Review
Biochemistry & Molecular Biology
Nemanja Useinovic, Stefan Maksimovic, Michelle Near, Nidia Quillinan, Vesna Jevtovic-Todorovic
Summary: Since its invention, general anesthesia has been crucial in modern surgery. However, concerns about the negative effects of anesthetics on the developing brain have been raised through preclinical studies and clinical evidence. Further understanding the molecular basis of anesthesia-induced neurotoxicity is important for developing protective strategies and ensuring safe usage during critical stages of brain development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anesthesiology
Nemanja Useinovic, Vesna Jevtovic-Todorovic
Summary: Advances in pediatric anesthesiology have allowed for complex procedures with minimal patient discomfort. However, preclinical studies have shown potential neurotoxicity of general anesthetics in young brains, challenging their safety in pediatric practice. Human observational studies have yielded inconsistent results. This article aims to highlight relevant human findings in the clinical literature based on preclinical evidence.
BEST PRACTICE & RESEARCH-CLINICAL ANAESTHESIOLOGY
(2023)
Review
Anesthesiology
Tarun Pant, Johanna K. DiStefano, Sara Logan, Zeljko J. Bosnjak
Summary: Long noncoding RNAs (lncRNAs) play critical roles in the brain under both normal and pathological conditions, and have been linked with anesthesia-related neurocognitive disorders such as perioperative neurocognitive disorder (PND) and anesthetic-induced developmental neurotoxicity (AIDN). They have the potential to serve as diagnostic and therapeutic targets for these disorders, but face challenges in identification and characterization.
ANESTHESIA AND ANALGESIA
(2021)
Article
Cell Biology
Ji-Hyung Lee, Seon-Wook Kim, Jun-Hyeong Kim, Hyun-Jun Kim, JungIn Um, Da-Woon Jung, Darren R. Williams
Summary: The study demonstrates that lithium chloride has therapeutic effects on inflammation-mediated skeletal muscle wasting, such as sepsis-induced muscle atrophy and cancer cachexia. Treatment with lithium chloride prevented muscle wasting in cell cultures and improved body weight, muscle mass, and muscle strength in animal models of sepsis and cancer cachexia.
Article
Biochemistry & Molecular Biology
Supachaya Sriphoosanaphan, Pakkapon Rattanachaisit, Kanjana Somanawat, Natcha Wanpiyarat, Piyawat Komolmit, Duangporn Werawatganon
Summary: This study found that calcitriol (VD3) can prevent acute liver injury induced by acetaminophen (APAP) and reduce mortality in mice through its anti-inflammatory and antioxidative activity. VD3 might be a novel treatment strategy for APAP-induced hepatotoxicity.
Article
Behavioral Sciences
Ziming Liu, Xuanyi Pan, Jiguang Guo, Liping Li, Yuxin Tang, Guangyi Wu, Ming Li, Hongjie Wang
Summary: This study used Drosophila as an animal model to investigate the long-term effects of early and prolonged sevoflurane exposure on learning and memory abilities. The results suggest that this type of anesthesia can only lead to temporary neuroapoptosis and cognitive deficits, which recede over time and disappear in late life.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Mega O. Oyovwi, Onome B. Oghenetega, Emojevwe Victor, Falajiki Y. Faith, Joseph Gregory Uchechukwu
Summary: The purpose of this study was to investigate the potential counteractive effects of quercetin on the reproductive capabilities of rats treated with levetiracetam. The study found that quercetin could alleviate the negative effects of levetiracetam on rat reproductive parameters.
Article
Neurosciences
Asmaa Oun, Ahmed Soliman, Marina Trombetta-Lima, Afroditi Tzepapadaki, Dikaia Tsagkari, Arjan Kortholt, Amalia M. Dolga
Summary: This study investigates the impact of LRRK2 on ferroptosis-induced cell death in immune cells. The results suggest a protective role of LRRK2 against erastin-induced ferroptosis through modulation of cellular metabolism and mitochondrial function.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Chemistry, Medicinal
Khadeja-Tul Kubra, Mohammad A. Uddin, Nektarios Barabutis
Summary: In this study, we found that the use of UPR inducer Tunicamycin can protect against injury caused by lipopolysaccharide. By modulating actomyosin remodeling and enhancing endothelial integrity, TM supports vascular barrier function. Our findings suggest that UPR activation may provide novel therapeutic opportunities for diseases related to endothelial dysregulation.
Article
Cell Biology
Jing-yan Li, Chao Ren, Li-Xue Wang, Ren-qi Yao, Ning Dong, Yao Wu, Ying-ping Tian, Yong-ming Yao
Summary: This study demonstrates the protective effect of Sesn2 on ferroptosis in DCs and its correlation with the ATF4-CHOP-CHAC1 pathway, indicating a potential antioxidative role for Sesn2 in suppressing ferroptosis in sepsis.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Theresa Failer, Michael Amponsah-Offeh, Ales Neuwirth, Ioannis Kourtzelis, Pallavi Subramanian, Peter Mirtschink, Mirko Peitzsch, Klaus Matschke, Sems M. Tugtekin, Tetsuhiro Kajikawa, Xiaofei Li, Anne Steglich, Florian Gembardt, Annika C. Wegner, Christian Hugo, George Hajishengallis, Triantafyllos Chavakis, Andreas Deussen, Vladimir Todorov, Irakli Kopaliani
Summary: DEL-1, an endogenous anti-inflammatory factor, improves endothelial function, prevents cardiovascular remodeling, and inhibits the progression of hypertension.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Ismael Gonzalez-Garcia, Oscar Freire-Agulleiro, Naoki Nakaya, Francisco J. Ortega, Pablo Garrido-Gil, Laura Linares-Pose, Johan Ferno, Jose Luis Labandeira-Garcia, Carlos Dieguez, Afia Sultana, Stanislav Tomarev, Jose Manuel Fernandez-Real, Miguel Lopez
Summary: The study found that the lack of OLFM2 in mice promotes anorexia and increased energy expenditure, leading to resistance to obesity induced by a high-fat diet. Overexpression of Olfm2 in a specific area of the brain is associated with weight gain.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Pharmacology & Pharmacy
Serdar Demirgan, Onat Akyol, Zeynep Temel, Aslihan Sengelen, Murat Pekmez, Ozancan Ulas, Mehmet Salih Sevdi, Kerem Erkalp, Aysin Selcan
Summary: This study demonstrates that pretreatment with levosimendan can effectively prevent anesthesia-induced cognitive dysfunction by regulating apoptotic-related proteins. There was no sex-dependent difference in the results, and intranasal administration proved to be a simple and effective protective strategy.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qingwen Yuan, Renjun Peng, Huijie Yu, Sinian Wang, Zhongmin Chen, Suhe Dong, Wei Li, Bo Cheng, Qisheng Jiang, Yuwen Cong, Fengsheng Li, Changzheng Li
Summary: The study demonstrates that disulfiram, an FDA-approved alcohol deterrent, shows radioprotective efficacy by affecting the cell cycle and regulating the DNA damage response and survival of intestinal stem cells. It could be a promising candidate for preventing radiation-induced intestinal injury (RIII) in cancer therapy and nuclear accidents.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sin Ri Kim, Ji Won Park, Byung-Hoon Lee, Kyung Min Lim, Tong-Shin Chang
Summary: Ultraviolet B (UVB) irradiation induces the production of reactive oxygen species (ROS), leading to damage in exposed skin cells. Mitochondria and NADPH oxidase are two major sources of ROS in UVB-irradiated keratinocytes. Peroxiredoxin V (PrxV) is a cysteine-dependent peroxidase enzyme found in mitochondria and cytosol, which effectively removes H2O2. We investigated the role of PrxV in protecting epidermal keratinocytes against UVB-induced ROS damage.
Article
Anesthesiology
Tom C. R. V. Van Zundert, Jan F. A. Hendrickx, Jan L. De Witte, David T. Wong, Davide Cattano, Joseph R. Brimacombe
JOURNAL OF CLINICAL ANESTHESIA
(2016)
Editorial Material
Clinical Neurology
Stephen A. Abraham Johnson, John J. Chen, W. Oliver Tobin
Article
Multidisciplinary Sciences
Kevin K. Noguchi, Stephen A. Johnson, Francesca M. Manzella, Kobe L. Masuoka, Sasha L. Williams, Lauren D. Martin, Gregory A. Dissen, Chrysanthy Ikonomidou, Katie J. Schenning, John W. Olney, Ansgar M. Brambrink
SCIENTIFIC REPORTS
(2018)
Letter
Anesthesiology
D. Cattano, P. Killoran, C. A. Hagberg
BRITISH JOURNAL OF ANAESTHESIA
(2014)
Review
Medicine, General & Internal
Felice Gragnano, Davide Cattano, Paolo Calabro
INTERNAL AND EMERGENCY MEDICINE
(2018)
Article
Multidisciplinary Sciences
Kevin K. Noguchi, Stephen A. Johnson, Lauren E. Kristich, Lauren D. Martin, Gregory A. Dissen, Emily A. Olsen, John W. Olney, Ansgar M. Brambrink
SCIENTIFIC REPORTS
(2016)
Editorial Material
Anesthesiology
Davide Cattano, Tom C. R. V. Van Zundert, Jacek Wojtczak
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2019)
Editorial Material
Clinical Neurology
Alejandra M. Marquez Loza, Kathryn B. Holroyd, Stephen A. Johnson, David M. Pilgrim, Anthony A. Amato
Review
Anesthesiology
Sanne Bombeek, Davide Cattano, Tom C. R. V. Van Zundert
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2022)
Article
Clinical Neurology
Stephen A. Johnson, Katherine M. Burke, Zoe A. Scheier, Mackenzie A. Keegan, Alison P. Clark, James Chan, Christina N. Fournier, James D. Berry
Summary: This study evaluated the longitudinal performance of the Rasch-Built Overall Amyotrophic Lateral Sclerosis Disability Scale (ROADS) compared to the Amyotrophic Lateral Sclerosis Functional Rating Scale Revised for Self-Entry (ALSFRS-RSE) as patient reported outcomes of functional status in people with ALS. The results showed high agreement between the two scales at different time points, but ROADS had some psychometric advantages. Therefore, further investigation is warranted to assess the potential of ROADS as a patient reported outcome measure of overall disability and efficacy in ALS trials.
Review
Pharmacology & Pharmacy
Stephen A. Johnson, Ton Fang, Fabiola De Marchi, Dylan Neel, Donatienne Van Weehaeghe, James D. Berry, Sabrina Paganoni
Summary: This article reviews existing ALS therapies and the current clinical drug development pipeline, highlighting the lack of effective treatments to stop or reverse disease progression. In addition to approved drugs, clinical trials are exploring small molecules and biologics such as stem cell transplantation.
Article
Health Care Sciences & Services
Stephen A. Johnson, Marta Karas, Katherine M. Burke, Marcin Straczkiewicz, Zoe A. Scheier, Alison P. Clark, Satoshi Iwasaki, Amir Lahav, Amrita S. Iyer, Jukka-Pekka Onnela, James D. Berry
Summary: This study found that mobile apps and wearable devices can be used to measure the progression of ALS through active and passive data collection.
NPJ DIGITAL MEDICINE
(2023)
Article
Clinical Neurology
Stephen Abraham Johnson, Benjamin Cox, Mai Lan Ho, Meghan Murphy, Eugene Scharf
Article
Anesthesiology
K. K. Noguchi, S. A. Johnson, G. A. Dissen, L. D. Martin, F. M. Manzella, K. J. Schenning, J. W. Olney, A. M. Brambrink
BRITISH JOURNAL OF ANAESTHESIA
(2017)
Letter
Orthopedics
Rashida Callender, Alfonso Altamirano, Tiffney Tezino, Evan G. Pivalizza, Davide Cattano
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
(2014)