期刊
ANALYTICAL CHEMISTRY
卷 90, 期 18, 页码 10858-10864出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.8b02196
关键词
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资金
- NSFC [21773046, 21775016, 21871069, 51703043, 51602083]
- China Postdoctoral Science Foundation [2016M600247]
- Postdoctoral Science Foundation [LBH-Z16066]
- Natural Science Foundation of Heilongjiang Province [E2016042, F2018014]
- Fundamental Research Funds for the Central Universities [HIT.NSRIF. 201830, N160502001]
In this paper, a signal-on electrochemiluminescence (ECL) cytosensing platform was developed based on nitrogen doped molybdenum oxynitride nanotube arrays (MoOxNyNTs) for the first time. The MoOxNy NTs exhibited excellent cathodic ECL behavior with 2-(dibutylamino)-ethanol (DBAE) as a coreactant. Owing to the surface plasmon resonance (SPR) of Au triggered by the ECL emission, the generation of hot electrons on AuNPs hampered DBAE to give off electrons and leads to the ECL quenching. This process could be hindered via adding barriers on the surface of AuNPs, such as antibody molecules and cells, to achieve the signal recovery. Based on the quenching-recovering mechanism, a facile label-free ECL cytosensor was constructed. The linear response of HepG2 cells was in the range of 50-13800 cells mL(-1) with a low detection limit of 47 cells mL(-1) (S/N = 3). Moreover, the proposed ECL cytosensor exhibits a satisfying performance in the practical application. Due to the anodic formation from a Mo metal substrate, the valuable feature is that the MoOxNy NTs-based ECL cytosensor can be used directly, thereby providing a stable and simplified ECL cytosensing platform for future clinical applications.
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