Article
Engineering, Biomedical
Gaoyang Guo, Jinpeng Hu, Fan Wang, Daihua Fu, Rifang Luo, Fanjun Zhang, Cheng Hu, Juan Chen, Xiangbin Pan, Li Yang, Yunbing Wang, Xingdong Zhang
Summary: Degradable heart occluders are promising replacements for currently used non-degradable ones, offering a potentially superior approach for repairing congenital VSD without interfering with the normal function of the heart. We developed a fully degradable VSD occluder with excellent shape recovery and secure fixation ability. The occluder provided robust fixation for the first 3 months and was completely absorbed within 12 months. Our degradable occluder showed desired occlusion and no complications in canines during a 24-month follow-up, demonstrating its potential clinical application.
Article
Cardiac & Cardiovascular Systems
Connor P. Callahan, Anusha Jegatheeswaran, David J. Barron, S. Adil Husain, Stephanie Fuller, David M. Overman, Brian W. McCrindle
Summary: This study aimed to determine factors associated with mortality after biventricular repair of atrioventricular septal defect (AVSD). The results showed that atrial fenestration placed during repair was associated with reduced long-term survival, challenging the routine practice of fenestration.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Oncology
Qian Li, Ying Tong, Guanzhong Gong, Yong Yin, Yaping Xu
Summary: This study quantified the margin of internal risk volume (IRV) on the atrial septum (AS) and ventricular septum (VS) based on ECG-gating 4DCT, finding that the margins could cover the movement of AS and VS induced by heartbeat in three directions. The emendatory margins significantly improved the coverage rates.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Thirza A. Berk, Thomas L. de Kroon, Martin J. Swaans, Bart P. van Putte
Summary: Interventricular septum defects are a known complication after aortic valve replacement, but rarely occur after mitral surgery. We report a case of a 65-year-old female who had unsuccessful mitral valvuloplasty followed by mechanical bioprosthesis replacement. Postoperatively, she developed multiple arrhythmias and poor recovery. Echocardiography revealed an interventricular septum rupture, which was repaired using polypropylene pledgeted mattress sutures via the right atrium and tricuspid valve. The tearing of deeply placed adjacent sutures is believed to be the most likely cause for localized weakening of the septum, emphasizing the importance of adequate exposure during surgery.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Pediatrics
Sara Hirani Lau-Jensen, Benjamin Asschenfeldt, Lars Evald, Vibeke E. Hjortdal
Summary: Patients with simple congenital heart defects have a higher symptom burden across all ADHD scores and all symptom sub-scores, with both inattention and hyperactivity symptoms driving the higher burden of ADHD. Close relatives were less aware of the inattention symptoms than the congenital heart defect patients themselves. Routine screening for ADHD symptoms may be warranted to facilitate adequate help and guidance as these symptoms are easily overlooked.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
Susanne J. Maurer, Lorena Moosholzer, Claudia Pujol, Nicole Nagdyman, Peter Ewert, Oktay Tutarel
Summary: This study aimed to analyze the outcomes of adults over the age of 40 with complete atrioventricular septal defects (cAVSD), finding significant morbidity and mortality in this patient population. The New York Heart Association (NYHA) class at the beginning of follow-up was identified as the only predictor for a worse outcome in these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Yuya Yamada, Kazushi Yasuda, Yukiko Hata, Naoki Nishida, Keiichi Hirono
Summary: This study reported a pediatric case of a 12-year-old girl with congenital heart disease and left ventricular noncompaction (LVNC) who had a novel variant in the NKX2-5 gene. The findings suggest that NKX2-5 variants should be considered in cases with LVNC, congenital heart disease, arrhythmia, and syncope to prevent sudden cardiac death.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Victor Waldmann, Francis Bessiere, Kevin Gardey, Sebastien Hascoet, Roland Henaine, Laurence Iserin, Magalie Ladouceur, Damien Bonnet, Eloi Marijon, Alice Maltret, Nicolas Combes, Natasja de Groot
Summary: This study aimed to investigate the main mechanisms of atrial tachyarrhythmias in patients with atrioventricular septal defect (AVSD) and analyse the outcomes after catheter ablation. The study found that most circuits involved the cavo-annular isthmus, but complex mechanisms were frequently encountered in patients who underwent repeated procedures. The acute success rate was excellent, but recurrences were common during follow-up.
Article
Medicine, General & Internal
Jakub Mercik, Aleksandra Gajek-Marecka, Jacek Marcin Zawadzki, Agnieszka Slawuta, Jacek Gajek
Summary: The study focused on a 74-year-old female patient with sick sinus syndrome (SSS) who had a previously implanted physiological DDD/R pacemaker. The pacing system located in the low interatrial septal region reduced P-wave duration but did not prevent the development of atrial arrhythmias.
Article
Clinical Neurology
Ruchi Kapoor, Lara Wadi, Brian Becerra, Michael Eskander, Ali Razmara, Dawn Lombardo, Annlia Paganini-Hill, Jin Kyung Kim, Mark Fisher
Summary: The study found a significant association of Left Atrial Septal Pouch (LASP) with the risk of cryptogenic stroke, suggesting LASP may function as a thromboembolic nidus. Additional studies are required to determine the generalizability of these findings and their therapeutic implications, supporting LASP as a stroke risk factor.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Mariel E. Turner, Ismail Bouhout, Christopher J. Petit, David Kalfa
Summary: The field of congenital interventional cardiology has grown significantly in recent years, with percutaneous device closure becoming a mainstay of treatment for many septal defects. This review discusses the current state, patient selection, procedural approach, and outcomes of transcatheter closure of atrial septal defects (ASDs) and ventricular septal defects (VSDs) in children and adults, as well as potential areas for future evolution and innovation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Lorenzo Longinotti, Biagio Castaldi, Francesco Bertelli, Vladimiro L. Vida, Massimo A. Padalino
Summary: This article reports a case of multiple apical complex muscular ventricular septal defects in a child closed through a hybrid approach with the aid of a 3-dimensional printed model. Three-dimensional reconstruction is helpful for surgeons to better understand and manage the location and structure of congenital cardiac defects.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Ahmed M. Al-Kaisey, Ramanathan Parameswaran, Robert Anderson, Joshua Hawson, Michael Nam, Hariharan Sugumar, David Chieng, Troy Watts, Alex McLellan, Peter M. Kistler, Geoffrey Lee, Jonathan M. Kalman
Summary: This study demonstrated complete wave front dissociation between the left and right interatrial septum in patients with persistent atrial fibrillation. The findings suggest that the two sides of the septum function as electrically discrete structures and may have implications for mapping and ablation of persistent atrial fibrillation.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Javier Ramos Jimenez, Alvaro Marco del Castillo, Daniel Rodriguez Munoz, Luis Borrego Bernabe, Adolfo Fontenla, Maria Lopez Gil
Summary: During surgery, interatrial dissociation and complete block of the sinus impulse to the AV node were observed.
Activation of the AV node became dependent on a subsidiary left atrial rhythm.
Anatomical location of intra and inter-atrial connections must be considered when performing extensive ablation procedures.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Li Lin, Jianwen Liu, Xiufen Guo, Hang Chen, Yu Huang, Huiying Zheng, Wanhua Chen, Lianglong Chen, Liangwan Chen, Zhaoyang Chen
Summary: The study found that the incidence of permanent CAVB after pmVSD closure was 0.7%, with only 0.5% requiring PPM implantation. The ratio of device to defect size was identified as the only independent risk factor for permanent CAVB.