Review
Clinical Neurology
Elahe Kazemeini, Eli van de Perck, Marijke Dieltjens, Marc Willemen, Johan Verbraecken, Sara Op de Beeck, Olivier M. Vanderveken
Summary: Understanding the pathophysiology of obstructive sleep apnea (OSA) is crucial for effective treatment. The collapsibility of the upper airway is an important factor in OSA. Finding effective methods to measure and evaluate upper airway collapsibility is a key concern.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Moon Young Oh, Jung-Man Lee, Dongwook Won, Tzu-Yen Huang, Che-Wei Wu, Gianlorenzo Dionigi, Hoon Yub Kim, Miyeon Seo, Hyun Suk Choi, Young Jun Chai
Summary: The study assessed the efficacy of neostigmine-glycopyrrolate as a neuromuscular blockade reversal agent for IONM during thyroid surgery, finding that it can effectively reduce the risk of IONM failure.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Physiology
Hanna A. Hensen, Jayne C. Carberry, Arun Krishnan, Amal M. Osman, Anne-Marie H. Mosch, Barbara Toson, Kevin L. Tay, Danny J. Eckert
Summary: This study explores the reflex function that protects the upper airway during negative pressure in individuals with multiple sclerosis (MS) and obstructive sleep apnea (OSA). It reveals that around 30% of MS patients have either no protective reflex or an abnormal reflex response, indicating impaired upper-airway reflex function may play a role in OSA for a significant proportion of MS patients.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Physiology
Elahe Kazemeini, Eli Van de Perck, Marijke Dieltjens, Marc Willemen, Johan Verbraecken, Scott A. Sands, Olivier M. Vanderveken, Sara Op de Beeck
Summary: In obstructive sleep apnea, drug-induced sleep endoscopy can be used to measure critical closing pressure (Pcrit) to evaluate upper airway collapse. The ventilation method was found to be more successful in assessing Pcrit in patients with epiglottic collapse.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Critical Care Medicine
Shane A. Landry, Dwayne L. Mann, Richard Beare, Richard McIntyre, Caroline Beatty, Luke D. J. Thomson, Jinny Collet, Simon A. Joosten, Garun S. Hamilton, Bradley A. Edwards
Summary: Wearing oronasal masks is associated with increased therapeutic pressure requirements and collapsibility of the upper airway compared to nasal masks.
Article
Medicine, General & Internal
Hsiao-Cheng Chang, Shih-Yuan Liu, Min-Jia Lee, Sing-Ong Lee, Chih-Shung Wong
Summary: Sugammadex is a direct reversal agent that effectively reverses deep neuromuscular block caused by muscle relaxants. Compared to neostigmine, it exhibits better reversal effects with fewer adverse effects. This retrospective review shows that sugammadex performs better than neostigmine/glycopyrrolate in terms of postoperative vomiting, postoperative urinary retention, and hemodynamic stability.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Anesthesiology
So Ron Choi, Jeong Ho Kim, Kyung Hyun Lee, Sang Yoong Park
Summary: The co-administration of calcium gluconate with neostigmine safely promoted early NMB recovery, and the neuromuscular recovery time of the calcium 10 group tended to be more evenly distributed than that of the calcium 5 group.
BMC ANESTHESIOLOGY
(2021)
Article
Clinical Neurology
Hong Huang, Wenyang Li, Hongyu Jin, Lei Zhang, Zhijing Wei, Wei Wang
Summary: This study found that an 8-week tongue strength training could gradually and transiently increase corticomotor excitability of genioglossus, elevate the genioglossus EMG activity, and ultimately enhance the stability of the upper airway during daytime, providing a theoretical foundation for TST as a promising treatment for OSA patients.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Otorhinolaryngology
Yingqian Zhou, Guoping Yin, Jinkun Xu, Xin Cao, Jingying Ye
Summary: This study aims to classify different genioglossus responses to upper airway negative pressure in obstructive sleep apnea patients. The method involves drug-induced sleep endoscopy with synchronous genioglossus electromyography and upper airway pressure monitoring. The results show that OSA patients with different genioglossus response modes have different outcomes in terms of tongue base collapse rate and improvement after nasopharyngeal tube placement. This novel method is useful for identifying suitable candidates for palatopharyngeal surgery.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Anesthesiology
Hannah Lu, Elizabeth A. Feldman, Robert W. Seabury, Luke A. Probst, William Darko, Christopher D. Miller
Summary: This study found no significant difference in time from the first NMBA reversal dose to recovery room between sugammadex and neostigmine/glycopyrrolate. The reintubation rates were similar. However, the total drug cost was significantly higher in the sugammadex group compared to the neostigmine/glycopyrrolate group.
TRENDS IN ANAESTHESIA AND CRITICAL CARE
(2022)
Article
Anesthesiology
Jee-Eun Chang, Taikyung Seol, Jin-Young Hwang
Summary: This study evaluated the effectiveness of the 25 degrees semisitting position on mask ventilation in anaesthetised paralysed obese patients. The results showed that the 25 degrees semisitting position improved mask ventilation compared to the supine position.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2021)
Article
Physiology
Guilherme J. M. Garcia, Josiah J. Wolf, David A. Campbell, Ryan S. Bailey, Rodney A. Sparapani, Charles M. Welzig, B. Tucker Woodson
Summary: A study found that mandibular advancement devices (MADs) reduce velopharyngeal collapsibility by increasing airway size rather than affecting soft palate compliance. These findings suggest that quantifying velopharyngeal cross-sectional area could be a potential biomarker for predicting the success of MAD therapy. (47 words)
PHYSIOLOGICAL REPORTS
(2023)
Editorial Material
Anesthesiology
Frank Herbstreit, Thomas E. Grissom, Evan G. Pivalizza
ANESTHESIA AND ANALGESIA
(2022)
Article
Medicine, General & Internal
David Fistera, Dirk Pabst, Maximilian Falk, Olympia E. Anastasiou, Stefan Goer, Sebastian Dolff, Margarethe Konik, Frank Herbstreit, Christian Taube, Clemens Kill, Joachim Risse
Summary: During the first twelve months of the COVID-19 pandemic, the university hospital of Essen had over 1400 COVID-19 inpatients with a mortality rate of 19.8%. Patients receiving standard care had a mortality rate of 10.6%, while those requiring intermediate/intensive care had a mortality rate of 35.5%. Age over 60, obesity, need for mechanical ventilation, nitric oxide therapy, ECMO, acute renal failure, and stroke were found to be independent predictors of mortality.
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2022)
Article
Dermatology
Lisa Kirchhoff, Lukas Miles Braun, Dirk Schmidt, Silke Dittmer, Jutta Dedy, Frank Herbstreit, Raphael Stauf, Nina Kristin Steckel, Jan Buer, Peter-Michael Rath, Joerg Steinmann, Hedda Luise Verhasselt
Summary: This study analyzed the 12-month prevalence of COVID-19-associated invasive pulmonary aspergillosis (CAPA) in a German tertiary care hospital and characterized clinical A. fumigatus isolates from two German hospitals. The study found a similar CAPA prevalence to other reports and a low azole-resistance rate.
Article
Microbiology
Ulrike Scharmann, Frank Herbstreit, Nina Kristin Steckel, Jutta Dedy, Jan Buer, Peter-Michael Rath, Hedda Luise Verhasselt
Summary: This study aimed to assess the prevalence of COVID-19-associated mucormycosis (CAM) in critically ill COVID-19 patients in a tertiary care hospital in Germany using direct microscopy, fungal culture, and PCR. One Mucorales-PCR positive result was found in bronchoalveolar lavage, while direct microscopy and fungal culture were negative in all cases. The conclusion was that routine screening for CAM in Germany is not necessary.
Article
Education, Scientific Disciplines
Cynthia Szalai, Sharaf-Eldin Shehada, Simona Iancu, Frank Herbstreit, Arjang Ruhparwar, Thorsten Brenner, Ali Haddad
Summary: This study aimed to investigate whether the level of experience of the tutor affects the effectiveness of learning among medical students using eFAST during a clinical scenario. The results showed that peer-teaching can effectively teach practical skills such as eFAST without a loss of clinical application skills. This is important for relieving the burden on doctors from patient care situations and maintaining teaching standards.
Article
Anesthesiology
Christian Waydhas, Teresa Deffner, Robert Gaschler, David Haske, Uwe Hamsen, Frank Herbstreit, Anke Hierundar, Oliver Kumpf, Georg Rohe, Aileen Spiekermann, Sonja Vonderhagen, Reiner M. Waeschle, Reimer Riessen
Summary: The survey revealed a high rate of moderate and deep sedation in oro-tracheally intubated patients, with lack of uniformity in sleep management and rare use of ear plugs and sleeping masks. The application of phonation techniques in tracheostomized patients during assisted breathing is low.
BMC ANESTHESIOLOGY
(2022)
Article
Medicine, General & Internal
Simon Dubler, Omer Can Turan, Karsten Daniel Schmidt, Peter-michael Rath, Hedda-Luise Verhasselt, Sandra Maier, Annabell Skarabis, Thorsten Brenner, Frank Herbstreit
Summary: Superinfections with Aspergillus spp. are increasing in COVID-19 patients, but dexamethasone treatment does not increase the risk of COVID-19-associated pulmonary aspergillosis (CAPA). The occurrence of CAPA may reflect the severity of the underlying disease rather than directly influencing treatment outcomes.
Editorial Material
Anesthesiology
Richard P. Dutton, Thomas E. Grissom, Frank Herbstreit, Evan G. Pivalizza
ANESTHESIA AND ANALGESIA
(2023)
Article
Immunology
Jaana Westmeier, Annika Brochtrup, Krystallenia Paniskaki, Zehra Karakoese, Tanja Werner, Kathrin Sutter, Sebastian Dolff, Andreas Limmer, Daniela Mittermueller, Jia Liu, Xin Zheng, Tetiana Koval, Igor Kaidashev, Marc Moritz Berger, Frank Herbstreit, Thorsten Brenner, Oliver Witzke, Mirko Trilling, Mengji Lu, Dongliang Yang, Nina Babel, Timm Westhoff, Ulf Dittmer, Gennadiy Zelinskyy
Summary: T cells in COVID-19 patients express receptors for macrophage migration inhibitory factor (MIF), which might contribute to the severity of pulmonary pathologies and prognosis. The expression of CD74 on T cells is higher in COVID-19 patients compared to healthy controls, and the expression of CXCR2 and CXCR4 increases upon SARS-CoV-2 infection. CD74+ T cells have a central memory phenotype early in infection, while cells with an effector and effector memory phenotype arise later during infection. Furthermore, CD74+ T cells produce more cytotoxic molecules and proliferation markers.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Willem Buys, Alexandra Bick, Rabea J. Madel, Astrid M. Westendorf, Jan Buer, Frank Herbstreit, Carsten J. Kirschning, Juergen Peters
Summary: For early sepsis patients who meet the Sepsis-3 criteria, only a fraction of the patients exhibit ongoing cytokine production ex vivo, and the suppressive response to TLR-blockade is only seen in high cytokine producing samples. Therefore, early sepsis patients are heterogeneous in terms of inflammation, and proper ex vivo assays may be useful in guiding treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Simone Kattner, Sivagurunathan Sutharsan, Marc Moritz Berger, Andreas Limmer, Lutz-Bernhard Jehn, Frank Herbstreit, Thorsten Brenner, Christian Taube, Francesco Bonella
Summary: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection has a variable disease course. KL-6 has the potential to be a candidate biomarker for predicting the severity and outcome of SARS-CoV-2 pneumonia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Henning Kuhlmann, Lena Garczarek, David Kuenne, Kevin Pattberg, Annabell Skarabis, Mirjam Frank, Boerge Schmidt, Sven Arends, Frank Herbstreit, Thorsten Brenner, Karsten Schmidt, Florian Espeter
Summary: This study investigated the association between skin HSI and organ dysfunction severity in critically ill COVID-19 patients, and found that HSI parameters were associated with the severity of the disease.
BIOENGINEERING-BASEL
(2023)
Meeting Abstract
Anesthesiology
Richard P. Dutton, Frank Herbstreit, Evan G. Pivalizza, Arman Dagal, Thomas E. Grissom
ANESTHESIA AND ANALGESIA
(2023)
Article
Critical Care Medicine
Johannes Herrmann, Christopher Lotz, Christian Karagiannidis, Steffen Weber-Carstens, Stefan Kluge, Christian Putensen, Andreas Wehrfritz, Karsten Schmidt, Richard K. Ellerkmann, Daniel Oswald, Gosta Lotz, Viviane Zotzmann, Onnen Moerer, Christian Kuehn, Matthias Kochanek, Ralf Muellenbach, Matthias Gaertner, Falk Fichtner, Florian Brettner, Michael Findeisen, Markus Heim, Tobias Lahmer, Felix Rosenow, Nils Haake, Philipp M. Lepper, Peter Rosenberger, Stephan Braune, Mirjam Kohls, Peter Heuschmann, Patrick Meybohm
Summary: This study investigated the factors affecting ICU survival of COVID-19 ARDS ECMO patients and found that age, comorbidities, and ECMO case volume were associated with survival. Treatment in high volume ECMO centers and careful patient selection were associated with higher ICU survival rates.
Article
Surgery
Achim Koch, Nikolaus Pizanis, Vasiliki Bessa, Frank Herbstreit, Erich Gulbins, Clemens Aigner, Markus Kamler
Summary: This case report presents a lung transplantation in a 31-year-old male recipient who developed irreversible ARDS respiratory failure after prolonged extracorporeal membrane oxygenation therapy for post-coronavirus disease 2019. The report also discusses potential changes in the acid sphingomyelinase/ceramide system as a mechanism for susceptibility to SARS-CoV-2 in the respiratory system.
THORACIC AND CARDIOVASCULAR SURGEON REPORTS
(2022)