Article
Immunology
Oscar Alberto Solis-Velazquez, Melesio Gutierrez-Lomeli, Pedro Javier Guerreo-Medina, Maria de Lourdes Rosas-Garcia, Maricarmen Iniguez-Moreno, Maria Guadalupe Avila-Novoa
Summary: This study found that nosocomial pathogens can develop biofilms on biomaterials, with lower densities of Gram-negative bacteria in mono-species biofilms compared to dual-species biofilms. Moreover, dual-species biofilms exhibited a higher concentration of proteins and eDNA in the extracellular matrix.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Pharmacology & Pharmacy
Huihui Zeng, Zihang Zeng, Xianglong Kong, Hongliang Zhang, Ping Chen, Hong Luo, Yan Chen
Summary: This retrospective study analyzed 107 Chinese patients with nosocomial pneumonia caused by MDR or XDR Gram-negative bacteria treated with intravenous polymyxin B. The findings suggest that disease severity and polymicrobial infection are risk factors for a poor clinical outcome, and early nephrotoxicity following 3 days of treatment may lead to later nephrotoxicity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Materials Science, Multidisciplinary
S. Ranjani, Matheen Abdul, A. Antony Jenish, S. Hemalatha
Summary: Poly bio-silver nanoparticles (PBSNp) synthesized from the extracts of Piper nigrum, Piper longum and Zingiber officinale showed promising antibacterial efficacy, outperforming antibiotics in controlling microbial growth. PBSNp has the potential to be developed as an alternative biomaterial for controlling bacterial pathogens in the future.
Article
Chemistry, Analytical
Haritha Kuttoth, Teena Thomas, Resmi V. Nair, N. Sandhyarani
Summary: In this study, a simple electrochemical detection platform using rGO and cuprous oxide nanoparticles for ultrasensitive detection of LPS was developed. The sensor showed a low detection limit and excellent sensitivity in detecting Gram-negative bacteria in whole blood and sewage water, demonstrating its potential applications in food, clinical and pharmaceutical safety.
ANALYTICA CHIMICA ACTA
(2023)
Review
Biochemistry & Molecular Biology
Hisataka Shoji, Steven M. Opal
Summary: Endotoxin removal therapy using PMX has been used clinically since 1994 for sepsis and septic shock patients, with effectiveness demonstrated for over a quarter of a century. However, a clear survival benefit has not been shown in a large, multicenter, randomized controlled trial. Ongoing research is exploring the potential long-term survival benefits of PMX therapy for septic patients, along with studies on the endotoxin adsorption capacity of PMX columns and immunomodulatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Eduarda Melquiades Pirette dos Santos, Carla Castelo Branco Martins, Joao Victor de Oliveira Santos, Wagner Roberto Cirilo da Silva, Sidicleia Bezerra Costa Silva, Miguel Angel Pelagio-Flores, Andre Galembeck, Isabella Macario Ferro Cavalcanti
Summary: The study evaluated the effectiveness of silver nanoparticles-chitosan composites against resistant bacteria and biofilm formation. Different morphologies of nanoparticles showed varying levels of antibacterial and antibiofilm activities, with smaller and spherical nanoparticles exhibiting the highest efficacy. The nanoparticles displayed promising potential in combating resistant bacteria and bacteria growing in biofilms without inducing tolerance.
JOURNAL OF NANOPARTICLE RESEARCH
(2021)
Article
Chemistry, Analytical
Giada Caniglia, Maria Chiara Sportelli, Anna Heinzmann, Rosaria A. Picca, Antonio Valentini, Holger Barth, Boris Mizaikoff, Nicola Cioffi, Christine Kranz
Summary: Ag-CFX thin films composed of encapsulated bioactive nanophases within a thin polymer coating were prepared by ion beam co-sputtering. The films' thickness and inorganic loading were accurately tuned. Spectroscopic and microscopy techniques were used to characterize the composition and swelling behavior of the films. It was found that silver(I) was released from the embedded silver nanoparticles, and the released concentration correlated with the swelling of the films. The films exhibited antimicrobial properties against biofilm formation, but re-colonization occurred after a certain period of time.
ANALYTICA CHIMICA ACTA
(2022)
Article
Immunology
Manjari Shukla, Vineeta Singh, Hamza Habeeballah, Mustfa F. Alkhanani, Manjul Lata, Yusuf Hussain, Madhuparna Mukherjee, Mukesh Pasupuleti, Abha Meena, Bhartendu Nath Mishra, Shafiul Haque
Summary: The inhibitory and degradation potential of Carissa carandas proteinaceous leaf extract against mixed bacterial biofilm responsible for nosocomial infections was evaluated. The extract showed significant inhibition and degradation of the biofilm, with the best degradation observed against Staphylococcus aureus biofilm. The presence of flavonoids, phenols, and tannins in the extract suggests their contribution to the antibiofilm property.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Physical
Siva Bala Subramaniyan, Sengan Megarajan, Karnan Singaravelu Dharshini, Anbazhagan Veerappan
Summary: Functionalizing nanoparticles to target bacteria surfaces is an effective approach to combat drug-resistant pathogens. This study synthesized N-myristoyltaurine capped silver nanoparticles (AgNPs) and functionalized them with jacalin from Artocarpus integrifolia seeds. The functionalized AgNPs (JAgNPs) had a lower minimum inhibitory concentration and showed superior biofilm inhibition activity against S. aureus compared to AgNPs, suggesting a unique way to use nanosilver for treating infections associated with S. aureus biofilm.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Review
Microbiology
Parvathy Venkateswaran, Priya M. Lakshmanan, Sudhiksha Muthukrishnan, Hema Bhagavathi, Sahana Vasudevan, Prasanna Neelakantan, Adline P. Solomon
Summary: Enterococcus faecalis, a commensal in the human gastrointestinal tract, is a known cause of nosocomial infections. Its transition from a planktonic to a sessile state, along with the acquisition of multidrug resistance, poses challenges for treatment. Several key genes and molecular pathways, including quorum sensing, aggregation substance, surface adhesions, stress-related response, and sex pheromones, play critical roles in the sessile state. It is crucial to decode the hidden agenda of E. faecalis and understand the factors influencing biofilm formation in order to develop novel strategies to combat infections.
FUTURE MICROBIOLOGY
(2022)
Article
Engineering, Environmental
Nihong Li, Shijun Zhu, Chen Wen, Hansen Xu, Chunyan Li, Shiqi Zhu, Rufei Li, Liqiang Chen, Xia Luo
Summary: This study investigated the adsorption, elimination, and toxicity of silver nanoparticles and silver nitrate in biofilms composed of the model bacterium Escherichia coli and natural mixed-species. The results showed that natural mixed-species biofilms were more tolerant to silver nanoparticles and silver ions than E. coli biofilms, and silver ions were more toxic to both biofilms than silver nanoparticles. The concentrations of certain biomolecules and metabolic enzymes were also found to be significantly different in the two types of biofilms, highlighting the advantages of metal-exposed natural mixed-species biofilms in terms of both structure and metabolic function. These findings contribute to our understanding of the environmental risks of engineered nanoparticles and provide insights into biofilm-based remediation of nanoparticles-contaminated aquatic environments.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Food Science & Technology
Supakit Paosen, Suttiwan Wunnoo, Siwaporn Bilhman, Sakkarin Lethongkam, Abdi Wira Septama, Supayang Piyawan Voravuthikunchai
Summary: Silver nanoparticles synthesized using industrial waste from Eucalyptus camaldulensis and sericin derived from Bombyx mori showed strong antioxidant activity and exhibited antibacterial effects against various foodborne pathogens, reducing biofilm production and hindering adhesion to and invasion of human epithelial cells.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Liping Peng, Henan Wei, Lei Tian, Jiachun Xu, Mingchun Li, Qilin Yu
Summary: This study developed a novel fungal pathogen-responsive assembly of cuprous oxide nanoparticles, which can efficiently target and inhibit the growth and biofilm formation of Candida albicans while exhibiting extremely low toxicity to mammalian cells. The assembly also showed high capacity in healing fungus-infected wounds in in vivo mouse wound model.
SCIENCE CHINA-MATERIALS
(2021)
Article
Infectious Diseases
Iyad Y. Natsheh, Mallak T. Elkhader, Ala'a A. Al-Bakheit, Majd M. Alsaleh, Bassam I. El-Eswed, Nedaa F. Hosein, Duaa K. Albadawi
Summary: This study aims to inhibit bacterial biofilm formation, evaluate the effectiveness of novel silica nanoparticles in inhibiting biofilm, and compare their effectiveness. The results showed that pure silica nanoparticles can target Acinetobacter biofilms without harming normal cells, and smaller doses of amoxicillin combined with silica nanoparticles may reduce toxic side effects and inhibit biofilm formation.
Article
Critical Care Medicine
George Tomlinson, Ali Al-Khafaji, Steven A. Conrad, Faith N. F. Factora, Debra M. Foster, Claude Galphin, Kyle J. Gunnerson, Sobia Khan, Roopa Kohli-Seth, Paul Mccarthy, Nikhil K. Meena, Ronald G. Pearl, Jean-Sebastien Rachoin, Ronald Rains, Michael Seneff, Mark Tidswell, Paul M. Walker, John A. Kellum
Summary: This study conducted a simulation analysis using Bayesian statistical methods to assess the impact of different uses of historical data and types of analysis on the results of a proposed trial for treating endotoxemic septic shock. The results demonstrate that incorporating historical data in a biologically justifiable manner through a prior distribution improves the statistical power of the trial compared to ignoring relevant historical data.
Article
Infectious Diseases
Amit Gaurav, Ashish Kothari, Balram Ji Omar, Ranjana Pathania
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2020)
Correction
Chemistry, Physical
Sitaramanjaneya Mouli Thalluri, Bin Wei, Katharina Welter, Rajesh Thomas, Vladimir Smirnov, Liang Qiao, Zhongchang Wang, Friedhelm Finger, Lifeng Liu
ACS ENERGY LETTERS
(2020)
Article
Chemistry, Physical
Nan Zhang, Junyuan Xu, Bin Wei, Junjie Li, Isilda Amorim, Rajesh Thomas, Sitaramanjaneya Mouli Thalluri, Zhongchang Wang, Weiya Zhou, Sishen Xie, Lifeng Liu
ACS APPLIED ENERGY MATERIALS
(2020)
Article
Chemistry, Physical
Anupma Thakur, Praveen Kumar, Sitaramanjaneya Mouli Thalluri, R. K. Sinha, Pooja Devi
Summary: The study demonstrates the use of polypyrrole decorated micro-porous laboratory filter paper as a photoanode for efficient and stable water splitting. The results show excellent photo-anodic PEC activity with a photocurrent density of -9.5 mA/cm(2) and stability for over 160 minutes in alkaline conditions.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Microbiology
Vineet Dubey, Rinki Gupta, Ranjana Pathania
Summary: In the study, it was found that treatment with the last-resort antibiotic polymyxin B caused continuous variations in tolerance among different clinical isolates of Acinetobacter baumannii. The activity of superoxide dismutase (sodB) was identified as a major contributor to the tolerance of A. baumannii to polymyxin B. Rifampicin was effective in eradicating polymyxin B-induced A. baumannii persisters by increasing the generation of reactive oxygen species (ROS), which was linked to significant downregulation of sodB. The combination of polymyxin B and rifampicin was proposed as an effective antipersister strategy in clearing polymyxin B-induced A. baumannii persisters.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biology
Amit Gaurav, Varsha Gupta, Sandeep K. Shrivastava, Ranjana Pathania
Summary: Gaurav et al. report a synergistic interaction between nalidixic acid and tetracycline against multi-drug resistant bacteria Acinetobacter baumannii and Escherichia coli. They find that this synergy does not work for clinical isolates susceptible to antibiotics, suggesting the potential application of nalidixic acid and tetracycline against the emergence of multi-drug resistant bacteria.
COMMUNICATIONS BIOLOGY
(2021)
Article
Infectious Diseases
Vineet Dubey, Kuldip Devnath, Vivek K. Gupta, Gazal Kalyan, Mangal Singh, Ashish Kothari, Balram Ji Omar, Ranjana Pathania
Summary: This study evaluated the efficacy of the FDA-approved drug disulfiram in combination with meropenem against MBL-expressing carbapenem-resistant Acinetobacter baumannii. The results demonstrated a synergistic interaction between disulfiram and meropenem, particularly against NDM and IMP-producing A. baumannii. The combination therapy showed improved bacterial clearance in mice models of infection and pneumonia.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Nanoscience & Nanotechnology
Piyush Kumar, Arshad Ali Shaikh, Pardeep Kumar, Vivek Kumar Gupta, Rajat Dhyani, Tarun Kumar Sharma, Ajmal Hussain, Krishnakant Gangele, Krishna Mohan Poluri, Korasapati Nageswara Rao, Ravinder Kumar Malik, Ranjana Pathania, Naveen Kumar Navani
Summary: In this study, a double-edged nanoplatform with excellent antibacterial activity and biocompatibility was developed. The nanoplatform showed high efficacy against various bacterial pathogens and prevented biofilm formation. Furthermore, it exhibited heat resistance and retained antibacterial activity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Rajesh Thomas, Magdalena Gurgul, Bruno Xavier, Sitaramanjaneya Mouli Thalluri, Isilda Amorim, Nan Zhang, Leszek Zaraska, Grzegorz D. Sulka, Lifeng Liu
Summary: Research shows that tin oxyphosphate (Sn/SnP2O7) exhibits better storage performance for lithium and sodium ions compared to Sn/SnOx, attributed to its unique metal/matrix structure.
APPLIED SURFACE SCIENCE
(2022)
Article
Electrochemistry
Bilal Bawab, Sitaramanjaneya M. Thalluri, Jhonatan Rodriguez-Pereira, Hanna Sopha, Raul Zazpe, Jan M. Macak
Summary: Pd nanoparticles prepared by ALD show good performance in methanol electro-oxidation, with TNT layers as the supporting material effectively preventing the formation of electrochemical poisoning species. Different Pd loadings influence the particle size of Pd and electrocatalytic performance.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Medicinal
Mahak Saini, Amit Gaurav, Ashish Kothari, Balram Ji Omar, Varsha Gupta, Amitabha Bhattacharjee, Ranjana Pathania
Summary: The rise of antibiotic resistance in skin-infecting pathogens is a serious threat to public health. This study aims to find a small molecule that can enhance the activity of currently used antibiotics. The novel antibacterial small molecule, IITR00693, was found to potentiate the antibacterial activity of polymyxin B against Staphylococcus aureus and Pseudomonas aeruginosa.
ACS INFECTIOUS DISEASES
(2023)
Article
Chemistry, Multidisciplinary
Sitaramanjaneya M. Thalluri, Jhonatan Rodriguez-Pereira, Raul Zazpe, Bilal Bawab, Eva Kolibalova, Ludek Jelinek, Jan M. Macak
Summary: The nucleation delay for ALD of Ru on carbon surfaces has been successfully reduced by constructive pretreatments, enhancing the C-O functionality. Ru species deposition on carbon papers (CP) was achieved with a minimum number of ALD cycles (25 cycles) and good conformality. Development of electrocatalysts from single atoms to nanoparticles on conductive supports with low metal loadings is crucial for improving electrocatalysis performance.
Review
Immunology
Afreen Shadan, Avik Pathak, Ying Ma, Ranjana Pathania, Rajnish Prakash Singh
Summary: This article reviews the mechanisms, virulence factors, and other factors associated with the pathogenesis of A. baumannii infection. Additionally, it discusses the role of innate and adaptive immune response, as well as the current progress in developing innovative strategies to combat this multidrug-resistant pathogen.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Geeta, Ajit S. Yadav, Suchismita Pradhan, Ravi Rajoria, Asok M. Kumar, M. Gopi, Naveen Kumar Navani, Ranjana Pathania
Summary: The study demonstrated that supplementing broiler feed with different concentrations of Lactobacillus fermentum NKN51 significantly improved growth performance, immune response, gut health, and intestinal absorption capacity of broiler chickens.
INDIAN JOURNAL OF ANIMAL RESEARCH
(2021)
Article
Microbiology
Arun Beniwal, Amit Gaurav, Rekha Sharma, Tamoghna Ghosh, Piyush Kumar, Urmila Netter, Ranjana Pathania, Naveen Kumar Navani
Summary: The draft genome sequence of Limosilactobacillus fermentum strain NKN-51 was isolated from naturally processed yak cheese in the western Himalayas of India. The genome is 1,879,705 bp in length with 1,730 protein-coding genes and 50 tRNA genes predicted.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2021)