Article
Medicine, Research & Experimental
Danielle Hewitt, Adam Byrne, Jessica Henderson, Kathryn Wilford, Rajiv Chawla, Manohar Lal Sharma, Bernhard Frank, Nicholas Fallon, Christopher Brown, Andrej Stancak
Summary: This study evaluated the effect of different pulse intensities of spinal cord stimulation (SCS) on cortical activation. The results indicate that burst and tonic SCS are mediated by different mechanisms. Tonic SCS showed a stronger reduction in cortical activation compared to burst SCS.
Article
Anesthesiology
Ryan S. D'Souza, Yeng F. Her
Summary: This study investigated the effectiveness of a stimulation holiday strategy in rescuing analgesia from spinal cord stimulation failure. The results showed that restarting spinal cord stimulation after a stimulation holiday significantly improved pain relief and responder rate.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Neurosciences
Xin Luo, Ouyang Chen, Zilong Wang, Sangsu Bang, Jasmine Ji, Sang Hoon Lee, Yul Huh, Kenta Furutani, Qianru He, Xueshu Tao, Mei-Chuan Ko, Andrey Bortsov, Christopher R. Donnelly, Yong Chen, Andrea Nackley, Temugin Berta, Ru-Rong Ji
Summary: The IL-23/IL-17A/TRPV1 axis regulates female-specific mechanical pain, with IL-23 inducing pain in females but impaired in mice lacking IL-23 or IL-23r. IL-23-induced pain is promoted by estrogen and suppressed by androgen.
Article
Medicine, Research & Experimental
John A. Hatheway, Vipul Mangal, Michael A. Fishman, Philip Kim, Binit Shah, Rainer Vogel, Vincent Galan, Steven Severyn, Tristan E. Weaver, David A. Provenzano, Eric Chang, Michael H. Verdolin, Gregory Howes, Armando Villarreal, Steven Falowski, Kelly Hendrickson, Katherine Stromberg, Lachlan Davies, Lisa Johanek, Matthew T. Kelly
Summary: The Vectors study demonstrated significant improvement in outcomes when following a standardized treatment approach for spinal cord stimulation, leading to pain relief, improved quality of life, and high patient satisfaction.
Article
Clinical Neurology
G. S. Piedade, S. Gillner, P. J. Slotty, J. Vesper
Summary: This study investigated the preference of patients for different waveforms in long-term follow-up of spinal cord stimulation therapy. The study found that tonic stimulation remained the preferred therapy for patients, and the use of microburst stimulation increased over time. Whisper and Contour waveforms were used as salvage options in complex cases.
ACTA NEUROCHIRURGICA
(2022)
Article
Neurosciences
Veronica Baron-Flores, Araceli Diaz-Ruiz, Jorge Manzanares, Camilo Rios, Masha Burelo, Gustavo Jardon-Guadarrama, Maria de los Angeles Martinez-Cardenas, Alfonso Mata-Bermudez
Summary: CBD has antinociceptive effects on neuropathic pain induced by spinal cord injury through reducing lipid peroxidation and increasing glutathione concentration.
NEUROSCIENCE LETTERS
(2022)
Article
Clinical Neurology
John E. Gilbert, Tianhe Zhang, Rosana Esteller, Warren M. Grill
Summary: Temporal patterns of spinal cord stimulation designed using a computational model could effectively inhibit pain-related neuronal activity and potentially increase the efficacy of spinal cord stimulation.
Article
Medicine, Research & Experimental
Rezvan Ahmadi, Mohammad Mehdi Hajiabadi, Andreas Unterberg, Christiane Geist, Benito Campos
Summary: The new wireless spinal cord stimulation (SCS) technology introduced promises minimal invasive SCS with a wide range of stimulation paradigms and MRI conditionality. Evaluation of 12 patients with therapy-resistant neuropathic pain showed that wireless SCS systems were feasible and safe, with most patients achieving 50% or more pain relief.
Article
Cell Biology
Zhi-Bin Wang, Yong-Da Liu, Shuo Wang, Ping Zhao
Summary: The study found that high-frequency spinal cord stimulation (HF-SCS) can provide long-lasting analgesic effects on neuropathic pain in rats by improving lysosomal dysfunction and alleviating autophagic flux.
NEURAL REGENERATION RESEARCH
(2022)
Review
Clinical Neurology
Christian Saleh, Tatiani Soultana Ilia, Phillip Jaszczuk, Margret Hund-Georgiadis, Anna Walter
Summary: This systematic review suggests that high-frequency rTMS applied to the primary motor cortex and left dorsolateral prefrontal cortex may be promising stimulation targets for neuropathic pain in individuals with spinal cord injury (SCI).
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Tomas Hoikkanen, Mette Nissen, Tiina-Mari Ikaheimo, Henna-Kaisa Jyrkkanen, Jukka Huttunen, Mikael von Und Zu Fraunberg
Summary: A retrospective study on 35 consecutive CRPS patients undergoing SCS treatment found that 70% continued using the SCS device over an 8-year follow-up period, but some patients experienced device explantation or complications, with no significant change in medication use.
Article
Biochemistry & Molecular Biology
Kwan Yeop Lee, Dongchul Lee, Zachary B. Kagan, Dong Wang, Kerry Bradley
Summary: The study found that low-intensity 10 kHz SCS can inhibit pain-sensory processing in the spinal DH by activating inhibitory interneurons, resulting in paresthesia-free pain relief.
Article
Medicine, Research & Experimental
Takafumi Tanei, Satoshi Maesawa, Yusuke Nishimura, Yoshitaka Nagashima, Tomotaka Ishizaki, Masahiko Ando, Yachiyo Kuwatsuka, Atsushi Hashizume, Shimon Kurasawa, Ryuta Saito
Summary: This study aims to investigate the effectiveness of new spinal cord stimulation (SCS) patterns without paresthesia compared to conventional tonic stimulation for neuropathic pain. A randomized clinical trial will be conducted to compare pain improvement between different stimulation patterns in participants. The study also aims to evaluate the relationship between causative disease and pain improvement, as well as long-term effects and adverse events related to the study.
Article
Clinical Neurology
Evan R. Rogers, Hans J. Zander, Scott F. Lempka
Summary: This study utilized computational modeling to investigate neural recruitment during conventional, burst, and 10-kilohertz spinal cord stimulation for chronic pain. The results revealed different mechanisms of action for these modes of stimulation, but the recruitment order was the same. Additionally, axon collateralization had complex effects on the activation thresholds of primary afferents. These findings provide context for interpreting clinical observations.
Article
Medicine, General & Internal
Soshi Samejima, Claire Shackleton, Raza N. Malik, Kawami Cao, Anibal Bohorquez, Tom E. Nightingale, Rahul Sachdeva, Andrei V. Krassioukov
Summary: Spinal cord injury (SCI) leads to severe cardiovascular dysfunction, and autonomic dysreflexia (AD) is one of the causes of high blood pressure in SCI patients. Recently, spinal cord stimulation (SCS) has been considered as a potential intervention to alleviate unstable blood pressure after SCI. This case series demonstrates the real-time effect of epidural SCS (eSCS) at the lumbosacral spinal cord in mitigating AD in individuals with SCI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Gastroenterology & Hepatology
Amit G. Singal, Jorge A. Marrero, Anna S. Lok, William M. Lee
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2013)
Editorial Material
Gastroenterology & Hepatology
Suna Yapali, Anna S. Lok
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2013)
Article
Gastroenterology & Hepatology
Suna Yapali, Nizar Talaat, Anna S. Lok
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2014)
Article
Chemistry, Inorganic & Nuclear
Hujun Cao, Yao Zhang, Jianhui Wang, Zhitao Xiong, Guotao Wu, Jieshan Qiu, Ping Chen
DALTON TRANSACTIONS
(2013)
Editorial Material
Gastroenterology & Hepatology
Suna Yapali, Anna S. Lok
Article
Gastroenterology & Hepatology
Gregory T. Everson, Norah A. Terrault, Anna S. Lok, Del R. Rodrigo, Robert S. Brown, Sammy Saab, Mitchell L. Shiffman, Abdullah M. S. Al-Osaimi, Laura M. Kulik, Brenda W. Gillespie, James E. Everhart
Article
Physics, Applied
M. R. Uddin, S. Majety, J. Li, J. Y. Lin, H. X. Jiang
JOURNAL OF APPLIED PHYSICS
(2014)
Article
Medicine, Research & Experimental
Ji-Tian Xu, Jian-Yuan Zhao, Xiuli Zhao, Davinna Ligons, Vinod Tiwari, Fidelis E. Atianjoh, Chun-Yi Lee, Lingli Liang, Weidong Zang, Dolores Njoku, Srinivasa N. Raja, Myron Yaster, Yuan-Xiang Tao
JOURNAL OF CLINICAL INVESTIGATION
(2014)
Article
Materials Science, Multidisciplinary
Jianhui Wang, Hai-Wen Li, Ping Chen
Editorial Material
Gastroenterology & Hepatology
Anna Suk-Fong Lok
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2013)
Article
Neurosciences
S. -Q. He, L. Han, Z. Li, Q. Xu, V. Tiwari, F. Yang, X. Guan, Y. Wang, S. N. Raja, X. Dong, Y. Guan
Article
Anesthesiology
Alec B. O'Connor, Dennis C. Turk, Robert H. Dworkin, Nathaniel P. Katz, Robert Colucci, Jennifer A. Haythornthwaite, Michael Klein, Charles O'Brien, Kelly Posner, Bob A. Rappaport, Gary Reisfield, Edgar H. Adams, Robert L. Balster, George E. Bigelow, Laurie B. Burke, Sandra D. Comer, Edward Cone, Penney Cowan, Richard A. Denisco, John T. Farrar, Richard W. Foltin, J. David Haddox, Sharon Hertz, Gary W. Jay, Roderick Junor, Ernest A. Kopecky, Deborah B. Leiderman, Michael P. McDermott, Pamela P. Palmer, Srinivasa N. Raja, Christine Rauschkolb, Michael C. Rowbotham, Cristina Sampaio, Beatrice Setnik, Shannon M. Smith, Marta Sokolowska, Joseph W. Stauffer, Sharon L. Walsh, James P. Zacny
Article
Dentistry, Oral Surgery & Medicine
Nita Chainani-Wu, Crystal Chang, A. J. Gross, S. S. Yom, Sol Silverman
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2014)
Article
Chemistry, Physical
Linfei Lai, Jixin Zhu, Zhenggang Li, Denis Y. W. Yu, Shuran Jiang, Xiaoyi Cai, Qingyu Yan, Yeng Ming Lam, Zexiang Shen, Jianyi Lin
Article
Chemistry, Applied
Zhang Jing, He Teng, Liu Bin, Liu Lin, Zhao Zelun, Hu Daqiang, Ju Xiaohua, Wu Guotao, Chen Ping
CHINESE JOURNAL OF CATALYSIS
(2013)