Article
Medicine, Research & Experimental
Yu Zhang, Jinyong Liu, Cuili Xie, Pingping Wu
Summary: miR-133b plays a crucial role in anesthesia-induced cognitive impairment, with its overexpression alleviating cognitive dysfunction and enhancing neuronal viability.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Pengfei Liu, Jing Yuan, Yetong Feng, Xin Chen, Guangsuo Wang, Lei Zhao
Summary: This study reveals that isoflurane induces ferroptosis in a dose-dependent and time-dependent manner in the hippocampus, affecting learning and memory abilities. The ferroptosis induced by isoflurane can be rescued by ferroptosis inhibitor (ferrostatin-1) and mitochondria activator (dimethyl fumarate), showing effective therapeutic action against isoflurane-induced learning and memory impairment.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Vikram Babu Kasaragod, Tomas Malinauskas, Ayla A. Wahid, Judith Lengyel, Frederic Knoflach, Steven W. Hardwick, Charlotte F. Jones, Wan-Na Chen, Xavier Lucas, Kamel El Omari, Dimitri Y. Chirgadze, A. Radu Aricescu, Giuseppe Cecere, Maria-Clemencia Hernandez, Paul S. Miller
Summary: This study investigates the structures of drugs bound to the alpha 5 subunit and reveals the molecular basis of their binding and alpha 5 selectivity. Additionally, positional displacement of the upper moiety in isoxazole drugs was observed. These findings provide insights into distinct modulator binding modes and inform future drug design campaigns.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Il-Gyu Ko, Jun-Jang Jin, Lakkyong Hwang, Sang-Hoon Kim, Chang-Ju Kim, Jung Won Jeon, Jun-Young Chung, Jin Hee Han
Summary: The study demonstrated that PDRN treatment can improve short-term memory impairment induced by cerebral ischemia by suppressing the production of pro-inflammatory cytokines and inactivation of MAPK signaling factors. This suggests that PDRN may be developed as the primary treatment for cerebral ischemia.
Article
Biochemistry & Molecular Biology
Patrik F. Schwarz, Alexander F. Perhal, Lucia N. Schoeberl, Martin M. Kraus, Johannes Kirchmair, Verena M. Dirsch
Summary: The natural product diosgenin has been identified as a direct ligand and inverse agonist of the nuclear receptor ROR alpha and ROR gamma. This finding provides a direct molecular target for diosgenin and explains its role in amending Th17-driven diseases.
Article
Oncology
Rumani Singh, Stacey Yu, Marwa Osman, Zintis Inde, Cameron Fraser, Abigail H. Cleveland, Nicole Almanzar, Chuan Bian Lim, Gaurav N. Joshi, Johan Spetz, Xingping Qin, Sneh M. Toprani, Zachary Nagel, Matthew C. Hocking, Robert A. Cormack, Torunn I. Yock, Jeffrey W. Miller, Zhi-Min Yuan, Timothy Gershon, Kristopher A. Sarosiek
Summary: Age- and differentiation-dependent apoptotic priming plays a pivotal role in driving radiotherapy-induced neurocognitive impairment and can be targeted for neuroprotection in pediatric patients.
Article
Behavioral Sciences
Saskia Boeckmann, Deetje Iggena, Stefanie Schreyer, Andre Rex, Barbara Steiner
Summary: General anesthesia is a risk factor for postoperative cognitive dysfunction, but the neuronal and cognitive consequences are unclear. Isoflurane, an anesthetic, was found to decrease neuronal proliferation in adult mice, but did not affect survival or cognition linked to neurogenesis. This adverse effect can be attenuated by physical activity.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Multidisciplinary Sciences
Faiga Magzal, Carmel Even, Iris Haimov, Maayan Agmon, Kfir Asraf, Tamar Shochat, Snait Tamir
Summary: Insomnia with short sleep duration is a severe phenotype that is associated with increased concentrations of short-chain fatty acids (SCFAs) in older adults. High levels of acetate, butyrate, and propionate, as well as total SCFAs, were linked to lower sleep efficiency and longer sleep onset latency. These findings suggest SCFAs may serve as potential biomarkers for identifying different insomnia phenotypes and contribute to understanding the gut-brain axis in sleep regulation.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Patryk Wekwejt, Urszula Wojda, Anna Kiryk
Summary: By investigating the relationship among diet, melanotropin hormone MT-II, and zebrafish behavior, this study found that a high-fat diet has negative effects on memory and emotions, and MT-II can reverse these changes.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Kaley Hogarth, Ramesh Babu Vanama, Greg Stratmann, Jason T. Maynes
Summary: The study revealed that early exposure to anesthesia can lead to adverse changes in mitochondrial quality maintenance pathways, autophagy, and mitochondrial biogenesis. Although oxidative stress markers increased, cellular redox compensatory responses weakened, and oxidative phosphorylation decreased. Furthermore, mitochondrial stress and proteotoxicity markers were upregulated, while mitochondrial unfolded protein response end-effectors were significantly reduced, contributing to increased inflammation.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Caiwen Chen, Yang Tao, Yongbin Han, Yanfeng Ding, Xingliang Jian, Dandan Li
Summary: This study successfully prepared germinated brown rice (GBR) with high γ-aminobutyric acid (GABA) content and short root by exposing brown rice (BR) to a magnetic field and incubating it in GABA solutions. The GABA content in GBR significantly increased, while the root length decreased. The accumulation of GABA was mainly caused by the absorption of exogenous GABA, which increased cell membrane permeability and root hairs. Despite the reduction in GABA aminotransferase activity, the hyperaccumulation of GABA inhibited the positive effects on enzymatic activity, starch structure, and antioxidant activity, resulting in shorter roots.
JOURNAL OF CEREAL SCIENCE
(2023)
Article
Neurosciences
Laise Figueiredo de Oliveira, Gabriela Godoy Poluceno, Tuane Bazanella Sampaio, Leandra Celso Constantino, Ana Paula Costa, Wagner Carbolin Martins, Tharine Dal-Cim, Karen Andrineia de Oliveira, Fabiana Kalyne Ludka, Rui Daniel Prediger, Frederico C. Pereira, Carla Ines Tasca
Summary: This study investigated the effects of neonatal exposure to isoflurane on the developing rat brain. The findings showed that a single exposure to isoflurane had different effects during infancy and adulthood. Behavioral analysis in adult rats revealed impaired short-term memory following neonatal isoflurane exposure, but no effects on anxiety-like behavior and locomotor activity.
NEUROTOXICITY RESEARCH
(2022)
Article
Psychology, Biological
Katia Baron-Quiroz, Martha Garcia-Ramirez, Eliezer Chuc-Meza
Summary: The study found that low-level globus pallidus dopaminergic denervation can negatively impact short-term memory in rats, while having minimal effects on motor activity.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Behavioral Sciences
Tiantian Liu, Jia Song, Qingyun Zhou, Shuaishuai Chu, Yujia Liu, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu
Summary: This study found that long-term isoflurane anesthesia can cause memory impairment, and blockade of 5-HT7R can attenuate this impairment. This finding helps improve understanding of the memory impairment induced by long-term isoflurane anesthesia and provides potential strategies for preventing and treating adverse effects after long-term isoflurane exposure.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2022)
Article
Toxicology
H. Liu, M. Wang, L. Xu, M. Li, M. Zhao
Summary: The study reveals that miR-204-5p plays a crucial role in isoflurane-induced learning and memory impairment, with its downregulation protecting rats from neuroinflammation and improving cognitive function. Additionally, miR-204-5p may serve as a potential therapeutic target for alleviating cognitive dysfunction induced by isoflurane.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Review
Behavioral Sciences
Sivaani Sivaselvachandran, Erinn L. Acland, Salsabil Abdallah, Loren J. Martin
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2018)
Article
Biochemistry & Molecular Biology
Loren J. Martin, Erinn L. Acland, Chulmin Cho, Wiebke Gandhi, Di Chen, Elizabeth Corley, Basil Kadoura, Tess Levy, Sara Mirali, Sarasa Tohyama, Sana Khan, Leigh C. MacIntyre, Erika N. Carlson, Petra Schweinhardt, Jeffrey S. Mogil
Article
Anesthesiology
Shannon N. Tansley, Leigh C. Macintyre, Laura Diamond, Susana G. Sotocinal, Nicole George, Lee Meluban, Jean-Sebastien Austin, Terence J. Coderre, Loren J. Martin, Jeffrey S. Mogil
Article
Anesthesiology
Marc Parisien, Alexander Samoshkin, Shannon N. Tansley, Marjo H. Piltonen, Loren J. Martin, Nehme El-Hachem, Concetta Dagostino, Massimo Allegri, Jeffrey S. Mogil, Arkady Khoutorsky, Luda Diatchenko
Article
Multidisciplinary Sciences
Joanes Grandjean, Alberto Corcoba, Martin C. Kahn, A. Louise Upton, Evan S. Deneris, Erich Seifritz, Fritjof Helmchen, Edward O. Mann, Markus Rudin, Bechara J. Saab
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Chulmin Cho, Vassilia Michalidis, Irene Lecker, Chereen Collymore, David Hanwell, Mary Loka, Matthew Danesh, Christine Pham, Paige Urban, Robert P. Bonin, Loren J. Martin
SCIENTIFIC REPORTS
(2019)
Review
Behavioral Sciences
Susanne Becker, Anne-Kathrin Braescher, Scott Bannister, Moustafa Bensafi, Destany Calma-Birling, Raymond C. K. Chan, Tuomas Eerola, Dan-Mikael Ellingsen, Camille Ferdenzi, Jamie L. Hanson, Mateus Joffily, Navdeep K. Lidhar, Leroy J. Lowe, Loren J. Martin, Erica D. Musser, Michael Noll-Hussong, Thomas M. Olino, Rosario Pintos Lobo, Yi Wang
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2019)
Correction
Multidisciplinary Sciences
Chulmin Cho, Vassilia Michailidis, Irene Lecker, Chereen Collymore, David Hanwell, Mary Loka, Matthew Danesh, Christine Pham, Paige Urban, Robert P. Bonin, Loren J. Martin
SCIENTIFIC REPORTS
(2019)
Article
Engineering, Biomedical
Abdulrhman H. Al-Jebrni, Brendan Chwyl, Xiao Yu Wang, Alexander Wong, Bechara J. Saab
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2020)
Article
Neurosciences
Soroush Darvish-Ghane, Clementine Quintana, Jean-Martin Beaulieu, Loren J. Martin
Article
Behavioral Sciences
Loren J. Martin, Sandra J. Poulson, Emma Mannan, Sivaani Sivaselvachandran, Moonjeong Cho, Fatima Setak, Claire Chan
Summary: Our findings suggest that depending on the sensory stimuli, pain responses in BTBR and Fmr1-KO mice may vary, with BTBR mice showing mixed nociceptive responses and Fmr1-KO mice displaying hyposensitivity to certain stimuli. Furthermore, neither BTBR nor Fmr1-KO mice exhibited emotional contagion of pain in social settings, indicating potential differences in empathy development in these ASD mouse models.
GENES BRAIN AND BEHAVIOR
(2022)
Article
Psychiatry
Horea-Ioan Loanas, Bechara John Saab, Markus Rudin
Summary: This article presents a study on VTA dopaminergic signaling in mice using optogenetic stimulation and functional Magnetic Resonance Imaging (fMRI). The results show that the function of VTA dopaminergic system is consistent with its structural projections, with some key differences. The variability of the assay with regard to experimental parameters is also discussed, and evidence-based recommendations for assay reuse are provided.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Soroush Darvish-Ghane, Jennet Baumbach, Loren J. Martin
Summary: Dopamine inhibits excitatory synaptic transmission in the ACC, but the modulation of inhibitory synaptic transmission and the E/I balance has been understudied. This study used patch-clamp recordings and found that DA did not significantly impact eEPSCs in the ACC. However, individual neurons showed varied responses to DA. The study suggests that CFA-induced inflammation and DA do not significantly affect the excitatory/inhibitory balance in ACC neurons. Evaluation: 6/10
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Utkarsh B. Subnis, Norman A. S. Farb, Katherine-Ann Laura Piedalue, Michael Speca, Sasha Lupichuk, Patricia A. Tang, Peter Faris, Mark Thoburn, Bechara J. Saab, Linda E. Carlson
JMIR RESEARCH PROTOCOLS
(2020)
Article
Psychiatry
Kathleen Marie Walsh, Bechara J. Saab, Norman A. S. Farb
JMIR MENTAL HEALTH
(2019)