Article
Multidisciplinary Sciences
Spiro Khoury, Volker Gudziol, Stephane Gregoire, Stephanie Cabaret, Susanne Menzel, Lucy Martine, Esther Meziere, Vanessa Soubeyre, Thierry Thomas-Danguin, Xavier Grosmaitre, Lionel Bretillon, Olivier Berdeaux, Niyazi Acar, Thomas Hummel, Anne Marie Le Bon
Summary: This study examined the lipid composition of the nasal mucosa, finding that saturated and polyunsaturated fatty acids were the predominant types present. It also suggested a positive correlation between arachidonic acid levels in the nasal mucosa and olfactory deficiency, as well as a potential use of plasma cholesteryl esters as an indicator of nasal arachidonic acid levels.
SCIENTIFIC REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Shishir Ram Shetty, Saad Wahby Al Bayatti, Natheer Hashim Al-Rawi, Hesham Marei, Sesha Reddy, Hossam Abdelatty Abdelmagyd, Sangeetha Narasimhan, Sausan Al Kawas, Asok Mathew
Summary: The width of inferior turbinates and presence of concha bullosa are associated with the degree of nasal septal deviation (NSD). Cone beam computed tomography (CBCT) is recommended for evaluating NSD, concha bullosa, and associated inferior turbinate hypertrophy due to its low radiation dose and accurate imaging capabilities.
Letter
Oncology
Dong Hoon Lee, Sang Chul Lim
Summary: The use of nasal cavity mucosal flap to cover the suprastructure maxillectomy cavity was effective in improving the patient's quality of life by minimizing wound problems and facial contour changes despite postoperative radiotherapy.
Article
Neurosciences
Chun-Gu Hong, Meng-Lu Chen, Ran Duan, Xin Wang, Zhi-Lin Pang, Li-Te Ge, Ming Lu, Hui Xie, Zheng-Zhao Liu
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease that is currently incurable. Transplantation of olfactory mucosa mesenchymal stem cells (OM-MSCs) can alleviate symptoms of AD, promote amyloid-beta clearance, and improve cognitive learning and locomotive behavior.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Amr Seifelnasr, Xiuhua April Si, Jinxiang Xi
Summary: This study proposes a new strategy to effectively deliver high doses to the olfactory region while minimizing drug losses in other regions of the nasal cavity. Through systematic evaluation in a 3D-printed anatomical model, it was found that a head position tilting 45-60 degrees, two doses, and no inhalation flow could achieve optimal olfactory deposition. An olfactory deposition fraction of 22.7 ± 3.7% was achieved with these optimized delivery variables.
Article
Otorhinolaryngology
Onur Ismi, Feyzi Mese, Harun Gur, Iclal Gurses, Yusuf Vayisoglu, Kemal Gorur, Cengiz Ozcan
Summary: This study investigated the correlation between the quantity of olfactory neuroepithelium in the middle turbinate and the postoperative olfactory function for middle turbinate concha bullosa patients. The results showed that the quantity of olfactory mucosa was not a determining factor for the postoperative smell function degree, suggesting that the olfactory deficit in these patients is more likely related to obstruction rather than the status of the middle turbinate's olfactory mucosa.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Article
Anthropology
Ingrid K. Lundeen, Richard F. Kay
Summary: The phyletic position of early Miocene platyrrhine Homunculus patagonicus is currently debated, with some considering it an early member of Pitheciidae and others viewing it as a stem platyrrhine. New details of its internal nasal anatomy help in resolving this debate and provide insight into the evolution of modern platyrrhine olfactory sensitivity. The fossil record data support the hypothesis that Homunculus functionally converged on modern platyrrhines rather than being an early representative of any extant clade.
JOURNAL OF HUMAN EVOLUTION
(2022)
Article
Pharmacology & Pharmacy
Harry Chiang, Hannah L. Martin, Ryan M. Sicard, Dennis O. Frank-Ito
Summary: This study investigates the effects of nasal midvault surgery on olfactory drug delivery. The results suggest that smaller particle size, slower spray velocity, and higher inhalation rate tend to optimize olfactory drug deposition.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Anatomy & Morphology
Timothy D. Smith, Brent A. Craven, Serena M. Engel, Blaire Van Valkenburgh, Valerie B. DeLeon
Summary: The study assessed mucosal thickness of the nasal fossa using high resolution mu-CT and histology in a cadaveric adult dog, finding that olfactory mucosa is thicker on average compared with non-olfactory mucosa and has lesser variability. Future work could explore the utility of diffusible iodine-based contrast enhanced CT techniques to differentiate mucosa types more effectively.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2021)
Article
Anatomy & Morphology
Asaad Abd Al-Hussain Mohammad Al-Shouk, Ilkan Tatar
Summary: The blood supply of the lateral nasal wall plays a crucial role in the treatment of clinical conditions such as epistaxis and endoscopic sinus and skull base surgeries. Detailed anatomical knowledge of the lateral nasal wall vasculature is important for successful treatment and closure of defects, reducing intraoperative bleeding and increasing endoscopic exposure.
ANATOMICAL SCIENCE INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Carlotta Pipolo, Daniele Bottai, Emanuela Fuccillo, Eleonora Aronica, Fabio Bruschi, Antonio Mario Bulfamante, Luca Castellani, Maria Paola Canevini, Davide Chiumello, Sergio Ferrari, Carla Martinelli, Stefano Muttini, Alberto Priori, Alberto Maria Saibene, Chiara Spoldi, Delfina Tosi, Gianluigi Zanusso, Gaetano Pietro Bulfamante, Giovanni Felisati
Summary: This study detected the presence of SARS-CoV-2 in the olfactory neuroepithelium of patients affected by COVID-19 and demonstrated the potential use of nasal brushing as a non-invasive procedure for detecting SARS-CoV-2 in the olfactory mucosa.
Article
Dentistry, Oral Surgery & Medicine
Pranidhi Baddam, Claudine Thereza-Bussolaro, Carlos Flores-Mir, Daniel Graf
Summary: This study investigated the presence of structural anomalies in the nasal cavity in patients at high risk or not of sleep-disordered breathing. The prevalence of subjective DNS and TH assessment was higher than objective assessments. Older patients are more likely to present with DNS.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2021)
Article
Biology
Ya Zhang, Zhenzhen Hu, Yusheng Wang, Miao Lou, Ruiping Ma, Minjie Gong, Jingliang Dong, Guoxi Zheng, Botao Wang
Summary: This study investigates the transport and deposition characteristics of inhaled nanoparticles in pediatric nasal airways with adenoid hypertrophy (AH), focusing on the olfactory region. Virtual nanoparticle inhalation studies were conducted on anatomically accurate child nasal airway models using computational fluid-particle dynamics (CFPD) method. The results show that nasopharyngeal obstruction leads to uneven airflow distribution and concentration of deposited nanoparticles in specific regions. The deposition efficiency in the olfactory region decreases with increasing nanoparticle size during inhalation. After adenoidectomy, ventilation and particle deposition in the olfactory region are significantly improved. Inhalation rate and exhalation process have a significant impact on nanoparticle deposition in the olfactory region.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Otorhinolaryngology
Xiangming Meng, Guochen Zhu
Summary: This narrative review provides an overview of the existing knowledge on nasal septal swell bodies (NSB), highlighting the lack of unified terminology, close relationship with the internal nasal valve, association with nasal diseases, and the potential for obstruction due to NSB hypertrophy. Surgical procedures for NSB have shown preliminary effectiveness, but long-term outcomes remain uncertain, emphasizing the need for more evidence to fully understand its physiological effects.
ENT-EAR NOSE & THROAT JOURNAL
(2021)
Article
Otorhinolaryngology
Maja S. Bogdan, Danijel O. Slavic, Sinisa S. Babovic, Biljana S. Zvezdin, Violeta P. Kolarov, Vladimir L. Kljajic
Summary: In this study, it was found that total nasal resistance and NOSE score were significantly lower in the luteal phase of the menstrual cycle. Odor identification ability was higher in the luteal phase, while odor intensity was higher in the ovulatory phase. The decongestive response of the nasal mucosa was better during the ovulatory phase.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2021)