Article
Health Care Sciences & Services
Ho-Young Gil, Ha-Yeon Kim, Hye-Sun Lee, Na-Young Kim, Ji-Eun Kim
Summary: The study assessed the impact of palonosetron on the effect-site concentration of remifentanil for preventing emergence cough in females. The results showed that palonosetron did not have a significant effect on the antitussive activity of remifentanil.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pediatrics
Jongyoon Baek, Sang Jin Park, Jun Oh Kim, Minhyun Kim, Do Young Kim, Eun Kyung Choi
Summary: The effects of remifentanil and fentanyl on the incidence of emergence agitation (EA) in pediatric patients undergoing strabismus surgery were investigated. The study found that there was no significant difference in the incidence of EA when fentanyl was administered during anesthetic induction and remifentanil was continuously infused during surgery in these pediatric patients.
Article
Anesthesiology
Dan Wang, Juan Xu, Xiao-Lin Yang, Yan-Xia Guo, Ping-Ping Jiang, Guo-Yuan Zhang
Summary: The study findings suggest that target-controlled infusion of remifentanil can effectively reduce the MAC(BAR) of sevoflurane during laparoscopic surgery in children. The infusion of different remifentanil target concentrations does not significantly affect the changes in epinephrine and noradrenaline concentrations at a similar level of MAC(BAR) effect.
BMC ANESTHESIOLOGY
(2021)
Article
Management
Anett Weber, Winfried J. Steiner
Summary: The study compared the performance of store sales models with discrete and continuous representations of heterogeneity, finding that models with discrete representations outperformed their continuous counterparts in terms of model likelihood and predictive accuracy. The predictive performance of models with discrete representations was also higher compared to the zone pricing model practiced by the retailer.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2021)
Article
Cell Biology
Julia Raitanen, Bernadette Barta, Marcus Hacker, Dietmar Georg, Theresa Balber, Markus Mitterhauser
Summary: Radiation therapy is an effective tool in cancer treatment, but its success rate varies. A study compared the radiation responses of 2D and 3D cell culture models of different human cancer cell lines. The results showed significant differences in radiation sensitivity between the two models, with 3D spheroids exhibiting higher resistance to radiation.
Article
Anesthesiology
Jinhyeok Jeong, Chanwoo Park, Youngjoon Yoon, Dojae Lee, Sangyun Cho
Summary: This study compared surgical field conditions and hemodynamic variables between two groups receiving low or high concentration of remifentanil. The results showed that the high-concentration remifentanil group had better surgical conditions and lower heart rate after 90 minutes of surgery, but there was no significant difference in stroke volume between the two groups.
BMC ANESTHESIOLOGY
(2023)
Article
Mathematics
Konstantin Gavrilov, Yuriy Rozhdestvenskii, Ildar Umurzakov
Summary: This article demonstrates the use of Markov's processes theory to analyze the change of rough surfaces in contact interaction. It applies this analysis to the friction process and fatigue failure mode, providing models for the influence of lubrication and examples for surface evolution estimation. Technical characteristics are evaluated as functions of friction path and load.
Article
Pharmacology & Pharmacy
Yong Chen, Hongkai Lin
Summary: The study found that the combined use of sevoflurane and remifentanil for anesthesia in laparoscopic surgery resulted in more stable vital signs, shorter postoperative recovery time, improved quality of recovery, and reduced stress response.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Chemistry, Physical
Neveen AlQasas, Asma Eskhan, Daniel Johnson
Summary: The surface energies (gamma), Hansen solubility parameters (HSP), and cohesive energy density are related. Modifications of solid surfaces can affect the surface properties, such as energy and adhesion characteristics, as well as HSP. In membrane technologies, the use of multi layered membranes like TFC is common, but it is difficult to selectively determine the HSP for the surface or top layer of a membrane.
SURFACES AND INTERFACES
(2023)
Article
Geosciences, Multidisciplinary
Francesca Carletti, Adrien Michel, Francesca Casale, Alice Burri, Daniele Bocchiola, Mathias Bavay, Michael Lehning
Summary: This study compares the performance of two degree-day models and one full energy-balance model in predicting discharge in two Alpine catchments. The results show that the degree-day implementation of Alpine3D produces results close to the full energy-balance model, while Poli-Hydro predicts lower snowmelt and a delayed melting season. Under climate change conditions, Alpine3D is more sensitive and simulates earlier snowmelt. However, the coarser temporal resolution and simplified melt models like Poli-Hydro are controversial for climate change applications compared to energy-balance models, especially under strong river regulation.
HYDROLOGY AND EARTH SYSTEM SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Nathaniel R. Twarog, Nancy E. Martinez, Jessica Gartrell, Jia Xie, Christopher L. Tinkle, Anang A. Shelat
Summary: The quantitative evaluation of drug combinations is crucial for drug development. Index-based methods are known to be biased and unstable, whereas response surface models are less prone to these defects and can be applied to a wide range of data.
DRUG DISCOVERY TODAY
(2021)
Article
Engineering, Civil
Qihao Jiang, Bo Wang, Guangqiu Jin, Hongwu Tang, Junzeng Xu, Xinli Zhu
Summary: This study investigates the response mechanism of riparian groundwater to pollution sources in the Gusong River, China. Anthropogenic activities and mineral weathering were identified as the main pollution sources. Anthropogenic inputs accounted for 11.4% of riparian groundwater pollution, while river water contributed more. Riparian groundwater acted as a sink for non-point pollutants and removed 13.7% of anthropogenic pollutants from the river water. However, it acted as a source for pollutants from mineral weathering and contributed an additional 19.3% to groundwater.
JOURNAL OF HYDROLOGY
(2023)
Article
Engineering, Civil
Tao Liu, Wenze Wang, Huakun Wang, Binjian Su
Summary: The rationality and reliability of the damping reduction factor are crucial for seismic design of building structures. Existing models predicting the factor show significant variations, largely due to regression models and considered factors. By analyzing the impact of various factors on the damping reduction factor, improved models were proposed for different response spectra, demonstrating reasonable expression and strong reliability in accurately predicting damping reduction factors.
ENGINEERING STRUCTURES
(2021)
Article
Oncology
Kun Wang, Ying Rao, Xuan Dong
Summary: This study found that sevoflurane combined with remifentanil anesthesia is superior to propofol and remifentanil anesthesia in patients undergoing laparoscopic radical hysterectomy for cervical cancer, as it can maintain stable hemodynamics and reduce physical stress.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Environmental Studies
Safiye Pinar Tunali, Necdet Dagdelen
Summary: This study evaluated the success of two different methods, interview-based reallocation and fuzzy logic-based reallocation, in land consolidation projects. The results showed that both methods were successful, with better results in consolidation rate, number of enterprises, and average parcel size achieved with the fuzzy logic method. The number of parcels per enterprise was equal in both methods. The fuzzy logic method had more single share parcels, while the interview-based method had larger single share parcel areas. In conclusion, the fuzzy logic method was more successful than the interview-based method.
Article
Anesthesiology
S. M. Ramaswamy, M. H. Kuizenga, M. A. S. Weerink, H. E. M. Vereecke, M. M. R. F. Struys, S. Belur Nagaraj
Summary: This study developed an automated system using machine learning to estimate sedation levels based on EEG features, which showed high predictive accuracy across different drugs, genders, and age groups.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2022)
Review
Anesthesiology
Douglas J. Eleveld, Jeroen V. Koomen, Anthony R. Absalom, Hong Su, Laura N. Hannivoort, Michel M. R. F. Struys
Summary: This article presents a clinical review of basic allometric scaling theory and its application to pharmacokinetic models in anesthesia and other fields in the biologic sciences.
Review
Anesthesiology
Dirk J. Bosch, Gertrude J. Nieuwenhuijs-Moeke, Matijs van Meurs, Wayel H. Abdulahad, Michel M. R. F. Struys
Summary: Nonsteroidal anti-inflammatory drugs are commonly used in the perioperative period for pain management, but their immune-modulating effects may have consequences on postoperative outcomes, including systemic inflammatory response syndrome and unexpected effects on various organ systems.
Article
Anesthesiology
Ricardo Alvarez-Jimenez, Maud A. S. Weerink, Laura N. Hannivoort, Hong Su, Michel M. R. F. Struys, Stephan A. Loer, Pieter J. Colin
Summary: This study developed a nonlinear three-compartment pharmacokinetic model that accurately described dexmedetomidine plasma concentrations. Simulations showed that currently approved dosing regimens in the intensive care unit may potentially lead to higher-than-expected dexmedetomidine plasma concentrations.
Review
Medicine, General & Internal
Ophelie Vandemoortele, Laura N. Hannivoort, Florian Vanhoorebeeck, Michel M. R. F. Struys, Hugo E. M. Vereecke
Summary: Target controlled infusion (TCI) is a computer-controlled method of drug administration that adjusts drug titration based on user-selected plasma- or effect-site concentrations. However, current commercially available PKPD models for TCI have limitations such as the risk of invalid model selection and the restriction to predicting plasma concentration. General purpose PKPD models, developed using advancements in computing and globally collected databases, address these limitations by considering factors such as body weight, composition, sex, and age, reducing the risk of invalid model selection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Tomasz T. Maciag, Kai van Amsterdam, Albertus Ballast, Fokie Cnossen, Michel M. R. F. Struys
Summary: This study demonstrates the potential of using Machine Learning techniques to generate meaningful alarms during general anesthesia without constraints on the type of procedure. Two approaches, Complication Detection and Anomaly Detection, were tested. The former achieved the best performance using a simple feed-forward Neural Network, while the latter utilized an Encoder-Decoder Long Short-Term Memory architecture that does not require a large manually-labeled dataset.
HEALTH INFORMATICS JOURNAL
(2022)
Review
Medicine, General & Internal
Remco Vellinga, Beatrijs I. Valk, Anthony R. Absalom, Michel M. R. F. Struys, Clemens R. M. Barends
Summary: This review discusses the current situation of anaesthetic drug development and methods of administration, as well as future prospects.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Anesthesiology
David G. Lambert, Michel M. R. F. Struys, Simon Howell
Summary: The British Journal of Anaesthesia organisation is a registered charity that focuses on publishing impactful papers and funding research in the field of anaesthesia. This editorial highlights their charitable activities, which include funding research infrastructure, supporting meetings, and providing grants for diverse international research projects.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Biochemistry & Molecular Biology
G. J. Julia Huisman, Nora A. Spraakman, Jeroen V. Koomen, A. Marrit Talsma, Robert A. Pol, Stefan P. Berger, Henri G. D. Leuvenink, Michel M. R. F. Struys, Gertrude J. Nieuwenhuijs-Moeke
Summary: Early non-invasive detection and prediction of graft function after kidney transplantation is important. The study analyzed four urinary biomarkers and found that KIM-1 and NAG at early timepoints after transplantation were significant predictors for eGFR, while NGAL and NAG at day 1 after transplantation were negative predictors. Including these biomarkers improved the prediction models for graft outcome. Factors such as timing of measurement and transplantation factors need to be considered when using urinary biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
I. A. Vos, E. Deuring, M. Kwant, B. W. J. Bens, B. Dercksen, R. Postma, E. M. F. Jorna, M. M. R. F. Struys, J. C. ter Maaten, B. Singer, E. ter Avest
Summary: This study aimed to investigate the benefit of pre-hospital initiation of extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) patients. Through temporal spatial analysis, it was found that 32% of OHCA patients in the north of the Netherlands met ECPR eligibility criteria. Initiating ECPR after 15 minutes of conventional CPR increased the number of potentially eligible patients.
Review
Anesthesiology
Remco Vellinga, Douglas J. Eleveld, Michel M. R. F. Struys, Johannes P. van den Berg
Summary: This article examines the usability of general-purpose models in relation to traditional models.
CURRENT OPINION IN ANESTHESIOLOGY
(2023)
Article
Anesthesiology
Hugo Carvalho, Michael Verdonck, Douglas J. Eleveld, David Ramirez, Jan D'Haese, Panagiotis Flamee, Lieselot Geerts, Jasper Wylleman, Wilfried Cools, Kurt Barbe, Michel M. R. F. Struys, Jan Poelaert
Summary: This study assessed the performance of published Rocuronium PK/PD models in predicting intraoperative Train-of-four (TOF) ratios when compared to electromyographic TOF measurements. The results showed that the published PK/PD models overestimated the clinically registered TOF ratios.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Chemistry, Analytical
Rianne van Melzen, Marjolein E. Haveman, Richte C. L. Schuurmann, Michel M. R. F. Struys, Jean-Paul P. M. de Vries
Summary: Incorporating technology into healthcare processes is essential for future high-quality care. Wearable sensors are a promising technology that can reduce workload, enable early detection of patient deterioration, and support clinical decision making. However, their widespread adoption in surgical wards is currently lacking. This report provides practical guidance based on the NASSS framework to support the clinical application of wearable sensors in surgical wards, discussing relevant topics and summarizing key lessons.
Proceedings Paper
Automation & Control Systems
Mihaela Ghita, Dana Copot, Isabela R. Birs, Cristina Muresan, Robin De Keyser, Martine Neckebroek, Michel M. R. F. Struys, Clara M. Ionescu
Summary: This paper proposes a novel control strategy to minimize uncertainty by infusing knowledge into the closed loop. The strategy aims to regulate the complex interaction between anesthesia and hemodynamics in a set of patients during general anesthesia using predictive control. The paper focuses on minimizing the risk of instability caused by large uncertainty in the patient model dynamics. The concept of digitalizing surgical actions as part of mimicking real-life decision-making process of anesthesiologists is explored, and simulations using an anesthesia-hemodynamics simulator support the claims. A feasibility study in an actual constrained input-output variable set confirms its clinical relevance in multi-drug optimization.
2022 IEEE 61ST CONFERENCE ON DECISION AND CONTROL (CDC)
(2022)