Article
Biochemistry & Molecular Biology
Asako Saito, Shigeo Matsui, Ayaka Chino, Shota Sato, Nobuaki Takeshita
Summary: In this study, a novel skeletal muscle-type nicotinic acetylcholine receptor (m-nAChR) positive allosteric modulator (PAM), AS3580239, was identified and found to enhance muscle contraction and improve neurotransmission. These findings suggest that m-nAChR PAMs could be a promising therapeutic approach for neuromuscular diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Genetics & Heredity
Kai Ma, Yuhan Chen, Lunni Zhou, Zhizhi Liu, Zhiwei Liu
Summary: Nicotinic acetylcholine receptors (nAChRs) are crucial in regulating the development and function of the nervous system. The study found that the AChR gamma-like gene in Pristella maxillaris could be a subunit of AChRs in muscle, with high expression in embryo and adult tissues.
Review
Biochemistry & Molecular Biology
Kinji Ohno, Bisei Ohkawara, Xin-Ming Shen, Duygu Selcen, Andrew G. Engel
Summary: Congenital myasthenic syndromes (CMS) are a group of heterogeneous disorders characterized by impaired neuromuscular signal transmission due to germline pathogenic variants in genes expressed at the neuromuscular junction (NMJ). A total of 35 genes have been reported in CMS, which can be classified into 14 groups based on the pathomechanical, clinical, and therapeutic features of CMS patients. Diagnosing CMS requires measurement of compound muscle action potentials elicited by repetitive nerve stimulation, and accurate diagnosis always requires genetic studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Haerin Rhim, Sunjun Jung, Namsoo Kim, Jae-Ik Han
Summary: This study evaluated the efficacy of topical rocuronium bromide as mydriatics in 4 bird species. The results showed significant mydriasis in all birds, but also observed some side effects. Therefore, further studies are needed to find the lowest effective dose to reduce drug-related side effects.
JOURNAL OF VETERINARY SCIENCE
(2023)
Article
Clinical Neurology
Kevin Silva Muller, Felipe Cantore Tiburcio, Jorge Willian Franco de Barros, Cintia Yuri Matsumura, Selma Maria Michelin Matheus
Summary: This study investigated the effects of rosuvastatin and simvastatin exposure during pregnancy on neuromuscular structures in rats. The results showed that these drugs led to alterations in neuromuscular junction morphology, which may be associated with the pathogenesis of statin-associated muscle symptoms (SAMS).
Article
Multidisciplinary Sciences
Hui -Lam Rachel Kwan, Zora Chui-Kuen Chan, Xinyi Bi, Justyna Kutkowska, Tomasz J. Proszynski, Chi Bun Chan, Chi Wai Lee
Summary: Junctional folds are unique membrane specializations that develop during the postnatal maturation of vertebrate neuromuscular junctions (NMJs). This study demonstrates the progressive development of membrane infoldings via nerve-independent, caveolin-3-dependent mechanisms and identifies their roles in AChR trafficking and redistribution during the structural maturation of NMJs.
Article
Chemistry, Medicinal
Julien Giribaldi, Yves Haufe, Edward R. J. Evans, David T. Wilson, Norelle L. Daly, Christine Enjalbal, Annette Nicke, Sebastien Dutertre
Summary: A novel alpha-conotoxin, CIC, with an extended N-terminal tail has been identified in the predatory venom of cone snails, which shows a significant influence on the rigidity of its three-dimensional structure compared to its truncated mutant Delta-CIC. Surprisingly, this structural effect does not alter the biological activity, as both peptides selectively inhibit specific receptors with almost identical inhibition constants. This suggests that chemical modifications on the N-terminal part of alpha-conotoxins can be accommodated without affecting their pharmacological properties.
Article
Anesthesiology
Anastasia D. Grivoyannis, Virginia Tangel, Cynthia A. Lien
Summary: The study found that the use of acceleromyography did not change the total dose of NMBA administered, but a higher frequency of monitor usage was associated with increased usage of rocuronium and vecuronium, as well as a shorter time interval between the last dose of neostigmine and extubation.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2022)
Article
Biochemistry & Molecular Biology
Nikita Zhilyakov, Arsenii Arkhipov, Artem Malomouzh, Dmitry Samigullin
Summary: Cholinergic neurotransmission plays a key role in both the peripheral and central nervous systems, but certain aspects of its regulation remain unclear. Studies suggest that nicotine can decrease ACh release by enhancing calcium influx through Ca(v)1 channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Jose A. Villegas, Jerome Van Wassenhove, Judith Merrheim, Karen Matta, Samy Hamadache, Clemence Flaugere, Pauline Pothin, Frederique Truffault, Sebastien Hascoet, Nicola Santelmo, Marco Alifano, Sonia Berrih-Aknin, Rozen le Panse, Nadine Dragin
Summary: Acetylcholine receptor (AChR) myasthenia gravis (MG) is a chronic autoimmune disease characterized by muscle weakness. The inflammatory IL-23/Th17 pathway in the thymus, blood and muscle plays a role in the disease's progression. This study investigated the potential therapeutic effects of targeting IL-23 in two preclinical MG models and found that it improved clinical symptoms and reduced inflammation and antibody production.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Pharmacology & Pharmacy
Lu Li, Huiquan Liu, Weili Tao, Su Wen, Xiaofen Fu, Shiying Yu
Summary: This study demonstrates the cachectic role of HMGB1 in colon cancer, whether it is in soluble form or secreted from tumor cells as exosomes. The HMGB1 inhibitor glycyrrhizin shows promise in relieving muscle wasting and attenuating cachexia progression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jun Yang, Jun Cao, Su Min, Ping Li, Feng Lv, Li Ren
Summary: Immobilization-induced Neuromuscular Dysfunction (NMD) significantly impacts the wellbeing of patients in Intensive Care Units, and the underlying mechanism of NMD is still not well understood. In this study, an immobilization rat model was used to investigate the role of NRG-1/ErbB pathway in NMD. The results showed that exogenous recombinant human neuregulin-1 (rhNRG-1) alleviated muscle loss, enhanced e-nAChR expression, and suppressed γ-and α7-nAChR production, suggesting that rhNRG-1 could be a promising therapeutic option for immobilization-induced myopathy.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Cell Biology
Rebecca L. McIntyre, Simone W. Denis, Rashmi Kamble, Marte Molenaars, Michael Petr, Bauke Schomakers, Mizanur Rahman, Siddhartha Gupta, Marton L. Toth, Siva A. Vanapalli, Aldo Jongejan, Morten Scheibye-Knudsen, Riekelt H. Houtkooper, Georges E. Janssens
Summary: Transcriptome-based drug screening is a powerful tool for identifying geroprotective compounds targeting age-related disease. The study identified FDA-approved compounds, such as atracurium, that activate FOXO downstream targets and extend lifespan in Caenorhabditis elegans. It highlights the role of the neuromuscular acetylcholine receptor in regulating the highly conserved FOXO/DAF-16 longevity pathway.
Article
Physiology
Manami Yamashita, Yoshihiro Egashira, Shuntaro Nakamura, Souhei Sakata, Fumihito Ono
Summary: This study found that pancuronium, a non-depolarizing muscle relaxant, inhibits fast muscle fibers at a lower concentration compared to slow muscle fibers in zebrafish. The researchers also discovered that this difference is due to the different composition of acetylcholine receptors between slow and fast muscle fibers in the neuromuscular junction of zebrafish.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Robert R. Redman, Harry Mackenzie, Kosala N. Dissanayake, Michael Eddleston, Richard R. Ribchester
Summary: Donepezil has various effects on synaptic transmission at neuromuscular junctions, including inhibition of AChE activity, prolongation of muscle contractions, and increased incidence of giant MEPPs. However, it does not significantly impair evoked ACh release.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Letter
Toxicology
Benjamin Flam, Emma Bendz, Malin Jonsson Fagerlund, Jonas Hojer
CLINICAL TOXICOLOGY
(2015)
Letter
Anesthesiology
Malin Jonsson Fagerlund, Heidrun Fink, Eva Baumueller, Kurt Ulm, Markus W. Hollmann, Claude Meistelman, Jennifer Hunter, Brigitte Leva, Sandrine Damster, Lars I. Eriksson, Manfred Blobner
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2016)
Article
Anesthesiology
A. Wiklund, D. Gustavsson, A. Ebberyd, E. Sundman, G. Schulte, M. Jonsson Fagerlund, L. I. Eriksson
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2012)
Article
Anesthesiology
Malin Jonsson Fagerlund, Jessica Kahlin, Anette Ebberyd, Gunnar Schulte, Souren Mkrtchian, Lars I. Eriksson
Article
Clinical Neurology
Niccolo Terrando, Lars I. Eriksson, Jae Kyu Ryu, Ting Yang, Claudia Monaco, Marc Feldmann, Malin Jonsson Fagerlund, Israel F. Charo, Katerina Akassoglou, Mervyn Maze
ANNALS OF NEUROLOGY
(2011)
Review
Anesthesiology
M. J. Fagerlund, L. I. Eriksson
BRITISH JOURNAL OF ANAESTHESIA
(2009)
Article
Anesthesiology
M. Jonsson Fagerlund, J. Sjodin, J. Krupp, M. A. Dabrowski
BRITISH JOURNAL OF ANAESTHESIA
(2010)
Article
Physiology
Jessica Kahlin, Souren Mkrtchian, Anette Ebberyd, Lalle Hammarstedt-Nordenvall, Britt Nordlander, Takashi Yoshitake, Jan Kehr, Nanduri Prabhakar, Lorenz Poellinger, Malin Jonsson Fagerlund, Lars I. Eriksson
EXPERIMENTAL PHYSIOLOGY
(2014)
Article
Neurosciences
Souren Mkrtchian, Jessica Kahlin, Anette Ebberyd, Constancio Gonzalez, Diego Sanchez, Alexander Balbir, Eric W. Kostuk, Machiko Shirahata, Malin Jonsson Fagerlund, Lars I. Eriksson
JOURNAL OF PHYSIOLOGY-LONDON
(2012)
Article
Physiology
Jessica Kahlin, Lars I. Eriksson, Anette Ebberyd, Malin Jonsson Fagerlund
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2010)
Letter
Anesthesiology
A. Sjoblom, A. Lodenius, M. Hedberg, M. J. Fagerlund
Letter
Anesthesiology
A. Sjoblom, M. Hedberg, A. Lodenius, M. Jonsson Fagerlund
Article
Medicine, General & Internal
Susanne Rysz, Malin Jonsson Fagerlund, Johan Lundberg, Mattias Ringh, Jacob Hollenberg, Marcus Lindgren, Martin Jonsson, Therese Djarv, Per Nordberg
Summary: This retrospective observational study examined the use of Levosimendan in out-of-hospital cardiac arrest patients and its association with outcomes. The results showed that the use of Levosimendan was more common in patients with certain characteristics, such as initial shockable rhythm and acute myocardial infarction. However, the use of Levosimendan was not associated with 30-day mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Critical Care Medicine
Susanne Rysz, Francesca Campoccia Jalde, Anders Oldner, Lars I. Eriksson, Johan Lundberg, Malin Jonsson Fagerlund
Article
Chemistry, Medicinal
Malin Jonsson Fagerlund, Johannes Krupp, Michael A. Dabrowski