Article
Chemistry, Multidisciplinary
Vladimir Kesler, Kaiyu Fu, Yihang Chen, Chan Ho Park, Michael Eisenstein, Boris Murmann, H. Tom Soh
Summary: This study demonstrates a novel strategy to distinguish molecules with miniscule differences in chemical composition by tuning the surface charge state, which can address the cross-reactivity issues of electrochemical biosensors in complex samples. The strategy successfully distinguishes DOX and its primary metabolite DOXol, and can accurately quantify mixtures of these two molecules.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Tzu-Ling Liu, Stacey F. Bent
Summary: Area-selective atomic layer deposition (AS-ALD) is typically limited by the requirement of substrate materials with substantially different chemical properties. This study introduces a new process using self-assembled monolayers (SAMs) as inhibitors for achieving selective ALD on patterns with chemically similar materials. By utilizing differential reactivity of SAMs on various dielectric surfaces, the research demonstrates high selectivity for ZnO and Al2O3 ALD, opening up new possibilities for applications in next generation electronic devices.
CHEMISTRY OF MATERIALS
(2021)
Article
Astronomy & Astrophysics
Richard E. L. Higgins, David F. Fouhey, Dichang Zhang, Spiro K. Antiochos, Graham Barnes, J. Todd Hoeksema, K. D. Leka, Yang Liu, Peter W. Schuck, Tamas I. Gombosi
Summary: This paper introduces a deep-learning-based approach that can simulate the existing HMI pipeline results two orders of magnitude faster than current algorithms.
ASTROPHYSICAL JOURNAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seung Kwan Kang, Daewoon Kim, Seong A. Shin, Yu Kyeong Kim, Hongyoon Choi, Jae Sung Lee
Summary: This paper proposes a novel method for automatic quantification of amyloid PET using deep learning-based spatial normalization (SN) of PET images, which does not require MRI or CT images of the same patient. The accuracy of the method was evaluated and compared with MRI-parcellation-based PET quantification using FreeSurfer. The results showed that the deep learning-based method had stronger correlations with the FreeSurfer estimates than the SPM-based method using MRI.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Spectroscopy
Le Wang, Xiuhuan Wang, Xiaoyun Liu, Yu Wang, Xueyang Ren, Ying Dong, Ruolan Song, Jiamu Ma, Qiqi Fan, Jing Wei, AXiang Yu, Lanzhen Zhang, Gaimei She
Summary: NIR spectroscopy combined with chemometrics tools was used for fast discrimination and quantification of Curcumae Radix from four botanical origins. HPLC was employed to develop a method for simultaneous determination of six bioactive compounds in Curcumae Radix. A support vector machine regression (SVMR) model successfully predicted the content of germacrone.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemical Research Methods
Mo Zhu, Kai Kang, Kang Ning
Summary: The study introduces the Meta-Prism method, which allows for fast and accurate comparison and search of a large number of microbiome samples. The method utilizes three computational techniques and demonstrates superiority in speed and accuracy compared to current methods.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Biochemical Research Methods
Sahil Ahlawat, Kaustubh R. Mote, Sreejith Raran-Kurussi, Vipin Agarwal
Summary: Band Selective Spectral Spin-Diffusion (BASS-SD) is a method that enables selective proton-proton contacts in proteins. By using low-amplitude proton spinlock radio frequency pulses and fast MAS frequency, BASS-SD allows for selective polarization exchange in fully protonated molecules. This method can be used to observe protein structures and provide useful constraints for protein structure determination.
JOURNAL OF MAGNETIC RESONANCE
(2022)
Article
Chemistry, Applied
Ryoichi Doi
Summary: Research has shown that using hue-shifting techniques to create new grayscale images can improve the accuracy and precision of test strips in the quantification of biochemical substances. Additionally, this method demonstrates more significant correlations compared to previous methods, through the synergistic effects between linear measures and significant grayscale images.
COLORATION TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Tingting Han, Tao Song, Yu Bao, Wei Wang, Ying He, Zhenbang Liu, Shiyu Gan, Dongxue Han, Johan Bobacka, Li Niu
Summary: This study proposes a fast and sensitive coulometric signal transduction method for ion-selective electrodes (ISEs) using a two-compartment cell. By increasing the capacitance of the working electrode (WE), the measured cumulated charge is amplified, and the observed slope of the cumulated charge is linearly proportional to the change in K+ ion activity. Using a commercial K+-ISE as reference electrode (RE) and GC/RGO as WE in the coulometric signal transduction allows for decreased response time and detection of a 0.2% change in K+ concentration.
Article
Chemistry, Multidisciplinary
Ole N. Jensen, Michael Beyer, Morten K. Sorensen, Maria Kreimeyer, Niels Chr Nielsen
Summary: Low-field NMR technology provides higher precision for measuring ammonium nitrogen and total nitrogen in animal slurry, but slightly lower precision for total phosphorus measurement. This technique can be adapted for analysis at farms, in slurry tankers/transporters, in biogas digesters, or in laboratories.
Article
Medical Laboratory Technology
Andreas Breenfeldt Andersen, Thomas C. Bonne, Joar Hansen, Peter Oturai, Carsten Lundby
Summary: This study demonstrates that the semi-automated CO-rebreathing device can accurately measure small changes in blood volume and has a high correlation with the dual-isotope methodology. These findings are clinically relevant due to the method's simplicity, speed (no need for radioactive tracers, reduced time requirements), and the ability for repeated measurements within a single day.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Computer Science, Software Engineering
Ayaan M. Kazerouni, James C. Davis, Arinjoy Basak, Clifford A. Shaffer, Francisco Servant, Stephen H. Edwards
Summary: Educators are now evaluating the adequacy of students' software tests by incorporating mutation analysis, which provides a stronger measure compared to code coverage. Research shows that in large programming courses, costs can be reduced while maintaining accuracy by selecting a subset of mutation operators.
JOURNAL OF SYSTEMS AND SOFTWARE
(2021)
Article
Oncology
Yan Kong, Huanhuan Hu, Yangyang Shan, Zhen Zhou, Ke Zen, Yulu Sun, Rong Yang, Zheng Fu, Xi Chen
Summary: This study identified the lineage of 3'-terminal 2'-O-methyl plant miRNAs using oxidative deep sequencing and compared different methods for quantifying this RNA modification. The results showed that stem-loop RT-qPCR was the only suitable approach for quantifying 3'-terminal 2'-O-methyl miRNAs in plants and human tissues.
FRONTIERS OF MEDICINE
(2022)
Article
Virology
Nicky Craig, Sarah L. Fletcher, Alison Daniels, Caitlin Newman, Marie O'Shea, Wenfang Spring Tan, Amanda Warr, Christine Tait-Burkard
Summary: Studying the complete virus replication cycle of SARS-CoV-2 is crucial for identifying host factors and treatments. A direct lysis RT-qPCR method was developed that is fast, accurate, sensitive, and cost-effective for quantifying SARS-CoV-2 in culture supernatant. This method has wider applicability to other enveloped viruses.
Article
Environmental Sciences
Ameny Farhat, Jihen Elleuch, Faten Ben Amor, Mohamed Barkallah, Kirsty F. Smith, Idriss Ben Neila, Slim Abdelkafi, Imen Fendri
Summary: In this study, a real-time PCR (qPCR) method targeting the toxic dinoflagellate K. veneficum was developed. This highly specific method allows for accurate detection and quantification of the species in marine environments.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)