management of neuromuscular blocking agents. The results showed that pharmacological reversal and neuromuscular monitoring during surgery were the most effective factors in reducing the risk of residual neuromuscular blockade and postoperative pulmonary complications.
SCIENTIFIC REPORTS
(2022)
Article
Anesthesiology
Thomas Ledowski, Zoltan Szabo-Maak, Pui San Loh, Berwin A. Turlach, Hong Seuk Yang, Hans D. de Boer, Laszlo Asztalos, Ina Ismiarti Shariffuddin, Lucy Chan, Bela Fulesdi
Summary: In high-risk older patients, reversing rocuronium neuromuscular block with sugammadex may result in a reduced risk of postoperative pulmonary complications on Day 7.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Anesthesiology
Douglas A. Colquhoun, Michelle T. Vaughn, Lori D. Bash, Allison Janda, Nirav Shah, Amir Ghaferi, Michael Sjoding, Graciela Mentz, Sachin Kheterpal
Summary: In this retrospective cohort study, the association between neuromuscular blocking agent reversal agent and postoperative pulmonary complications was assessed. The use of sugammadex was independently associated with a reduced risk of subsequent development of pneumonia or respiratory failure compared to neostigmine.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Anesthesiology
Luca J. Wachtendorf, Tim M. Tartler, Elena Ahrens, Annika S. Witt, Omid Azimaraghi, Philipp Fassbender, Aiman Suleiman, Felix C. Linhardt, Michael Blank, Sarah Y. Nabel, Jerry Y. Chao, Pavel Goriacko, Parsa Mirhaji, Timothy T. Houle, Maximilian S. Schaefer, Matthias Eikermann
Summary: This study evaluated the effects of sugammadex on hospital costs and found that it was associated with lower direct costs compared to neostigmine. However, in high-risk patients, sugammadex was associated with higher total costs.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Medicine, General & Internal
Juan Fiorda Diaz, Marco Echeverria-Villalobos, Alan Esparza Gutierrez, Olufunke Dada, Nicoleta Stoicea, Wiebke Ackermann, Mahmoud Abdel-Rasoul, Jarrett Heard, Alberto Uribe, Sergio D. D. Bergese
Summary: This study compared the effectiveness and cost-effectiveness of sugammadex and neostigmine for moderate neuromuscular blockade reversal. The results showed that sugammadex achieved faster reversal without increasing perioperative costs.
FRONTIERS IN MEDICINE
(2022)
Review
Anesthesiology
Hong-Mei Liu, Hong Yu, Yi-Ding Zuo, Peng Liang
Summary: In this systematic review and meta-analysis, sugammadex was found to be more effective than neostigmine in reducing the incidence of postoperative pulmonary complications, including pneumonia, atelectasis, noninvasive ventilation, and reintubation.
BMC ANESTHESIOLOGY
(2023)
Article
Anesthesiology
Marc Schmidt, Julian Rossler, Jack Brooker, Valentina Lara-Erazo, Elyad Ekrami, Xuan Pu, Alparslan Turan, Daniel I. Sessler, Kurt Ruetzler
Summary: This study aimed to compare the postoperative lung function of patients undergoing neuromuscular block reversal using sugammadex versus neostigmine. The results showed similar lung function with both methods, but patients given sugammadex had more minor pulmonary complications.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Anesthesiology
Ana B. Serrano, Oscar Diaz-Cambronero, Javier Melchor-Ripolles, Alfredo Abad-Gurumeta, Jose M. Ramirez-Rodriguez, Javier Martinez-Ubieto, Miriam Sanchez-Merchante, Rita Rodriguez, Laura Jorda, Silvia Gil-Trujillo, Mercedes Cabellos-Olivares, Daniel Bordonaba-Bosque, Cesar Aldecoa
Summary: The study found that optimal neuromuscular blockade management in colorectal surgery did not lead to reduced moderate-severe complications, length of hospital stay, or mortality postoperatively within an enhanced recovery program. Reversing neuromuscular blockade with neostigmine was associated with a higher mortality rate compared to using sugammadex.
MINERVA ANESTESIOLOGICA
(2021)
Article
Anesthesiology
T. Andrew Bowdle, Kishanee J. Haththotuwegama, Srdjan Jelacic, Sharon T. Nguyen, Kei Togashi, Kelly E. Michaelsen
Summary: Sugammadex dose titration is necessary for effective reversal of neuromuscular blockade after rocuronium administration. Most patients require less than the recommended dose, but some may need more, and recurrent paralysis can occur.
Article
Microbiology
Amedee Ego, Lorenzo Peluso, Julie Gorham, Alberto Diosdado, Giovanni Restuccia, Jacques Creteur, Fabio Silvio Taccone
Summary: Patients with COVID-19 related ARDS had significantly longer duration and higher consumption of sedatives and NMBA compared to non-COVID ARDS patients, suggesting the need for different sedation strategies and protocols in COVID-19 patients with ARDS.
Article
Medicine, Research & Experimental
Lori D. Bash, Vladimir Turzhitsky, Wynona Black, Richard D. Urman
Summary: This study analyzed the changes in the use of NMB and NMB reversal agents among surgical inpatients in the US since the introduction of sugammadex. The study found complex relationships between patient, site, procedural characteristics, and NMB management choices. Factors such as patient characteristics, hospital size, and time since 2016 influenced the choice of NMB reversal agent used. Overall, the study highlights the evolution of NMB management practices over time and the impact of various factors on treatment choices.
ADVANCES IN THERAPY
(2021)
Article
Anesthesiology
A. Suleiman, R. Munoz-Acuna, O. Azimaraghi, T. T. Houle, G. Chen, S. Rupp, A. S. Witt, B. A. Azizi, E. Ahrens, D. Shay, K. Wongtangman, L. J. Wachtendorf, T. M. Tartler, M. Eikermann, M. S. Schaefer
Summary: Reversing neuromuscular blockade with sugammadex or neostigmine did not significantly reduce postoperative respiratory complications or advanced healthcare utilisation.
Article
Anesthesiology
Jia-Feng Wang, Zhen-Zhen Zhao, Zheng-Yu Jiang, Hui-Xing Liu, Xiao-Ming Deng
Summary: A meta-analysis found that using sugammadex to reverse NMB was associated with a lower risk of postoperative pulmonary complications, specifically a lower incidence of postoperative respiratory failure.
PERIOPERATIVE MEDICINE
(2021)
Article
Anesthesiology
Omid Azimaraghi, Elena Ahrens, Karuna Wongtangman, Annika S. Witt, Samuel Rupp, Aiman Suleiman, Tim M. Tartler, Luca J. Wachtendorf, Philipp Fassbender, Curtis Choice, Timothy T. Houle, Matthias Eikermann, Maximilian S. Schaefer
Summary: The use of sugammadex in ambulatory surgery can reverse neuromuscular block faster and reduce post-operative length of stay and costs compared to neostigmine, especially in older and high-risk patients.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Review
Oncology
Wentao Ji, Xiaoting Zhang, Jia Liu, Guolin Sun, Xiandong Wang, Lulong Bo, Xiaoming Deng
Summary: Neostigmine has been shown to effectively reduce post-anesthesia care unit stay, time to recovery of train-of-four ratio =0.9, and extubation time in patients recovering from general anesthesia. However, there were no significant differences in adverse events between the neostigmine and control groups. Subgroup analyses based on neostigmine dosage did not affect the overall results. Neostigmine can safely enhance neuromuscular recovery from nondepolarizing muscle relaxants in patients under general anesthesia.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Letter
Anesthesiology
Matthew J. Meyer, Nobuo Sasaki, Matthias Eikermann
Editorial Material
Anesthesiology
Matthew J. Meyer, Joseph A. Hyder, Daniel J. Cole, Nirav V. Kamdar
ANESTHESIA AND ANALGESIA
(2016)
Article
Anesthesiology
Jeroen C. P. Simons, Eric Pierce, Daniel Diaz-Gil, Sanjana A. Malviya, Matthew J. Meyer, Fanny P. Timm, Janne B. Stokholm, Carl E. Rosow, Robert M. Kacmarek, Matthias Eikermann
Article
Medicine, General & Internal
Stefan J. Schaller, Matthew Anstey, Manfred Blobner, Thomas Edrich, Stephanie D. Grabitz, Ilse Gradwohl-Matis, Markus Heim, Timothy Houle, Tobias Kurth, Nicola Latronico, Jarone Lee, Matthew J. Meyer, Thomas Peponis, Daniel Talmor, George C. Velmahos, Karen Waak, J. Matthias Walz, Ross Zafonte, Matthias Eikermann
Article
Anesthesiology
Matthew J. Meyer, Walter H. Dzik, Wilton C. Levine
ANESTHESIA AND ANALGESIA
(2018)
Review
Anesthesiology
Nobuo Sasaki, Matthew J. Meyer, Matthias Eikermann
Article
Anesthesiology
Hooman Mirzakhani, June-Noelle Williams, Jennifer Mello, Sharma Joseph, Matthew J. Meyer, Karen Waak, Ulrich Schmidt, Emer Kelly, Matthias Eikermann
Article
Anesthesiology
Olivia M. D'Angelo, Daniel Diaz-Gil, Danuza Nunn, Jeroen C. P. Simons, Chloe Gianatasio, Noomi Mueller, Matthew J. Meyer, Eric Pierce, Carl Rosow, Matthias Eikermann
Article
Critical Care Medicine
Alexander R. Levine, Matthew J. Meyer, Edward A. Bittner, Sheri Berg, Rebecca Kalman, Anne B. Stanislaus, Cheryl Ryan, Stephanie A. Ball, Matthias Eikermann
JOURNAL OF CRITICAL CARE
(2013)
Article
Surgery
Brooks Udelsman, Nicolas Govea, Zara Cooper, David C. Chang, Angela Bader, Matthew J. Meyer
Article
Surgery
Matthew J. Meyer, Tyler Chafitz, Kaiyi Wang, Nafisa Alamgir, Pumoli Malapati, Jeffrey W. Gander, Derek T. Ward, Seema Gandhi
Summary: Surgeons are aware of the significant waste in operating rooms and are willing to change their workflow to reduce waste. Reducing operating room waste is beneficial for health system finances and population health improvement, with a focus on eliminating unnecessary waste of sterile surgical supplies.
Article
Multidisciplinary Sciences
Matthew J. Meyer, Slater A. Jameson, Edward J. Gillig, Ankur Aggarwal, Sarah J. Ratcliffe, Mary Baldwin, Karen E. Singh, W. Darrin Clouse, Randal S. Blank
Summary: Peripheral artery disease and cardiac disease often coexist. Echocardiography can be used as a preoperative diagnostic tool to assess the functional cardiac status and predict the risk of major adverse cardiac events (MACE). However, in this retrospective cohort study, no significant association was found between echocardiographic findings and the incidence of expanded MACE after vascular surgery.
Letter
Anesthesiology
Matthew J. Meyer, Matthias Eikermann
Article
Anesthesiology
Matthew J. Meyer, Walter H. Dzik, Wilton C. Levine
ANESTHESIA AND ANALGESIA
(2017)