Article
Chemistry, Analytical
Mingzhen Zhu, Liang Feng
Summary: A sensitive and rapid sensing platform based on triple-helix molecular switch and CMC-EDC/NHS covalent immobilized paper was constructed to detect Ochratoxin A (OTA). The platform achieved a lower detection limit of 0.012 ng/mL with a linear range of 0.025-100 ng/mL. The sensing could be completed in less than 15.5 minutes without complex concentration process or expensive equipment.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Rongfeng Cai, Zhongwen Zhang, Haohan Chen, Yaping Tian, Nandi Zhou
Summary: An electrochemical biosensor for Staphylococcus aureus has been designed based on a triple-helix molecular switch which provides high sensitivity, specificity, and versatility. The sensor demonstrated broad dynamic range and low detection limit, showing promising application prospects for detecting harmful bacteria in various samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Miao Zhong, Shengyuan Yang, Lei Chen, Chen Liu, Jiao Shi, Hao Liang, Xilin Xiao, Le Li, Jinquan Liu
Summary: A novel fluorescent sensing method for highly sensitive detection of Hg2+ was developed using a triple-helix molecular switch (THMS) and exonuclease III (Exo III)-assisted signal amplification. The method showed a linear detection range of 0.01-50 nM and could detect Hg2+ at concentrations as low as 1.04 pM. It demonstrated potential applications in environmental and food monitoring.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemical Research Methods
Xiaoying Wang, Xuan Gu, Linyu Li, Bingjia Yu, Liangrui Lv, Qingqing Chen, Mingming Xu
Summary: An innovative aptasensor was developed for the electrochemical detection of amyloid-beta oligomers, utilizing a triple-helix aptamer switch for target-triggered signal transduction DNA displacement events. The sensor demonstrated sensitive detection of trace A beta Os with a wide linear range and high recovery rate in serum samples. This assay provides a potential platform for Alzheimer's disease monitoring and treatment studies.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Ke Li, Delai Kang, Yu Li, Weizhe Zhu, Lian Zhu, Juntao Zhang, Chengzhi Xu, Benmei Wei, Haibo Wang
Summary: In this study, a quantitative determination method for collagen triple helix integrity was developed using bovine skin collagen peptide-protected Au/Ag nanoclusters as a fluorescent probe.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Min Yuan, Ye Yang, Nguyen Thi Quynh Chau, Qinqin Zhang, Xiuxiu Wu, Jiaye Chen, Zhiwei Wu, Heng Zhong, Yuanyuan Li, Fei Xu
Summary: A novel aptamer-based fluorescent-sensing platform using a triple-helix molecular switch (THMS) was developed for detecting arsenic(III) ion. The detection process was rapid, simple, and sensitive, with a limit of detection of 69.95 nM. The THMS-based aptasensor also showed excellent stability and selectivity, and was successfully used for arsenic detection in a real water sample from Huangpu River.
Article
Chemistry, Analytical
Rongrong Yuan, Zhuojun Yan, Alateng Shaga, Hongming He
Summary: A novel porous organic polymer (POP) with high surface area and stability was successfully prepared and used to fabricate an ultrasensitive electrochemical aptasensor for detecting trace ampicillin. The biosensor exhibited a low detection limit and accurate monitoring ability for detecting amp in multiple real samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Dheyaa Hussein Mohsin, Muthana Saleh Mashkour, Fataneh Fatemi
Summary: An electrochemical aptasensor was developed for earlier detection of Hepatitis B virus infection. It demonstrated high sensitivity, selectivity, and stability, with one of the lowest reported limits of detection for HBsAg in the literature. The sensor was successfully applied to spiked human serum samples for HBsAg determination.
Article
Chemistry, Analytical
Haobo Sun, Lisheng Qian, Jinming Kong, Xueji Zhang
Summary: A novel electrochemical biosensor platform with triple helix structure switch and double signal amplification strategy was proposed for nucleic acid detection, achieving ultra-sensitivity and high selectivity. The biosensor showed a detection limit as low as 1.954 aM and a linear range of 7 orders of magnitude. Additionally, it demonstrated excellent anti-interference ability when analyzing DNA in serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biophysics
Asma Verdian, Zahra Khoshbin, Chih-Hsin Chen
Summary: This article describes a liquid crystal-based aptasensor that detects OTA by changing the P-shaped DNA structure to trigger liquid crystal rearrangement. The developed sensor has a wide linear range, ultra-low detection limit, and high quantitative recovery, making it suitable for rapid, sensitive, and accurate detection of hazardous analytes in real samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Mei-Yao Zhou, Zhen Wang, Shan-Shan Qi, Ya-Ni Bai, Jing Han, Huai-Yu Bu
Summary: A novel self-powered 3D DNA walking machine triggered by triple-helix molecular switch has been developed for imaging miRNA-21 in living cells. This design enables autonomous motion without the need for external fuel DNA strands or protein enzymes, simplifying the experimental steps and improving efficiency. Additionally, this assay provides a new signal amplification strategy for evaluating intracellular miRNA levels.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemical Research Methods
Alicia Climent-Catala, Thomas E. Ouldridge, Guy-Bart Stan, Wooli Bae
Summary: Synthetic RNA systems have advantages over protein-based networks in terms of faster response, increased specificity, and programmability. In this study, we developed an in vitro RNA toggle switch using RNA aptamers to inhibit the transcriptional activity of two different RNA polymerases. The switch was successfully controlled by adding DNA sequences. The results demonstrated that the RNA-based toggle switch has potential applications in synthetic biology.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Chemistry, Analytical
Yulan Tian, Shuge Liu, Yage Liu, Yating Chen, Beenish Noureen, Liping Du, Da Jing, Chunsheng Wu
Summary: A novel method based on a triple-helix molecular switch (THMS)-based light-addressable potentiometric aptasensor (LAPA) is proposed for highly sensitive and selective label-free detection and spatiotemporal imaging of Okadaic acid (OA). The detection platform allows for the multichannel detection of OA with low sample consumption and a detection time of 27 min/channel, as well as spatiotemporal imaging analysis with high resolution and frame duration. This method provides a promising approach for label-free detection and spatiotemporal analysis of OA with high sensitivity, specificity, and detection efficiency; low sample dosage; and simple operation.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Nanoscience & Nanotechnology
Fan Yang, Hung- Lin, Peng Chen, Juejun Hu, Tian Gu
Summary: 3-D depth sensing is crucial for various applications. Passive depth sensing techniques based on a double-helix point-spread-function (PSF) feature advantages such as high depth estimation precision, minimal power consumption, and reduced system complexity compared to active sensing methods. In this study, we propose and experimentally implement a polarization-multiplexed DH metalens designed using an autonomous direct search algorithm. By utilizing two contra-rotating DH PSFs encoded in orthogonal polarization states, monocular depth perception is achieved, and concurrent depth calculation and scene reconstruction with minimum distortion and high resolution in all three dimensions are demonstrated using a developed reconstruction algorithm.
Article
Chemistry, Multidisciplinary
Chan Ho Park, Ian A. P. Thompson, Sharon S. Newman, Linus A. Hein, Xizhen Lian, Kaiyu X. Fu, Jing Pan, Michael Eisenstein, H. Tom Soh
Summary: Cells rely on secreted signaling molecules to coordinate essential biological functions, but direct measurement of these signals is challenging. This study presents an aptamer-conjugated hydrogel matrix that enables real-time measurement of specific secreted analytes. By monitoring inter-cellular cAMP signals in amoeba cells, the researchers achieved direct measurements of oscillatory cAMP signaling. This approach can be generalized to visualize diverse extracellular signaling processes and their effects on recipient cells.
ADVANCED MATERIALS
(2023)
Article
Engineering, Environmental
Kai Guo, Yuxiang Zhu, Zhen Yan, Annai Liu, Xiangze Du, Xin Wang, Wei Tan, Lulu Li, Jingfang Sun, Qing Tong, Changjin Tang, Lin Dong
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Engineering, Biomedical
Richard Johnson, Michael Rafuse, Prakash Parthiban Selvakumar, Wei Tan
Summary: This study evaluated the impacts of allogeneic bone marrow-derived stromal cells and recipient age on the long-term remodeling of vascular grafts. The results showed significant effects of these factors on graft outcomes. Additionally, compared to acellular grafts, cellular grafts showed efficient recruitment of vascular cells to form more organized structures.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Physical
Yaxin Yu, Wei Tan, Dongqi An, Xiuwen Wang, Annai Liu, Weixin Zou, Changjin Tang, Chengyan Ge, Qing Tong, Jingfang Sun, Lin Dong
Summary: Research has shown that SO2 poisoning of NH3-SCR catalysts at low temperature remains a challenge. The formation of sulfate species inhibits the adsorption of NOx, while the formation of ferric sulfate enhances surface acidity, leading to an increase in catalytic activity.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2021)
Article
Engineering, Environmental
Wei Tan, Annai Liu, Shaohua Xie, Yong Yan, Thomas E. Shaw, Yu Pu, Kai Guo, Lulu Li, Shuohan Yu, Fei Gao, Fudong Liu, Lin Dong
Summary: Investigating catalytic reaction mechanisms can guide catalyst design, as demonstrated by the innovative CeO2-SiO2 mixed oxide catalyst (CeSi2) with excellent SO2/H2O resistance in harsh working conditions. The strong Ce-O-Si interaction and abundant surface hydroxyl groups on CeSi2 provide active acid sites and inhibit SO2 adsorption, enhancing the NH3-SCR performance through an enhanced Eley-Rideal mechanism. This work offers a strategy to develop an environmentally friendly NH3-SCR catalyst with superior SO2 resistance.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Environmental
Shaohua Xie, Zhiwei Wang, Wei Tan, Yatong Zhu, Samantha Collier, Lu Ma, Steven N. Ehrlich, Peng Xu, Yong Yan, Tao Xu, Jiguang Deng, Fudong Liu
Summary: A novel two-step wetness impregnation method was developed to fabricate a unique and highly stable CeO2/Al2O3 support, enabling Pd catalysts anchored on this support to exhibit higher activity and thermal stability in CO and hydrocarbon oxidations. This approach can be applied as a universal method to prepare stable metal oxide-alumina-based supports, with broad applications in environmental catalyst design.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Applied
Wei Tan, Jin Wang, Yandi Cai, Lulu Li, Shaohua Xie, Fei Gao, Fudong Liu, Lin Dong
Summary: This study proposes a new strategy of Mo doping to improve the low-temperature SCR activity of CeSi2. A Mo-Ce-Si mixed-oxide catalyst was prepared by a simple co-precipitation method. Mo doping significantly enhances the NH3-SCR activity of CeSi2 and exhibits superior N2 selectivity and resistance to SO2/H2O poisoning.
Article
Chemistry, Multidisciplinary
Wang Song, Jiawei Ji, Kai Guo, Xin Wang, Xiaoqian Wei, Yandi Cai, Wei Tan, Lulu Li, Jingfang Sun, Changjin Tang, Lin Dong
Summary: CeO2/TiO2 catalysts prepared by solid-phase impregnation showed better catalytic activity in low-temperature selective catalytic reduction of NOx with NH3. Surface changes of TiO2 were found to have a significant impact on the improved activity.
CHINESE CHEMICAL LETTERS
(2022)
Article
Engineering, Environmental
Wei Tan, Shaohua Xie, Yandi Cai, Meiyu Wang, Shuohan Yu, Ke-Bin Low, Yuejin Li, Lu Ma, Steven N. Ehrlich, Fei Gao, Lin Dong, Fudong Liu
Summary: This study explores the engineering of surface defects on CeO2 supports through ZrO2 doping to enhance the catalytic performance of Pt/CZO catalysts. Activation by H-2 reduction significantly boosts the catalytic oxidation performance of Pt/CZO catalyst and improves thermal stability, making it superior to Pt/CeO2 in vehicle emission control applications.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Environmental
Wei Tan, Chunying Wang, Shuohan Yu, Yaobin Li, Shaohua Xie, Fei Gao, Lin Dong, Fudong Liu
Summary: The study revealed that the NH3-SCR activity of Nb2O5-CeO2 and WO3-CeO2 catalysts depends significantly on the strong interaction between the redox component (CeO2) and acidic component (Nb2O5 or WO3), as well as the presence of paired redox-acid sites. At lower temperatures (200 degrees Celsius), NH3-SCR activity is primarily influenced by the surface acidity of the catalysts, while at higher NOx conversion rates, the activity is more determined by the redox properties.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Applied
Lulu Li, Jiawei Ji, Wei Tan, Wang Song, Xin Wang, Xiaoqian Wei, Kai Guo, Wanyu Zhang, Changjin Tang, Lin Dong
Summary: In this work, a supported catalyst consisting of FeOx and MnOx co-supported on aluminum-modified CeO2 was synthesized and applied in the low-temperature NH3-selective catalytic reduction (NH3-SCR) of NO. The study revealed that the SCR activity of the catalyst was significantly influenced by the amount of added aluminum and the appropriate Ce/Al molar ratio. The Fe-Mn/Ce1Al2 catalyst exhibited over 90% NO conversion at a temperature range of 75-250 degrees Celsius and displayed better resistance to SO2 compared to FeeMn/CeO2.
JOURNAL OF RARE EARTHS
(2022)
Article
Engineering, Environmental
Wei Tan, Shaohua Xie, Xin Wang, Chunying Wang, Yaobin Li, Thomas E. Shaw, Lu Ma, Steven N. Ehrlich, Annai Liu, Jiawei Ji, Fei Gao, Lin Dong, Fudong Liu
Summary: The study focuses on the improvement of Pt-CeO2 catalysts by designing new ceria-based supports. Through a unique T-IWI method, a Pt single site catalyst with excellent thermal stability was synthesized on a CZA-T support. The catalyst showed higher oxidation activity and Oxygen storage capacity (OSC) compared to traditional Pt catalysts on regular CeO2/Al2O3 and one-step prepared CeZrOx/Al2O3 supports. The higher Pt dispersion and stronger Pt-O-Ce interaction on the CZA-T support played a vital role in the CO oxidation performance and OSC of the catalyst.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Physical
Shaohua Xie, Wei Tan, Yuejin Li, Lu Ma, Steven N. Ehrlich, Jiguang Deng, Peng Xu, Fei Gao, Lin Dong, Fudong Liu
Summary: In this study, an efficient NbCuCe oxide catalyst for reducing NOx emissions in cold-start diesel engines is reported. The catalyst exhibits higher DeNO(x) activity below 200 degrees C compared to the Cu-CHA zeolite catalyst, along with superior sulfur resistance, faster response, and lower NH3 slip. Atomically dispersed Cu species facilitate strong interaction between Cu and the Nb/Ce base catalyst, leading to improved low-temperature redox properties and NH3 adsorption/activation. The developed NbCuCe catalyst shows promising potential for efficient DeNO(x) in cold-start diesel engines and can be combined with Cu-CHA for a broader temperature range of operation.
Article
Chemistry, Multidisciplinary
Shaohua Xie, Liping Liu, Yu Lu, Chunying Wang, Sufeng Cao, Weijian Diao, Jiguang Deng, Wei Tan, Lu Ma, Steven N. Ehrlich, Yaobin Li, Yan Zhang, Kailong Ye, Hongliang Xin, Maria Flytzani-Stephanopoulos, Fudong Liu
Summary: The local coordination structure of metal sites plays a crucial role in the performance of supported metal catalysts. This study successfully fabricated Pt atomic single-layer structures with precisely controlled local coordination environment, which exhibited higher turnover frequency and improved catalytic activity in CO oxidation. This work provides new insights for achieving 100% atomic utilization efficiency and optimal intrinsic catalytic activity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Wei Tan, Shaohua Xie, Xin Wang, Juntian Xu, Yong Yan, Kaili Ma, Yandi Cai, Kailong Ye, Fei Gao, Lin Dong, Fudong Liu
Summary: In this study, an efficient CuO catalyst supported on a CeO2-Al2O3 support (CA-T) prepared by two-step incipient wetness impregnation (T-IWI) method was successfully developed. The Cu/CA-T catalyst exhibited better catalytic performance in CO oxidation and NO reduction by CO (NO + CO reaction) as well as higher thermal stability compared to the CuO catalyst loaded on conventional CeO2-Al2O3 support (Cu/CA). The microstructure of CuO-CeO2-Al2O3 catalysts, especially the state of Cu species, was systematically investigated using various characterization techniques. The mechanisms of CO oxidation and NO + CO reactions on Cu/CA and Cu/CA-T catalysts were collaboratively revealed.
Article
Chemistry, Multidisciplinary
Qinglong Liu, Peng Yang, Wei Tan, Haowei Yu, Jiawei Ji, Cong Wu, Yandi Cai, Shaohua Xie, Fudong Liu, Song Hong, Kaili Ma, Fei Gao, Lin Dong
Summary: The size effect on nanoparticles plays a crucial role in catalysis performance. Tuning the oxygen vacancies on a metal-oxide support can help reduce the size of Pt particles, thus improving the catalysis performance of the supported catalyst. In this study, Ce-Sn solid solutions (CSO) with abundant oxygen vacancies were synthesized. After CO reduction, the catalytic CO oxidation performance of Pt/CSO was significantly better than that of Pt/CeO2. This improvement was attributed to the creation of smaller Pt clusters on CSO with more exposed active sites.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)