Making Sense of Optogenetics

Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice

(2015) M M Sidor et al.   MOLECULAR PSYCHIATRY

Optical Neural Interfaces

(2014) Melissa R. Warden et al.   Annual Review of Biomedical Engineering

Natural Neural Projection Dynamics Underlying Social Behavior

(2014) Lisa A. Gunaydin et al.   CELL

Circuit dynamics of adaptive and maladaptive behaviour

(2014) Karl Deisseroth   NATURE

Independent optical excitation of distinct neural populations

(2014) Nathan C Klapoetke et al.   NATURE METHODS

Optogenetics: the age of light

(2014) Michael Häusser   NATURE METHODS

Targeting cells with single vectors using multiple-feature Boolean logic

(2014) Lief E Fenno et al.   NATURE METHODS

Noninvasive optical inhibition with a red-shifted microbial rhodopsin

(2014) Amy S Chuong et al.   NATURE NEUROSCIENCE

Simultaneous cellular-resolution optical perturbation and imaging of place cell firing fields

(2014) John Peter Rickgauer et al.   NATURE NEUROSCIENCE

Illuminating cell signalling with optogenetic tools

(2014) Doug Tischer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure-Guided Transformation of Channelrhodopsin into a Light-Activated Chloride Channel

(2014) A. Berndt et al.   SCIENCE

Conversion of Channelrhodopsin into a Light-Gated Chloride Channel

(2014) J. Wietek et al.   SCIENCE

Progress in understanding mood disorders: optogenetic dissection of neural circuits

(2013) S. Lammel et al.   GENES BRAIN AND BEHAVIOR

Diverging neural pathways assemble a behavioural state from separable features in anxiety

(2013) Sung-Yon Kim et al.   NATURE

Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking

(2013) Billy T. Chen et al.   NATURE

Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin

(2013) Gül Dölen et al.   NATURE

ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation

(2013) John Y Lin et al.   NATURE NEUROSCIENCE

Targeting neurons and photons for optogenetics

(2013) Adam M Packer et al.   NATURE NEUROSCIENCE

Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors

(2013) E. Burguiere et al.   SCIENCE

Creating a False Memory in the Hippocampus

(2013) S. Ramirez et al.   SCIENCE

Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior

(2013) S. E. Ahmari et al.   SCIENCE

Optogenetics, physiology, and emotions

(2013) Alexxai V. Kravitz et al.   Frontiers in Behavioral Neuroscience

Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics

(2013) Jasper Akerboom et al.   Frontiers in Molecular Neuroscience

Potential Utility of Optogenetics in the Study of Depression

(2012) Mary Kay Lobo et al.   BIOLOGICAL PSYCHIATRY

Optogenetic Insights into Social Behavior Function

(2012) Ofer Yizhar   BIOLOGICAL PSYCHIATRY

Diode probes for spatiotemporal optical control of multiple neurons in freely moving animals

(2012) Eran Stark et al.   JOURNAL OF NEUROPHYSIOLOGY

Crystal structure of the channelrhodopsin light-gated cation channel

(2012) Hideaki E. Kato et al.   NATURE

A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge

(2012) Melissa R. Warden et al.   NATURE

Dopamine neurons modulate neural encoding and expression of depression-related behaviour

(2012) Kay M. Tye et al.   NATURE

Optogenetic stimulation of a hippocampal engram activates fear memory recall

(2012) Xu Liu et al.   NATURE

Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation

(2012) Rohit Prakash et al.   NATURE METHODS

When the electricity (and the lights) go out: transient changes in excitability

(2012) Emily Ferenczi et al.   NATURE NEUROSCIENCE

Optogenetic silencing strategies differ in their effects on inhibitory synaptic transmission

(2012) Joseph V Raimondo et al.   NATURE NEUROSCIENCE

Optogenetic investigation of neural circuits underlying brain disease in animal models

(2012) Kay M. Tye et al.   NATURE REVIEWS NEUROSCIENCE

Activation of VTA GABA Neurons Disrupts Reward Consumption

(2012) Ruud van Zessen et al.   NEURON

The Development and Application of Optogenetics

(2011) Lief Fenno et al.   Annual Review of Neuroscience

Optogenetic Modulation of Neural Circuits that Underlie Reward Seeking

(2011) Garret D. Stuber et al.   BIOLOGICAL PSYCHIATRY

A wirelessly powered and controlled device for optical neural control of freely-behaving animals

(2011) Christian T Wentz et al.   Journal of Neural Engineering

Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking

(2011) Garret D. Stuber et al.   NATURE

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

Amygdala circuitry mediating reversible and bidirectional control of anxiety

(2011) Kay M. Tye et al.   NATURE

Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function

(2011) Shengli Zhao et al.   NATURE METHODS

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins

(2011) Joanna Mattis et al.   NATURE METHODS

Recombinase-Driver Rat Lines: Tools, Techniques, and Optogenetic Application to Dopamine-Mediated Reinforcement

(2011) Ilana B. Witten et al.   NEURON

Optogenetics in Neural Systems

(2011) Ofer Yizhar et al.   NEURON

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics

(2010) Viviana Gradinaru et al.   CELL

Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex

(2010) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

High-performance genetically targetable optical neural silencing by light-driven proton pumps

(2010) Brian Y. Chow et al.   NATURE

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

Ultrafast optogenetic control

(2010) Lisa A Gunaydin et al.   NATURE NEUROSCIENCE

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures

(2010) Feng Zhang et al.   Nature Protocols

Cell Type-Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward

(2010) M. K. Lobo et al.   SCIENCE

Cholinergic Interneurons Control Local Circuit Activity and Cocaine Conditioning

(2010) I. B. Witten et al.   SCIENCE

Structural Guidance of the Photocycle of Channelrhodopsin-2 by an Interhelical Hydrogen Bond

(2009) Christian Bamann et al.   BIOCHEMISTRY

Characterization of Engineered Channelrhodopsin Variants with Improved Properties and Kinetics

(2009) John Y. Lin et al.   BIOPHYSICAL JOURNAL

Temporally precise in vivo control of intracellular signalling

(2009) Raag D. Airan et al.   NATURE

Bi-stable neural state switches

(2009) André Berndt et al.   NATURE NEUROSCIENCE

Optical Deconstruction of Parkinsonian Neural Circuitry

(2009) V. Gradinaru et al.   SCIENCE

Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

(2009) H.-C. Tsai et al.   SCIENCE

Optogenetic dissection of neuronal circuits in zebrafish using viral gene transfer and the Tet system

(2009) Peixin Zhu   Frontiers in Neural Circuits

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri

(2008) Feng Zhang et al.   NATURE NEUROSCIENCE