Article
Chemistry, Analytical
Mei Li, Wei Huang, Hong Chen, Dandan Jiang, Weiguo Wang, Yao Xiao, Chuang Chen, Haiyang Li
Summary: The DAPI-IMS technique utilizes a dopant and NH3 sample gas to achieve specific and sensitive detection of NH3 in high humidity and complex matrix background, with a linear response range of 20-800 ppb(v) and a sensitivity of 0.20 fC/ppb(v).
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Vitaly A. Kostarev, Gennadii E. Kotkovskii, Alexander A. Chistyakov, Artem E. Akmalov
Summary: This study investigates the sensing capability of the FAIMS detector for nitro-explosives using dopants toluene and 1-methylnaphtalene combined with ultraviolet laser ionization. The results demonstrate that the presence of dopants leads to a significant increase in ion yield at lower laser intensities. Dopant-assisted laser ionization improves the limits of detection, suggesting a potential way to enhance the sensitivity of detectors and improve the portability of laser-based FAIMS prototypes.
Article
Biochemical Research Methods
Hui Liu, Lei Xia, Chengyin Shen, Chaoqun Huang, Yannan Chu
Summary: This study developed a new method to detect MA in the presence of nicotine by using pyridine as a dopant in a homemade ion mobility spectrometry. Under optimized conditions, the interference of nicotine can be eliminated, providing an effective on-site detection method for MA.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Yuxuan Wen, Yuanyuan Xie, Yixue Cao, Yi Yu, Yi Chen, Lei Hua, Ping Chen, Haiyang Li
Summary: A gas flow assisted negative photoionization mass spectrometry method was developed for monitoring the single-exhalation hydrogen cyanide (HCN) profile. By introducing helium to eliminate humidity influence and reducing low mass cutoff effect, the sensitivity of the method was significantly improved. The method achieved a limit of detection of 0.3 ppbv and time resolution of 0.5 s, showing potential application in detecting Pseudomonas aeruginosa infection in cystic fibrosis patients.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Weiguo Wang, Hang Li, Wei Huang, Chuang Chen, Chuting Xu, Huiwen Ruan, Bin Li, Haiyang Li
Summary: Peroxide-based explosives (PBEs) are becoming more common in criminal and terrorist activities due to their easy synthesis and high explosive power. This paper reviews the developments in techniques and instruments for detecting PBEs over the past ten years, focusing on advancements in ion mobility spectrometry, ambient mass spectrometry, fluorescence techniques, colorimetric methods, and electrochemical methods. The paper emphasizes the need for improved detection performance in terms of sensitivity, selectivity, high-throughput, and wide explosives coverage, and discusses future prospects for PBE detection.
Article
Chemistry, Analytical
Monika Szyposzynska, Aleksandra Splawska, Michal Ceremuga, Piotr Kot, Miroslaw Maziejuk
Summary: Detecting trace amounts of explosives is crucial for national security. This paper presents the design of a stationary device and ion mobility spectrometers for detecting trace amounts of explosives and explosive taggants. The device successfully detected selected explosives in just 5 seconds.
Article
Chemistry, Applied
Arezoo Najafi, Bahman Farajmand, Hamid Reza Sharafi, Mohammad Reza Yaftian
Summary: The new method of dispersive liquid-phase microextraction (DLPME) assisted by a homogenizer is efficient for chloramphenicol extraction and preconcentration. By combining this method with ion mobility spectrometry (IMS), a fast and sensitive analysis of chloramphenicol in food samples can be achieved. The method's parameters can be adjusted to optimize performance and obtain appropriate calibration curves, with good stability and accuracy demonstrated during evaluation.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Chemistry, Analytical
Juha Kangasluoma, Jyri Mikkila, Verner Hemmila, Oskari Kausiala, Jani Hakala, Evgenia Iakovleva, Paxton Juuti, Mikko Sipila, Heikki Junninen, H. J. Jost, Aleksei Shcherbinin
Summary: Illegal explosives pose a threat to public safety, aviation, transportation, and critical infrastructure. Researchers have developed a trace explosives detection instrument with high sensitivity and efficient workflows. The instrument utilizes thermal desorption of filters for the analysis of liquid and solid phase samples, followed by selective atmospheric pressure chemical ionization and detection with a mass spectrometer. The experiments demonstrated that the system has low detection limits and can effectively detect various common explosives.
Article
Chemistry, Analytical
Miroslaw Maziejuk, Monika Szyposzynska, Aleksandra Splawska, Monika Wisnik-Sawka, Michal Ceremuga
Summary: Researchers attempted to develop an instrument using DMS technology to simultaneously detect both TATP and HMTD. By using a specially designed gas sample injection system, they successfully detected the presence of TATP and HMTD. During the detection process, impurities from the technological process can affect the results, but the addition of ammonia can mitigate this impact.
Article
Biochemical Research Methods
Rebecca Brendel, Sascha Rohn, Philipp Weller
Summary: The study aimed to enhance the selectivity of IMS for isomeric monoterpenes by adding NO as a dopant, leading to the formation of additional product ions and improved discrimination of monoterpenes in volatile profiles. The use of NO as a dopant facilitated the identification of monomeric, dimeric, and trimeric ion clusters, shedding light on isomerization mechanisms in the ion signals.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Wojciech Fabianowski, Miroslaw Maziejuk, Monika Szyposzynska, Monika Wisnik-Sawka
Summary: The article presents a technique of differential ion mobility spectrometry (DMS) for the detection and identification of volatile organic compounds (VOCs) from various categories. It analyzes the possibility of mixture identification using only the DMS spectrometer and provides several examples. The article also discusses the analysis of different compounds, their mechanisms of fragmentation, influence on effective ion temperature, and high electric field intensity.
Article
Chemistry, Multidisciplinary
Yanmei Yang, Weihua Niu, Weiqing Wang, Siyun Qi, Lili Tong, Xiaoyan Mu, Zhenzhen Chen, Weifeng Li, Bo Tang
Summary: The introduction of fluorinated boron nitride nanosheet (h-FBN) greatly improves the detection sensitivity and signal stability in negative ion mode paper spray mass spectrometry (PS-MS).
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Brian C. Hauck, Charles S. Harden, Vincent M. McHugh
Summary: The search for suitable ion mobility spectrometry (IMS) calibrant compounds continues, with a focus on accurately measuring reduced ion mobility (K-0) values under various instrumental conditions. Isoflurane (IsoF) is highlighted as a strong candidate for negative ion mode calibrant, and its accurately measured K-0 values are discussed in this report. The evaluation of IsoF as a negative ion mode calibrant for IMS applications is the main focus of this study.
ANALYTICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Lu Wang, Dandan Jiang, Lei Hua, Chuang Chen, Dongming Li, Weiguo Wang, Yiqian Xu, Qimu Yang, Haiyang Li, Song Leng
Summary: In this study, an acetone-modifier positive photoionization ion mobility spectrometry (AM-PIMS) method was developed for accurate qualitative and quantitative analysis of exhaled ammonia (NH3) with high selectivity and sensitivity. The introduction of acetone as a modifier improved the peak-to-peak resolution and the accuracy of NH3 qualitative identification. Online dilution and purging sampling reduced interference and memory effects, enabling breath-by-breath measurement. The AM-PIMS method showed great potential for clinical disease diagnosis.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Chemistry, Analytical
Xiang Dong, Xu Cao, You-jiang Liu, Fan Yuan, Shao-min Liu, Chi-lai Chen
Summary: This study developed a self-made UV-FAIMS method for sensitive and rapid detection of isoprene and alpha-pinene. The detection parameters and ability to identify mixtures were investigated. The results showed that UV-FAIMS had a high linear response and low detection limit for isoprene and alpha-pinene. It also demonstrated good accuracy in identifying mixtures of these compounds.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Ningbo Wan, Jichun Jiang, Fan Hu, Ping Chen, Kaixin Zhu, Dehui Deng, Yuanyuan Xie, Chenxin Wu, Lei Hua, Haiyang Li
Summary: Photoionization mass spectrometry (PI-MS) is a powerful and highly sensitive analytical technique for online monitoring of volatile organic compounds (VOCs). However, there are limitations in detecting compounds with low PI cross sections and high ionization energies using lamp-based PI-MS. A new nonuniform electric field high-pressure photoionization/photoionization-induced chemical ionization (NEF-HPPI/PICI) source was developed to improve ion transmission efficiency and reduce cluster ions formation. Through this new source, the analytical capacity was demonstrated by monitoring hydrocarbons and oxygenated VOC products during catalytic reactions, showing potential applications in process monitoring and online quality control.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Jichun Jiang, Lei Hua, Yuanyuan Xie, Yixue Cao, Yuxuan Wen, Ping Chen, Haiyang Li
Summary: A high mass resolution multireflection time-of-flight secondary ion mass spectrometer was designed and constructed in this work, achieving higher mass resolving power and ion transmission efficiency compared to conventional TOF-SIMS.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2021)
Article
Chemistry, Physical
Kaixin Zhu, Suxia Liang, Xiaoju Cui, Rui Huang, Ningbo Wan, Lei Hua, Haiyang Li, Hongyu Chen, Zhenchao Zhao, Guangjin Hou, Mingrun Li, Qike Jiang, Liang Yu, Dehui Deng
Summary: This study introduces a highly selective and efficient method for methane conversion to formic acid by confining atomically dispersed Fe sites in the nano-channels of ZSM-5. The research demonstrates that the confined Fe-O active centers within ZSM-5 can dissociate C-H bonds and catalyze the oxidation of methane to formic acid via free radical mechanisms under mild conditions. This innovative approach opens up a new path for engineering the microenvironment of confined Fe sites within nanochannels for highly selective methane conversion with low energy input.
Article
Chemistry, Analytical
Ningbo Wan, Jichun Jiang, Hengding Wang, Ping Chen, Hongjun Fan, Weiguo Wang, Lei Hua, Haiyang Li
Summary: This study developed a new VUV lamp-based cluster-mediated chemical ionization source for the direct and rapid analysis of glyoxal. By using ethanol as the reactant ion and co-sampling it with glyoxal, the signal intensity of glyoxal was significantly enhanced. The analytical capacity of the system was demonstrated by trace analysis of glyoxal in food contact papers, highlighting the importance of chemical ionization mass spectrometry for VOCs measurement.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemical Research Methods
Yixue Cao, Ping Chen, Lei Hua, Weiguo Wang, Yi Chen, Yuxuan Wen, Yuanyuan Xie, Haiyang Li
Summary: The study showed that a square waveform phase modulation strategy can improve the resolution and sensitivity of QIT/TOFMS by optimizing the phase angle. The best performance was observed at specific phase angles, leading to significant enhancements in mass resolution and signal intensity for certain m/z values.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Chemistry, Analytical
Hanwei Li, Jichun Jiang, Lei Hua, Ping Chen, Yuanyuan Xie, Zhigang Fan, Di Tian, Haiyang Li
Summary: The newly developed PNCI-TOFMS technology enables real-time and continuous monitoring of aldehydes and benzenes in vehicles, with detection limits down to sub-ppbv levels. This technology has broad potential applications in air pollutants monitoring and in-vehicle air quality analysis.
Article
Agriculture, Multidisciplinary
Yan Wang, Lei Hua, Qianwen Fu, Chenxin Wu, Chong Zhang, Haiyang Li, Guangzhi Xu, Qinxue Ni, Youzuo Zhang
Summary: High-pressure photoionization time-of-flight mass spectrometry combined with dynamic headspace sampling was developed for rapid identification of adulteration in extra virgin olive oil. The VOC fingerprints of different edible oils were obtained in just 1.5 min, allowing satisfactory classification. Unique VOCs were identified in specific oils, and the adulteration proportions as low as 3% could be successfully identified. The method showed good agreement between actual and predicted adulteration proportions.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Analytical
Zhongya Guo, Ke Zhang, Qi Zhang, Lili Fu, Ze Liu, Zhen Kong, Le Wang, Chuan Liu, Lei Hua, Bin Li
Summary: The interplay among tobacco extractive components during pyrolysis affects the product distribution, but its impact is not yet fully understood.
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
(2022)
Article
Biochemical Research Methods
Yixue Cao, Ping Chen, Yi Chen, Yuxuan Wen, Lei Hua, Yuanyuan Xie, Haiyang Li
Summary: This paper investigates the differences in mass range, resolution, sensitivity, and ion fragmentation of LIT/TOFMS driven by square and sinusoidal waveforms. It is found that the square mode has a wider mass range, better mass resolution, and higher sensitivity compared to the sinusoidal mode. Additionally, the square mode exhibits softer behavior and less ion fragmentation. Therefore, LIT/TOFMS driven by a square waveform shows greater potential in complex matrix systems with a wide mass range.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Instruments & Instrumentation
Yi Chen, Ping Chen, Tao Zhang, Yixue Cao, Lei Hua, Haiyang Li
Summary: A novel design method of the Schwarzschild microscope with a high numerical aperture (NA) of 0.47 was proposed in this paper. The aberration distributions and compensation methods were investigated through tolerance analysis. The results showed that the tilt and decenter tolerances become the dominant factors limiting the spatial resolution, which could only be improved by ensuring the alignment accuracy of mirrors. Finally, the spatial resolution of the microscope in the home-built SIMS reached 2.19 μm.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2023)
Article
Engineering, Environmental
Min Dang, Mei Li, Jing Li, Ruidong Liu, Yingzhe Guo, Keyong Hou
Summary: This study found that foam mats are a potential source of formamide and ammonia exposure for children. The emissions of formamide and ammonia from different types of foam mats were measured to be high. The study also assessed the exposure dose for children aged 0.5-6 years and found that the dermal exposure for the age group of 0.5-2 years was much higher than others. The results provide key information for further studies on children's exposure to indoor air pollution from foam mats.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Chemical
Xinbo Wang, Hao Qiu, Cong Yu, YuanJu Jing, Chun Kang, Xin Qin, Keyong Hou, Zhaojie Cui, Ben Hang Yin, Bin Shan
Summary: In this study, a thioamide incorporated polymer of intrinsic microporosity, TPIM, was synthesized and it exhibited high intrinsic microporosity and good solubility. It showed high CO2 capacity, good CO2/N2 mixture separation performance, and facile regeneration ability. The porosity and CO2 capacity of TPIM could be easily restored through a simple dissolution-separation-precipitation (DSP) approach, providing a new insight for the design of regenerable adsorbents.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Mei Li, Bing Liu, Taotao Chen, Ruidong Liu, Yingzhe Guo, Keyong Hou
Summary: We introduced neon gas as a tracer gas in natural gas pipelines and used a miniature time-of-flight mass spectrometry (mini-TOFMS) for on-site detection to locate underground natural gas pipeline leaks. The mini-TOFMS employed capillary tube sampling to directly analyze leaked neon gas without sample preparation, with a single sample analysis time of only 60 s, significantly faster than the traditional off-line gas chromatography (GC) method. The mini-TOFMS showed a linear response range from 69 ppmv to 3.0 x 105 ppmv, with a limit of detection (LOD, S/N = 3) of 19.0 ppmv. The correlation between GC and mini-TOFMS for quantitative analysis of neon was as high as 0.98. The newly designed method using mini-TOFMS was successfully demonstrated in on-site locating underground natural gas pipeline leaks, particularly for pipes with differing gas pressures buried under the same road, providing more efficient and accurate results.
Article
Chemistry, Analytical
Jing Li, Mei Li, Ruidong Liu, Yingzhe Guo, Dong Yang, Keyong Hou
Summary: A homogeneous sampling membrane inlet was developed and coupled with a homemade mass spectrometer for ethane detection. Compared with traditional membrane inlets, the new design improved the sensitivity of ethane detection by a factor of 3. The method allows for highly sensitive analysis under controlled humidity and temperature conditions.
Article
Chemistry, Analytical
Bing Liu, Wenxi Tang, Hang Li, Ruidong Liu, Fengshuo Dong, Yingzhe Guo, Jianjun Li, Keyong Hou
Summary: In this study, a magnetic field enhanced photoelectron ionization miniature time-of-flight mass spectrometer (MEPEI-TOFMS) was developed for detecting the relationship between postoperative agitation symptoms and sevoflurane concentration in exhaled breath. The MEPEI source could directly ionize sevoflurane and obtain its characteristic ion, and the analysis time of exhaled breath was only 60 s. Quantitative detection of sevoflurane in different scenarios was achieved, and a strategy for identifying and treating child patients with agitation symptoms was established using partial least squares-discriminant analysis (PLS-DA).