期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 16, 期 12, 页码 28218-28229出版社
MDPI
DOI: 10.3390/ijms161226092
关键词
schizophrenia; autism; animal model; polyI:C; astrocyte; interleukin-6; interferon-induced transmembrane 3; matrix metalloproteinase 3; gut microbiome
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) (Tokyo, Japan) [15H06719, 26293053, 26670121, 15H01284]
- Ministry of Health, Labor and Welfare of Japan (Tokyo, Japan)
- Smoking Research Foundation of Japan
- Program for Promotion of Fundamental Studies in Health Sciences of National Institute of Biomedical Innovation (Tokyo, Japan)
- Grants-in-Aid for Scientific Research [26293053, 15H01284, 15H06719, 26670121] Funding Source: KAKEN
Increasing epidemiological evidence indicates that perinatal infection with various viral pathogens enhances the risk for several psychiatric disorders. The pathophysiological significance of astrocyte interactions with neurons and/or gut microbiomes has been reported in neurodevelopmental disorders triggered by pre- and postnatal immune insults. Recent studies with the maternal immune activation or neonatal polyriboinosinic polyribocytidylic acid models of neurodevelopmental disorders have identified various candidate molecules that could be responsible for brain dysfunction. Here, we review the functions of several candidate molecules in neurodevelopment and brain function and discuss their potential as therapeutic targets for psychiatric disorders.
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