期刊
ANALYTICAL CHEMISTRY
卷 85, 期 15, 页码 7302-7307出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac401198d
关键词
-
资金
- National Natural Science Foundation of China [21175135, 21205119]
- National Basic Research program of China (973 program) [2010CB933600]
- 100 Talents program of the Chinese Academy of Sciences
Both Pb2+ and Ba2+ can bind with high affinity to some specific DNA sequences, inducing the formation of unimolecular G-quadruplex structures. Trans location of a DNA probe containing such sequences through an alpha-hemolysin nanopore in the presence of Pb2+ or Ba2+ . would result in much prolonged DNA translocation events. Quantification of these events can reveal the concentrations of Pb2+ or Ba2+ at as low as 0.8 nM. Besides, Pb2+ and Ba2+ in the solution can be simultaneously detected and individually identified. Furthermore, the probe is highly selective for Pb2+ and Ba2+ detection without interference from other metal ions. This sensing strategy can be extended to many other analytes which can bind to DNA molecules with high affinity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据