期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 10, 期 -, 页码 6055-6074出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S92162
关键词
natural products; nanomedicine; drug delivery; bioavailability; targeting; controlled release
资金
- Virginia Tech new faculty startup funds
- Hatch Program of National Institute of Food and Agriculture of US Department of Agriculture
- Diabetes Action Research and Education Foundation
- Virginia Tech Center for Drug Discovery
- Virginia Tech's Open Access Subvention Fund
Natural products have been used in medicine for many years. Many top-selling pharmaceuticals are natural compounds or their derivatives. These plant-or microorganism-derived compounds have shown potential as therapeutic agents against cancer, microbial infection, inflammation, and other disease conditions. However, their success in clinical trials has been less impressive, partly due to the compounds' low bioavailability. The incorporation of nanoparticles into a delivery system for natural products would be a major advance in the efforts to increase their therapeutic effects. Recently, advances have been made showing that nanoparticles can significantly increase the bioavailability of natural products both in vitro and in vivo. Nanotechnology has demonstrated its capability to manipulate particles in order to target specific areas of the body and control the release of drugs. Although there are many benefits to applying nanotechnology for better delivery of natural products, it is not without issues. Drug targeting remains a challenge and potential nanoparticle toxicity needs to be further investigated, especially if these systems are to be used to treat chronic human diseases. This review aims to summarize recent progress in several key areas relevant to natural products in nanoparticle delivery systems for biomedical applications.
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