期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 16, 期 7, 页码 15872-15902出版社
MDPI
DOI: 10.3390/ijms160715872
关键词
coarse-grained; atomistic; empirical force field; catalytic mechanism; editing
资金
- Wake Forest University Center for Molecular Communication and Signaling
- National Science Foundation [MCB-1052402]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1052402] Funding Source: National Science Foundation
While tRNA and aminoacyl-tRNA synthetases are classes of biomolecules that have been extensively studied for decades, the finer details of how they carry out their fundamental biological functions in protein synthesis remain a challenge. Recent molecular dynamics (MD) simulations are verifying experimental observations and providing new insight that cannot be addressed from experiments alone. Throughout the review, we briefly discuss important historical events to provide a context for how far the field has progressed over the past few decades. We then review the background of tRNA molecules, aminoacyl-tRNA synthetases, and current state of the art MD simulation techniques for those who may be unfamiliar with any of those fields. Recent MD simulations of tRNA dynamics and folding and of aminoacyl-tRNA synthetase dynamics and mechanistic characterizations are discussed. We highlight the recent successes and discuss how important questions can be addressed using current MD simulations techniques. We also outline several natural next steps for computational studies of AARS:tRNA complexes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据