Article
Biochemistry & Molecular Biology
Manuel Gentiluomo, Alice Luddi, Annapaola Cingolani, Marco Fornili, Laura Governini, Ersilia Lucenteforte, Laura Baglietto, Paola Piomboni, Daniele Campa
Summary: The study found no significant association between sperm telomere length (STL) and leukocyte telomere length (LTL) with sperm quality parameters, but identified five single nucleotide polymorphisms (SNPs) that were statistically significantly associated with sperm variables. The results suggest moderate involvement of telomere length in male fertility, while indicating the potential pleiotropic effects of certain SNPs on sperm parameters independent of telomere homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Benoit Berby, Cynthia Bichara, Aurelie Rives-Feraille, Fanny Jumeau, Pierre Di Pizio, Veronique Setif, Louis Sibert, Ludovic Dumont, Chistine Rondanino, Nathalie Rives
Summary: This study found that infertile males with conventional semen parameter alterations have higher levels of oxidative stress and chromatin condensation defects in sperm, with a positive correlation between the number of telomere signals and the percentage of spermatozoa with chromatin condensation defects.
Article
Cell Biology
Alessandro Medoro, Luciano Saso, Giovanni Scapagnini, Sergio Davinelli
Summary: This review explores the impact of NRF2 dysregulation and oxidative stress on telomere shortening and age-related diseases, emphasizing the importance of studying this functional link.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Tina Levstek, Katarina Trebusak Podkrajsek
Summary: Telomeres are dynamic DNA nucleoprotein structures located at the end of chromosomes that maintain genomic stability. Shortened telomeres contribute to cellular senescence and degenerative diseases such as chronic kidney diseases (CKDs). Oxidative stress also accelerates telomere shortening. This review examines the association between telomere length and CKDs, particularly in patients receiving kidney replacement therapy. Understanding the relationship between telomere attrition and kidney disease can contribute to new strategies for managing CKDs.
Article
Biochemistry & Molecular Biology
Manassanan Jitjumnong, Pornpan Chalermkitpanit, Tanyawan Suantawee, Sinsuda Dechsupa, Ladawan Vajarintarangoon, Sittisak Honsawek
Summary: This study found that patients with lumbar disc degeneration (LDD) had shorter telomeres, increased oxidative stress, and decreased antioxidant levels. The telomere length was negatively correlated with the severity of LDD, while oxidative stress markers (MDA and 8-OHdG) showed positive correlations with severity. These findings suggest that telomere length, as well as MDA and 8-OHdG levels, may be potential non-invasive biomarkers for assessing the severity of LDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Environmental Sciences
Pheerasak Assavanopakun, Ratana Sapbamrer, Sirinart Kumfu, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Air pollution poses a major threat to health, affecting cellular senescence and oxidative stress. Telomere length serves as a useful biomarker for early detection of health issues related to air pollution exposure. Different factors influence the association between telomere length and air pollution, with even low levels of exposure causing alterations.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biochemistry & Molecular Biology
Fani Konstantinidou, Maria Cristina Budani, Guya Diletta Marconi, Francesca Gonnella, Annalina Sarra, Oriana Trubiani, Liborio Stuppia, Gian Mario Tiboni, Valentina Gatta
Summary: This study found that smoking can lead to a decrease in telomere length and mitochondrial DNA copy number in the CCs of females who underwent in vitro fertilization, as well as a down-regulation of genes and proteins like TERF1, TERF2, and POT1. These findings expand our understanding of the impact of smoking on CCs, providing important clues for uncovering the effects of smoking on fertility potential.
Article
Biochemistry & Molecular Biology
Xu Li, Meijie Wang, Wei Zheng, Wei Huang, Zeyu Wang, Kairang Jin, Lin Liu, Zhongbo Yu
Summary: Chromosome stability is primarily determined by telomere length, which is regulated by the core subunit TRF1 of shelterin. Research on the dynamics of TRF1 has shown its role in telomere organization, compaction, and interaction at telomeric DNA forks. Understanding these mechanisms can facilitate future studies on telomeres and the development of shelterin-targeted drugs.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Endocrinology & Metabolism
Andrea L. Millan, Sofia I. Trobo, Alejandro de Dios, Martina Cerrato Garcia, Maria S. Perez, Gloria E. Cerrone, Gustavo D. Frechtel, Ariel P. Lopez
Summary: The study aimed to investigate telomere length in MODY patients and found that both MODY2 and MODY3 types exhibit telomere shortening, which is related to HbA1c and fasting plasma glucose levels. These findings suggest similar mechanisms underlying telomere attrition in MODY patients.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Environmental Sciences
Stina George Fernandes, Rebecca Dsouza, Ekta Khattar
Summary: The external environment influences cellular physiological processes and genome stability, particularly impacting telomeres. Telomeres protect genome integrity by preventing DNA damage response and end-to-end fusions. External factors like oxidative stress and inflammation impact telomere stability.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eva Hassler, Gunter Almer, Gernot Reishofer, Gunther Marsche, Harald Mangge, Hannes Deutschmann, Markus Herrmann, Stefan Leber, Felix Gunzer, Wilfried Renner
Summary: Telomeres play a crucial role in genomic integrity, with shortened telomeres linked to increased risks of diseases like cancer. This study shows a significant positive correlation between serum total antioxidant capacity (TAC) and leucocyte telomer length (LTL) in healthy males, but not in females. Further studies are needed to investigate the sex-specific effects of oxidative stress on telomere length and telomerase activity.
Article
Andrology
Ashok Agarwal, Renata Finelli, Manesh Kumar Panner Selvam, Kristian Leisegang, Ahmad Majzoub, Nicholas Tadros, Edmund Ko, Neel Parekh, Ralf Henkel, Damayanthi Durairajanayagam, Giovanni M. Colpi, Chak Lam Cho, Hassan N. Sallam, Hyun Jun Park, Ramadan Saleh, Sava Micic, Rafael F. Ambar, Armand Zini, Kelton Tremellen, Juan G. Alvarez, Ayad Palani, Mohamed Arafa, Marcello M. Gava, Sunil Jindal, Edouard Amar, Zsolt Kopa, Mohammad Reza Moein, Gian Maria Busetto, Pallav Sengupta, Parviz Kavoussi, Israel Maldonado, Jamal Fikri, Edson Borges, Marlon Martinez, Djordje Bojovic, Osvaldo Rajmil, Kaan Aydos, Sijo Parekattil, Joel L. Marmar, Omar Sefrioui, Andreas Jungwirth, Marcelo Gabriel Rodriguez Pena, Emerson B. Cordts, Haitham Elbardisi, Taymour Mostafa, Marjan Sabbaghian, Mohammad Ali Sadighi Gilani, Yoshiharu Morimoto, Marco G. Alves, Aleksandra Spasic, Uros Kenic, Jonathan Ramsay, Ebenezer Oluwole Akande, Amina Oumeziane, Dmitri Dozortsev, Eric Chung, Ernestine Gwet Bell, Adolfo Allegra, Vasilios Tanos, Moise Fiadjoe, Timur Gurgan, Michel Abou-Abdallah, Hazem Al-Rumaih, Ivana Oborna, Hesham Arab, Sandro Esteves, Medhat Amer, Ates Kadioglu, Oleksandr Yuzko, Vladislav Korsak, Rupin Shah
Summary: This study conducted an online survey to evaluate the practice pattern of reproductive specialists in the use of oxidative stress testing and antioxidant prescriptions for the treatment of male infertility. The results showed a global understanding of the importance of this therapeutic option and a widespread use of antioxidants for male infertility treatment. It emphasizes the necessity of evidence-based clinical practice guidelines from professional societies.
WORLD JOURNAL OF MENS HEALTH
(2021)
Article
Andrology
Zumna Sharif, Muhammad Furqan Akhtar, Hamna Sharif, Ammara Saleem, Muhammad Imran Khan, Amjad Riaz
Summary: This study evaluated the sub-chronic effect of organic nitrates (GTN and IM) on the reproductive system in male rats. The findings showed a significant decrease in sperm parameters and serum testosterone in the GTN and IM treated groups, as well as changes in sperm morphology. High dose drug treatment led to increased oxidative stress levels. All drug treated groups exhibited significant increases in follicle stimulating hormone and decreases in testosterone levels. Histological examination revealed changes in the seminiferous tubules.
Article
Biochemistry & Molecular Biology
Mateusz Lejawa, Kamila Osadnik, Tadeusz Osadnik, Natalia Pawlas
Summary: This study found associations between oxidative stress, metabolic health, and telomere length in both healthy and unhealthy individuals. Total oxidation status, total antioxidant capacity, and telomere length were significantly linked with metabolically unhealthy obesity. The findings suggest that obesity can lead to telomere shortening through metabolic disturbances and oxidative stress associated with MetS. Further research is needed to explore these pathways in young individuals with different metabolic health statuses.
Article
Pediatrics
Mohamed E. Suliman, Mohammed G. A. Ansari, Mohamed A. Rayis, Muaawia A. Hamza, Abdullah A. Saeed, Abdul Khader Mohammed, Nasser M. Al-Daghri
Summary: This study investigated telomere length and plasma TRF2 levels in children with sickle cell disease (SCD) in Saudi Arabia. Children with SCD had shorter telomere length compared to healthy controls, with no association between telomere length and TRF2 observed. Hydroxyurea treatment had no impact on telomere length in children with SCD. This study is the first of its kind in children with SCD and may lead to further research with a larger sample size in different populations to validate these findings.
PEDIATRIC RESEARCH
(2022)
Article
Genetics & Heredity
Kevin A. Strauss, Robert N. Jinks, Erik G. Puffenberger, Sundararajan Venkatesh, Kamalendra Singh, Iteen Cheng, Natalie Mikita, Jayapalraja Thilagavathi, Jae Lee, Stefan Sarafianos, Abigail Benkert, Alanna Koehler, Anni Zhu, Victoria Trovillion, Madeleine McGlincy, Thierry Morlet, Matthew Deardorff, A. Micheil Innes, Chitra Prasad, Albert E. Chudley, Irene Nga Wing Lee, Carolyn K. Suzuki
AMERICAN JOURNAL OF HUMAN GENETICS
(2015)
Meeting Abstract
Clinical Neurology
G. Nimmo, A. Pandey, C. Marshall, S. Venkatesh, L. Hazrati, S. Ahmed, J. Cameron, P. Ray, C. Suzuki, G. Yoon
NEUROMUSCULAR DISORDERS
(2017)
Article
Biochemistry & Molecular Biology
Graeme A. King, Maryam Hashemi Shabestari, Kees-Karel H. Taris, Ashutosh K. Pandey, Sundararajan Venkatesh, Jayapalraja Thilagavathi, Kamalendra Singh, Rama Krishna Koppisetti, Dmitry Temiakov, Wouter H. Roos, Carolyn K. Suzuki, Gijs J. L. Wuite
NUCLEIC ACIDS RESEARCH
(2018)
Letter
Pharmacology & Pharmacy
Ashutosh K. Pandey, Sundararajan Venkatesh
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Graeme A. M. Nimmo, Sundararajan Venkatesh, Ashutosh K. Pandey, Christian R. Marshall, Lili-Naz Hazrati, Susan Blaser, Sohnee Ahmed, Jessie Cameron, Kamalendra Singh, Peter N. Ray, Carolyn K. Suzuki, Grace Yoon
HUMAN MOLECULAR GENETICS
(2019)
Article
Cardiac & Cardiovascular Systems
Sundararajan Venkatesh, Min Li, Toshiro Saito, Mingming Tong, Eman Rashed, Satvik Mareedu, Peiyong Zhai, Clea Barcena, Carlos Lopez-Otin, Ghassan Yehia, Junichi Sadoshima, Carolyn K. Suzuki
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2019)
Article
Multidisciplinary Sciences
Sundararajan Venkatesh, Manju Chauhan, Carolyn Suzuki, Neeraj Chauhan
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Biochemistry & Molecular Biology
Gomathi Priya Jeyapal, Rajendiran Krishnasamy, Carolyn K. Suzuki, Sundararajan Venkatesh, M. J. N. Chandrasekar
BIOORGANIC CHEMISTRY
(2019)
Review
Cell Biology
Sundararajan Venkatesh, Carolyn K. Suzuki
Article
Physiology
Sundararajan Venkatesh, Erdene Baljinnyam, Mingming Tong, Toshihide Kashihara, Lin Yan, Tong Liu, Hong Li, Lai-Hua Xie, Michinari Nakamura, Shin-ichi Oka, Carolyn K. Suzuki, Diego Fraidenraich, Junichi Sadoshima
Summary: The study found that in human induced pluripotent stem cell-derived cardiomyocytes differentiated from human heart cells, an increase in mitochondrial proteins regulates metabolic pathways such as fatty acid oxidation, potentially through regulators like LonP1, IR, and Rb1. These findings may help optimize the maturation of iPSC-CMs.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Shin-Ichi Oka, Jaemin Byun, Chun-Yang Huang, Nobushige Imai, Guersom Ralda, Peiyong Zhai, Xiaoyong Xu, Sanchita Kashyap, Junco S. Warren, John Alan Maschek, Trevor S. Tippetts, Mingming Tong, Sundararajan Venkatesh, Yoshiyuki Ikeda, Wataru Mizushima, Toshihide Kashihara, Junichi Sadoshima
Summary: This study investigated the role of Nampt in the development of diabetic cardiomyopathy induced by high-fat diet consumption. The findings suggest that overexpression of Nampt can alleviate cardiac diabetic pathology and oxidative stress, protecting cardiac function.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jae Lee, Ashutosh K. Pandey, Sundararajan Venkatesh, Jayapalraja Thilagavathi, Tadashi Honda, Kamal Singh, Carolyn K. Suzuki
Summary: This study identifies specific inhibitors of LonP1, which could be of significant importance for future development of chemotherapeutic agents.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Suruthi Sankar, Monisha Jayabalan, Sundararajan Venkatesh, Muhammed Ibrahim
Summary: This study used zebrafish embryos to investigate the effects of gestational diabetes on the structural and functional changes in developing hearts. The results showed that exposure to high glucose levels significantly affected the size, morphology, and blood flow of the embryos' hearts. There was also a reduction in the thickness of the heart walls and number of cardiomyocytes. Interestingly, the expression of key gene regulators in heart development, tbx5a and nppa, was altered in response to high glucose levels. These findings suggest that the developing heart is susceptible to hyperglycemia, resulting in developmental defects.
CELL BIOLOGY INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Kavya Srinivasan, Ashutosh Kumar Pandey, Ashlena Livingston, Sundararajan Venkatesh
Summary: SARS-CoV-2 has been shown to enter cells primarily through the angiotensin-converting enzyme-2 (ACE-2) receptor, but the cellular mechanisms behind the pathology of COVID-19 remain poorly understood. Recent studies suggest that host mitochondria play crucial roles in virus-mediated immune responses, pathologies, and infections, making them a potential target for COVID-19 research and treatment.
MOLECULAR BIOMEDICINE
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Venkatesh Sundararajan, Tong Mingming, Erdene Baljinnyam, Anjaneyalu Murari, Zhai Peiyong, Edward Owusu-Ansah, Diego Fraidenraich, Junichi Sadoshima, Carolyn K. Suzuki
CIRCULATION RESEARCH
(2019)