Article
Fisheries
Abeer M. Hegazy, Nan Chen, Hanzuo Lin, Sarath Babu, Feng Li, Youcheng Yang, Zhendong Qin, Fei Shi, Jun Li, Li Lin
Summary: The study investigated the regulatory potential of apoptosis signals during SHVV infection, revealing that viral M protein induces apoptosis through the intrinsic apoptotic pathway.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Fisheries
Pan Cao, Wei Sun, Yanbing Zhang, Zicheng Zhou, Xiaojun Zhang, Xiaodan Liu
Summary: The study found that SHVV is highly pathogenic to hybrid snakehead, leading to symptoms such as acute hemorrhages and enlarged visceral organs in infected fish. Histopathological analysis revealed significant inflammatory responses in major tissues of diseased fish infected with SHVV. The research also showed enhanced immune responses in hybrid snakehead after SHVV infection, providing insights into the pathogenic mechanism of SHVV and potential for future prevention and treatment strategies.
Article
Biochemistry & Molecular Biology
Xiangmou Qin, Shuangshuang Feng, Yanwei Zhang, Jianguo Su, Li Lin, Yong-an Zhang, Jiagang Tu
Summary: The study identified two groups of SHVV leader RNAs and revealed that one of the groups, le(group1), affects SHVV replication by interacting with the viral nucleoprotein (N). The critical region for this interaction was identified as nucleotides 6-10 of le(group1) and amino acids 1-45 of the N protein. This research provides insights into the role of leader RNA in regulating the replication of negative-stranded RNA viruses.
Article
Virology
Yanwei Zhang, Yong-An Zhang, Jiagang Tu
Summary: This study identified heat shock protein 90 (Hsp90) as an interacting partner of the Snakehead vesiculovirus (SHVV) L protein, which is required for the stability of SHVV L and replication. Dysfunction of Hsp90 destabilized SHVV L and inhibited viral replication. Hsp90 plays a crucial role in the maturation of SHVV L and ensuring effective replication, making it a potential target for antiviral therapies against SHVV.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
An-Qi Liu, Xiangmou Qin, Hui Wu, Hao Feng, Yong-An Zhang, Jiagang Tu
Summary: In this study, twelve hnRNPs were screened for their effects on the replication of snakehead vesiculovirus (SHVV). Three hnRNPs, including hnRNPA1, were identified as anti-SHVV factors. Knockdown of hnRNPA1 promoted SHVV replication, while overexpression of hnRNPA1 inhibited it. Furthermore, hnRNPA1 was found to interact with the viral phosphoprotein (P) and disrupt the viral P-N interaction. Overexpression of hnRNPA1 also enhanced the polyubiquitination and degradation of the P protein.
Article
Virology
Xiangmou Qin, Yong-An Zhang, Jiagang Tu
Summary: This study identified the phosphorylated sites on the phosphoprotein (P) of snakehead vesiculovirus (SHVV) and the related host kinases, and revealed the effects of phosphorylation on SHVV replication. The phosphorylation of P at T160 was found to be critical for SHVV replication and mediated by p38MAPK and GSK3 kinases. These findings provide potential targets for the development of antiviral drugs and live-attenuated vaccines against SHVV.
JOURNAL OF VIROLOGY
(2023)
Article
Fisheries
Ming Xian Chang
Summary: This paper summarizes recent advances in understanding of negative regulators of the RLR signaling pathway in fish, with a focus on regulatory mechanisms inhibiting the function of RIG-I, MDA5, and other factors. The study also discusses important directions for future research in this field.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Virology
Zhongwei Li, Hongmei Yong, Wenwen Wang, Yue Gao, Pengfei Wang, Xintian Chen, Jun Lu, Junnian Zheng, Jin Bai
Summary: The study reveals that PRMT5 catalyzes the methylation of ACE2, which plays a crucial role in the binding of SARS-CoV-2. The specific inhibitor GSK3326595 can reduce ACE2 binding with the virus, indicating its potential as a promising candidate for inhibiting SARS-CoV-2 infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemical Research Methods
Tianpeng Liu, Wenwen Wang, Jihong He, Xuewen Wang, Kongjun Dong, Yongshui Hao, Mei Wang, Lei Zhang, Ruiyu Ren, Peng Yang, Zhengsheng Zhang, Tianyu Yang
Summary: This study identified differentially expressed genes and TCP transcription factors in broomcorn millet under simulated drought conditions. The results provide insights into the mechanisms of drought resistance in broomcorn millet.
PLANT MOLECULAR BIOLOGY REPORTER
(2023)
Article
Chemistry, Physical
Wenwen Wang, Xinyi Bai, Xiaochu Yuan, Yumin Liu, Lin Yang, Fangfang Chang
Summary: In this study, a method for preparing ultrathin PtnCo100-n nanowire catalysts with high activity was reported. The PtnCo100-n NW alloy catalysts synthesized by single-phase surfactant-free synthesis have adjustable compositions and (111) plane and strain lattices. The experimental results show that the activity of PtnCo100-n for the oxidation of methanol and ethanol is related to the exposed crystal surface, strain lattice, and composition of catalysts. This discovery provides a new pathway to design high activity, stability nanocatalysts to enhance direct alcohol fuel cells.
Article
Chemistry, Physical
Yumei Tan, Xinyan Lv, Wenwen Wang, Canyu Cui, Yiran Bao, Shihui Jiao
Summary: Polydopamine coated hydrogen titanate nanowires (PDA-HTN) were synthesized through dopamine self-polymerization. The obtained PDA-HTN exhibited excellent adsorption properties for methylene blue (MB). The adsorption characteristics of PDA-HTN were investigated in terms of isotherm, kinetics, and thermodynamics. The results showed that PDA-HTN spontaneously adsorbed MB and the adsorption process followed the Langmuir and pseudo-second-order model. Furthermore, PDA-HTN demonstrated outstanding cyclic adsorption property and could also adsorb other cationic dyes such as basic yellow 1 (BY1) and crystal violet (CV) with high adsorption capacities of 586.7 mg g-1 and 865.1 mg g-1, respectively.
APPLIED SURFACE SCIENCE
(2023)
Article
Materials Science, Paper & Wood
Junjie Wang, Jinhao Chen, Wenwen Wang, Jing Lu, Yingying Li, Ting Bai, Jiahui Chen, Zongmin Zhu, Dong Wang
Summary: A new boron-containing chitosan-based compound (HBS) was synthesized and used in combination with ammonium polyphosphate (APP) to improve the flame retardancy of epoxy resin. The modified epoxy composites showed enhanced flame retardant properties, with high LOI value, low heat release rate and smoke production. The addition of HBS and APP also increased the char residue, providing a dense and protective layer on the surface of the epoxy resin.
Correction
Engineering, Environmental
Yingying Li, Yanqiu Wang, Jing Lu, Wenwen Wang, Dong Wang
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Jingxuan Qu, Hongbao Jia, Wenwen Wang, Ying Wang, Shihai Zhu
Summary: A three-layer tri-wavelength broadband antireflective (AR) coating was successfully fabricated on a quartz substrate using acid-catalyzed silica sols via a sol-gel route. Ordered mesoporous SiO2 films were prepared using an ethylene oxide-propylene oxide-ethylene oxide triblock copolymer as a template. The film thickness for each layer was optimized based on the actual optical constants of the three mesoporous silica films using Filmstar thin film design software. The resulting AR coating exhibited high transmittance at 351 nm, 527 nm, and 1053 nm, with values of 99.24%, 99.66%, and 99.64%, respectively. The mesoporous SiO2 films with tough skeletons and different porosity provided good abrasion resistance to the coating. Additionally, the surface of the AR coating was modified using 1H, 1H, 2H, 2H-Perfluorodecyltriethoxysilane to improve its experimental stability. This work provides valuable references for the production of AR coatings using the sol-gel technique.
Article
Pharmacology & Pharmacy
Mingchao Yu, Meidai Liang, Qi An, Wenwen Wang, Baoxi Zhang, Shiying Yang, Jian Zhou, Xiuying Yang, Dezhi Yang, Li Zhang, Guanhua Du, Yang Lu
Summary: This study aimed to develop an effective treatment for diabetes and diabetic complications by using the complementary strategy of drug-drug salt. Multicomponent molecular salts containing metformin (MET) and rhein (RHE) were synthesized, and their structures were analyzed. The evaluation results showed that the salts had similar hygroscopicity with metformin hydrochloride (MET center dot HCl) and the solubility of RHE component increased significantly. The MET-RHE salt exhibited better hypoglycemic activity compared to the individual drugs and physical mixtures. This study provides new possibilities for the treatment of diabetic complications.
Article
Pharmacology & Pharmacy
Qian Ma, Lei Chang, Wenwen Wang, Lingyi Che, Xiaoqin Song, Gailing Li, Ying Zhang, Yibing Chen, Zhuoyu Gu, Xin Ge
Summary: This study investigated the expression and function of LNPEP in the tumor microenvironment of ovarian cancer (OV). High expression of LNPEP was found to be associated with poor prognosis in OV patients. Furthermore, LNPEP was correlated with immune infiltration, immunomodulators, and chemokines. Thus, LNPEP may serve as an important biomarker for predicting prognosis and a potential therapeutic target in OV.
PHARMACOGENOMICS & PERSONALIZED MEDICINE
(2023)
Article
Physics, Multidisciplinary
Zaiwei Fu, Feng Gao, Wenwen Wang, Jingkai Xia
Summary: Two systems were built to study the effect of geomagnetic field on photomultiplier tubes. The dynode structure and orientation of the tubes were found to significantly influence their performance. Various methods, including the use of high-permeability permalloy foil shielding, were proposed and tested to reduce these effects.
FRONTIERS IN PHYSICS
(2023)
Article
Materials Science, Multidisciplinary
Yayun Hu, Jing Lu, Chunliu He, Wenwen Wang, Dong Wang
Summary: In this study, the structure, water dynamic, and antifouling performance of cross-linked APA and APA modified with AESA membranes were investigated using molecular dynamic simulation and density functional theory. The results showed that the hydrophilicity, water flux, and antifouling performance of AESA-APA membrane were improved compared to APA membrane. The protective water shell formed by the strong hydrophilicity of the AESA-APA membrane prevented foulant from entering its interior region. The comprehensive understanding of the sulfonamide-modified APA membrane is beneficial for the development of novel and high-performance APA-based RO membranes.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Aolei Gao, Wenwen Wang, Peng Wang, Hongchao Wu, Chenliang Gong, Aogui Wu, Gongyi Wei, Lei Wang
Summary: A nitrogen-rich rigid PBI binder (PBPBI-3CN) is prepared, which has a functionalized structure, good thermal stability, and good solubility in an environmentally friendly solvent. It can be used to fabricate high-performance MEA in high-temperature proton exchange membrane fuel cells, providing high peak power density, low resistance, and good stability. The protonation, hydrogen bond networks, and platform for proton transfer in the binder are confirmed.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Environmental
Mingqi Xu, Wenwen Wang, Hong Han, Yupu Wei, Jingquan Sha, Guodong Liu
Summary: To enhance the peroxides-like activities of metal sulfides as nanozymes, a Co3S4/MoS2 heterostructure was designed and fabricated, anchored on N-doped porous carbon (NPC). The results showed that Co3S4/MoS2@NPC had improved electron transfer ability and higher affinity to substrates compared to other nanozymes, resulting in enhanced catalytic activity and selectivity.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Fisheries
Wenwen Wang, Qian Xu, Xinbao Liu, Hongning Liu, Zhujun Li, Qingxin Fan, Suxu Tan, Kunpeng Shi, Yanting Xia, Zhenxia Sha
Summary: This study explored the relationship between bacterial concentrations and host mortality, inflammatory reaction, and immune response in half-smooth tongue sole after infection with Vibrio anguillarum. The results indicated that the 24-48 hour period post-infection was a key time node for early detection and intervention of vibriosis. Excessive activation of the complement system and inflammatory reaction may contribute to mass death in fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Wenwen Wang, Zhiyao Zheng, Jianyong Lei
Summary: Liquid biopsy has been shown to play a critical role in the diagnosis, treatment, and prognosis of thyroid cancer. This review focuses on the clinical potential of liquid biopsy, including its role as diagnostic and prognostic biomarkers and its impact on therapy response. The progress of liquid biopsy components in thyroid cancer is also discussed, providing reference for further research in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)