期刊
ANALYTICAL LETTERS
卷 46, 期 1, 页码 107-119出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00032719.2012.706851
关键词
Artemisinin; Molecularly imprinted polymer; Solid-phase extraction
资金
- Natural Science Foundation of Hunan Province [11JJ6010]
- Hunan Provincial Education Department [10A115, 11C1203]
- Xiangtan University [2011XZX07]
Molecular imprinted polymer (MIP) was prepared through thermal polymerization by using artemisinin as the template molecule, styrene as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linker, and azobisisobutyronitrile (AIBN) as the initiator. Evaluated by static, kinetic, and bonding capacity adsorption tests, the polymer exhibited a special selective rebinding to artemisinin. Scatchard analysis revealed that two different binding sites were formed in the polymers. The novel imprinted polymer was used as a solid-phase extraction (SPE) sorbent for the extraction of artemisinin from Artemisia annua L., followed by HPLC-UV analysis. The maximum static adsorption capacity of the artemisinin-imprinted sorbent for artemisinin was 8.46 mg g-1.The application of artemisinin-imprinted polymers with high affinity and excellent selectivity toward artemisinin in SPE might offer a novel method for the enrichment and determination of the active ingredient in Chinese medicine.
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