Article
Behavioral Sciences
Daniele Cavaleri, Federico Moretti, Alessandra Bartoccetti, Stefano Mauro, Cristina Crocamo, Giuseppe Carra, Francesco Bartoli
Summary: Based on meta-analyses, this overview suggests that the brain-derived neurotrophic factor (BDNF) may serve as a potential biomarker for major depressive disorder (MDD) and antidepressant response. People with MDD show lower peripheral and central BDNF levels compared to non-depressed individuals, and blood BDNF levels are negatively correlated with symptom severity. Antidepressant treatment can lead to increased blood BDNF levels, proportional to symptom improvement, while non-pharmacological interventions do not affect BDNF concentrations.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Psychiatry
Shakila Meshkat, Yazen Alnefeesi, Muhammad Youshay Jawad, Joshua D. Di Vincenzo, Nelson B. Rodrigues, Felicia Ceban, Leanna M. W. Lui, Roger S. McIntyre, Joshua D. Rosenblat
Summary: This synthesis study found that TRD treatments can affect peripheral BDNF levels, but changes in peripheral BDNF levels are not significantly associated with antidepressant effects.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Houman Rashidian, Mehala Subramaniapillai, Caroline Park, Orly Lipsitz, Hannah Zuckerman, Kayla Teopiz, Bing Cao, Yena Lee, Hartej Gill, Roger Ho, Kangguang Lin, Nelson B. Rodrigues, Michelle Iacobucci, Joshua D. Rosenblat, Roger S. McIntyre, Rodrigo B. Mansur
Summary: The study revealed that insulin resistance affects the efficacy of the antidepressant vortioxetine in patients with Major Depressive Disorder. Higher baseline insulin resistance predicted decreased early improvements in depressive symptoms and worsening cognitive function and functional impairment at the end of treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Gustavo C. Medeiros, Todd D. Gould, William L. Prueitt, Julie Nanavati, Michael F. Grunebaum, Nuri B. Farber, Balwinder Singh, Sudhakar Selvaraj, Rodrigo Machado-Vieira, Eric D. Achtyes, Sagar V. Parikh, Mark A. Frye, Carlos A. Zarate, Fernando S. Goes
Summary: (R,S)-ketamine and (S)-ketamine have rapid and substantial antidepressant effects, but there is no well-accepted method to differentiate responders from non-responders. The association between blood-based biomarkers and response to ketamine was examined in a systematic review/meta-analysis, revealing limited evidence of a consistent relationship.
MOLECULAR PSYCHIATRY
(2022)
Article
Dermatology
Tegexibaiyin Wang, Fen Liu, Xiujuan Jia, Jing Tan, Baopeng Qi, Jingxue Guo, Qiri Mu, Hong Zhang
Summary: This study found that serum BDNF levels were lower in patients with rosacea and rosacea with depression, and were negatively correlated with the severity of depression. This indicates that serum BDNF levels have the potential to be a biomarker for identifying depression in patients with rosacea.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2022)
Article
Neurosciences
Louise A. Stolz, Jordan N. Kohn, Sydney E. Smith, Lindsay L. Benster, Lawrence G. Appelbaum
Summary: This study analyzed a large database to predict treatment response in patients with major depressive disorder using neurophysiological measures. The results identified age and baseline symptom severity as significant predictors of treatment response, with EEG measures contributing to the predictive models.
Article
Clinical Neurology
Jessica R. Gilbert, Jessica L. Gerner, Courtney R. Burton, Allison C. Nugent, Carlos A. Zarate, Elizabeth D. Ballard
Summary: This study investigated the magnetoencephalographic (MEG) correlates of suicidal ideation (SI) and suicide attempt history in patients with treatment-resistant major depression (TRD), both at baseline and after subanesthetic-dose ketamine infusion. The findings showed that ketamine significantly reduced SI and depression in the sample. Following ketamine infusion, attempters showed improved accuracy on the task, while non-attempters showed reduced accuracy. SI was positively associated with gamma power in frontal and parietal cortices. In an extended amygdalahippocampal region, attempters differed significantly in their emotional reactivity to angry versus happy faces as indexed by theta power differences, regardless of drug. Ketamine also reduced the association between alpha power and SI for angry compared to happy faces in a fronto-insular/anterior cingulate region important for regulating sensory attentiveness.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Jingjing Piao, Yingwei Wang, Tianqi Zhang, Jiayu Zhao, Qianyu Lv, Mengyu Ruan, Qin Yu, Bingjin Li
Summary: Depression is a mental disorder affecting approximately 350 million individuals globally. Current main treatments, such as medication and psychological therapy, often have limited effectiveness. Nutritional psychiatry, which emphasizes the potential benefits of a balanced diet, is emerging as a promising approach for managing depressive symptoms.
Article
Clinical Neurology
Houman Rashidian, Mehala Subramaniapillai, Caroline Park, Orly Lipsitz, Hannah Zuckerman, Bing Cao, Yena Lee, Hartej Gill, Roger Nelson Rodrigues, Joshua D. Di Vincenzo, Michelle Iacobucci, Saja Jaberi, Joshua D. Rosenblat, Roger S. McIntyre, Rodrigo B. Mansur
Summary: This study assessed changes in insulin resistance (IR) after antidepressant treatment and found that exacerbation of IR mediated non-response to treatment. In contrast, responders showed a reduction in IR. These findings further elucidate the role of IR in antidepressant response.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Julia Lechinger, Jakob Koch, Sara Lena Weinhold, Mareen Seeck-Hirschner, Karoline Stingele, Cornelia Kropp-Naef, Milena Braun, Henning Johannes Drews, Josef Aldenhoff, Christian Huchzermeier, Robert Goeder
Summary: Research suggests that REM sleep abnormalities may indicate a distinct endophenotype of depression, and pharmacotherapy with SSRI/SSNRI may be more effective than psychotherapy in these patients.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Multidisciplinary Sciences
Wei Zheng, Yan-Ling Zhou, Cheng-Yu Wang, Xiao-Feng Lan, Bin Zhan, Su-Miao Zhou, Su Yan, Yu-Ping Ning
Summary: The study found that baseline plasma BDNF concentrations appeared to be correlated with ketamine's antidepressant efficacy in Chinese patients with depression. High levels of pBDNF were associated with better treatment outcomes.
Article
Multidisciplinary Sciences
Wei Zheng, Qiaomei Cen, Sha Nie, Minyi Li, Rong Zeng, Sumiao Zhou, Dongbin Cai, Miaoling Jiang, Xiong Huang
Summary: Based on the study of 30 patients with treatment-refractory depression, it was found that serum BDNF levels do not seem to be a reliable biomarker to determine the antidepressant effects of ketamine as an anaesthesia in ECT. Further studies with larger sample sizes are needed to confirm these findings.
Review
Medicine, General & Internal
Anna Mosiolek, Jadwiga Mosiolek, Slawomir Jakima, Aleksandra Pieta, Agata Szulc
Summary: Major depressive disorder (MDD) is a multifactorial disease with ongoing research on the role of neurotrophic factors in its pathophysiology. Antidepressant treatment can modify serum levels of neurotrophins, such as BDNF, leading to clinical improvement of MDD. Further research is needed to understand the correlation between different antidepressant drugs and neurotrophic factor serum levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Psychiatry
Laura M. Fiori, Massimiliano Orri, Zahia Aouabed, Jean Francois Theroux, Rixing Lin, Corina Nagy, Benicio N. Frey, Raymond W. Lam, Glenda M. MacQueen, Roumen Milev, Daniel J. Muller, Sagar Parikh, Susan Rotzinger, Rudolf Uher, Jane A. Foster, Sidney H. Kennedy, Gustavo Turecki
Summary: By longitudinally assessing gene expression, we offer insights into the biological processes involved in the intermediate stages of escitalopram response, highlighting several genes with potential utility as biomarkers of antidepressant response.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Hao Hua, Chaoli Huang, Hanyu Liu, Xiangyang Xu, Xiangqing Xu, Zifeng Wu, Cunming Liu, Yuanyuan Wang, Chun Yang
Summary: The discovery of the antidepressant actions of ketamine and its role in regulating the gut microbiome through the microbiota-gut-brain axis is a significant advancement in depression treatment. However, the precise mechanisms underlying these effects are still unclear.
Review
Clinical Neurology
Eva Z. Reininghaus, Mirko Manchia, Nina Dalkner, Nina Bonkat, Alessio Squassina, Isabel Hodl, Eduard Vieta, Andreas Reif, Tomas Hajek, Mikael Landen, Christoph U. Correll, Jan Scott, Bruno Etain, Marcella Rietschel, Veerle Bergink, Monica Martinez-Cengotitabengoa, Lars Vedel Kessing, Andrea Fagiolini, Michael Bauer, Guy Goodwin, Ana Gonzalez-Pinto, Ralph W. Kupka, Thomas G. Schulze, Trine Lagerberg, Aysegul Yildiz, Chantal Henry, Gunnar Morken, Phillip Ritter, Rene Ernst Nieslen, Rasmus W. Licht, Andreas Bechdolf, Ole A. Andreassen, Frederike Tabea Fellendorf
Summary: Patients with bipolar disorder may have a higher risk of contracting COVID-19, leading to worsened clinical outcomes. However, research on vaccination in individuals with BD is limited and lacks substantial evidence.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Kathrine Bang Madsen, Merete Lund Maegbaek, Nete Stubkjaer Thomsen, Xiaoqin Liu, Malin Eberhard-Gran, Alkistis Skalkidou, Veerle Bergink, Trine Munk-Olsen
Summary: A study on psychiatric disorders in expecting and new fathers found that becoming a father did not significantly increase the risk of severe mental disorders compared to new mothers. The research showed an increasing trend in the incidence and prevalence of psychiatric episodes in fathers during the perinatal period and postpartum, with most psychiatric disorders being treated in primary care.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Eline M. P. Poels, Lisanne Schrijver, Tonya J. H. White, Sabine J. Roza, Milan G. Zarchev, Hilmar Bijma, Adriaan Honig, Inge L. van Kamp, Witte J. G. Hoogendijk, Astrid M. Kamperman, Veerle Bergink
Summary: This study found no evidence for significantly altered neuropsychological functioning of lithium-exposed children at the age of 6-14 years, when compared to non-lithium-exposed controls.
Article
Immunology
Anna Suleri, Elisabet Blok, Melisa Durkut, Anna-Sophie Rommel, Lot de Witte, Vincent Jaddoe, Veerle Bergink, Tonya White
Summary: This study examines the long-term impact of Maternal Immune Activation (MIA) on brain morphology in 10-year-old children. The results suggest sex-specific effects on brain morphology after MIA, which might be influenced by acute infections or severe inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Clinical Neurology
Jana Freff, Eva C. Beins, Lisa Broeker, Kathrin Schwarte, Rafael Leite Dantas, Carlo Maj, Volker Arolt, Udo Dannlowski, Markus M. Noethen, Bernhard T. Baune, Andreas J. Forstner, Judith Alferink
Summary: This study characterizes the expression pattern of CCR4 and its ligands CCL17 and CCL22 in major depressive disorder (MDD) and explores their clinical relevance in predicting disease severity. The results show that decreased CCR4 expression and increased CCL17/CCL22 levels are associated with MDD. CCR4 expression on CD4(+) T cells is correlated with depression severity and specific symptoms. Additionally, CCR4 and polygenic risk score (PRS) have predictive capacity for disease severity.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Trine Munk-Olsen, Xiaoqin Liu, Kathrine Bang Madsen, Mette-Marie Zacher Kjeldsen, Liselotte Vogdrup Petersen, Veerle Bergink, Alkistis Skalkidou, Simone N. Vigod, Vibe G. Frokjaer, Carsten B. Pedersen, Merete L. Maegbaek
Summary: The study aimed to develop and validate an individualized prediction model for postpartum depression (PPD), using various predictors to identify the likelihood of an individual developing PPD. The recalibrated Extended model, with 14 variables, achieved the highest performance in terms of calibration and discrimination, with previous psychiatric history, maternal age, low education, and hyperemesis gravidarum being the most important predictors.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Eline M. P. Poels, Astrid M. Kamperman, Hilmar H. Bijma, Adriaan Honig, Inge L. van Kamp, Steven A. Kushner, Witte J. G. Hoogendijk, Veerle Bergink, Tonya White
Summary: This study investigated the brain structure of children born to women with bipolar disorder who were exposed to lithium during pregnancy. The researchers found no significant differences in brain structure between the lithium-exposed and non-lithium-exposed children. However, compared to the general population, the lithium-exposed children had reduced volumes of subcortical gray matter and cortical white matter. Further studies with larger datasets are needed to confirm and expand upon these initial findings.
Article
Clinical Neurology
Irfan Ahmed, Muhammad Shehzad Khan, Victor Ma, Hina Magsi, Renardi Gunawan, Abdul-Mojeed Olabisi Ilyas, Najeeb ur Rehman Lashari, Naveed Wassan, Santosh Paidi, Zulfiqar Ali, Alan W. L. Law, Yanpeng Zhang, William C. C. Cho, Martin Alda, Veerle Bergink, Ishan Barman, Condon Lau
Summary: This study investigated the effects of lithium medication on the offspring of nursing rats and found that lithium can be transferred to the pups through breast milk, leading to long-term effects on their kidneys and thyroid glands. However, these effects were reversed after discontinuation of lithium exposure.
Article
Clinical Neurology
Nina M. Molenaar, Merete L. Maegbaek, Anna-Sophie Rommel, Erona Ibroci, Xiaoqin Liu, Trine Munk-Olsen, Veerle Bergink
Summary: This study investigated the incidence and recurrence of depressive episodes before, during, and after pregnancy, and found a significant increase in first-time and recurrent psychiatric inpatient admissions after childbirth, especially in the first months. In contrast, outpatient psychiatric treatment incidence and recurrence were increased both during pregnancy as well as in the postpartum period.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Zoltan Kovacs, Peter Vestergaard, Rasmus W. Licht, Sune P. V. Straszek, Anne Sofie Hansen, Allan H. Young, Anne Duffy, Bruno Mueller-Oerlinghausen, Florian Seemueller, Gabriele Sani, Janusz Rubakowski, Josef Priller, Lars Vedel Kessing, Leonardo Tondo, Martin Alda, Mirko Manchia, Paul Grof, Phillip Ritter, Tomas Hajek, Ute Lewitzka, Veerle Bergink, Michael Bauer, Rene Ernst Nielsen
Summary: This article presents a step-by-step algorithm for the initial management of emergent hypercalcemia during lithium treatment based on a narrative review of the effects of lithium on calcium and parathyroid hormone homeostasis. This standardized consensus-driven management can reduce the potential risk of clinicians avoiding the use of lithium due to uncertainties about managing side effects.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2022)
Article
Psychiatry
Esther M. Pluijms, Poul T. Vinther, Astrid M. Kamperman, Tom K. Birkenhager
Summary: High relapse rates are observed after electroconvulsive therapy (ECT) for major depression. Identifying risk factors for relapse can help in intensifying treatment post-ECT, leading to reduced relapse rates. This study aimed to determine clinical characteristics associated with relapse within 2 years after successful ECT. Patients with psychotic features, higher symptom severity, and medication resistance prior to ECT showed a significantly decreased risk of relapse. A sustained remission rate of 50% over 2 years in patients with severe major depression treated with nortriptyline monotherapy after successful ECT is encouraging.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Review
Biochemistry & Molecular Biology
Frederieke A. J. Gigase, Emma Smith, Brett Collins, Kendall Moore, Gijsje J. L. J. Snijders, Daniel Katz, Veerle Bergink, M. Mercedes Perez-Rodriquez, Lotje D. De Witte
Summary: This systematic review and meta-analysis revealed poor correlation between peripheral and central inflammatory markers in paired blood-CSF samples, with increased correlations in certain study populations.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Kathrine Bang Madsen, Thalia K. K. Robakis, Xiaoqin Liu, Natalie Momen, Henrik Larsson, Julie Werenberg Dreier, Helene Kildegaard, Jane Bjerg Groth, Jeffrey H. H. Newcorn, Per Hove Thomsen, Trine Munk-Olsen, Veerle Bergink
Summary: A study found no significant long-term adverse effects on the neurodevelopment and growth outcomes of children exposed to ADHD medication during pregnancy compared to children whose mothers discontinued medication before pregnancy.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Nhung T. H. Trinh, Trine Munk-Olsen, Naomi R. Wray, Veerle Bergink, Hedvig M. E. Nordeng, Angela Lupattelli, Xiaoqin Liu
Summary: Approximately half of women with affective disorders discontinue antidepressant use during pregnancy, which could lead to relapse postpartum. A study investigated the associations between antidepressant use during pregnancy and postpartum psychiatric outcomes, finding that continuing antidepressant treatment may benefit women with severe mental illness who are currently on stable treatment.
Meeting Abstract
Neurosciences
Emma Smith, Ashlyn Delaney, Tonia Ogundipe, Kellyn Kuczarski, Amaliya Leila, Sylvia Saxenian, Deborah Li, Revana Rahman, Antonia S. New, Erin A. Hazlett, Harold W. Koenigsberg, Julie Spicer, Robert Pietrzak, Veerle Bergink, Siobhan M. Dolan, Margaret McClure, Lotje De Witte, M. Mercedes Perez-Rodriguez
BIOLOGICAL PSYCHIATRY
(2022)