Article
Critical Care Medicine
Moiz Salahuddin, Mona Sarkiss, Ala-Eddin S. Sagar, Ioannis Vlahos, Christopher H. Chang, Archan Shah, Bruce F. Sabath, Julie Lin, Juhee Song, Teresa Moon, Peter H. Norman, George A. Eapen, Horiana B. Grosu, David E. Ost, Carlos A. Jimenez, Gouthami Chintalapani, Roberto F. Casal
Summary: This study compared the effects of standard ventilation and a ventilatory strategy on the incidence of atelectasis during bronchoscopy under general anesthesia. The results showed that the ventilatory strategy significantly reduced the occurrence of atelectasis and had a sustained effect over time.
Review
Respiratory System
Asad Khan, Sami I. Bashour, Roberto F. Casal
Summary: Atelectasis is a common occurrence during surgery under general anesthesia, and recent studies have found a high incidence of up to 89% during bronchoscopy under general anesthesia. It can affect the accuracy of peripheral bronchoscopy, and efforts should be made to prevent its development when planning the procedure.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Surgery
Maria Carolina Cabrera Schulmeyer, Carlos Polanco Lazo
Summary: This study evaluated the feasibility of using an abbreviated focus-assessed transthoracic echocardiography protocol in morbidly obese patients. The results showed that good images could be obtained in most patients, which could be helpful for cardiopulmonary screening and real-time monitoring.
Article
Multidisciplinary Sciences
Karolina Galmen, Jan G. Jakobsson, Gaetano Perchiazzi, Jacob Freedman, Piotr Harbut
Summary: The aim of this study was to assess the formation of atelectasis during HFJV in patients undergoing liver tumour ablation under general anaesthesia. The results showed that atelectasis increased over the first 45 minutes of HFJV but had no impact on normoinflated lung volume.
Article
Anesthesiology
Philipp Simon, Felix Girrbach, David Petroff, Nadja Schliewe, Gunther Hempel, Mirko Lange, Thomas Bluth, Marcelo Gama de Abreu, Alessandro Beda, Marcus J. Schultz, Paolo Pelosi, Andreas W. Reske, Hermann Wrigge
Summary: The study demonstrated that individualized positive end-expiratory pressure (PEEP) in obese patients undergoing laparoscopic surgery improved oxygenation, reduced driving pressures, and redistributed ventilation towards dependent lung areas when compared to fixed PEEP.
Article
Anesthesiology
Thomas Riva, Fabio Pascolo, Markus Huber, Lorenz Theiler, Robert Greif, Nicola Disma, Alexander Fuchs, Joana Berger-Estilita, Thomas Riedel
Summary: The study found that children undergoing deep sedation showed an increase in poorly ventilated lung units, but this did not significantly impact ventilation homogeneity, which was fully restored upon discharge from the PACU.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Review
Medicine, General & Internal
Joao M. Neto, Ana Rita Teles, Joselina Barbosa, Orquidea Santos
Summary: This review investigates the incidence of dental injuries in adults undergoing anesthesia that requires airway management. The results indicate a correlation between the type of airway management and dental damage. Therefore, it is crucial to consider the patient's dental condition and choose the appropriate approach to prevent dental injuries during airway management.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Patchareya Nivatpumin, Tripop Lertbunnaphong, Siritorn Maneewan, Nutha Vittayaprechapon
Summary: This study compared the perioperative outcomes and anesthetic-related complications in morbidly obese and super-obese parturients undergoing cesarean section. The super-obese patients had higher intraoperative bleeding, more hypotensive episodes, and greater vasopressor requirement than the morbidly obese patients. Anesthesiologists should be prepared for adverse perioperative events in super-obese parturients.
ANNALS OF MEDICINE
(2023)
Article
Medicine, General & Internal
Jiaxin Lang, Xulei Cui, Jia Zhang, Yuguang Huang
Summary: Hemidiaphragmatic paralysis is a common complication of brachial plexus block, which can cause severe respiratory complications for patients with preexisting compromised cardiorespiratory function.
Review
Anesthesiology
Choon-Hak Lim, Ju-young Han, Seung-ha Cha, Yun-Hee Kim, Kyung-Yeon Yoo, Hyun-Jung Kim
Summary: High perioperative FiO2 did not affect short-term mortality in non-thoracic surgical patients, but may increase the incidence of atelectasis. Other postoperative outcomes showed no significant differences between high and low FiO2 groups.
JOURNAL OF CLINICAL ANESTHESIA
(2021)
Article
Anesthesiology
Hyun Il Kim, Ji Young Min, Jeong-Rim Lee, Choi Kwan Woong, Matthew R. Cho, Hyo-Jin Byon
Summary: In pediatric patients, using lower oxygen concentration during induction can reduce atelectasis formation, but this effect does not last until the end of surgery.
PEDIATRIC ANESTHESIA
(2021)
Article
Anesthesiology
Qiushi Gao, Haiyin Ji, Ziyi Wu, Ping Zhao
Summary: This study aimed to investigate the effectiveness of ultrasound-guided lung recruitment maneuvers in reducing the incidence of atelectasis in infants <3 months during laparoscopy under general anesthesia. The results showed that the incidence of atelectasis was lower in the ultrasound group compared to the control group. Therefore, ultrasound-guided alveolar recruitment can reduce the risk of postoperative atelectasis in infants undergoing laparoscopy.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Computer Science, Artificial Intelligence
Gabriel Schamberg, Marcus Badgeley, Benyamin Meschede-Krasa, Ohyoon Kwon, Emery N. Brown
Summary: This study introduces a novel deep reinforcement learning algorithm for automated anesthetic drug dosing, which performs well in both simulated patient demographics and real-world clinical data, producing dosing decisions consistent with best practices in anesthesia care.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2022)
Review
Nutrition & Dietetics
Giuseppe Massimo Sangiorgi, Alberto Cereda, Nicola Porchetta, Daniela Benedetto, Andrea Matteucci, Michela Bonanni, Gaetano Chiricolo, Antonino De Lorenzo
Summary: Obesity is a major global health issue, with the prevalence increasing worldwide, making novel strategies to combat it crucial. Endovascular bariatric surgery (EBS) is seen as a promising innovation for weight and hormonal imbalance reduction in obese individuals, offering less invasiveness and faster recovery compared to traditional surgical methods.
Article
Medicine, Research & Experimental
Qing-Yuan Wang, Yu-Wei Ji, Li-Xin An, Lei Cao, Fu-Shan Xue
Summary: This study aims to compare the effects of optimal static lung compliance-guided iPEEP and EIT-guided iPEEP on postoperative atelectasis in obese patients undergoing laparoscopic surgery, in order to provide a feasible and convenient method for individualized PEEP setting for anesthesiologists.
Article
Biotechnology & Applied Microbiology
Chirag M. Vaswani, Amir K. Varkouhi, Sahil Gupta, Amin M. Ektesabi, James N. Tsoporis, Sadiya Yousef, Pamela J. Plant, Adriana L. da Silva, Yuchen Cen, Yi-Chieh Tseng, Sabrina S. Batah, Alexandre T. Fabro, Suzanne L. Advani, Andrew Advani, Howard Leong-Poi, John C. Marshall, Cristiana C. Garcia, Patricia R. M. Rocco, Guillermo M. Albaiceta, Steffen Sebastian-Bolz, Tania H. Watts, Theo J. Moraes, Vera L. Capelozzi, Claudia. C. dos Santos
Summary: Virus-induced lung injury is associated with loss of pulmonary epithelial-endothelial tight junction integrity. The influenza virus exploits miR-193b-5p to target occludin and evade the host antiviral defense system. Inhibiting miR-193b-5p enhances antiviral responses, reduces lung injury, and improves survival.
Article
Critical Care Medicine
Denise Battaglini, Elena Ciaravolo, Salvatore Caiffa, Lara Delpiano, Lorenzo Ball, Antonio Vena, Daniele R. Giacobbe, Matteo Bassetti, Basil Matta, Paolo Pelosi, Chiara Robba
Summary: This study evaluated the effects of physiotherapy on respiratory and cerebral function in mechanically ventilated patients. The results showed that physiotherapy improved gas exchange in COVID-19 patients and cerebral oxygenation in non-COVID-19 patients. This indicates that physiotherapy is beneficial for functional improvement and rehabilitation in mechanically ventilated patients.
Article
Physiology
Gustavo R. Zubieta-Calleja, Natalia Zubieta-DeUrioste, Felipe de Jesus Montelongo, Manuel Gabriel Romo Sanchez, Aurio Fajardo Campoverdi, Patricia Rieken Macedo Rocco, Denise Battaglini, Lorenzo Ball, Paolo Pelosi
Summary: COVID-19 can severely affect respiratory function and result in life-threatening hypoxia. Understanding the histopathological and functional patterns is crucial for understanding the pathophysiology of COVID-19 and developing new therapeutic strategies. Patients with COVID-19 may have different respiratory stages, which are associated with the extent of lung involvement and can affect ventilation and perfusion relationships.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2023)
Article
Physiology
Carla M. Silva, Debora S. Ornellas, Felipe M. Ornellas, Raquel S. Santos, Sabrina V. Martini, Debora Ferreira, Caroline Muiler, Fernanda F. Cruz, Christina M. Takiya, Patricia R. M. Rocco, Marcelo M. Morales, Pedro L. Silva
Summary: This study evaluated the early effects of bone marrow-derived mononuclear cell (BMDMC) therapy on lung and kidney in experimental polymicrobial sepsis. The results showed that BMDMC therapy can reduce lung and kidney damage in a time-dependent manner. Therefore, BMDMCs may represent a potential therapy for sepsis induction.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2023)
Article
Microbiology
Jana Gruttner, Jorik M. van Rijn, Petra Geiser, Alexandra Florbrant, Dominic-Luc Webb, Per M. Hellstrom, Magnus Sundbom, Mikael E. Sellin, Staffan G. Svard
Summary: Giardia intestinalis is a parasite that infects the upper small intestine of mammals. It can cause diarrhoeal disease in humans, but many infections do not cause symptoms. The molecular mechanisms behind these different outcomes are still unclear.
Article
Cell Biology
Debora P. Ferreira, Sabrina V. Martini, Helena A. Oliveira, Adriana L. Silva, Siddharth Shenoy, Daiqin Chen, Valentina Simon, Eric Han, Natalie E. West, Jung Soo Suk, Patricia R. M. Rocco, Hilda Petrs-Silva, Marcelo M. Morales, Fernanda F. Cruz
Summary: This study successfully demonstrated the effective delivery of gene therapy to the lung using a mutant AAV8 vector, which showed high efficiency in penetrating mucus. The transfer of the PEDF gene did not have any adverse effects on lung parameters, providing a basis for further research on PEDF gene therapy.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Anesthesiology
Denise Battaglini, Lara Delpiano, Denise Masuello, Pedro Leme Silva, Patricia R. M. Rocco, Basil Matta, Paolo Pelosi, Chiara Robba
Summary: The aim of this study was to evaluate the effects of PEEP augmentation test on brain oxygenation, systemic oxygen cascade, and metabolism in patients with acute brain injury. The results showed that PEEP augmentation test did not affect cerebral oxygenation, systemic oxygen cascade parameters, and metabolism.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Editorial Material
Respiratory System
Magnus Sundbom
JOURNAL OF THORACIC DISEASE
(2023)
Article
Endocrinology & Metabolism
Eva Randell, Petros Katsogiannos, Janeth Leksell, Jan W. W. Eriksson, Magnus Sundbom, Maria Svedbo Engstrom
Summary: This qualitative study examined how adults with previous type 2 diabetes perceived different sources of support two years after bariatric surgery. The findings revealed that support needs changed over time and that long-term professional and day-to-day support from family and other networks were essential and complementary.
Meeting Abstract
Critical Care Medicine
C. C. Araujo, R. S. Santos, N. N. Rocha, N. S. Felix, V. L. Capelozzi, G. Cipriano Junior, P. L. Silva, P. R. M. Rocco
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
John J. J. Marini, Lauren T. T. Thornton, Patricia R. M. Rocco, Luciano Gattinoni, Philip S. S. Crooke
Summary: Assessing the risk of ventilator-induced lung injury (VILI) at the bedside requires parameters that can be easily measured. Driving pressure (DP) and end-inspiratory static 'plateau' pressure (P-s) are useful in this regard, but lack key information about associated volume changes and cumulative strain. 'Mechanical power', a comprehensive variable that accounts for ventilating frequency and energy cost per tidal cycle, has been suggested as a useful concept. However, the absolute levels of energy and power alone may not provide precise enough information for safe ventilatory practice.
Article
Critical Care Medicine
Lavienraj Premraj, Christopher Camarda, Nicole White, Daniel Agustin Godoy, Brian H. Cuthbertson, Patricia R. M. Rocco, Paolo Pelosi, Chiara Robba, Jose I. Suarez, Sung-Min Cho, Denise Battaglini
Summary: This meta-analysis investigated the association between the timing of tracheostomy and mortality, neurological outcomes, and ICU/hospital length of stay in stroke patients. The results showed that the timing of tracheostomy was not associated with these outcomes.
Review
Critical Care Medicine
Pedro Leme Silva, Martin Scharffenberg, Patricia Rieken Macedo Rocco
Summary: Mechanical ventilation is a life-saving therapy in clinical situations, but it can also cause lung injury. This review discusses the mechanisms of ventilator-induced lung injury (VILI) and strategies for mitigating it.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2023)
Review
Pharmacology & Pharmacy
Denise Battaglini, Ida Giorgia Iavarone, Lou'i Al-Husinat, Lorenzo Ball, Chiara Robba, Pedro Leme Silva, Fernanda F. Cruz, Patricia R. M. Rocco
Summary: Despite progress in pharmacotherapy, anti-inflammatory strategies for ARDS treatment remain controversial. However, personalized medicine may be a promising approach for identifying specific subgroups that may benefit from anti-inflammatory treatment.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Critical Care Medicine
Christoph Boesing, Laura Schaefer, Peter T. Graf, Paolo Pelosi, Patricia R. M. Rocco, Thomas Luecke, Joerg Krebs
Summary: In ARDS patients treated with VV ECMO, adjusting PEEP to 10 cmH(2)O can reduce MP, improve hemodynamic parameters, and increase oxygen delivery.
JOURNAL OF CRITICAL CARE
(2024)