Preclinical to Clinical Translation of CNS Transporter Occupancy of TD-9855, a Novel Norepinephrine and Serotonin Reuptake Inhibitor

Norepinephrine transporter occupancy by nortriptyline in patients with depression: a positron emission tomography study with (S,S)-[18F]FMeNER-D2

(2013) Harumasa Takano et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Noradrenergic modulation of cognition: Therapeutic implications

(2013) Samuel R Chamberlain et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Decreased norepinephrine transporter availability in obesity: Positron Emission Tomography imaging with (S,S)-[11C]O-methylreboxetine

(2013) Chiang-shan R. Li et al.   NEUROIMAGE

Clinical doses of atomoxetine significantly occupy both norepinephrine and serotonin transports: Implications on treatment of depression and ADHD

(2013) Y.-S. Ding et al.   NEUROIMAGE

Relative Contributions of Norepinephrine and Serotonin Transporters to Antinociceptive Synergy between Monoamine Reuptake Inhibitors and Morphine in the Rat Formalin Model

(2013) Fei Shen et al.   PLoS One

Monoamine neurocircuitry in depression and strategies for new treatments

(2013) Michel Hamon et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Association of Posttraumatic Stress Disorder With Reduced In Vivo Norepinephrine Transporter Availability in the Locus Coeruleus

(2013) Robert H. Pietrzak et al.   JAMA Psychiatry

Safety and efficacy of esreboxetine in patients with fibromyalgia: A fourteen-week, randomized, double-blind, placebo-controlled, multicenter clinical trial

(2012) Lesley M. Arnold et al.   ARTHRITIS AND RHEUMATISM

Occupancy of serotonin and norepinephrine transporter by milnacipran in patients with major depressive disorder: a positron emission tomography study with [11C]DASB and (S,S)-[18F]FMeNER-D2

(2012) Tsuyoshi Nogami et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The emerging role of norepinephrine in cognitive dysfunctions of Parkinson's disease

(2012) Elena M. Vazey et al.   Frontiers in Behavioral Neuroscience

Quantitative PK–PD Model-Based Translational Pharmacology of a Novel Kappa Opioid Receptor Antagonist Between Rats and Humans

(2011) Cheng Chang et al.   AAPS Journal

The Roles of Dopamine and Noradrenaline in the Pathophysiology and Treatment of Attention-Deficit/Hyperactivity Disorder

(2011) Natalia del Campo et al.   BIOLOGICAL PSYCHIATRY

Clinically Relevant Doses of Methylphenidate Significantly Occupy Norepinephrine Transporters in Humans In Vivo

(2010) Jonas Hannestad et al.   BIOLOGICAL PSYCHIATRY

Prediction of Repeat-Dose Occupancy from Single-Dose Data: Characterisation of the Relationship between Plasma Pharmacokinetics and Brain Target Occupancy

(2010) Sergio Abanades et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Monitoring Adults With ADHD

(2010) Lenard A. Adler   JOURNAL OF CLINICAL PSYCHIATRY

A greater role for the norepinephrine transporter than the serotonin transporter in murine nociception

(2010) F.S. Hall et al.   NEUROSCIENCE

Norepinephrine transporter occupancy by antidepressant in human brain using positron emission tomography with (S,S)-[18F]FMeNER-D2

(2010) Mizuho Sekine et al.   PSYCHOPHARMACOLOGY

The Neuropsychopharmacology of Fronto-Executive Function: Monoaminergic Modulation

(2009) T.W. Robbins et al.   Annual Review of Neuroscience

Forebrain pain mechanisms

(2009) Volker Neugebauer et al.   BRAIN RESEARCH REVIEWS

Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial

(2009) Ian Gilron et al.   LANCET

Target site occupancy: Emerging generalizations from clinical and preclinical studies

(2009) Sarah Grimwood et al.   PHARMACOLOGY & THERAPEUTICS

Influence of ligand binding kinetics on functional inhibition of human recombinant serotonin and norepinephrine transporters

(2009) Pamela R. Tsuruda et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI)

(2008) Dongpei Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antidepressants for the Treatment of Chronic Pain

(2008) Bénédicte Verdu et al.   DRUGS

Atomoxetine for the treatment of executive dysfunction in Parkinson's disease: A pilot open-label study

(2008) Laura Marsh et al.   MOVEMENT DISORDERS