期刊
ANALYTICAL CHEMISTRY
卷 86, 期 6, 页码 3043-3047出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac4039652
关键词
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资金
- National University of Singapore via the Life Sciences Institute (LSI)
- Singapore National Research Foundation under CRP Award [2007-04]
- Biochemical Research Council [BMRC-SERC Diag-034]
Current mass spectrometry-based lipidomics aims to comprehensively cover wide ranges of lipid classes. We introduce a strategy to capture phospho-monoester lipids and improve the detection of long-chain base phosphates (LCB-Ps, e.g., sphingosine-1-phosphate). Ten novel LCB-Ps (d18:2, t20:1, odd carbon forms) were discovered and characterized in tissues from human and mouse, as well in D. rnelanogaster and S. cerevisiae. These findings have immediate relevance for our understanding of sphingosine-1-phosphate biosynthesis, signaling, and degradation.
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