Article
Chemistry, Analytical
Lydia Colvin, Dandan Tu, Darin Dunlap, Alberto Rios, Gerard Cote
Summary: The field of glucose biosensors for diabetes management has been of great interest over the past 60 years. Continuous glucose monitoring (CGM) is important for better management of the disease. This study developed a glucose biosensor using ConA and a fluorescent probe, which showed promising results for subcutaneous glucose monitoring.
Article
Chemistry, Analytical
Satoshi Okada, Satoko Takayasu, Akira Sumiyoshi, Ichio Aoki, Hiroyuki Nakamura
Summary: The magnetic glucose sensor based on SPIO nanoparticles showed significant T2 changes in physiological glucose levels, with rapid responses to glucose detection and the ability to measure multiple samples within minutes using a benchtop MRI scanner. This relaxometric glucose sensor has the potential for high throughput direct assay of blood samples for point-of-care testing.
ANALYTICAL SCIENCES
(2021)
Article
Chemistry, Analytical
Qinghua Yu, Junhao Jiang, Zhiqiong Chen, Chuyi Han, Xianming Zhang, Shiyu Yang, Ping Zhou, Tao Deng, Chao Yu
Summary: The development of a multimodal photoluminescence bioplatform, R-CDs/B2O3, allows for simple and cost-effective glucose monitoring, with a good linear relationship observed. The fluorescent color variations of the gel were monitored using a UV lamp and processed with a smartphone, showing potential for portable serum glucose testing.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Electrical & Electronic
Trinh Bich Hoang, Bjorn Torger Stokke, Ulrik Hanke, Erik Andrew Johannessen, Agne Johannessen
Summary: The study utilized a quartz crystal microbalance to investigate the mass and viscoelastic properties associated with the binding of ConcanavalinA (Con A) and dextran in an affinity assay with varying glucose concentrations. The results showed that the system demonstrated a resolution equivalent to +/- 0.4mM in the presence of 40 mM glucose, with the mass changes depending on the viscoelastic properties of the lectin layer. The assay was reversible with a higher sensitivity to lower glucose concentrations, but with a decreasing signal magnitude for each cycle.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Soyeon Yoo, Kiyoon Min, Giyoong Tae, Min Su Han
Summary: A simple paper-based analytical device for glucose detection was developed using an artificial peroxidase-functionalized and glucose oxidase-loaded nanocarrier. The device quantitatively measured glucose in human serum and buffer, maintaining detection efficiency during storage at room temperature for 6 weeks. This PAD offers a sensitive and selective method for glucose detection using smartphone readout or naked-eye observation.
Article
Chemistry, Multidisciplinary
Seyed Mostafa Jafari, Saeed Masoum, Seyed Ali Hosseini Tafreshi
Summary: In this study, ACDs were synthesized from Chlorella vulgaris and utilized as sensors for glucose and hydrogen peroxide detection. The detection limits were found to be 2.84 µM and 975 nM, respectively, based on fluorescence quenching.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Devangsingh Sankhala, Abha Umesh Sardesai, Madhavi Pali, Kai-Chun Lin, Badrinath Jagannath, Sriram Muthukumar, Shalini Prasad
Summary: This paper introduces a highly novel and completely non-invasive sweat sensor platform technology that can measure and report glucose concentrations from passively expressed human eccrine sweat in real time. The study shows promising results in accurately capturing glucose progression trends.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Jun Sawayama, Shoji Takeuchi
Summary: A new type of hydrogel glucose sensor has been developed in this study, which effectively mitigates foreign body reactions and demonstrates good blood glucose monitoring capabilities in animal experiments.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Niyati H. Mudliar, Prabhakar M. Dongre, Prabhat K. Singh
Summary: Thrombin is an important enzyme involved in blood clotting pathways, and an imbalance in its activity is associated with various diseases. This study presents a simple, selective, sensitive, and label-free fluorescence detection scheme for Thrombin, offering robust quantification even in complex media. The scheme utilizes the interaction between Thrombin and a fluorescent complex of Heparin with a molecular rotor dye, providing a ratiometric response for accurate quantification.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Multidisciplinary
Vishal Kumar, Saurabh Kumar Saini, Neha Choudhury, Anshu Kumar, Binoy Maiti, Priyadarsi De, Mahesh Kumar, Soumitra Satapathi
Summary: In this study, optically resonant donor copolymers were utilized to enhance the sensitivity of a fluorescent copolymer towards electron-deficient nitroaromatic compounds (NACs) through ultrafast Forster resonance energy transfer (FRET). This method achieved a sensitivity of less than 1 mu M with a high Stern-Volmer constant. Comprehensive analysis using various spectroscopic techniques elucidated the quenching mechanism involved in the detection of NACs.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Engineering, Environmental
Pramod Kumar Mehta, Lok Nath Neupane, See-Hyoung Park, Keun-Hyeung Lee
Summary: The study synthesized an aggregation-induced emission fluorophore and developed a corresponding fluorescent peptidyl probe for selective detection of silver ions and silver nanoparticles in water. This fluorescent detection method allows for rapid and accurate quantification of silver nanoparticles in water.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Analytical
Zahra Rasouli, Marcel Maeder, Hamid Abdollahi
Summary: The study utilized the chemical system of interaction between boronic acids and diols to simultaneously determine the concentrations of glucose and fructose by changing pH values. Through optimizing the composition of sensor elements and using a nonlinear calibration method, accurate detection of analytes in different concentration ranges was achieved.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Tran Van Tam, Seung Hyun Hur, Jin Suk Chung, Won Mook Choi
Summary: Aniline functionalized graphene quantum dots (a-GQDs) are synthesized and modulated with phenyl boric acid (PBA) for glucose detection, demonstrating high sensitivity and selectivity. The paper-based fluorescent sensor using a-GQDs ink is prepared for portable devices, while the aGQDs/hydrogel film is evaluated for wearable and fiber optic-based sensors, exhibiting remarkable performance in glucose detection with excellent recyclability. Furthermore, the a-GQD/PBA system shows excellent biocompatibility in detecting glucose in HeLa cells, providing a novel approach for developing low-cost and flexible sensors for the portable and visual detection of glucose.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Engineering, Electrical & Electronic
Xiaoyong Chen, Wenwei Lin, Pin Xu, Lixin Chen, Wenwen Meng, Xuehao Hu, Hang Qu, Yukun Cui, Jinghua Sun
Summary: In this study, a glucose sensor with a low limit of detection and a wide measured range is proposed and experimentally demonstrated. The sensor is made of a plasmonic tilted fiber grating with a graphene oxide layer coated over the metallic surface, and pyrene-1-boric acid immobilized on the GO layer serves as bio-detectors for specific detection of glucose. The sensor has a fM-level limit of detection and a linear range of 1 fM - 10 pM within the measured range from 1 fM to 1 nM. The sensor shows good potentials for detecting glucose in sweat and tear in the future.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Chemistry, Applied
Hsin-Yueh Chang, Lien-Chen Fu, He-Shin Huang, Yao-Chun Yeh, Mei-Yu Yeh
Summary: Diabetes is a global public health issue with significant consequences for daily functioning and health. A glucose sensor based on hydrazide-hydrazone phenyl-boronic acid (PBA) molecules has been developed, which does not require alkaline agents. Compound 3a showed high sensitivity to glucose due to intramolecular Lewis acid-base interactions, while compound 3c demonstrated selective glucose detection through intermolecular Lewis acid-base interactions.