Article
Chemistry, Multidisciplinary
Hao Li, Dong Luo, Chaonan Yuan, Xinning Wang, Jing Wang, James P. Basilion, Thomas J. Meade
Summary: PSMA is a transmembrane protein highly expressed in aggressive prostate cancer, utilized in various imaging modalities as a biomarker. MR imaging provides detailed information but requires development of molecular contrast agents for improved sensitivity. In this study, targeted and activatable MR contrast agents were successfully used to differentiate between PSMA+ and PSMA- prostate cancer cells.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Inorganic & Nuclear
Ramachandran Vinayagam, Kyung Eun Lee, Ernest David, Muhammad Nurul Matin, Sang Gu Kang
Summary: A novel wedelolactone-loaded poly-lactic-co-glycolic acid nanoparticle was synthesized and showed significant antibacterial and anticancer properties. The nanoparticles exhibited stable spherical shape with a surface charge of -33.0 mV, and effective inhibition of bacterial growth and breast cancer cell proliferation.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Materials Science, Biomaterials
Ying An, Weiwei Chen, Yiran Li, Hongxia Zhao, Deju Ye, Huipu Liu, Kun Wu, Huangxian Ju
Summary: Albumin-manganese-based nanocomposites (AMNs) with simple preparation and good biocompatibility have been widely used for in vivo T-1-weighted magnetic resonance imaging (MRI) and cancer theranostics. In this study, an aggregation and crosslinking assembly strategy was proposed to enhance the T-1 relaxivity of the AMN. The synthesized C-BM/ICG nanocomposite showed remarkable performance in in vivo multimodal imaging of tumors and cancer phototherapy, providing a promising multifunctional nanoprobe for cancer theranostics.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Acoustics
Francesco Garzella, Paolo Bianchini, Alberto Diaspro, Aba Losi, Wolfgang Gartner, Stefania Abbruzzetti, Cristiano Viappiani
Summary: The GAF3 domain of the cyanobacteriochrome Slr1393 can undergo photochromicity and be used for photoacoustic imaging. The light-modulatable photoacoustic waveforms arising from GAF3 can be distinguished from background signals originating from non-modulatable competitive absorbers and scattering media. This effect was verified using a phantom filled with either GAF3 or E.coli overexpressing GAF3.
Review
Multidisciplinary Sciences
Partha Laskar Pranav, Partha Laskar, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
Summary: This review discusses the functionalization of nanomaterials for the diagnosis and therapy of prostate cancer. The authors emphasize the classification and comparison of nanomaterials based on their biofunctionalization strategy and source of biomolecules. They highlight the opportunities for using highly specific biological targeting moieties and biomimetic nanomaterials for early detection and drug delivery in prostate cancer. The review provides insights for the development of biofunctionalized nanomaterials in clinical settings.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Yingshan Jin, Yuting Lu, Anbazhagan Sathiyaseelan, Xin Zhang, Kumar Vishven Naveen, Myeong-Hyeon Wang
Summary: Peony seed cake extract (PSCE) was used to synthesize silver nanoparticles (Ag NPs) with antibacterial, antioxidant, and cytotoxicity properties. The PSCE-Ag NPs showed a spherical shape, average size of 105.6 ± 3.49 nm, and a zeta potential of -41.8 ± 12.6 mV. They effectively inhibited the growth and biofilm formation of various bacteria and exhibited strong free radical scavenging ability. Furthermore, the PSCE-Ag NPs were non-toxic to erythrocytes, egg-chorioallantoic membrane, and human embryonic kidney cells (HEK293), while significantly suppressing breast cancer cell (BT474) growth.
Article
Chemistry, Multidisciplinary
Zonglang Zhou, Jun Xie, Sihan Ma, Xian Luo, Jiajing Liu, Shengyu Wang, Yuqiang Chen, Jianghua Yan, Fanghong Luo
Summary: Novel high-efficiency nanotheranostic agents with multimodal imaging guidance have been synthesized for precise cancer treatment. These agents can combine CT/PA imaging and PDT/PTT therapy, showing enhanced photothermal effects and efficient tumor ablation through the induction of reactive oxygen species (ROS). Additionally, they exhibit potential antibacterial properties, which could minimize the risk of infection during cancer therapy and offer broad clinical application prospects.
Article
Biotechnology & Applied Microbiology
Akhtar Rasool, Thamaraiselvi Kanagaraj, Mohammad Imran Mir, Muhammad Zulfajri, Vinoth Kumar Ponnusamy, Mohammad Mahboob
Summary: In this study, copper oxide nanospheres were synthesized using Long pepper extract and characterized using various techniques. The synthesized nanospheres showed unique optical, morphological, antibacterial, and anticancer behaviors. The study demonstrated the effectiveness of Long pepper extract in controlling cell division and reducing cancer growth.
BIOCHEMICAL ENGINEERING JOURNAL
(2022)
Article
Acoustics
Hailey I. Kilian, Chenshuo Ma, Huijuan Zhang, Maomao Chen, Anoop Nilam, Breandan Quinn, Yuqi Tang, Jun Xia, Junjie Yao, Jonathan F. Lovell
Summary: This study investigated the use of a surfactant-based NIR-II dye (BIBDAH) as a contrast agent in longitudinal preclinical PA imaging. The results showed that intraperitoneal administration of BIBDAH in mice resulted in a more consistent and sustained dye concentration in plasma compared to intravenous administration.
Article
Chemistry, Multidisciplinary
Shan Gao, Yutaka Miura, Akira Sumiyoshi, Satoshi Ohno, Keisuke Ogata, Takahiro Nomoto, Makoto Matsui, Yuto Honda, Minoru Suzuki, Megumi Iiyama, Kensuke Osada, Ichio Aoki, Nobuhiro Nishiyama
Summary: Nano-sized contrast agents (NCAs) have the potential to enhance tumor contrast during magnetic resonance imaging. This study introduces a novel molecular mechanism to enhance the relaxation of NCAs, resulting in sharp tumor imaging. The self-folding molecular design allows for minimal loading of gadolinium complexes and selective accumulation in tumor tissues, providing effective anti-tumor results through gadolinium neutron capture therapy.
Review
Engineering, Environmental
Ashkan Bigham, Vahid Rahimkhoei, Payam Abasian, Masoud Delfi, Jamal Naderi, Matineh Ghomi, Farnaz Dabbagh Moghaddam, Tayyab Waqar, Yavuz Nuri Ertas, Sina Sharifi, Navid Rabiee, Sezgin Ersoy, Aziz Maleki, Ehsan Nazarzadeh Zare, Esmaeel Sharifi, Esmaiel Jabbari, Pooyan Makvandi, Ali Akbari
Summary: Polyphenol-based materials have gained significant attention due to their unique structure and properties. Tannic acid, as a polyphenolic compound, can interact with various substances through multiple modes, enabling the development of advanced materials with medical applications. This review highlights the recent advancements of tannic acid-incorporated materials in medicine.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Medicine, Research & Experimental
Kelsey P. Kubelick, Mohammad Mehrmohammadi
Summary: Superparamagnetic nanoparticles have become an important tool in biomedicine due to their controllable small size, biocompatibility, and magnetic properties. The magnetically-induced motion of these nanoparticles has been investigated as a new source of imaging contrast. Multiple imaging modalities can utilize magneto-motive contrast to monitor smaller scale biological events with enhanced contrast and sensitivity.
Article
Multidisciplinary Sciences
Leonardo Ayala, Tim J. Adler, Silvia Seidlitz, Sebastian Wirkert, Christina Engels, Alexander Seitel, Jan Sellner, Alexey Aksenov, Matthias Bodenbach, Pia Bader, Sebastian Baron, Anant Vemuri, Manuel Wiesenfarth, Nicholas Schreck, Diana Mindroc, Minu Tizabi, Sebastian Pirmann, Brittaney Everitt, Annette Kopp-Schneider, Dogu Teber, Lena Maier-Hein
Summary: Laparoscopic surgery is a key technique for cancer diagnosis and therapy, but visually inspecting tissue perfusion remains challenging. We developed a laparoscopic real-time multispectral imaging system, providing functional information at a video rate of 25 Hz. By using an ensemble of invertible neural networks, we enable contrast agent-free ischemia monitoring during laparoscopic partial nephrectomy, demonstrating the feasibility of our approach and the potential of spectral imaging combined with deep learning-based analysis tools for functional laparoscopic imaging.
Article
Chemistry, Multidisciplinary
Swati Kataria, Jifa Qi, Ching-Wei Lin, Zhongming Li, Eric L. Dane, Archana Mahadevan Iyer, Jay Sacane, Darrell J. Irvine, Angela M. Belcher
Summary: Only a minority of patients benefit from cancer immunotherapy, and researchers are actively trying to address this variability. The infiltration of immune cells into tumors is a vital indicator of response and survival, but noninvasive sampling of immune cells in the tumor microenvironment remains limited. In this study, researchers demonstrate the use of rare-earth nanocrystals for noninvasive imaging of tumor-infiltrating T-cells in an aggressive melanoma model.
Review
Medicine, Research & Experimental
Beatriz Brito, Thomas W. Price, Juan Gallo, Manuel Banobre-Lopez, Graeme J. Stasiuk
Summary: This review introduces smart theranostics that integrate multiple functions, especially responsive agents for MRI, aiming to improve cancer therapy efficiency and diagnostic accuracy. The challenges and obstacles in the design and application are also discussed.
