Review
Food Science & Technology
Jun Bai, Yusong Zhou, Xin Luo, Jia Hai, Xuemeng Si, Jun Li, Huiyang Fu, Zhaolai Dai, Ying Yang, Zhenlong Wu
Summary: This review summarizes the characteristics, metabolism, toxicity, and deleterious effects of Zearalenone (ZEA) exposure in various tissues of animals. The article highlights the involvement of stress response signaling in ZEA toxicity and discusses potential therapeutic options for reducing the harmful effects of ZEA in animals.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Yurong Fu, Yongcheng Jin, Yue Tian, Hao Yu, Ruqi Wang, Huiyu Qi, Bo Feng, Jing Zhang
Summary: The synergistic effect of ZEA and LPS aggravates cytotoxicity by increasing the accumulation of ROS and MDA, decreasing MMP and SOD levels, and reducing GSH levels. Additionally, ZEA and LPS promote cell apoptosis by activating ER stress and suppressing anti-apoptotic proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yazhou Guo, Chen Yang, Rong Guo, Ruijie Huang, Yongxia Su, Shuai Wang, Yezi Kong, Jianguo Wang, Chengjian Tan, Chonghui Mo, Chenchen Wu, Baoyu Zhao
Summary: The study revealed that MCT exhibits significant cytotoxicity on primary rat hepatocytes and induces ER stress, leading to apoptosis. Inhibiting ER stress or knocking down CHOP can partially alleviate cell apoptosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Li Ma, Sirao Hai, Chenlong Wang, Chuangjiang Chen, Sajid Ur Rahman, Chang Zhao, Mansoor Ahmed Bazai, Shibin Feng, Xichun Wang
Summary: This study aimed to investigate the molecular mechanism of Zearalenone (ZEA)-induced dysfunction of mitochondria-associated endoplasmic reticulum membranes (MAM) in piglet Sertoli cells (SCs) through the endoplasmic reticulum stress (ERS) pathway. The results showed that ZEA damaged cell viability, disrupted MAM structure, and altered protein expression of various markers related to MAM function. The inhibition of ERS reduced the cytotoxicity of ZEA and restored the normal function of MAM in SCs.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Agriculture, Dairy & Animal Science
Jun Bai, Jun Li, Ning Liu, Hai Jia, Xuemeng Si, Yusong Zhou, Zhian Zhai, Ying Yang, Fazheng Ren, Zhenlong Wu
Summary: This study investigated the toxicological effect and mechanism of Zearalenone (ZEA) exposure on reproduction in pigs during early stages of pregnancy. It was found that ZEA can cause cell cycle arrest, apoptosis, endoplasmic reticulum (ER) stress, and autophagy in trophoblast ectoderm cells. Furthermore, inhibiting ER stress can reduce cell death, suggesting a critical role of ER stress in the activation of autophagy.
Article
Pharmacology & Pharmacy
Yurong Song, Linlin Liu, Bin Liu, Rui Liu, Youwen Chen, Chenxi Li, Guangzhi Liu, Zhiqian Song, Cheng Lu, Aiping Lu, Yuanyan Liu
Summary: The study indicates that nobiletin protects renal function from MTX-induced nephrotoxicity by reducing the accumulation of 7-OH MTX and modulating the ER stress-related PERK/CHOP pathway.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Immunology
Garyfallia Gouna, Christian Klose, Mar Bosch-Queralt, Lu Liu, Ozgun Gokce, Martina Schifferer, Ludovico Cantuti-Castelvetri, Mikael Simons
Summary: Microglia play a key role in promoting myelin repair after demyelinating injury, with cholesterol esterification being essential for myelin debris clearance and lipid droplet generation. TREM2 is crucial for adapting to excess cholesterol exposure and regulating lipid droplet formation, ultimately impacting the innate immune response and remyelination.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yanyi Liu, Yueqin Zhu, Lili Wang, Kuayue Li, Na Du, Xuesheng Pan, Yangyang Li, Rui Cao, Bowen Li, Huimin Lin, Yonghu Song, Yunting Zhang, Xian Wu, Chengmu Hu, Yuanyuan Wang, Songyan Liao, Yan Huang
Summary: This study found that ASIC1a regulates TNF-alpha expression in LPS-induced ALI through the ERS-CHOP-C/EBP alpha signaling pathway. The results showed that blocking or silencing ASIC1a can reduce the expression of TNF-alpha, GRP78, and CHOP, and weaken intracellular Ca2+ influx. Immunoprecipitation results indicated that CHOP and C/EBP alpha interact in macrophages. Silencing CHOP increased C/EBP alpha expression and decreased TNF-alpha expression. Luciferase reporter results indicated that C/EBP alpha directly binds to TNF-alpha.
MOLECULAR IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hang Su, Yu Mei, Shuangxue Luo, Haixia Wu, Yan He, Yasunaga Shiraishi, Pingping Hu, Richard A. Cohen, Xiaoyong Tong
Summary: The substitution of SERCA2 C674 thiol accelerates the development of atherosclerosis by inducing ER stress and inflammation. This study highlights the importance of SERCA2 C674 redox state in the context of atherosclerosis and proposes a novel therapeutic strategy to combat atherosclerosis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mengdie Luo, Emmanuel Opoku, C. Alicia Traughber, Qimin Hai, Peggy Robinet, Stela Berisha, Jonathan D. Smith
Summary: The study showed that AKR and DBA/2 mouse macrophages exhibit different levels of free cholesterol and CHOP expression after cholesterol loading due to variations in the Soat1 gene. Inhibition of ACAT enzyme revealed that differences in free cholesterol levels were responsible for the differential induction of CHOP.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Nutrition & Dietetics
Bo Zhang, Jun-Ting Cao, Yong-Bao Wu, Ke-Xin Gao, Ming Xie, Zheng-Kui Zhou, Jing Tang, Shui-Sheng Hou
Summary: Riboflavin deficiency induces cell apoptosis by triggering endoplasmic reticulum stress and the CHOP pathway.
Article
Agriculture, Dairy & Animal Science
Xiaoya Li, Huali Chen, Zelin Zhang, Jiaxin Duan, Rongmao Hua, Xiaodi Li, Li Yang, Jianyong Cheng, Qingwang Li
Summary: This study investigated the therapeutic effect of isorhamnetin on ZEA-induced damage in porcine ovarian granulosa cells and elucidated its molecular mechanism. The results showed that isorhamnetin protected ovarian granulosa cells from ZEA-induced damage, promoting proliferation and alleviating apoptosis, endoplasmic reticulum stress, oxidative stress, and steroidogenesis disorder.
Article
Hematology
Lei Hua, Nianhui Yang, Yue Li, Kexiu Huang, Xinya Jiang, Fangshu Liu, Zhi Yu, Jie Chen, Jing Lai, Juan Du, Hui Zeng
Summary: The combination of metformin and venetoclax has been found to effectively inhibit the growth of AML cells both in vitro and in vivo. This combination treatment induces cell apoptosis and increases the expression levels of the endoplasmic reticulum stress-related marker CHOP, which plays a crucial role in the anti-leukemic activity.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Marihan S. Shafik, Abeer Bishr, Dalia M. El-Tanbouly, Amina S. Attia
Summary: This study found that rosuvastatin protects against colistin-induced renal injury by regulating the expression of miR-205 and EGLN2, activating the Nrf2 pathway, suppressing the ATF4/CHOP trajectory, and exerting antioxidant and anti-apoptotic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Environmental
Xudan Liu, Yao Chen, Huanhuan Wang, Yuting Wei, Ye Yuan, Qianqian Zhou, Fang Fang, Sainan Shi, Xiaojing Jiang, Yinqiao Dong, Xin Li
Summary: Arsenic is the primary toxicant among hazardous environmental chemicals, implicated in neurotoxicity such as cognitive dysfunction, neurodevelopmental changes, and neurodegenerative diseases. It is believed that sustained pro-inflammatory response may trigger arsenic-induced neurotoxicity, potentially involving microglia activation and release of pro-inflammatory cytokines. Further research is needed to clarify the role of these cytokines in arsenic-induced neurotoxicity.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Analytical
Lanjie Lei, Chao Zhao, Xiaofei Zhu, Shuai Yuan, Xing Dong, Yinxiu Zuo, Hong Liu
Summary: The study presents a nonenzymatic electrochemical sensor for wearable glucose monitoring, which demonstrates acceptable selectivity and reliability for continuous glucose detection up to 30 days, as well as good biocompatibility. A fully integrated wearable glucose monitoring system with wireless connectivity to a smartphone has been developed.
Article
Materials Science, Biomaterials
Lanjie Lei, Qizhuang Lv, Yan Jin, Hong An, Zhe Shi, Ge Hu, Yuze Yang, Xiangguo Wang, Lei Yang
Summary: The study identified poor vascular development as a key cause of thin endometrium and proposed inducing angiogenesis as an effective treatment strategy. By developing angiogenic hydrogel microspheres based on HAMA, the study demonstrated increased drug-loading ability, controlled drug-release rate, promotion of new blood vessel formation, and endometrial regeneration for thin endometrium treatment.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Materials Science, Multidisciplinary
Lanjie Lei, Xiangguo Wang, Yulin Zhu, Wentao Su, Qizhuang Lv, Dong Li
Summary: Growth factors are essential for regulating cellular responses in wound healing, and a novel multifunctional chitosan microsphere has been developed for efficient growth factor delivery and wound repair. The microspheres exhibit antibacterial properties and have been shown to significantly promote wound healing in a rat model.
MATERIALS & DESIGN
(2022)
Article
Engineering, Environmental
Xing Dong, Biao Ma, Lanjie Lei, Yichen Chen, Chengtao Xu, Chao Zhao, Hong Liu
Summary: This article reports the fabrication of three-dimensional (3D) NC material for minimally invasive bioassays in tumor interstitial fluid. The material showed enough mechanical strength and biocompatibility for penetration into mouse skin, and the highly ordered photonic structure on the surface greatly improved the sensitivity for fluorescence immunoassay of trace biomarkers. The method was successfully used to quantitatively detect TNF-alpha in mouse TIF, demonstrating its potential for future cancer diagnostics and treatment.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Jinlong Zhang, Rongrong Ye, Jason William Grunberger, Jiaqi Jin, Qianru Zhang, Raziye Mohammadpour, Nitish Khurana, Xianyu Xu, Hamidreza Ghandehari, Fenglei Chen
Summary: This study found that low doses of SNPs can enhance testosterone secretion by activating autophagy in PLCs. SNPs promote autophagy process by altering the expression levels of autophagy-related proteins. Furthermore, SNPs also increase the expression of steroidogenic acute regulatory protein, further enhancing testosterone production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Analytical
Lanjie Lei, Biao Ma, Chengtao Xu, Hong Liu
Summary: Cancer, a dangerous disease with high mortality rate, has attracted much attention. The development of tumor-on-chips (TOCs), which can model the dynamic microenvironment and interactions of tumor tissues, has provided a promising platform for oncology research. Integrated electrochemical biosensors have shown potential applications in cancer research at cellular and molecular levels in TOCs.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Cell Biology
Qianru Zhang, Jason William Grunberger, Nitish Khurana, Xin Zhou, Xianyu Xu, Hamidreza Ghandehari, Fenglei Chen
Summary: This study verifies the role of SNP-induced autophagy in regulating apoptosis in Leydig cells and demonstrates that autophagy alleviates SNP-induced cell apoptosis by modulating caspase 8 levels. Accumulation of SNPs in the testes leads to histological changes and a reduction in Leydig cell populations.
Article
Cell Biology
Fenglei Chen, Jiarong Sun, Yujing Wang, Jason William Grunberger, Zhen Zheng, Nitish Khurana, Xianyu Xu, Xin Zhou, Hamidreza Ghandehari, Jinlong Zhang
Summary: This study reveals the mechanisms of silica nanoparticles (SNPs) inducing follicular atresia and apoptosis in granulosa cells. SNPs are found to increase calcium ion concentration in the cytoplasm and activate endoplasmic reticulum (ER) stress. The PERK-ATF4-CHOP-ERO1 alpha pathway plays an essential role in SNP-induced ovarian toxicity, leading to apoptosis via IP3R1-mediated calcium mobilization.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mengrong Su, Lian Ruan, Xiaoyu Dong, Shujing Tian, Wen Lang, Minhui Wu, Yujie Chen, Qizhuang Lv, Lanjie Lei
Summary: Intelligent hydrogels have significant potential in biomedical engineering due to their good biocompatibility, rapid response, and stimulus response mode. In this article, a systematic review of the properties, types, mechanisms, materials, morphologies, and applications of smart hydrogels in biomedical engineering is conducted. The paper also discusses the shortcomings of current research and presents future prospects for the development of smart hydrogels in this field.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Analytical
Biao Ma, Jin Zhang, Gangsheng Chen, Yi Chen, Chengtao Xu, Lanjie Lei, Hong Liu
Summary: A simple and efficient method has been reported to create shape-programmable liquid metal fibers using gallium phase transition. These fibers offer enhanced stretchability and invariable conductance, making them suitable for various applications such as strain sensors and heart rate monitors.
Article
Engineering, Biomedical
Bin Wang, Qinglai Tang, Qian Yang, Mengmeng Li, Shiying Zeng, Xinming Yang, Zian Xiao, Xinying Tong, Lanjie Lei, Shisheng Li
Summary: Due to their unique properties such as low immunogenicity, biomimetic internal environment, tissue-and organ-like physicochemical properties, and functionalization potential, decellularized extracellular matrix (dECM) materials have gained considerable attention in tissue engineering. This review provides an overview of the composition of extracellular matrices and their role in stem-cell differentiation, discusses the advantages and disadvantages of existing decellularization techniques, and presents methods for the functionalization and characterization of decellularized scaffolds. Additionally, the review discusses the progress and shortcomings of using dECMs in cartilage, skin, nerve, and muscle repair, as well as the transplantation or regeneration of different whole organs, and examines the future prospects of refunctionalization in tissue and organ repair. It aims to systematize the application of functionalized dECMs in tissue/organ transplantation and keep researchers informed about the latest progress in dECM usage.
MATERIALS TODAY BIO
(2023)
Review
Engineering, Biomedical
Pu Yang, Yikun Ju, Yue Hu, Xiaoyan Xie, Bairong Fang, Lanjie Lei
Summary: This paper reviews the recent research advances in the application of 3D bioprinting in plastic surgery. It introduces the printing process and basic principles of 3D bioprinting technology, describes the currently available bioprinting materials, and analyzes the rationale for special dynamic 3D bioprinting. The focus is on the viable clinical applications and effects of 3D bioprinting in plastic surgery.
BIOMATERIALS RESEARCH
(2023)
Article
Chemistry, Analytical
Lanjie Lei, Chengtao Xu, Xing Dong, Biao Ma, Yichen Chen, Qing Hao, Chao Zhao, Hong Liu
Summary: Conventional enzyme-based glucose sensors using dissolved oxygen as the electron-transfer mediator may cause biased detection results, affect sensor response, and compromise long-term stability due to fluctuation of oxygen and continuous production of corrosive hydrogen peroxide. In this study, we introduce an oxygen-independent nonenzymatic glucose sensor based on water splitting-assisted electrocatalysis, which shows acceptable sensitivity, reliability, and biocompatibility for continuous glucose monitoring in hypoxic environments. This technique holds promise for monitoring glucose in clinically hypoxic patients.
Review
Polymer Science
Lanjie Lei, Yujing Bai, Xinyun Qin, Juan Liu, Wei Huang, Qizhuang Lv
Summary: This review introduces the wide applications of hydrogels in the field of biomedicine, including drug delivery and tissue regeneration. It covers the characteristics and crosslinking methods of natural and synthetic hydrogels, as well as the design and principle of intelligent hydrogels for drug release. The review also discusses the applications, limitations, and research directions of hydrogels in drug release and tissue engineering.
Article
Engineering, Environmental
Lanjie Lei, Yulin Zhu, Xinyun Qin, Senlin Chai, Guixiu Liu, Wentao Su, Qizhuang Lv, Dong Li
Summary: This study introduces novel multifunctional biohybrid microspheres for one-step protein separation and their application in chronic wound healing. By capturing and isolating the growth factor bFGF and combining with natural anti-inflammatory and anti-oxidative agents, these microspheres show significant promotion of angiogenesis in chronic wounds. This flexible and biohybrid microsphere system has potential for various bioactive proteins design and biomedical applications.
CHEMICAL ENGINEERING JOURNAL
(2021)