Review
Neurosciences
Xiaohan Xu, Catherine Yu, Li Xu, Jijun Xu
Summary: Keratinocytes play important roles in various physiological processes, such as pain sensation, itch, and inflammation. They can detect and respond to thermal, mechanical, and chemical stimuli through sensory receptors and ion channels. Additionally, keratinocytes produce and respond to neurotransmitters and pro-inflammatory cytokines, amplifying neuroinflammation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Hematology
Wuwei Rong, Chenchen Liu, Xiaoming Li, Naifu Wan, Lijiang Wei, Wentong Zhu, Peiyuan Bai, Ming Li, Yangjing Ou, Fang Li, Lingxia Wang, Xuanhui Wu, Jianling Liu, Mingyan Xing, Xiaoming Zhao, Han Liu, Haibing Zhang, Ankang Lyu
Summary: This study reveals the role of caspase-8 in regulating IL-1 beta activation in macrophages and its involvement in pulmonary arterial hypertension (PAH). Caspase-8 promotes inflammatory cell infiltration and pulmonary arterial smooth muscle cell proliferation via NLRP3/IL-1 beta activation, contributing to the pathogenesis of PAH.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kenta Fujimura, Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Yoshiko Mizushina, Chintogtokh Baatarjav, Takayoshi Matsumura, Kinya Otsu, Norihiko Takeda, Hiroaki Mizukami, Kazuomi Kario, Masafumi Takahashi
Summary: Sepsis is a life-threatening syndrome, and its associated mortality is increased when cardiac dysfunction and damage (septic cardiomyopathy [SCM]) occur. The NLRP3 inflammasome plays a critical role in the pathophysiology of SCM, with the activation of IL-1 beta and IL-18 contributing to the development of SCM.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Immunology
Nourelhouda Ghozali, Houda Belguendouz, Djamel Messaoudene, Zohra Hadjimi, Sarah Ihammichene, Arezki Chekaoui, Sara Benchabane, Malika Terahi, Islam Kediha, Lamia Ali Pacha, Chafia Touil-Boukoffa
Summary: Nicotine significantly reduces NO and IL-1 beta levels in patients with Behcet's disease while increasing IL-37 production, suggesting a potential therapeutic strategy targeting inflammation during Behcet's disease. Sex differences were not observed in the effects of nicotine on the production of nitric oxide, IL-1 beta, and IL-37 in PBMC of patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Andrea Borrego, Francesca Colombo, Jean Gabriel de Souza, Jose Ricardo Jensen, Alice Dassano, Rocco Piazza, Barbara Anais Rodrigues dos Santos, Orlando Garcia Ribeiro, Marcelo De Franco, Wafa Hanna Koury Cabrera, Marcelo Yudi Icimoto, Nancy Starobinas, Geraldo Magalhaes, Leticia Figueiredo Monteleone, Silas Fernandes Eto, Carlos DeOcesano-Pereira, Mauricio Barbugiani Goldfeder, Kerly Fernanda Mesquita Pasqualoto, Tommaso A. Dragani, Olga Celia Martinez Ibanez
Summary: We identified Pycard and BC017158 genes as potential effectors of a Quantitative Trait locus (QTL) on chromosome 7, controlling acute inflammatory response and IL-1 beta production. A mutation in ASC protein was found to play a crucial role in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jan Hettwer, Julia Hinterdobler, Benedikt Miritsch, Marcus-Andre Deutsch, Xinghai Li, Carina Mauersberger, Aldo Moggio, Quinte Braster, Hermann Gram, Avril A. B. Robertson, Matthew A. Cooper, Olaf Gross, Markus Krane, Christian Weber, Wolfgang Koenig, Oliver Soehnlein, Nicholas H. Adamstein, Paul Ridker, Heribert Schunkert, Peter Libby, Thorsten Kessler, Hendrik B. Sager
Summary: This study investigates the mechanisms of IL-1 beta-targeted therapies and finds that anti-IL-1 beta treatment and NLRP3-inflammasome inhibition can reduce vascular inflammation and progression of atherosclerosis through decreased supply and uptake of inflammatory leucocytes in the blood.
CARDIOVASCULAR RESEARCH
(2022)
Article
Immunology
Hana Starobova, Mercedes Monteleone, Christelle Adolphe, Lena Batoon, Cheyenne J. Sandrock, Bryan Tay, Jennifer R. Deuis, Alexandra V. Smith, Alexander Mueller, Evelyn Israel Nadar, Grace Pamo Lawrence, Amanda Mayor, Elissa Tolson, Jean-Pierre Levesque, Allison R. Pettit, Brandon J. Wainwright, Kate Schroder, Irina Vetter
Summary: The study found that vincristine-induced peripheral neuropathy is driven by activation of the NLRP3 inflammasome and release of interleukin-1 beta. Treatment with NLRP3 inhibitor or IL-1 receptor antagonist could effectively reduce mechanical allodynia and gait disturbances. Repurposing anakinra may be an effective co-treatment strategy to prevent vincristine-induced peripheral neuropathy.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Dermatology
Franziska Rademacher, Joachim Bartels, Regine Glaser, Meno Rodewald, Sabine Schubert, Daniel Drucke, Holger Rohde, Jurgen Harder
Summary: Staphylococcus epidermidis (SE) plays an important role in skin defense by activating IL-1 signaling. A serine protease called Esp produced by SE was found to be crucial in the release of mature IL-beta in a caspase-1-independent manner.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Chemistry, Medicinal
Yeo Dae Yoon, Myeong Youl Lee, Byeong Jo Choi, Chang Woo Lee, Hyunju Lee, Joo-Hee Kwon, Jeong-Wook Yang, Jong Soon Kang
Summary: This study found that Terrein has a protective effect against LPS-induced endotoxemia by reducing the production of inflammatory cytokines. The anti-inflammatory effect of Terrein might be mediated, at least in part, by blocking the activation of NF-kappa B, JNK, and p38 MAPK signaling pathways.
Article
Cell Biology
Areej Al-Roub, Ashraf Al Madhoun, Nadeem Akhter, Reeby Thomas, Lavina Miranda, Texy Jacob, Ebaa Al-Ozairi, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Summary: The overexpression of IL-6 in the adipose tissue of obese individuals may lead to insulin resistance. IL-1 beta and TNF alpha, which are increased in obese adipose tissue, cooperate to enhance the production of IL-6 in adipocytes. This cooperative interaction depends on CREB binding and H3K14 acetylation and provides an interesting pathophysiological connection among IL-1 beta, TNF alpha, and IL-6 in obesity settings.
Article
Physiology
Fabio Zambolin, Gaia Giuriato, Fabio Giuseppe Laginestra, Matteo Maria Ottaviani, Thomas Favaretto, Elisa Calabria, Pablo Duro-Ocana, Liam Bagley, Azmy Faisal, Tiago Pecanha, Jamie Stewart McPhee, Massimo Venturelli
Summary: This study tested the separate and combined effects of mechanoreflex activation and nociception on central and peripheral hemodynamics. The results showed that the combination of mechanoreflex and nociception led to increased central hemodynamics and decreased resting limb blood flow.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Christian Koenig, Enrique Vazquez, Sabrina Ess, Matthias Ebbinghaus, Bjoern Vorpahl, Andrea Ebersberger, Hans-Georg Schaible
Summary: Both spinal TNF and IL-6 contribute to mechanical spinal hyperexcitability in inflammatory pain states, with IL-6 potentially mediating TNF effects. IL-1 beta, also involved in inflammatory pain, induces spinal hyperexcitability, with TNF limiting its effects through IL-6 signaling. TNF stimulates the release of IL-1Ra, an endogenous IL-1 beta antagonist, which may modulate the effects of IL-1 beta on spinal excitability.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Anesthesiology
Ping Wu, Xiaoqi Wu, Guohua Zhou, Yin Wang, Xiaojun Liu, Run Lv, YanSong Liu, Qingping Wen
Summary: This study investigated the role of the P2X7 receptor in bone cancer pain (BCP) and its underlying molecular mechanism. The findings suggest that targeting the microglial P2X7 receptor activated NLRP3/IL-1 beta signaling pathway may be a potential strategy for BCP treatment.
Article
Neurosciences
Laszlo Ducza, Andrea Gajtko, Krisztina Hegedus, Erzsebet Bakk, Greta Kis, Botond Gaal, Roland Takacs, Peter Szucs, Klara Matesz, Krisztina Hollo
Summary: This study provides new evidence for the involvement of neuronal and glial P2X4 receptors in the development of inflammatory pain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Immunology
Wen-Wu Li, Yang Yang, Tian-Zhi Guo, Peyman Sahbaie, Xiao-you Shi, Qin Guang, Wade S. Kingery, Leonore A. Herzenberg, J. David Clark
Summary: In a murine tibia fracture model of complex regional pain syndrome (CRPS), up-regulated IL-6 signaling was found to be crucial for the development of nociceptive sensitization, vascular changes, and IgM immune complex deposition in the injured limbs. These findings suggest that anti-IL-6 therapies may be effective in reducing pain in the context of limb fracture or CRPS.
BRAIN BEHAVIOR AND IMMUNITY
(2021)