期刊
ANALYTICAL CHEMISTRY
卷 86, 期 13, 页码 6710-6714出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac501682y
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资金
- NIH (NIH) [R01 EB014277]
- NSF Center for Hierarchical Manufacturing (NSF) [CMMI-1025020]
- NSF SURE program
- Japan Society for the Promotion of Sciences (JSPS)
Synthetic host-guest chemistry is a versatile tool for biomedical applications. Characterization and detection of host-guest complexes in biological systems, however, is challenging due to the complexity of the biological milieu. Here, we describe and apply a mass spectrometric method to monitor the association and dissociation of nanoparticle (NP)-based host-guest interactions that integrates NP-assisted laser desorption/ionization (LDI) and matrix assisted laser desoption/ionization (MALDI) mass spectrometry. This LDI/MALDI approach reveals how NP surface functionality affects host-guest interactions in cells, information difficult to achieve using other techniques.
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