Extracellular Vesicles in Alzheimer’s Disease: Friends or Foes? Focus on Aβ-Vesicle Interaction

Autophagy-Related Protein 7 Deficiency in Amyloid β (Aβ) Precursor Protein Transgenic Mice Decreases Aβ in the Multivesicular Bodies and Induces Aβ Accumulation in the Golgi

(2015) Per Nilsson et al.   AMERICAN JOURNAL OF PATHOLOGY

Invited review: Prion-like transmission and spreading of tau pathology

(2015) Florence Clavaguera et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease

(2014) Federica Agosta et al.   ANNALS OF NEUROLOGY

A potential function for neuronal exosomes: Sequestering intracerebral amyloid-β peptide

(2014) Kohei Yuyama et al.   FEBS LETTERS

Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice

(2014) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease

(2014) L Kordelas et al.   LEUKEMIA

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes

(2014) Soyon Hong et al.   NEURON

Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum

(2014) Giovanni Meli et al.   Nature Communications

Truncated and modified amyloid-beta species

(2014) Markus P Kummer et al.   Alzheimers Research & Therapy

Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

(2013) P Joshi et al.   CELL DEATH AND DIFFERENTIATION

Classical and unconventional pathways of vesicular release in microglia

(2013) Ilaria Prada et al.   GLIA

The Pathogenic Aβ43 Is Enriched in Familial and Sporadic Alzheimer Disease

(2013) Anna Sandebring et al.   PLoS One

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

(2013) Takeshi Katsuda et al.   Scientific Reports

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo

(2013) Kyongman An et al.   Molecular Brain

Extracellular membrane microvesicles and nanotubes in the brain: understanding their nature, their function in cell-to-cell communication, their role in transcellular spreading of pathological agents and their therapeutic potential

(2013) Claudia Verderio   Frontiers in Physiology

Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders

(2012) Anja Schneider et al.   CELL AND TISSUE RESEARCH

Novel AβIsoforms in Alzheimer's Disease - Their Role in Diagnosis and Treatment

(2012) Erik Portelius et al.   CURRENT PHARMACEUTICAL DESIGN

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

(2012) Rocio Perez-Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

(2012) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotoxicity and Memory Deficits Induced by Soluble Low-Molecular-Weight Amyloid- 1-42 Oligomers Are Revealed In Vivo by Using a Novel Animal Model

(2012) J. Brouillette et al.   JOURNAL OF NEUROSCIENCE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in thetrans-Golgi network

(2012) Regina Wai-Yan Choy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Trafficking Pathways in Alzheimer's Disease

(2012) Lawrence Rajendran et al.   TRAFFIC

Potential Contribution of Exosomes to the Prion-Like Propagation of Lesions in Alzheimer’s Disease

(2012) Valérie Vingtdeux et al.   Frontiers in Physiology

Microvesicles: Novel Biomarkers for Neurological Disorders

(2012) Elisa Colombo et al.   Frontiers in Physiology

Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases?

(2012) Shayne A. Bellingham et al.   Frontiers in Physiology

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles

(2011) Diana Simón et al.   FEBS LETTERS

Protein Targeting to Exosomes/Microvesicles by Plasma Membrane Anchors

(2011) Beiyi Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced Spine Density in Specific Regions of CA1 Pyramidal Neurons in Two Transgenic Mouse Models of Alzheimer's Disease

(2011) C. Perez-Cruz et al.   JOURNAL OF NEUROSCIENCE

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

(2011) Jan Bieschke et al.   Nature Chemical Biology

Potent amyloidogenicity and pathogenicity of Aβ43

(2011) Takashi Saito et al.   NATURE NEUROSCIENCE

Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer’s disease

(2010) Erik Portelius et al.   ACTA NEUROPATHOLOGICA

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

(2010) Irfan Y. Tamboli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion-like transmission of protein aggregates in neurodegenerative diseases

(2010) Patrik Brundin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Cystatin C is released in association with exosomes: A new tool of neuronal communication which is unbalanced in Alzheimer's disease

(2009) Roberta Ghidoni et al.   NEUROBIOLOGY OF AGING

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

(2009) Adriano Aguzzi et al.   NEURON

Paracrine Diffusion of PrPC and Propagation of Prion Infectivity by Plasma Membrane-Derived Microvesicles

(2009) Vincenzo Mattei et al.   PLoS One

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Inhibition of γ-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

(2008) Robyn A. Sharples et al.   FASEB JOURNAL

Exosomes: The Trojan horses of neurodegeneration

(2008) Roberta Ghidoni et al.   MEDICAL HYPOTHESES