Article
Biochemistry & Molecular Biology
Denis Kravtsov, Anna Gubal, Victoria Chuchina, Natalya Ivanenko, Nikolay Solovyev, Alexander Stroganov, Han Jin, Alexander Ganeev
Summary: This study investigated the effect of discharge conditions on VOC fragmentation using a combination of pulsed glow discharge and time-of-flight mass spectrometer. The use of discharge afterglow significantly reduced VOC fragmentation and provided low detection limits.
Article
Materials Science, Coatings & Films
Kei Kiyokawa, Reiko Saito, Masato Morita, Tetsuo Sakamoto
Summary: This article investigates the impact of metal redeposition on the sputtering rate in ion sputtering and finds that redeposition significantly enhances the rate. The experimental data align with the model equation, explaining the sputtering by desorbed redeposited metal and the reduction of sublimation enthalpy by adsorbed redeposited metal. This finding provides new insights for the application of sputtering technology.
JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A
(2022)
Article
Physics, Multidisciplinary
Nandana Pattathadathil, S. Sunil Kumar
Summary: In this work, numerical simulations were conducted to analyze the extraction characteristics of biomolecular ions stored in 16-pole and 16-wire ion traps. The results show that the ions extracted from a wire trap with a simple upgrade exhibit time-of-flight distributions two orders of magnitude narrower than that typically results from conventional ion traps. Furthermore, the upgraded design allows the ions to be confined within a much narrower region, making it compatible with fluorescence spectroscopy measurements due to higher optical access of the wire trap configuration.
Review
Chemistry, Multidisciplinary
Xiaoxu Peng, Zheng Wang
Summary: The article provides an overview of the development of solution electrode glow discharge (SEGD) in various fields and discusses its discharge mechanism. SEGD has unique advantages for optical emission spectrometry and mass spectrometry, and it has broad research potential in biology and medicine, material synthesis, electrochemistry, etc.
CHINESE CHEMICAL LETTERS
(2022)
Article
Spectroscopy
Anna Gubal, Victoria Chuchina, Yegor Lyalkin, Natalya Ivanenko, Nikolay Solovyev, Alexander Stroganov, Alexander Ganeev
Summary: Recent studies have shown that glow discharge analysis is capable of effectively ionizing volatile organic compounds, enabling the analysis of VOCs in ambient air and gas mixtures. Direct determination of different classes of VOCs in ambient air using microsecond pulsed glow discharge time-of-flight mass spectrometry was demonstrated, with low fragmentation benefitting quantitative determination.
ATOMIC SPECTROSCOPY
(2021)
Article
Physics, Atomic, Molecular & Chemical
Christopher J. Brais, Steven J. Ray
Summary: A novel computational method is developed to calculate the mass bias of orthogonal acceleration time-of-flight mass spectrometers by considering the energy-dependent transmission of ions and the ion sampling efficiency. The method estimates the resultant mass bias by evaluating these factors and can be applied to different ionization sources and ion energy distributions.
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
(2022)
Article
Physics, Applied
Karna Patel, Anup Saha, Tanbo Zhou, Terrence R. Meyer, Sally Bane, Aman Satija
Summary: This study investigates the temporal dynamics of atmospheric-pressure nanosecond pulsed plasma discharges in a pin-to-pin electrode configuration using streak-camera line imaging. The discharge emission starts uniformly throughout the interelectrode gap and then decays in two distinct phases. The plasma emission in air and N-2 environments shows significant differences in their temporal dynamics. The formation and relaxation timescales of electronically excited states of N-2 are quantified with sub-nanosecond resolution. The streak-OES technique allows for quantitative time-resolved studies of key chemical species in ultra-short-pulsed plasmas.
APPLIED PHYSICS LETTERS
(2022)
Article
Spectroscopy
Sunil P. Badal, Paul B. Farnsworth, George C-Y Chan, Brian T. Molnar, Jessica R. Hellinger, Jacob T. Shelley
Summary: Plasma-based ambient desorption/ionization sources often use helium as the primary discharge gas, but studies show advantages of mixed-gas plasmas. Adding H-2 to helium can decrease reagent-ion signals while preserving analyte-ion signals. Nitrogen addition increases negative reagent ions for enhanced ion signal of specific compounds. Various molecular gases impact emission characteristics and plasma parameters in mixed-gas systems.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2021)
Article
Engineering, Chemical
A. Maisser, K. Barmpounis, S. Holm, M. Attoui, A. Schmidt-Ott, J. Kangasluoma, G. Biskos
Summary: This study demonstrates the potential of using atmospheric-pressure spark ablation to produce silver and gold clusters in argon gas, and analyze their chemical composition using atmospheric pressure interface time-of-flight mass spectrometer. The experimental results show that the reactivity towards oxygen and water traces varies depending on the number of metal atoms, polarity, and compositions of the clusters. The low cost of the technique makes it promising for various technological applications.
JOURNAL OF AEROSOL SCIENCE
(2021)
Article
Spectroscopy
Ashley A. Perkins, Edward D. Hoegg, R. Kenneth Marcus
Summary: The liquid sampling atmospheric pressure glow discharge (LS-APGD) microplasma technology shows potential in the fields of optical emission spectroscopy and mass spectrometry, allowing for applications in elemental/isotopic analysis and providing high resolution analyses. The SGC mode has been determined to perform the best in terms of elemental intensity, accuracy, and precision for isotope ratio measurements.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Marcos Bouza, Julio Garcia-Martinez, Bienvenida Gilbert-Lopez, Sebastian Brandt, Juan F. Garcia-Reyes, Antonio Molina-Diaz, Joachim Franzke
Summary: Dielectric barrier discharge ionization (DBDI) is a versatile tool for small-molecule mass spectrometry applications, covering a wide range of molecules from polar to low polar. However, the complex plasma gas-phase interactions in DBDI have not been well studied. In this study, the ionization mechanisms of a two-ring DBDI ion source were evaluated using different discharge gases for vaporized liquid samples. The results showed that APCI and DBDI exhibited different ionization trends during PAH analysis, with APCI mainly producing [M + H]+ ions and DBDI showing the prevalence of charge exchange reactions. The addition of dopants in the gas phase shifted the ionization mechanisms towards charge exchange reactions and facilitated the formation of [M]??+ ion species.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Krzysztof Greda, Pawel Pohl
Summary: A new method of optical emission spectrometry (OES) using micmplasma source was developed for the determination of Na, K, Mg, Ca, and Zn in wine, without the need for acid digestion. The study also found that red wines have higher levels of K and Mg, and different grape varieties can be distinguished based on the concentrations of K and Ca.
Article
Physics, Fluids & Plasmas
Audrey Chatain, Ana Sofia Morillo-Candas, Ludovic Vettier, Nathalie Carrasco, Guy Cernogora, Olivier Guaitella
Summary: The addition of small amounts of H-2 in a DC glow discharge in N-2 at low pressure and low power was studied. The presence of H-2 greatly affects the N-2 plasma discharges, increasing the electric field and electron energy. It also leads to the formation of new species, including ammonia and hydrogen-bearing ions. This research provides insights into the plasma species in the ionosphere of Titan.
PLASMA SOURCES SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alvaro Javier Gomez Rodriguez, Dagoberto Oyola Lozano, Humberto Bustos Rodriguez, Yebrail Rojas Martinez, German Antonio Perez Alcazar, Ligia Edith Zamora Alfonso, Juan Sebastian Trujillo Hernandez
Summary: The objective of this study is to evaluate the applicability of exchange coupling between nanoparticles of Nd2Fe14B and Fe90Al10 as permanent magnets produced by surfactant-assisted mechanical alloying. The results show a significant decrease in coercive force with temperature and percentage of soft phase during the sintering process.
Article
Chemistry, Multidisciplinary
Qianhan Han, Ying Guo, Yarong Zhang, Jing Zhang, Jianjun Shi
Summary: In this experimental study, a plasma plume generated by radio frequency atmospheric pressure glow discharge was enhanced in terms of length and intensity by pulsed discharge. The enhanced plume was used to improve the O/C ratio of carbon fiber.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Analytical
Luis Javier Fernandez-Menendez, Cristina Mendez-Lopez, Cristina Gonzalez-Gago, Jorge Pisonero, Nerea Bordel
Summary: Nowadays, diatomic molecular emission is commonly used in laser-induced breakdown spectroscopy (LIBS) for multiple purposes. However, these signals are often interfered with by other spectral emissions, which can hinder accurate analysis. In this study, a methodology to eliminate interferences from CaO and Na was developed and evaluated. The use of Ar was recommended to improve Cl determination by reducing interference from Na.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Chemistry, Analytical
Marina Martinez-Minchero, Adolfo Cobo, Ana Mendez-Vicente, Jorge Pisonero, Nerea Bordel, Igor Gutierrez-Zugasti, Patrick Roberts, Alvaro Arrizabalaga, Jose Valdiande, Jesus Mirapeix, Jose Miguel Lopez-Higuera, Asier Garcia-Escarzaga
Summary: The elemental composition of marine mollusk shells can provide valuable information about environmental conditions. This study proposes the use of Laser-Induced Breakdown Spectroscopy (LIBS) for rapid measurement and estimation of Mg/Ca concentration profiles within limpet shells. The results show a significant correlation between LIBS and traditional analytical methods, indicating the accuracy of LIBS in inferring Mg/Ca concentrations in shells.
Article
Chemistry, Analytical
Paula Menero-Valdes, Ana Lores-Padin, Beatriz Fernandez, C. Derrick Quarles Jr, Montserrat Garcia, Hector Gonzalez-Iglesias, Rosario Pereiro
Summary: Single cell-inductively coupled plasma-mass spectrometry (sc-ICP-MS) and laser ablation (LA)-ICP-MS were used to comprehensively study the expression of APOE and claudin-1 in ARPE-19 cells treated with glucose. The introduction of microFAST Single Cell set-up improved cellular transport efficiency, and specific immunoprobes labelled with IrNCs were used for protein determination. The results obtained by sc-ICP-MS were validated with commercial ELISA kits, and the distribution of target proteins in individual cells was revealed by LA-ICP-MS with high resolution images.
Article
Engineering, Biomedical
Alejandro Rodriguez-Penedo, Pablo Rioboo-Legaspi, Andrea Gonzalez-Lopez, Ana Lores-Padin, Rosario Pereiro, Maria del Mar Garcia-Suarez, Maria Dolores Cima-Cabal, Estefania Costa-Rama, Beatriz Fernandez, M. Teresa Fernandez-Abedul
Summary: In this paper, the detection of SARS-CoV-2 is carried out using reverse transcription loop-mediated isothermal amplification, and palladium nanoclusters are used as indicators of the amplification reaction at end point. The catalytic activity of palladium nanoclusters on the oxygen reduction reaction can be electrochemically observed due to the decrease in pH during the reaction. By premodifying flexible and small-size screen-printed electrodes with palladium nanoclusters, and using a simple and small electrochemical equipment, their integration into field-deployable devices is greatly facilitated, enabling faster detection of SARS-CoV-2 as well as future microbial threats after easy adaptation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Javier Garcia, Ruth Gutierrez, Ana S. Gonzalez, Ana I. Jimenez-Ramirez, Yolanda Alvarez, Victor Vega, Heiko Reith, Karin Leistner, Carlos Luna, Kornelius Nielsch, Victor M. Prida
Summary: Tuning and controlling the magnetic properties of nanomaterials is crucial for implementing new technologies. In this study, core/shell Ni@(NiO, Ni(OH)2) nanowire arrays were fabricated using an electrochemical approach, and their magnetic properties were characterized. The results showed surface oxidation-induced magnetic hardening in the nanowires and an increasing exchange bias effect at low temperatures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Jenniffer Linares, Monica Varese, Anna Sallent-Aragay, Ana Mendez, Sergio Palomo-Ponce, Mar Iglesias, Eduard Batlle, Jorge Pisonero, Clara Montagut, Ernest Giralt, Daniele Lo Re, Alexandre Calon
Summary: We report the synthesis of a novel Pt(IV) cell-penetrating peptide conjugate, C-POC, with reduced impact on nonmalignant cells. In vitro and in vivo evaluation showed that C-POC maintains robust anticancer efficacy while reducing accumulation in healthy organs and adverse toxicity compared to standard Pt-based therapy. Our findings highlight the importance of considering the off-target impact of anticancer treatment on normal cells for improved drug development and patient care.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Ana Laura Cuevas, Victor Vega, Antonia Dominguez, Ana Silvia Gonzalez, Victor M. Prida, Juana Benavente
Summary: Optical characterization of nanoporous alumina-based structures was performed using spectroscopic ellipsometry and photoluminescence spectra. The results showed the dependence of refractive index and extinction coefficient on wavelength, as well as the influence of sample geometry and cover-layer material. Photoluminescence curves exhibited similar shapes but different intensity values. This study highlights the potential applications of these structures in nanophotonics, optical sensing, or biosensing.
Article
Nutrition & Dietetics
Ana Alvarez-Barrios, Lydia Alvarez, Enol Artime, Montserrat Garcia, Imre Lengyel, Rosario Pereiro, Hector Gonzalez-Iglesias
Summary: This study investigated the imbalance of zinc (Zn) and changes in metalloproteins in early age-related macular degeneration (AMD) using a primary human fetal retinal pigment epithelium (RPE) cell culture model. The study found that Zn concentration decreased in RPE cells, while Cu, Na, and K concentrations increased. Additionally, Zn-regulating proteins and Zn transporters were deregulated, oxidative stress increased, and the expression of antioxidant enzymes changed. This study provides evidence for Zn imbalance during AMD development.
FRONTIERS IN NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Ana Silvia Gonzalez, Javier Garcia, Victor Vega, Rafael Caballero Flores, Victor M. Prida
Summary: In this study, a novel 3D nanostructured silver electrode was designed and its chemical surface and electrochemical properties were investigated. The electrode exhibited high capacitance retention, Coulombic efficiency, and cycle stability, making it suitable for applications in micro-supercapacitors or electrochemical devices.
Article
Chemistry, Analytical
Paula Menero-Valdes, Michail I. Chronakis, Beatriz Fernandez, Jr C. Derrick Quarles, Hector Gonzalez-Iglesias, Bjoern Meermann, Rosario Pereiro
Summary: An automated and straightforward detection and data treatment strategy using sc-ICP-ToF-MS was proposed to determine the protein relative concentration in individual human cells. Metal nanocluster-labeled specific antibodies and ruthenium red staining were employed to evaluate the number of cell events and cell volume. The proposed approach allows for the determination of both the mass and relative concentration of target proteins in each individual cell.
ANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Falk Muench, Sandra Schaefer, Miguel Mendez, Jose Angel Fernandez-Roldan, A. Silvia Gonzalez-Garcia, Victor Vega, Ulrike Kunz, Wolfgang Ensinger, Javier Garcia, Victor M. Prida
Summary: The properties and potential applications of three-dimensional ferromagnetic nanotubes have received a lot of attention. However, there have been limited studies on ferromagnetic nanotubes, especially those with irregular cross-sections. In this study, we introduce a synthetic platform for creating novel ferromagnetic nanotubes with diamond-shaped cross-sections and high aspect ratios. The nanotubes were plated using an electroless-plating deposition method, which allowed precise control over their geometry.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Review
Chemistry, Analytical
E. Hywel Evans, Jorge Pisonero, Clare M. M. Smith, Rex N. Taylor
Summary: This review of atomic spectrometry covers developments in various techniques, such as emission, absorption, fluorescence, and mass spectrometry, from November 2019 to November 2020. It focuses on novel developments in instrumentation, techniques, and methodology. The analysis of nanoparticles, elemental tagging using nanoparticles, matrix effects in ICP-MS, and developments in laser-based spectroscopy are discussed. Data treatment, isotopic analysis methods, and double spiking as a mass fractionation correction method are also highlighted.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Biochemical Research Methods
Jaime Martinez-Garcia, Alicia Villa-Vazquez, Beatriz Fernandez, Hector Gonzalez-Iglesias, Rosario Pereiro
Summary: Extracellular vesicles (EVs) are crucial components that influence various pathophysiological processes, such as cellular homeostasis, cancer progression, and neurological disease. However, the lack of standardized methods for EV isolation and classification, coupled with ambiguity in biochemical markers associated with EV subtypes, remains a major challenge. This article highlights common approaches for EV isolation and characterization and discusses the recent application of elemental mass spectrometry (MS) for analyzing metals and biomolecules in EVs obtained from biofluids or in vitro cellular models. Furthermore, the article explores the potential analysis of EVs at the single-vesicle and single-cell levels using ICP-MS, which could provide valuable insights into the individual characteristics and functions of EVs, contributing to a deeper understanding of their role in biological processes.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)