Article
Chemistry, Physical
Lokesh K. Gangwar, Vikash Sharma, Amit Choudhary, Gajjala Sumana, S. S. Pandey, Hirofumi Tanaka, Ashok M. Biradar, Rajesh
Summary: A dielectric biosensor based on a nematic liquid crystal (LC) platform was developed for the detection of human cardiac troponin I (cTnI). The optical and dielectric responses of the biosensor were studied as a function of cTnI concentration. Gold nanoparticles conjugated with detection antibody were used to enhance the signal of the biosensor. The binding of AB-GNP with cTnI caused disturbances in LC alignment and a change in transmission. The dielectric response of the biosensor was fitted with a Hill-Langmuir equation, revealing strong binding affinity between cTnI and the substrate antibody.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Polymer Science
Ruslan Shakurov, Svetlana Sizova, Stepan Dudik, Anna Serkina, Mark Bazhutov, Viktorija Stanaityte, Petr Tulyagin, Valery Konopsky, Elena Alieva, Sergey Sekatskii, Julia Bespyatykh, Dmitry Basmanov
Summary: We propose and demonstrate dendrimer-based coatings that enhance the sorption of small molecules and sensitivity of a label-free biosensor. Our results show that the PAMAM-modified chip has significantly higher sorption efficiency compared to other materials. This dendrimer-based biosensor method has the potential to be an advanced tool for detecting biomolecule interactions.
Article
Engineering, Multidisciplinary
V. R. Balaji, M. A. Ibrar Jahan, T. Sridarshini, S. Geerthana, Arun Thirumurugan, Gopalkrishna Hegde, R. Sitharthan, Shanmuga Sundar Dhanabalan
Summary: In this paper, a novel 2D Photonic Crystal-based cancer biosensor is proposed, which utilizes resonant cavities and machine learning techniques for early and accurate cancer detection. The biosensor has a high-quality factor and sensitivity.
Article
Biophysics
Soaram Kim, Heeju Ryu, Sheldon Tai, Michael Pedowitz, John Robertson Rzasa, Daniel J. Pennachio, Jenifer R. Hajzus, Donald K. Milton, Rachael Myers-Ward, Kevin M. Daniels
Summary: This study reported a rapid detection method for SARS-CoV-2 using a portable sensor, which could detect the virus even at concentrations as low as 60 copies/mL in infected patients. The sensor could detect the S1 spike protein antigen of the virus in seconds, with a low detection concentration, and can distinguish B.1.1.7 variant positive samples with a fast response time.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Haiyang Yu, Zheng Zhao, Bichen Xiao, Minghua Deng, Zhaoliang Wang, Ziqin Li, Huibin Zhang, Lei Zhang, Jingwen Qian, Jinhua Li
Summary: Thrombin detection using solution-gated graphene transistors (SGGTs) with ssDNA aptamers immobilized on the gate electrode achieved high sensitivity, with a limit of detection up to fM. The sensitivity was attributed to the folding of ssDNA induced by thrombin molecules and the electropositivity of thrombin molecules, providing a promising sensing strategy for medical diagnosis.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Jordi Salazar, Miquel-Angel Amer, Antoni Turo, Nagore Castro, Marc Navarro, Sara Soto, Yaiza Gabasa, Yuly Lopez, Juan-Antonio Chavez
Summary: Bacterial biofilms are a major cause of harm related to medical infections and biofouling, accounting for 80% of total infections. Knowledge of biofilm formation stages is crucial to develop effective treatments to prevent their formation in medical implants, tools, and devices. QCM sensors are becoming a good alternative to analytical methods for real-time monitoring of bacterial growth in liquid media culture.
Article
Engineering, Electrical & Electronic
Hameed Miyan, Rajan Agrahari, Sanjay Kumar Gowre, Manpuran Mahto, Pradip Kumar Jain
Summary: A computational study was conducted to design a compact and highly sensitive photonic crystal for early detection of cancer cells. The proposed sensor provided a wide band structure and excellent light confinement, resulting in high sensitivity to refractive index variations. The combination of lattice constant and sensing region radius influenced the biosensor sensitivity. A sensitivity of 15 085 nm/RIU and a Q-factor of 81.58 were achieved, demonstrating a low detection limit and high Figure of Merit (FOM), which could be attributed to label-free biosensing in cancer cell detection and other medical diagnosis applications.
IEEE SENSORS JOURNAL
(2022)
Article
Engineering, Electrical & Electronic
Hameed Miyan, Rajan Agrahari, Sanjay Kumar Gowre, Pradip Kumar Jain, Manpuran Mahto
Summary: A novel approach utilizing 2-D photonic crystal structures is proposed in this article to detect the concentration of virus with different refractive indices in saliva. The proposed hexagonal PC structure consists of air holes in a silicon slab and the PWE method is used to find the PBG. The sensor exhibits a maximum sensitivity of 1206.4 nm/RIU for 100% concentration of virus and a minimum sensitivity of 950.4 nm/RIU for 0% concentration of virus.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Sokhuoy Sam, Siheon Sung, Doseok Kim
Summary: This study investigates the interaction between DPTAP molecules and a biomembrane using sum-frequency vibrational spectroscopy. The results show that the spectrum characteristic of the neat monolayer changes when the molecular area of the DPTAP molecules increases, and the sum-frequency signal reappears when aromatic molecules are introduced, indicating their adhesion and the interaction strength with DPTAP.
Article
Physics, Applied
Tingting Tang, Yujie Tang, Lei Bi, Tongtong Kang, Xiao Liang, Jun Qin, Jie Li, Li Luo, Chaoyang Li
Summary: This study utilizes the photonic spin Hall effect and quantum weak measurement to achieve real-time detection and highly sensitive analysis of the phase transition process of VO2 films. It does not involve mechanical adjustment and provides high measurement resolution and visualization capability.
APPLIED PHYSICS LETTERS
(2022)
Article
Engineering, Electrical & Electronic
Sumit Sharma, Akshay Moudgil, Sanjay Singh, Prashant Mishra, Samaresh Das
Summary: This article demonstrates an ultrasensitive field-effect transistor (FET) for the detection of hydrogen sulfide (H2S) in human blood or plasma. The biosensor utilizes multiple layers of MoSe2 as the channel material and achieves detection of H2S at concentrations as low as 1 μM. With a wide linear dynamic range and low detection limit, this FET device is suitable for quick and real-time detection of H2S in plasma.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Multidisciplinary Sciences
Fan Jiang, Lei Wang, Nana Jin, Jing Yuan, Yanbin Li, Jianhan Lin
Summary: An electrochemical biosensor combining magnetic grid based bacterial separation and enzymatic catalysis based signal amplification was developed for Salmonella detection. The sensor was able to detect 50 CFU/mL Salmonella typhimurium in 1 hour.
Article
Nanoscience & Nanotechnology
Israr Ahmed, Mohamed Elsherif, Seongjun Park, Ali K. Yetisen, Haider Butt
Summary: This study developed rapid, reliable, and reusable alcohol sensors based on hydrogel-based fiber optic probes. The sensors were fabricated using a simple, rapid, and facile process by imprinting Aztec microstructures onto alcohol-sensitive hydrogels. The sensors showed real-time sensing capability towards various concentrations of ethanol, isopropanol, methanol, and dimethyl sulfoxide. The developed optical fiber sensors exhibited fast response time, high sensitivity, and low limit of detection, making them suitable for remote and real-time alcohol sensing in multiple industries.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Physical
Jincheng Tong, Amadou Doumbia, Michael L. Turner, Cinzia Casiraghi
Summary: Real-time monitoring of crystallization events is crucial for understanding molecular dynamics associated with nucleation and crystal growth. Recent observations suggest that molecular assembly during nucleation can range from crystalline to partially ordered to amorphous phases, and can change its structure during the crystallization process. Developing methods with high temporal resolution for real-time monitoring of molecular interactions is of critical importance.
NANOSCALE HORIZONS
(2021)
Article
Biophysics
Monireh Bakhshpour, Elisa Chiodi, Iris Celebi, Yeseren Saylan, Nese Lortlar Unlu, M. Selim Unlu, Adil Denizli
Summary: Given the limitations of traditional detection techniques, innovative research has focused on developing new sensors for label-free, highly sensitive, real-time, low-cost, and rapid detection of biomolecular interactions. In this study, the Interferometric Reflectance Imaging Sensor (IRIS) system is used for real-time and label-free kinetic measurements to detect immunoglobulin G (IgG) in aqueous solutions. The sensor's performance is comprehensively evaluated through kinetic characterization experiments, and a high correlation coefficient (>0.94) is achieved in the IgG concentration range of 1-50 μg/mL with a low detection limit (0.25 μg/mL or 1.67 nM). The highly sensitive imaging system ensures accurate quantification and reliable validation of binding events, presenting new perspectives for direct biomarker detection in clinical applications.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Physical
Won Jin Choi, Gong Cheng, Zhengyu Huang, Shuai Zhang, Theodore B. Norris, Nicholas A. Kotov
Article
Materials Science, Multidisciplinary
Heather George, Jennifer Reed, Manuel Ferdinandus, Clayton DeVault, Alexei Lagutchev, Augustine Urbas, Theodore B. Norris, Vladimir M. Shalaev, Alexandra Boltasseva, Nathaniel Kinsey
OPTICAL MATERIALS EXPRESS
(2019)
Article
Optics
Miao-Bin Lien, Che-Hung Liu, Il Yong Chun, Saiprasad Ravishankar, Hung Nien, Minmin Zhou, Jeffrey A. Fessler, Zhaohui Zhong, Theodore B. Norris
Article
Optics
Nooshin M. Estakhri, Theodore B. Norris
Summary: The ability of phase-change materials to rapidly switch between two stable phases has led to their incorporation in metasurfaces for controlling optical fields. These structures enable the control of nonclassical two-photon quantum interference, with high switching speeds and no static power consumption. The development of compact and rapidly controllable quantum devices is opening up new possibilities in quantum applications and improving quantum logic gates and other systems.
Article
Multidisciplinary Sciences
Dehui Zhang, Zhen Xu, Zhengyu Huang, Audrey Rose Gutierrez, Cameron J. Blocker, Che-Hung Liu, Miao-Bin Lien, Gong Cheng, Zhe Liu, Il Yong Chun, Jeffrey A. Fessler, Zhaohui Zhong, Theodore B. Norris
Summary: In recent years, new approaches to optical imaging have rapidly evolved, with a focus on extracting three-dimensional information from traditionally two-dimensional image capture. The integration of transparent focal stack imaging systems using graphene photodetector arrays with advanced neural networks has enabled real-time 3D optical imaging and object tracking, showcasing promising new frontiers in imaging technology.
NATURE COMMUNICATIONS
(2021)
Article
Physics, Applied
Zhen Xu, Zhe Liu, Dehui Zhang, Zhaohui Zhong, Theodore B. Norris
Summary: The study reveals rapid electron transfer from graphene to MoS2 and non-exponential back transfer of thermalized electrons from MoS2 to graphene layer, indicating that MoS2 states are localized by disorder and interlayer transfer process is dominated by random coupling.
APPLIED PHYSICS LETTERS
(2021)
Article
Optics
Zhengyu Huang, Jeffrey A. Fessler, Theodore B. Norris
Summary: This research proposes the use of a focal stack camera as a novel secure imaging device for localizing modified regions in manipulated images. The results show that applying convolutional neural network detection methods to focal stack images achieves significantly better detection accuracy.
Article
Multidisciplinary Sciences
Dehui Zhang, Zhen Xu, Gong Cheng, Zhe Liu, Audrey Rose Gutierrez, Wenzhe Zang, Theodore B. Norris, Zhaohui Zhong
Summary: In this study, the authors propose a new hybrid photoconductive switch design by engineering a hot-carrier fast lane using graphene on silicon. This design allows for a high-speed photoconductive switch without sacrificing the generated power.
NATURE COMMUNICATIONS
(2022)
Article
Physics, Applied
Yuanpeng Wu, Ping Wang, Woncheol Lee, Anthony Aiello, Parag Deotare, Theodore Norris, Pallab Bhattacharya, Mackillo Kira, Emmanouil Kioupakis, Zetian Mi
Summary: Both 2D TMDs and III-V semiconductors are potential platforms for quantum technology, but each with its limitations. 2D TMDs have a large exciton binding energy and customizable quantum properties, but compatibility issues with existing industrial processes. On the other hand, III-nitrides have been widely used in light-emitting devices and power electronics but lack exploitation of excitonic quantum aspects. Recent advancements in 2D III-nitrides have shown promise in achieving room-temperature quantum technologies.
APPLIED PHYSICS LETTERS
(2023)
Article
Optics
Zhengyu Huang, Jeffrey A. Fessler, Theodore B. Norris
Summary: In this study, the impact of various camera parameters, including aperture size, sensor resolution, and number of sensor planes, on the depth estimation accuracy of focal stack cameras based on transparent sensors was investigated. The deep learning based depth estimation performance was analyzed and compared between focal stack cameras and light field cameras, providing guidelines for future focal stack camera design.
Proceedings Paper
Acoustics
Zhengyu Huang, Jeffrey A. Fessler, Theodore B. Norris, Il Yong Chun
2020 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING
(2020)
Proceedings Paper
Engineering, Electrical & Electronic
Dehui Zhang, Zhen Xu, Gong Cheng, Zhe Liu, Audrey Rose Gutierrez, Theodore B. Norris, Zhaohui Zhong
2020 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO)
(2020)
Proceedings Paper
Engineering, Electrical & Electronic
Zhen Xu, Zhe Liu, Zhaohui Zhong, Theodore B. Norris
2020 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO)
(2020)
Proceedings Paper
Nanoscience & Nanotechnology
Nooshin M. Estakhri, Theodore B. Norris
QUANTUM NANOPHOTONIC MATERIALS, DEVICES, AND SYSTEMS 2019
(2019)
Proceedings Paper
Engineering, Electrical & Electronic
Dehui Zhang, Zhen Xu, Zhengyu Huang, Audrey Rose Gutierrez, Il Yong Chun, Cameron J. Blocker, Gong Cheng, Zhe Liu, Jeffrey A. Fessler, Zhaohui Zhong, Theodore B. Norris
2019 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO)
(2019)