Article
Cell Biology
Desiree Forstner, Jacqueline Guettler, Beatrice A. Brugger, Freya Lyssy, Lena Neuper, Christine Daxboeck, Gerhard Cvirn, Julia Fuchs, Kristin Kraeker, Alina Frolova, Daniela S. Valdes, Christina Stern, Birgit Hirschmugl, Herbert Fluhr, Christian Wadsack, Berthold Huppertz, Olivia Nonn, Florian Herse, Martin Gauster
Summary: Tissue insults in response to inflammation, hypoxia and ischemia cause the release of ATP, which modulates various pathological processes. CD39 and CD73 are two major enzymes that convert extracellular ATP into adenosine. This study investigated the expression of CD39 and CD73 in placental tissue and their regulation in response to platelet-derived factors and oxygen conditions. The results showed that placental CD39 expression increased in preeclampsia and platelet-derived factors led to deregulated CD39 expression. CD39 overexpression decreased extracellular ATP levels and abolished the upregulation of pro-inflammatory cytokine interleukin-1 beta. These findings suggest that increased placental CD39 could be an important anti-coagulant defense mechanism of the placenta.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Justyna Suwara, Ewa Radzikowska-Cieciura, Arkadiusz Chworos, Roza Pawlowska
Summary: ATP is a crucial molecule for nucleic acids biosynthesis and intracellular energy storage, but it also functions as a signaling molecule. This article summarizes the latest data on the role of ATP in intra- and extracellular signaling pathways, including purinergic signaling, MAP kinase pathway, mTOR, and calcium signaling. The importance of ATP-dependent processes in maintaining the proper functioning of various systems and the potential pathological consequences of ATP imbalance are discussed, including neurodegenerative diseases, cardiovascular diseases, diabetes, obesity, cancers, and immune pathogenesis.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Naina Kumar
Summary: Male infertility is a major concern, with mitochondria being a crucial organelle involved in sperm function. Sperm mitochondria play a vital role in energy production, reactive oxygen species production, calcium signaling, apoptosis, and hyperactivation of sperm. Dysfunction of sperm mitochondria leads to increased reactive oxygen species, oxidative stress, reduced energy production, DNA damage, impaired motility, and reduced fertility. Mutations in sperm mitochondrial DNA are also linked to male infertility.
CURRENT MOLECULAR MEDICINE
(2023)
Review
Endocrinology & Metabolism
Nadine Mundt, Lina Kenzler, Marc Spehr
Summary: Adenosine triphosphate (ATP) is not only the essential source of cellular energy, but also functions as an extracellular signal that activates purinergic receptors. Purinergic signaling plays a crucial role in male reproductive system functions, particularly in spermatogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Waldemar Schaefer, Tobias Staehler, Carolina Pinto Espinoza, Welbeck Danquah, Jan Hendrik Knop, Bjoern Rissiek, Friedrich Haag, Friedrich Koch-Nolte
Summary: P2X7, an ion channel gated by extracellular ATP, plays important roles in inflammation and apoptosis. Polymorphisms in the P2X7 gene are common, and their frequencies vary among different human populations. Considering P2X7 variants of participants is important in designing clinical trials targeting P2X7.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nathalie Le Foll, Jean-Christophe Pont, Audrey L'Hostis, Thomas Guilbert, Frederic Bouillaud, Jean-Philippe Wolf, Ahmed Ziyyat
Summary: cFEE improves gamete interaction in humans by enhancing sperm movement parameters and increasing the percentage of hyperactivated sperm. However, it does not significantly impact the analyzed mitochondrial bioenergetic parameters, indicating that it may act through a more efficient use of energy resources.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Duo Wang, Zirui Zeng, Mengyue Shen, Ryuji Okazaki, Hironori Miyata, Tomo Yonezawa, Yasuhiro Yoshida
Summary: Neutrophil endocytosis is closely related to ATP-centered energy metabolism. Inhibition of dynamin inhibits ATP consumption triggered by neutrophil endocytosis, while inhibition of ATP synthase and nicotinamide adenine dinucleotide phosphate oxidase suppresses neutrophil endocytosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Estefaniia Delgado-Pinar, Matilde Medeiros, Telma Costa, J. Sergio Seixas de Melo
Summary: Chemical derivatives of PEI with either TPA or Cou can form stable complexes with adenine and guanine nucleotides in water based on noncovalent interactions such as pi-pi stacking and hydrogen bonding. PEI-TPA acts as a chemosensor with recognition based on AIE and pi-pi interaction, while the Cou derivative relies on electrostatic interaction. The study provides valuable insights into designing receptors for selective recognition of nucleotides in water.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Developmental Biology
Qiushi Wang, Ruijun He, Lianwan Chen, Qi Zhang, Jin Shan, Peng Wang, Xia Wang, Yanmei Zhao
Summary: In nematodes, MIG-23 regulates sperm migration by modulating extracellular ATP levels, which is essential for major sperm protein dynamics and sperm motility.
Article
Biology
Jack Greiner, Thomas Glonek
Summary: The lens and muscle tissues have high concentrations of ATP despite low metabolic requirements, suggesting a non-metabolic function of ATP in cellular and tissue function evolution.
Article
Neurosciences
Yaru Xu, Ge Gao, Xiaoru Sun, Qidong Liu, Cheng Li
Summary: Postoperative delirium (POD) is a major complication after surgery with general anesthesia, and the neurotoxicity of general anesthetics plays a key role. Sevoflurane, a common general anesthetic, is shown to induce inflammatory response and caspase-3 activation through upregulation of ATPIF1 in microglia. ATP supplementation may be a potential therapeutic strategy for alleviating sevoflurane-induced POD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Environmental Sciences
Tania Paola Mendoza-Tinoco, Victor Sanchez-Vazquez, Maria del Carmen Fajardo-Ortiz, Ignacio Gonzalez, Ricardo Beristain-Cardoso
Summary: This review focuses on the biochemical aspects of anaerobic digestion (AD) and the influence of a low-magnitude electric field (LMEF) on metabolisms during wastewater treatment and methane production enhancement.
Article
Environmental Sciences
Renjie Pan, Kejia Zhang, Cheng Cen, Xinyan Zhou, Jia Xu, Jiajia Wu, Xiaogang Wu
Summary: The study shows that switching to improved water quality may initially lead to bacteria release in the distribution system, but after 42 days, the biofilm gradually stabilizes, leading to an improvement in water quality.
ENVIRONMENTAL POLLUTION
(2021)
Article
Cardiac & Cardiovascular Systems
William D. Watson, Peregrine G. Green, Andrew J. M. Lewis, Per Arvidsson, Giovanni Luigi De Maria, Hakan Arheden, Einar Heiberg, William T. Clarke, Christopher T. Rodgers, Ladislav Valkovic, Stefan Neubauer, Neil Herring, Oliver J. Rider
Summary: The study shows that even in nonischemic heart failure patients with severely impaired systolic function, the heart retains significant metabolic flexibility, including the ability to change substrate use to match arterial supply and workload changes. Increasing the uptake and oxidation of long-chain fatty acids is associated with improved myocardial energetics and contractility.
Article
Chemistry, Multidisciplinary
Shampa Kundu, Md Majharul Islam, Sukhendu Mandal, Prithidipa Sahoo
Summary: A unique fluorescence chemosensing method has been developed for the simultaneous selective determination of ATP. Through UV-vis and fluorescence measurements, NMR titrations, and TDDFT calculations, the sensing mechanism and electronic properties of the receptor-donor complex were thoroughly studied. This method has been successfully used to detect and quantify ATP in human cancer cells.
NEW JOURNAL OF CHEMISTRY
(2021)