Article
Biochemistry & Molecular Biology
Leanne E. Mocniak, Zachary T. Bitzer, Neil Trushin, John P. Richie
Summary: Tobacco smoke free radicals, which depend on the intrinsic nitrate levels in tobacco, are closely associated with adverse health effects. The levels of gas phase radicals are highly correlated with nitrate levels in different tobacco types and brands. Nitrate addition to tobacco leaves increases the production of gas phase radicals and NNK in smoke. Tobacco nitrate plays a key role in the production of gas phase radicals and has implications for health regulation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Food Science & Technology
Prasenjit Manna, Saikat Dewanjee, Swarnalata Joardar, Pratik Chakraborty, Hiranmoy Bhattacharya, Shrestha Bhanja, Chiranjib Bhattacharyya, Manas Bhowmik, Shovonlal Bhowmick, Achintya Saha, Joydeep Das, Parames C. Sil
Summary: This study revealed that CA has a protective effect against Dox-induced cardiotoxicity by suppressing oxidative stress and interfering with pathological signaling events. CA can potentially be used as an effective agent to alleviate Dox-induced cardiotoxicity in the future.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Nese Basak Turkmen, Hande Yuce, Muhterem Aydin, Asli Taslidere, Aysegul Dogan, Dilan Askin Ozek, Taha Bartu Hayal, Seyma Yasar, Osman Ciftci, Songul Unuvar
Summary: Based on the experimental results, it can be deduced that nerolidol has a significant ameliorating effect on lipid peroxidation, oxidative stress, inflammation, histopathological damage, and apoptosis accompanying PCOS in female rats.
Article
Thermodynamics
Lucelia A. Macedo, Edgar A. Silveira, Patrick Rousset, Jeremy Valette, Jean-Michel Commandre
Summary: This study investigates the synergistic behavior between oxidative atmosphere and potassium catalytic effects on woody and non-woody biomass. The results show that the potassium content indicates biomass oxidation, and the oxidative conditions enhance the catalytic effect. Additionally, the potassium content has a significant impact on the yield of condensable compounds, especially under oxidative conditions.
Article
Cell Biology
Yiwei Liao, Sha Huang, Yuhu Zhang, Honghai Zhang, Haiting Zhao
Summary: CCN1 is found to be involved in the process of epilepsy seizure, and its decrease can protect brain tissue from oxidative stress and neuronal apoptosis.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sebastian Zimmer, Philip Roger Goody, Matthias Oelze, Alexander Ghanem, Cornelius F. Mueller, Ulrich Laufs, Andreas Daiber, Felix Jansen, Georg Nickenig, Sven Wassmann
Summary: The study found that inhibiting Rac1 GTPase can reduce vascular oxidative stress and atherosclerotic lesion formation, improve endothelial function, and decrease macrophage infiltration. This identifies Rac1 as a potential target for anti-atherosclerotic therapy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Bingbing Liu, Yatong Liang, Weihua Huang, Hui Zhang, Daiwei Zhou, Xiaoshan Xiao
Summary: This study found that Dexmedetomidine (DEX) can exert a protective effect in spinal cord ischemia-reperfusion injury (SCIRI) by regulating oxidative stress and apoptosis-related proteins (including Bcl-2, Bax, mitochondria, and Caspase-3).
CURRENT MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Michael Moustakas, Ilektra Sperdouli, Ioannis-Dimosthenis S. Adamakis, Julietta Moustaka, Sumrunaz Isgoren, Begum Sas
Summary: This study found that foliar applied salicylic acid can improve photosynthesis in tomato plants under non stress conditions. Salicylic acid decreases chlorophyll content and offers photoprotection, reducing phototoxicity and reactive oxygen species production, thus enhancing the efficiency of photosystem II.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Linlin Jing, Yanru Huang, Huiping Ma, Haibo Wang
Summary: The study found that a synthesized compound called HPN-C-6, which is a nitronyl nitroxide radical, can protect against brain damage caused by hypobaric hypoxia. HPN-C-6 reduces oxidative stress, decreases inflammation, and inhibits cell apoptosis by preventing the release of mitochondrial cytochrome C.
NEUROSCIENCE LETTERS
(2022)
Article
Geriatrics & Gerontology
Rogerio N. Soares, Francisco Ramirez-Perez, Francisco J. Cabral-Amador, Mariana Morales-Quinones, Christopher A. Foote, Thaysa Ghiarone, Neekun Sharma, Gavin Power, James A. Smith, R. Scott Rector, Luis A. Martinez-Lemus, Jaume Padilla, Camila Manrique-Acevedo
Summary: The study demonstrates that SGLT2 inhibition with Empa improves endothelial function and reduces arterial stiffness in an aging preclinical model, offering a potential therapeutic alternative for reducing the progression of cardiovascular disease in older individuals.
Article
Medicine, Research & Experimental
P. S. Thana Lakshme, R. Gayathri, V. Vishnu Priya
Summary: ———
This study analyzed the phytochemicals and estimated the total phenol content of Opuntia dillenii, revealing that the plant is rich in various phytochemicals, especially phenolic compounds, and has great potential as an antioxidant.
JOURNAL OF RESEARCH IN MEDICAL AND DENTAL SCIENCE
(2021)
Article
Medicine, General & Internal
Yi-Chun Lo, Su-Chuan Han, Ching-Kai Lin, Chung-Chih Shih, Ya-Jung Cheng
Summary: Bronchoscopic interventions and airway management for bronchoscopy are high-risk procedures for healthcare workers, as they expose them to COVID-19-containing droplets. Perioperative changes can be made to anesthetic management to reduce the spread of the virus.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Gastroenterology & Hepatology
Hou-Ying Cheng, Cheng-Maw Ho, Chih-Yang Hsiao, Ming-Chih Ho, Yao-Ming Wu, Po-Huang Lee, Rey-Heng Hu
Summary: This study investigated the changes in transplantability between primary and recurrent Hepato-cellular carcinoma (HCC) after hepatic resection (HR) and identified risk factors for nontransplantable recurrence (NTR). The study found that tumor diameter, resection extent, pathological grade, microvascular invasion, and early recurrence were associated with NTR. The overall transplantable pool increased after HR, suggesting that liver transplantation may not be necessary for some patients.
Article
Gastroenterology & Hepatology
Huey-Huey Chua, Mei-Hwei Chang, Ya-Hui Chen, Daw-Jen Tsuei, Yung-Ming Jeng, Po-Huang Lee, Yen-Hsuan Ni
Summary: We identified RBMY as a predictive biomarker for hepatocellular carcinoma metastasis. Provirus integration phosphorylates RBMY, leading to stabilized and translocated RBMY that promotes epithelial-mesenchymal transition and mitochondrial dysregulation in hepatocellular carcinoma, resulting in distant metastasis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ping-Jui Yu, Cheng-Maw Ho, Chih-Yang Hsiao, Yao-Ming Wu, Ming-Chih Ho, Po-Huang Lee, Rey-Heng Hu
Summary: Primary sclerosing cholangitis (PSC) is a rare disease in Asia and little research has been conducted on this ethnic group, especially in wait-listed patients for liver transplantation (LT). This study aimed to investigate the prognosis and outcomes of wait-listed patients with PSC in an Asian transplant center. The results showed that female PSC patients had higher AST to platelet ratio index scores and bilirubin levels compared to males, and were more likely to present with decompensating events. Female gender and LT were identified as protective factors for overall survival in multivariable analysis.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Wei -Han Chou, Sing-Ong Lee, Min-Hsuan Sun, Ying-Chih Tseng, Kuang-Cheng Chan, Ying-Hsi Chen, Chun-Yu Wu
Summary: This study validated the Chinese version of the Obstetric Quality of Recovery questionnaire (ObsQoR-11) and found that it is suitable for assessing post-cesarean recovery at 24 hours and 96 hours.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Wen-Ying Lin, Feng-Sheng Lin, Chung-Chih Shih, Yi-Jung Sung, An -Yu Chen, Yu -Chin Piao, Jin-Shing Chen, Ya-Jung Cheng
Summary: This study compared the intraoperative oxygenation and perioperative outcomes between non-intubated video-assisted thoracic surgery (NIVATS) with supra-glottic airway devices (SADs) and NIVATS with high flow nasal oxygenation (HFNO). The results showed that the HFNO group had a higher desaturation event rate, lower nadir SPO2, and longer hospitalization. However, propensity score matching analysis revealed no significant between-group difference in the desaturation rate. Smoking and HFNO were associated with intraoperative desaturation.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Letter
Critical Care Medicine
Madeleine Zheng, Wei-Zen Sun
JOURNAL OF BURN CARE & RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Hou-Ying Cheng, Rey-Heng Hu, Chih-Yang Hsiao, Ming-Chih Ho, Yao-Ming Wu, Po-Huang Lee, Cheng-Maw Ho
Summary: This retrospective study analyzed 726 patients who experienced intrahepatic recurrence after primary hepatectomy for hepatocellular carcinoma (HCC). The results showed that both radiofrequency ablation (RFA) and transarterial chemoembolization (TACE) were effective in improving long-term survival, particularly in patients with hepatitis B virus (HBV). Antiviral treatment complemented the survival of patients with hepatitis C virus (HCV) after RFA, especially in late first recurrence.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Medicine, General & Internal
Kuang-Cheng Chan, Li-Lin Wu, Su-Chuan Han, Jin-Shing Chen, Ya-Jung Cheng
Summary: This study compared the analgesic and sedative effects of thoracoscopic intercostal nerve blocks (TINBs) during nonintubated and intubated video-assisted thoracic surgery (VATS). The results showed that TINBs reduced the requirement for anesthesia and analgesia in VATS. However, nonintubated VATS had a significantly higher risk of hypotension after TINBs. Real-time data provided by density spectral arrays (DSAs) were beneficial for the preemptive management, especially in nonintubated VATS.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Education & Educational Research
Cheng-Maw Ho, Chi-Chuan Yeh, Jann-Yuan Wang, Rey-Heng Hu, Po-Huang Lee
Summary: This study explored medical students' preferences for synchronous class formats and their experiences with preclass online video learning. The results showed that students who chose face-to-face and HyFlex formats were more concerned about learning efficiency, focus concentration, and course attractiveness. However, the choice of class format did not affect short-term learning outcomes.
MEDICAL EDUCATION ONLINE
(2023)
Article
Health Care Sciences & Services
Jia-Lin Chen, Shung-Tai Ho, Wei-Zen Sun, Yu-Chuan Tsai, Kuang- Cheng, Yen-Chin Liu, Yi-Jer Hsieh, Yeong-Ray Wen, Po-Kai Wang, Chun-Sung Sung, Chun-Chang Yeh, Tso-Chou Lin
Summary: The study found that the COVID-19 outbreak in 2020 did not interrupt access to long-term opioid prescriptions for most registered patients with chronic pain in Taiwan, but some patients experienced an increase in opioid dosage. 60% of patients reported experiencing constipation.
Letter
Surgery
Chao-Ming Hung, Kuo-Chuan Hung, Po-Huang Lee, Kang Lu, Meng-Che Hsieh, Chong-Chi Chiu
BRITISH JOURNAL OF SURGERY
(2022)
Letter
Surgery
Chao-Ming Hung, Kuo-Chuan Hung, Po-Huang Lee, I-Ting Tsai, Hui-Ming Lee, Chong-Chi Chiu
BRITISH JOURNAL OF SURGERY
(2022)
Letter
Surgery
Chao-Ming Hung, Po-Huang Lee, Chao-Sung Chang, Kun-Ming Rau, Jung-Fa Tsai, Chong-Chi Chiu
BRITISH JOURNAL OF SURGERY
(2022)