Intrapartum Neuraxial Analgesia and Breastfeeding Outcomes: Limitations of Current Knowledge

Although numerous studies have addressed the relationship between intrapartum neuraxial analgesia, particularly epidural fentanyl, and breastfeeding, substantial study design limitations have precluded the current literature from furnishing strong, clinically significant conclusions. Lack of randomized controlled trials, nonstandardization of breastfeeding evaluations across studies, and failure to control for confounding variables all pose significant problems. Further research is needed to elucidate the specific relationship between neuraxial opioids and breastfeeding and, if there are significant associations, whether, these drugs act directly on neonatal brain tissue to attenuate exhibition Of breastfeeding behaviors. In this review, I will detail the deficiencies of the current literature and make recommendations for future research. (Anesth Analg 2013;116:399-405)