Article
Biochemistry & Molecular Biology
Jingqian Su, Siyuan Chen, Jianbin Xiao, Zhihua Feng, Shan Hu, Qiaofen Su, Qi Chen, Duo Chen
Summary: This study explores the therapeutic potential of aloe-emodin (AE) in the treatment of CLP-induced sepsis, demonstrating its ability to mitigate systemic inflammation and regulate the gut microbiota. The study provides novel insights into the molecular mechanisms underlying the anti-inflammatory effects of AE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Bin Zhang, Feng Zheng, Anpeng Liu, Zhen Li, Fei Zheng, Qiangsheng Liu, Liu Yang, Kai Chen, Yanlin Wang, Zongze Zhang, Qianwen He, Jia Zhan
Summary: Activation of CB2 receptors plays a protective role in sepsis by inhibiting pyroptosis and reducing the release of inflammatory mediators. The protective effect depends on the presence of endogenous CB2 receptors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Raquel Pires Nakama, Aparecida Donizette Malvezi, Maria Isabel Lovo-Martins, Lucas Felipe dos Santos, Ana Paula Canizares Cardoso, Gustavo Scacco, Andressa Mendes Dionisio de Freitas, Marli Cardoso Martins-Pinge, Phileno Pinge-Filho
Summary: The study found that metabolic syndrome can improve survival rates in septic mice, prevent damage to hematological and cardiovascular functions, and reduce the typical feature of increased nitric oxide in sepsis.
Review
Medicine, General & Internal
Laura Jansen, Bente F. H. Dubois, Markus W. Hollmann
Summary: Every year, millions of patients are diagnosed with cancer and undergo surgical resection with anesthesia. However, a significant number of these patients experience recurrence or metastasis after surgery. The effect of different anesthesia techniques on postoperative outcomes in oncological surgery is still controversial and lacks substantial evidence.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Aliaa Anter, Al-Shaimaa F. Ahmed, Asmaa S. A. Hammad, Waleed Hassan Almalki, Sara Mohamed Naguib Abdel Hafez, AlShaimaa W. Kasem, Mohamed A. El-Moselhy, Mohammad W. Alrabia, Ahmed R. N. Ibrahim, Mahmoud El-Daly
Summary: The study aimed to evaluate the effect of menthol against sepsis-induced mortality, acute lung injury (ALI), and acute kidney injury (AKI). Menthol improved survival after sepsis and alleviated the development of ALI and AKI. Additionally, menthol also suppressed inflammation and apoptosis markers, showing its protective role in experimental sepsis.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Pratsanee Hiengrach, Peerapat Visitchanakun, Pakteema Tongchairawewat, Ponphisudti Tangsirisatian, Thitiphat Jungteerapanich, Patcharee Ritprajak, Dhammika Leshan Wannigama, Pattarin Tangtanatakul, Asada Leelahavanichkul
Summary: BAM15 shows potential as an adjuvant therapy against sepsis hyperinflammation by attenuating multiple aspects of septic conditions, such as survival, organ damage, apoptosis, and brain injury, as well as regulating mitochondrial functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Cheng-Long Ge, Wei Chen, Li-Na Zhang, Yu-Hang Ai, Yu Zou, Qian-Yi Peng
Summary: Our study reveals the important role of the HPC-PFC pathway in improving cognitive dysfunction in a mouse model of CLP sepsis and provides a novel pathogenetic mechanism for SAE.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Toxicology
Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa
Summary: In the study of polymicrobial sepsis, pro-inflammatory cytokines play a vital role in regulating hepatic drug transporter expression. The research found that both CLP and LPS can reduce the expression of drug transporters, but IL-6 is the major factor in the downregulation of hepatic multidrug transporters caused by polymicrobial sepsis.
TOXICOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Donghwan Park, MyungJa Ro, A-Jin Lee, Dong-Wook Kwak, Yunro Chung, Jae-Hong Kim
Summary: The study found that BLT2, a receptor for leukotriene B-4 with low affinity, plays a role in sepsis, a systemic inflammatory response syndrome caused by infection. Levels of BLT2 ligands and synthesizing enzymes for LTB4 and 12(S)-HETE were significantly increased in lung and liver tissues in a septic mouse model. Blocking BLT2 suppressed the production of sepsis-associated cytokines and alleviated lung inflammation in the sepsis group, suggesting that BLT2 may be a potential therapeutic target for sepsis patients.
MOLECULES AND CELLS
(2021)
Article
Physiology
Jose Maria Moreno-Navarrete, Ferran Comas, Vincent de Jager, Jose Manuel Fernandez-Real, Hjalmar R. Bouma
Summary: The study found that sepsis reduces the expression of adipogenesis-related genes in white adipose tissue while promoting inflammation in adipose tissue. In contrast, sepsis increases inflammation in brown adipose tissue without affecting the expression of thermogenic genes.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Claudia V. de Araujo, Frederik Denorme, W. Zac Stephens, Qing Li, Mark J. Cody, Jacob L. Crandell, Aaron C. Petrey, Kimberly A. Queisser, John L. Rustad, Judah L. Evangelista, Michael S. Kay, Joshua D. Schiffman, Robert A. Campbell, Christian C. Yost
Summary: Neutrophil extracellular traps (NETs) can contribute to host inflammatory tissue damage during sepsis. This study investigated a novel therapeutic agent, neonatal NET-Inhibitory Factor (nNIF), and found that nNIF inhibited NET formation and improved survival in a mouse model of sepsis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa
Summary: Sepsis affects drug metabolism and the expression of cytochrome P450s. The study shows that cecal ligation and puncture (CLP) induces the expression of proinflammatory cytokines and leads to decreased survival in IL-6(-/-) mice. CLP also downregulates the expression of Cyp2c and Cyp3a11 genes, but this effect is abolished by IL-6 depletion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Changnan Wang, Jihong Yuan, Jiankui Du
Summary: The study showed that resveratrol could alleviate sepsis-induced acute lung injury/acute respiratory distress syndrome by regulating mitochondrial function and mitophagy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Critical Care Medicine
Danillo Menezes dos Santos, Eric Aian Pereira Da Silva, Jeferson Yuri Santos Oliveira, Yandra Yssa de Menezes Marinho, Izabel Rodrigues de Santana, Luana Heimfarth, Erik Willyame Menezes Pereira, Lucindo Jose Quintans Junior, Jamil Assreuy, Igor Alexandre Cortes Menezes, Marcio Roberto Viana dos Santos
Summary: The study suggests that HDZ has the potential to improve clinical outcomes in sepsis by reducing inflammatory response and oxidative stress through the PI3K/Akt pathway. This indicates that HDZ may be a new therapeutic alternative for treating sepsis.
Article
Biochemistry & Molecular Biology
Deepa Mathew, Julia Barillas-Cerritos, Ana Nedeljkovic-Kurepa, Mabel Abraham, Matthew D. Taylor, Clifford S. Deutschman
Summary: Cecal ligation and puncture (CLP) attenuates the tyrosine phosphorylation of insulin receptor β-subunit (IRβ) and insulin receptor substrate molecules (IRS)-1 and IRS-2.
MOLECULAR MEDICINE
(2023)
Article
Anesthesiology
Thomas A. Neff, Julia Braun, Dhanu Rana, Milo Puhan, Miodrag Filipovic, Manfred Seeberger, Frank Stueber, Simona B. Neff, Beatrice Beck-Schimmer, Martin Schlaepfer
Summary: This study investigated the correlation between postoperative inflammatory markers and complications, finding a relationship between elevated IL-6 levels and severe complications. Monitoring IL-6 postoperatively may be helpful for risk estimation after lung surgery.
ANESTHESIA AND ANALGESIA
(2022)
Article
Chemistry, Physical
Felix J. Geissel, Varvara Platania, Alexander Gogos, Inge K. Herrmann, Georgios N. Belibasakis, Maria Chatzinikolaidou, Georgios A. Sotiriou
Summary: This study demonstrates that the concentration of Ag ions in solution is the major factor driving the antibiofilm effect of nanosilver coatings, independent of Ag size and coating thickness. The antibiofilm effect predominantly stems from the released Ag ions rather than direct bacterial contact inhibition, especially for coatings featuring the smallest Ag particle sizes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biophysics
Andreas Boss, Laura Heeb, Divya Vats, Fabian H. L. Starsich, Alice Balfourier, Inge K. Herrmann, Anurag Gupta
Summary: The aim of this study is to detect and quantify the distribution of iron-based nanoparticles in mouse models using ultrashort-echo-time (UTE) sequences. The results showed that UTE sequences can reliably detect the signal decay of nanoparticles in various tissues, and the change in transverse relaxation time is related to the quantity and composition of nanoparticles.
NMR IN BIOMEDICINE
(2022)
Article
Medicine, General & Internal
Martin Urner, Adrian G. Barnett, Gianluigi Li Bassi, Daniel Brodie, Heidi J. Dalton, Niall Ferguson, Silver Heinsar, Carol L. Hodgson, Giles Peek, Kiran Shekar, Jacky Y. Suen, John F. Fraser, Eddy Fan
Summary: An observational study found that extracorporeal membrane oxygenation (ECMO) is associated with a reduced risk of mortality in adults with COVID-19 associated respiratory failure. Age, severity of hypoxaemia, and duration and intensity of mechanical ventilation were identified as modifiers of treatment effectiveness, and should be taken into consideration when deciding to initiate ECMO in patients with COVID-19.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Thomas Rduch, Elena Tsolaki, Yassir El Baz, Sebastian Leschka, Diana Born, Janis Kinkel, Alexandre H. C. Anthis, Tina Fischer, Wolfram Jochum, Rene Hornung, Alexander Gogos, Inge K. Herrmann
Summary: The study finds that preeclamptic placentae have elevated levels of heavy metals, but the correlation between calcifications and preeclampsia remains controversial. The role of other inorganic components in placental tissue in the development of preeclampsia is also not well understood.
FRONTIERS IN MEDICINE
(2022)
Article
Anesthesiology
Ghislaine Doufle, Martin Urner, Laura Dragoi, Aditi Jain, Ryan Brydges, Dominique Piquette
Summary: Limited data exist on advanced critical care echocardiography (CCE) training programs for intensivists. This study aimed to describe a longitudinal echocardiography program and investigate the effect of different supervision models and a laboratory rotation on learners' engagement. The findings suggest that lack of time and limited supervision, as well as the complexity of skills, were major barriers to independent practice.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2022)
Article
Anesthesiology
Diana Morales Castro, Etienne Abdelnour-Berchtold, Martin Urner, Laura Dragoi, Marcelo Cypel, Eddy Fan, Ghislaine Doufle
Summary: The study demonstrated the safety and efficacy of using TEE guidance for ECMO cannulation in patients with COVID-19, with a high success rate and low complication rate.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Multidisciplinary Sciences
Lukas R. H. Gerken, Alexander Gogos, Fabian H. L. Starsich, Helena David, Maren E. Gerdes, Hans Schiefer, Serena Psoroulas, David Meer, Ludwig Plasswilm, Damien C. Weber, Inge K. Herrmann
Summary: Nanoparticles can serve as radioenhancers in radiation therapy. This research investigates the dose enhancement capabilities of various nanoparticles based on their metal core composition and beam characteristics, providing design criteria for their optimal performance in specific radiotreatments.
NATURE COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
Anne Bertolini, Michael Prummer, Mustafa Anil Tuncel, Ulrike Menzel, Maria Lourdes Rosano-Gonzalez, Jack Kuipers, Daniel Johannes Stekhoven, Niko Beerenwinkel, Franziska Singer
Summary: Single-cell RNA sequencing (scRNA-seq) is a powerful technique for understanding tissue composition and disease mechanisms at the single-cell level. However, analyzing and interpreting the large amounts of data generated by scRNA-seq is challenging. In this study, we developed a workflow called scAmpi (Single Cell Analysis mRNA pipeline) that processes and analyzes scRNA-seq data from raw sequencing to provide clinically relevant information. The workflow removes low quality cells, identifies cell types, and visualizes gene expression and functional pathways in single cells. Additionally, scAmpi can link gene expression to potential drug candidates for disease treatment.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Anesthesiology
Marc T. Schmidt, Marc Studer, Andres Kunz, Sandro Studer, John M. Bonvini, Marco Bueter, Lucas Kook, Sarah R. Haile, Andreas Pregernig, Beatrice Beck-Schimmer, Martin Schlapfer
Summary: This study aimed to assess if cerebral apnea tolerance can be improved in obese patients under general anesthesia when comparing O-2/Air to O-2/CO2. The results showed that O-2/CO2 can improve cerebral tissue oxygenation index (TOI) and arterial oxygen partial pressure (PaO2) in anesthetized bariatric patients, but cannot confirm its ability to improve apnea tolerance.
BMC ANESTHESIOLOGY
(2023)
Article
Anesthesiology
Giovanna A. Lurati Buse, Eckhard Mauermann, Daniela Ionescu, Wojciech Szczeklik, Stefan De Hert, Miodrag Filipovic, Beatrice Beck-Schimmer, Savino Spadaro, Purificacion Matute, Daniel Bolliger, Sanem Cakar Turhan, Judith van Waes, Filipa Lagarto, Kassiani Theodoraki, Anil Gupta, Hans-Joerg Gillmann, Luca Guzzetti, Katarzyna Kotfis, Hinnerk Wulf, Jan Larmann, Dan Corneci, Frederique Chammartin-Basnet, Simon J. Howell
Summary: This study aimed to investigate the predictive value of self-reported functional capacity for major adverse cardiovascular events (MACEs) after noncardiac surgery. The results showed that self-reported functional capacity was associated with MACEs, but did not improve the accuracy of prediction.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Biochemistry & Molecular Biology
Stefanie Janker, Simon Doswald, Roman R. Schimmer, Urs Schanz, Wendelin J. Stark, Martin Schlapfer, Beatrice Beck-Schimmer
Summary: Our research group successfully removed circulating tumor cells using magnetic nanoparticles. In a small pilot study, we tested the efficiency of particles in removing CD19-positive B lymphocytes from blood samples of chronic lymphocytic leukemia (CLL) patients. The study found that alemtuzumab-coated carbon-coated cobalt nanoparticles were able to reduce B lymphocyte count, especially in patients with high lymphocyte count.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anesthesiology
Thomas W. Schnider, Gertrude J. Nieuwenhuijs-Moeke, Beatrice Beck-Schimmer, Thomas M. Hemmerling
Summary: This article discusses the debate on whether all general anesthesia should be done using target-controlled propofol anesthesia guided by monitoring of depth of anesthesia. The Pro side argues that total intravenous anesthesia causes less postoperative nausea and higher patient satisfaction than anesthesia using volatile anesthetics. The Con side argues that volatile anesthetics might have advantages in certain situations such as ischemia and reperfusion injury or severe inflammation, and in times of drug shortages.
ANESTHESIA AND ANALGESIA
(2023)
Correction
Critical Care Medicine
Joseph E. Tonna, Martin Urner, Heather T. Keenan, Daniel Brodie, Eddy Fan
INTENSIVE CARE MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Lorena Moor, Subas Scheibler, Lukas Gerken, Konrad Scheffler, Florian Thieben, Tobias Knopp, Inge K. Herrmann, Fabian H. L. Starsich
Summary: This study investigates the influence of magnetic coupling phenomena on the magnetic particle imaging (MPI) signal. The researchers found that the inter-particle distance and the silica shell thickness affect the magnetic properties and signal/noise ratio. Commercial tracers showed poor signal stability in PBS, while the flame-made samples exhibited excellent signal stability.